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A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath

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当代医学科学（英文） 2024年第4期44卷 827-832页

作者： Hong-yu WU Ban LUO Gang YUAN Qiu-xia WANG Ping liU ya-li zhao lin-han ZHAI Wen-zhi LV Jing ZHANG Lang CHEN Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Imaging Guangdong Second Provincial General HospitalGuangzhou 510317China Department of Radiology Sir Run Run Shaw Hospital Affiliated with the School of Medicine of Zhejiang UniversityHangzhou 310000China Department of Artificial Intelligence Julei Technology CompanyWuhan 430030China

Objective:This study aimed to develop and test a model for predicting dysthyroid optic neuropathy(DON)based on clinical factors and imaging markers of the optic nerve and cerebrospinal fluid(CSF)in the optic nerve ***:This retrospective study included patients with thyroid-associated ophthalmopathy(TAO)without DON and patients with TAO accompanied by DON at our *** imaging markers of the optic nerve and CSF in the optic nerve sheath were measured on the water-fat images of each patient and,together with clinical factors,were screened by Least absolute shrinkage and selection ***,we constructed a prediction model using multivariate logistic *** accuracy of the model was verified using receiver operating characteristic curve ***:In total,80 orbits from 44 DON patients and 90 orbits from 45 TAO patients were included in our *** variables(optic nerve subarachnoid space and the volume of the CSF in the optic nerve sheath)were found to be independent predictive factors and were included in the prediction *** the development cohort,the mean area under the curve(AUC)was 0.994,with a sensitivity of 0.944,specificity of 0.967,and accuracy of ***,in the validation cohort,the AUC was 0.960,the sensitivity was 0.889,the specificity was 0.893,and the accuracy was ***:A combined model was developed using imaging data of the optic nerve and CSF in the optic nerve sheath,serving as a noninvasive potential tool to predict DON.

关键词： dysthyroid optic neuropathy magnetic resonance imaging optic nerve optic nerve subarachnoid space water-fat sequence

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A meta-analysis of association between acne vulgaris and Demodex infestation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 192-202页

作者： ya-e zhao li HU li-ping WU Jun-xian MA Department of Immunology and Pathogen Biology Xi ＇an Jiaotong University College of Medicine Xi ＇an 710061 China

Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDliNE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants in-cluding students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34-3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.

关键词： Demodex infestation Acne vulgaris Case-control study Meta-analysis

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Psychological reactions of healthcare workers deployed to Wuhan from Shanxi province and how they cope during coronavirus disease 2019(COVID-19)outbreak

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Chinese Medical Journal 2021年第5期134卷 587-589页

作者： li-Na Dong ya-li zhao Yi liu Yu-Zhi Wu Jun-Ping Wang Central Laboratory Shanxi Provincial People's Hospital Affiliated to Shanxi Medical UniversityTaiyuanShanxi 030012China Health Commission of Shanxi Province TaiyuanShanxi 030013China Department of Neurology Shanxi Provincial People's Hospital Affiliated to Shanxi Medical UniversityTaiyuanShanxi 030012China Department of Pulmonary and Critical Care Medicine Shanxi Provincial People's Hospital Affiliated to Shanxi Medical UniversityTaiyuanShanxi 030012China Department of Gastroenterology Shanxi Provincial People's Hospital Affiliated to Shanxi Medical UniversityShanxi Provincial Clinical Research Center for Digestive DiseasesTaiyuanShanxi 030012China

To the Editor:Since the outbreak of coronavirus disease 2019(COVID-19),a large number of healthcare workers(HCWs)volunteered to leave their familiar working and living environments to travel to Hubei province to undertake emergency response *** most medical workers who traveled to Hubei province,this was their first time participating in such a crisis *** studies have reported that HCWs face a double blow of high-intensity work and high psychological pressure,making them particularly prone to mental health difficulties.

关键词： workers travel province

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Purification Technology and Antimicrobial Activity Analysis of Antimicrobial Peptide from Ovotransferrin

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Chemical Research in Chinese Universities 2011年第3期27卷 361-365页

作者： ZHANG Tie-hua ZHENG Jian YE Hai-qing YU ya-li zhao Ping liU Jing-bo College of light Industry and Economics ＆ Management Jilin University Changchun 130062 P. R. China

Antibacterial peptides mixture purified from Ovotransferrin by pepsin digest was used as the raw material. Peptide sections with good antibacterial activity were determined after bacteriostasis experiments, its molecular weight and amino acid composition were analyzed. The results of experiments indicate that with Sephadex G-50 and distilled water as mobile phase, detection wavelength 220 nm, flow rate 1.5 mL/min, sample density 0.2 g/mL, and volume 0.2 mL are the optimal conditions. Bacteriostasis experiments of the fraction of purified peaks were carried out and the result was： peak 1peak 3peak 2; the molecular weight of peak 1 was about 3015 by high performance liquid chromatography; active peptide possessed positive charges by amino acid analysis, its cationic characteristics are in accordance with the nature of antimicrobial peptides.

关键词： Ovotransferrin Purification Molecular weight Amino acid

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FHL2 Antagonizes Id1-Promoted Proliferation and Invasive Capacity of Human MCF-7 Breast Cancer Cells

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Chinese Journal of Cancer Research 2010年第3期22卷 194-200页

作者： Wei-dong Han Zhi-qiang Wu ya-li zhao Yi-ling Si Ming-zhou Guo Xiao-bing Fu Department of Molecular Biology Institute of Basic Medicine Department of Gastroenteropathy Chinese PLA General Hospital Beijing 100853 China

Objective：FHL2 was previously identified to be a novel interacting factor of Id family *** aim of this study was to investigate,the effects of FHL2 on Id1-mediated transcriptional regulation activity and its oncogenic activity in human breast cancer ***：Cell transfection was performed by Superfect ***1 stably overexpressed MCF-7 cells was cloned by G418 *** protein level of Id1 was detected by western blot *** relative luciferase assays were used to measure the effect of E47-mediated transcriptional activity in MCF-7 human breast cancer *** assay was used to measure cell *** assay was used to measure the invasive capacity of MCF-7 cancer ***：The basic helix-loop-helix（bHLH） factor E47-mediated transcription activity was markedly repressed by Id1 in MCF-7 *** Id1-mediated repression was effectively antagonized by FHL2 *** of Id1 markedly promoted the proliferation rate and invasive capacity of MCF-7 cells;however,these effects induced by Id1 were significantly suppressed by overexpression of FHL2 in ***：FHL2 can inhibit the proliferation and invasiveness of human breast cancer cells by repressing the functional activity of *** findings provide the basis for further investigating the functional roles of FHL2-Id1 signaling in the carcinogenesis and development of human breast cancer.

关键词： FHL2 Id1 Repressor MCF-7 Proliferation Invasiveness

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Radiomics for predicting perineural invasion status in rectal cancer

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World Journal of Gastroenterology 2021年第33期27卷 5610-5621页

作者： Mou li Yu-Mei Jin Yong-Chang Zhang ya-li zhao Chen-Cui Huang Sheng-Mei liu Bin Song Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Chengdu Seventh People’s HospitalChengdu 610213Sichuan ProvinceChina Department of Research Collaboration R&D CenterBeijing Deepwise&League of PHD Technology Co.LtdBeijing 100080China

BACKGROUND Perineural invasion(PNI),as a key pathological feature of tumor spread,has emerged as an independent prognostic factor in patients with rectal cancer(RC).The preoperative stratification of RC patients according to PNI status is beneficial for individualized treatment and improved ***,the preoperative evaluation of PNI status is still *** To establish a radiomics model for evaluating PNI status preoperatively in RC *** This retrospective study enrolled 303 RC patients in a single institution from March 2018 to October *** patients were classified as the training cohort(n=242)and validation cohort(n=61)at a ratio of 8:2.A large number of intraand peritumoral radiomics features were extracted from portal venous phase images of computed tomography(CT).After deleting redundant features,we tested different feature selection(n=6)and machine-learning(n=14)methods to form 84 *** best performing classifier was then selected to establish ***,the clinicoradiological model(combined model)was developed by combining Rad-score with clinical *** models for predicting PNI were compared using receiver operating characteristic curve(ROC)analysis and area under the ROC curve(AUC).RESULTS One hundred and forty-four of the 303 patients were eventually found to be *** factors including CT-reported T stage(cT),N stage(cN),and carcinoembryonic antigen(CEA)level were independent risk factors for predicting PNI *** established Rad-score by logistic regression analysis after selecting features with the L1-based *** combined model was developed by combining Rad-score with cT,cN,and *** combined model showed good performance to predict PNI status,with an AUC of 0.828[95%confidence interval(CI):0.774-0.873]in the training cohort and 0.801(95%CI:0.679-0.892)in the validation *** comparison of the models,the combined model achieved a higher AUC than the clinic

关键词： Radiomics Perineural invasion Rectal cancer Computed tomography Preoperative prediction Model building

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Numerical simulation study on the mold strength of magnetic mold casting based on a coupled electromagnetic-structural method

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China Foundry 2024年第5期21卷 577-587页

作者： Wei-li Peng Jian-hua zhao Cheng Gu ya-jun Wang College of Materials Science and Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China

The properties of the magnetic mold in magnetic mold casting directly determine the quality of the final cast *** this study,the magnetic mold properties in magnetic mold casting,were studied utilizing a coupled electromagnetic-structural method through numerical *** study investigated key factors including equivalent stress,the distribution of tensile and compressive stresses,and the area ratio of tensile *** compared molds made entirely of magnetic materials with those made partially of magnetic *** results indicate that as current increases from 4 A to 8 A,both the initial magnetic mold and the material-replaced magnetic mold initially show an increasing trend in equivalent stress,tensile-compressive stress,and the area ratio of tensile stress,peaking at 6 A before *** material replacement,the area ratio of tensile stress at 6 A decreases to 19.84%,representing a reduction of 29.72%.Magnetic molds comprising a combination of magnetic and non-magnetic materials exhibit sufficient strength and a reduced area ratio of tensile stress compared to those made entirely from magnetic *** study provides valuable insights for optimizing magnetic mold casting processes and offers practical guidance for advancing the application of magnetic molds.

关键词： magnetic mold casting coupled electromagnetic-structural method numerical simulation stress analysis

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Novel self-assembled porous yolk-shell NiO nanospheres with excellent electrochromic performance for smart windows

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Particuology 2024年第1期84卷 72-80页

作者： Baoshun Wang ya Huang Siming zhao Run li Di Gao Hairong Jiang Rufan Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing100084China

With the rapid development of optoelectronics,electrochromic(EC)materials(ECMs)with the advan-tages of low power consumption,easy viewing,high contrast ratio,etc have attached more and more attention from the fields of smart windows,electronic billboards,emerging wearable and portable electronics,and other next-generation *** oxide(NiO)is a promising candidate for high-performance ECMs because of its neutral-colored states and low ***,NiO-based ECMs still face the problem of slow switching speed due to their low electrical conductivity and small lattice ***-organic frameworks(MOFs)are promising candidates to fabricate hollow and porous transition metal oxides(TMOs)with high ion transport efficiency,excellent specific capacitance,and electrochemical *** this work,porous yolk-shell NiO nanospheres(PYS-NiO NSs)were syn-thesized via a solvothermal and subsequent calcination process of Ni-MOF,which exhibited outstanding EC *** the large specific surface areas and hollow porous nanostructures were conducive to ionic transport,PYS-NiO NSs exhibited a fast coloring/bleaching speed(3.6/3.9 s per one coloring/bleaching cycle)and excellent cycling stability(82%of capacity retention after 3000 cycles).These superior EC properties indicated that the PYS-NiO NSs was a promising candidate for high-performance EC *** work provides a new and feasible strategy for the efficient preparation of TMOs ECMs with good EC performance,especially fast switching speed.

关键词： Electrochromic Nickel oxide Metal-organic frameworks Hollow structure Smart windows

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Herbal medicines and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第30期22卷 6890-6905页

作者： Hong yao Yu-Jie Qiao ya-li zhao Xu-Feng Tao li-Na Xu lian-Hong Yin yan Qi Jin-Yong Peng College of Pharmacy Dalian Medical University Dalian 116044 Liaoning Province China

Nonalcoholic fatty liver disease(NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines(including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future.

关键词： Herbal medicines Nonalcoholic fatty liver disease Natural product Traditional Chinese medicines Review

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Prevalence of musculoskeletal symptoms among industrial employees in a modern industrial region in Beijing,China

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Chinese Medical Journal 2019年第7期132卷 789-797页

作者： Ting Wang ya-li zhao li-Xiao Hao Jian-Guo Jia Department of General Practice The School of General Practice and Continuing EducationCapital Medical UniversityBeijing 100069China Department of General Medicine Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China

Background:Growing industrialization of China exposes its labor population to the risk of musculoskeletal disorders(MSDs).This study aimed to investigate the prevalence and risk factors of MSDs in a modern industrial region of ***:A cross-sectional study included 1415 employees in six industrial companies was conducted between January 2018 and May 2018 in Fangshan district,Beijng,*** Musculoskeletal Questionnaire(NMQ)was used to collect the information about *** factors,lifestyle factors,health and medical factors,and work-related factors were collected as independent *** statistics,the chi-squared(/2)test,and binary logistic regression analysis were used to analyze ***:Among 1415 participants,498 reported *** regions involved were the neck(25.16%),shoulders(17.17%),and upper back(13.29%).There was a significant statistical difference between frontline industrial workers and other staff in the prevalence of self-reported symptoms involving the shoulders(Х^2=4.33,P=0.037),wrists and hands(Х^2=8.90,P=0.003),and ankles and feet(Х^2=12.88,Plimited access to health information(P=0.004,OR=0.49),and negative attitude towards seeking healthcare(P=0.010,OR=1.77;P=0.009,OR=2.75)were associated with MSDs in frontline *** gender(Plimited access to health information(P=0.013,OR=0.53),far distance to medical institution(P=0.009,OR=1.83),and negative propensity(P=0.009,OR=1.94;P=0.014,OR=2.74)were associated with MSDs in other ***:The prevalence of MSDs

关键词： Cross-sectional study Musculoskeletal disorders Occupational injuries Epidemiology

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