检索结果-南通市图书馆

同方期刊数据库

Erythrodermic mycosis fungoides: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第1期12卷 130-135页

作者： Wu-Bing Xu ya-ping zhang Su-ping Zhou Hao-yang Bai Department of Radiology Shaoxing People’s HospitalKey Laboratory of Functional Molecular Imaging of Tumor and Interventional Diagnosis and Treatment of Shaoxing CityShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Mycosis fungoides is the most common primary cutaneous T-cell lymphoma,whereas generalized erythroderma is *** this report,we describe a case of mycosis fungoides with generalized erythroderma using complete clinical data and[18F]fluoroDglucose positron emission tomography/computed tomography(18F-FDG PET/CT)*** SUMMARY Systemic skin redness with desquamation for three years confirmed mycosis fungoides within one *** patient underwent left axillary lymphadenectomy biopsy;pathological biopsy suggested abnormal T-cell lesions consistent with mycosis fungoides involving lymph *** patient received methotrexate,5 mg twice weekly,as part of their chemotherapy *** January half after discharge,no obvious cause of high fever,left axillary lymph nodes with red heat pain,and rupture entered our hospital for *** The 18F-FDG PET/CT is essential for early diagnosis and timely treatment.

关键词： Mycosis fungoides Positron emission tomography/computed tomography Imaging Diagnosis Differential diagnosis Treatment Case report

A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu Jian Sun Lian Jin Hai-Bing Xie Jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin Zhuang Min-Sheng Peng ya-Jun Guo Wei-Zhu Qian Newton OOtecko Wei-Jie Sun Liang-Hu Qu Jie He Zhao-Li Chen Rong Liu Ce-Shi Chen ya-ping zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

同方期刊数据库

Salivary Fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第30期28卷 4120-4132页

作者： Wen-Dan Chen Xin zhang Meng-Jiao zhang ya-ping zhang Zi-Qi Shang Yi-Wei Xin Yi zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND As one of the most common tumors,gastric cancer(GC)has a high mortality rate,since current examination approaches cannot achieve early *** nucleatum(Fn)primarily colonized in the oral cavity,has been reported to be involved in the development of gastrointestinal *** now,little is known about the relationship between salivary Fn and *** To determine whether salivary Fn could be a biomarker to diagnose GC and explore the influence of Fn on GC *** The abundance of Fn in saliva was quantified by droplet digital polymerase chain reaction in 120 GC patients,31 atrophic gastritis(AG)patients,35 non-AG(NAG)patients,26 gastric polyp(GP)patients,and 20 normal controls(NC)from Qilu Hospital of Shandong University from January 2019 to December *** operating characteristic(ROC)curve analysis was performed to evaluate the diagnostic value of Fn as well as traditional serum tumor markers,including carcinoembryonic antigen(CEA),carbohydrate antigen(CA)19-9,and *** assay and wound-healing assay were conducted to assess the influence of Fn infection on GC *** expression of epithelial-mesenchymal transition(EMT)markers was detected using western blot *** We found that the level of salivary Fn in GC patients was significantly increased compared with those in AG,NAG,and GP patients and NC(P<0.001).ROC curve analysis showed a favorable capability of Fn(73.33% sensitivity;82.14%specificity;area under the curve:0.813)in GC diagnosis,which was superior to that of CEA,CA19-9,CA72-4,ferritin,and sialic *** Fn level in saliva of GC patients was increased as the TNM stage *** patients with lymph node metastasis had higher Fn levels than those without *** transwell and wound-healing assays indicated that Fn infection promoted the migration and invasion of GC *** blot analysis showed that Fn infection decreased the expression of E-cadherin and increased the expressions of

关键词： Gastric cancer Fusobacterium nucleatum Saliva Prognosis Metastasis Epithelialmesenchymal transition

The twin-beginnings of COVID-19 in Asia and Europe—one prevails quickly

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第4期9卷 51-59页

作者： Yongsen Ruan Haijun Wen Mei Hou Ziwen He Xuemei Lu Yongbiao Xue Xionglei He ya-ping zhang Chung-I Wu State Key Laboratory of Biocontrol School of Life SciencesSouthern Marine Science and Engineering Guangdong Laboratory (Zhuhai)Sun Yat-sen University Department of Ecology and Evolution University of Chicago State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Beijing Institute of Genomics Chinese Academy of Sciencesand China National Centre for Bioinformation

In the spread of SARS-C oV-2,there have been multiple waves of replacement between strains,each of which having a distinct set of *** first wave is a group of four mutations(C241 T,C3037 T,C14408 T and A23403 G [this being the amino acid change D614 G];all designated 0 to 1 below).This DG(D614 G) group,fixed at the start of the pandemic,is the foundation of all subsequent waves of ***,the DG group is absent in early Asian samples but present(and likely common) in Europe from the *** data show that the high fitness of DG1111 requires the synergistic effect of all four ***,the European strains would have had no time to evolve the four DG mutations(0 to1),had they come directly from the early Asian DG0000 *** likely,the European DG1111 strain had acquired the highly adaptive DG mutations in pre-pandemic Europe and had been spreading in parallel with the Asian *** recent reports further support this twin-beginning *** was a period of two-way spread between Asia and Europe but,by May 2020,the European strains had supplanted the Asian strains *** large-scale replacement of one set of mutations for another has since been replayed many times as COVID-19 progresses.

关键词： COVID-19 D614G SARS-CoV-2 fitness advantage twin-beginnings

Influence of pressure disturbance wave on dynamic response characteristics of liquid film seal for multiphase pump

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 2048-2065页

作者： Qing-ping Li Jin-ya zhang Jia-Xiang zhang Yong-Xue zhang CNOOC Research Institute Company Limited State Key Laboratory of Natural Gas Hydrate College of Mechanical and Transportation Engineering China University of Petroleum

Slug flow or high GVF(Gas Volume Fraction) conditions can cause pressure disturbance waves and alternating loads at the boundary of mechanical seals for multiphase pumps, endangering the safety of multiphase pump units. The mechanical seal model is simplified by using periodic boundary conditions and numerical calculations are carried out based on the Zwart-Gerber-Belamri cavitation model. UDF(User Define Function) programs such as structural dynamics equations, alternating load equations, and pressure disturbance equations are embedded in numerical calculations, and the dynamic response characteristics of mechanical seal are studied using layered dynamic mesh technology. The results show that when the pressure disturbance occurs at the inlet, as the amplitude and period of the disturbance increase, the film thickness gradually decreases. And the fundamental reason for the hysteresis of the film thickness change is that the pressure in the high-pressure area cannot be restored in a timely manner. The maximum value of leakage and the minimum value of axial velocity are independent of the disturbance period and determined by the disturbance amplitude. The mutual interference between enhanced waves does not have a significant impact on the film thickness, while the front wave in the attenuated wave has a promoting effect on the subsequent film thickness changes, and the fluctuation of the liquid film cavitation rate and axial velocity under the attenuated wave condition deviates from the initial values. Compared with pressure disturbance conditions, alternating load conditions have a more significant impact on film thickness and leakage. During actual operation, it is necessary to avoid alternating load conditions in multiphase pump mechanical seals.

关键词： Multiphase pump Liquid film seal Pressure disturbance wave Dynamic response characteristics

Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2022年第3期42卷 538-547页

作者： Wen-dan CHEN Xin zhang ya-ping zhang Cong-bo YUE yan-lei WANG Hong-wei PAN yan-li zhang Hui LIU Yi zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityJinan 250012China Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Clinical Laboratory Shandong Provincial Third HospitalJinan 250031China

Objective Increasing evidence has indicated that there is a correlation between Fusobacterium nucleatum(***)abundance and poor prognosis of colorectal cancer(CRC).Furthermore,tumor metastasis plays a decisive role in the prognosis of CRC ***,it was hypothesized that the abundance of *** in CRC tissues affects the tumor *** In the present study,*** DNA obtained from 141 resected CRC samples was quantified by qPCR to determine whether there were differences in *** abundance between groups with and without CRC *** The results revealed that *** was more abundant in CRC patients with metastasis,and CRC tissues enriched with *** had a higher risk of lymph node metastasis and distant *** receiver operating characteristic curve indicated that *** in CRC tissues could be used as an indicator for CRC metastasis,to some ***,the in vitro experiments(electron microscopy,and migration and invasion trials)revealed that *** was a highly invasive bacterial strain,and could significantly enhance the invasion and migration capacity of SW480 and SW620 *** addition,a meta-analysis comprehensively indicated a slight correlation between *** abundance and advanced CRC stage(RR=1.17,95%CI:1.00–1.37,P=0.04,random effect).Conclusion There is a correlation between *** abundance and CRC metastasis,and *** may serve as a metastasis biomarker for CRC patients.

关键词： Fusobacterium nucleatum colorectal cancer metastasis

Unveiling the functional and evolutionary landscape of RNA editing in chicken using genomics and transcriptomics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2022年第6期43卷 1011-1022页

作者： Yun-Mei Wang Ling-Qun Ye Ming-Shan Wang Jin-Jin zhang Saber Khederzadeh David M Irwin Xiao-Die Ren ya-ping zhang Dong-Dong Wu State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingYunnan650223China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Department of Ecology and Evolutionary Biology Howard Hughes Medical InstituteUniversity of California Santa CruzSanta CruzCA 95064USA Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada Kunming Natural History Museum of Zoology Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

The evolutionary and functional features of RNA editing are well studied in mammals,cephalopods,and insects,but not in ***,we integrated transcriptomic and whole-genomic analyses to exhaustively characterize the expansive repertoire of adenosine-to-inosine(A-to-I)RNA editing sites(RESs)in the *** addition,we investigated the evolutionary status of the chicken editome as a potential mechanism of *** detected the lowest editing level in the liver of chickens,compared to muscles in humans,and found higher editing activity and specificity in the brain than in non-neural tissues,consistent with the brain’s functional *** a certain extent,specific editing activity may account for the specific functions of *** results also revealed that sequences critical to RES secondary structures remained conserved within avian ***,the RNA editome was shaped by purifying selection during chicken domestication and most RESs may have served as a selection pool for a few functional RESs involved in chicken domestication,including evolution of nervous and immune *** of RNA editing in chickens by adenosine deaminase acting on RNA(ADAR)enzymes may be affected by non-ADAR factors whose expression levels changed widely after ADAR ***,we provide comprehensive lists of candidate RESs and non-ADAR-editing regulators in the chicken,thus contributing to our current understanding of the functions and evolution of RNA editing in animals.

关键词： RNA editing Transcriptomics Population genomics Domestication Evolution Chicken

Strong-coupling superconductivity with Tc above 70 K in Be-decorated monolayer T-graphene

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 99-105页

作者： Liu yang Peng-Fei Liu Hao-Dong Liu ya-ping Li Na Jiao Hong-yan Lu Bao-Tian Wang ping zhang School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Using first-principles calculations,we predict a new type of two-dimensional(2D)beryllium(Be)-decorated T-graphene named BeC_(2),where Be atoms are inserted into C–C bonds linking the carbon tetrarings of *** band structure shows that BeC_(2)is metallic,thus,the possible phonon-mediated superconductivity is explored based on the Eliashberg *** calculated electron-phonon coupling(EPC)constantλis up to 4.07,and the corresponding superconducting critical temperature(Tc)is 72.1 K,approaching the liquid nitrogen *** reason for the high Tc is the strong *** it is proved to be an anisotropic single-gap superconductor by analyzing the superconducting gap?kof BeC_(2).The electronic susceptibility calculation shows strong nesting effect in BeC_(2).Since rare 2D superconductors show such a strong EPC constantλwhich originates from the coupling between electrons in C-pzorbital and in-plane vibrations of Be and C atoms,the predicted BeC_(2)provides a new platform for investigating strong EPC 2D superconductor.

关键词： two-dimensional carbon-based superconductor electron-phonon coupling strong coupling high superconducting critical temperature

Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lower Ordovician in Tazhong area of Tarim Basin

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 115-124页

作者： Wen-yang Wang Xiong-Qi Pang ya-ping Wang zhang-Xin Chen Fu-Jie Jiang Ying Chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship between the ratio of drilling to the dry layer and the *** this study,by establishing the relationships between the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships between the depth and dry layer ratio were obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lower Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model