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Fixed-Time Anti-Disturbance Average-Tracking for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第3期37卷 985-1002页

作者： LI Yuling liu Chenglin ZHANG ya CHEN yangyang Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuci 214122China School of Automation Southeast UniversityNanjing 210096China

In this paper,the authors tackle a fixed-time average-tracking problem for multi-agent systems which do not require velocity measurements and are affected by external mismatched and matched *** objective requires the considered agents with second-order dynamics to follow the average value of several time-varying reference signals,each of which is acquired by only one *** of all,the average value is estimated by using a novel distributed average estimator in a fixed ***,an original observer is created to provide estimated values in a fixed time for external mismatched and matched disturbances as well as unmeasured velocities of ***,the authors propose a novel fixed-time anti-disturbance average-tracking protocol with the aid of the observer and a sliding mode *** the end,the feasibility of theoretical analysis is illustrated by some simulation experiments.

关键词： Average-tracking control fixed-time algorithm fixed-time observer mismatched distur-bances multi-agent systems velocity measurements

Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 495-501页

作者： jun-jun Jia ya-Fen Cheng Mei-Bao Feng Li liu Ming-Qi Shuai Xiao-Dong Shen Xiao-Feng Tang Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of International Healthcare Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Library the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Biliary mucinous cystic neoplasms(BMCNs) are rare hepatobiliary cystic tumors, which can be divided into noninvasive and invasive types. This study aimed to investigate the diagnosis, treatment, and prognosis of BMCNs in a large single center. Methods: We analyzed 49 patients with BMCNs confirmed by postoperative pathology at the First Afflliated Hospital, Zhejiang University School of Medicine between January 2007 and December 2021. Results: Among the 49 patients, 37 were female(75.5%), and the average age was 57.04 years. Common symptoms included abdominal discomfort, jaundice and fever, while 22 patients(44.9%) had no symptoms. Serum carbohydrate antigen(CA) 19-9 and CA125 concentrations were elevated in 34.8% and 19.6% of patients, respectively. Forty-eight patients had tumors in the intrahepatic bile ducts and only one had a tumor in the extrahepatic bile duct. Forty-eight patients with noninvasive intrahepatic BMCNs were further analyzed in terms of pathological features: 34(70.8%) had low-grade intraepithelial neoplasms(LGINs), and 14(29.2%) had high-grade intraepithelial neoplasms(HGINs). The potential immunohistochemical markers of BMCNs were cytokeratin(CK) 19, CK7, estrogen receptor and progesterone receptor. Follow-up data for 37 patients with intrahepatic BMCNs were obtained. The median overall survival(OS) of BMCNs was not reached. The longest survival time was 137 *** 5-and 10-year OS rates were 100% and 85.4%, respectively. The 5-and 10-year recurrence-free survival(RFS) rates were 93.9% and 80.2%, respectively. Conclusions: BMCNs are rare cystic neoplasms that commonly occur in middle-aged females. BMCNs can only be diagnosed and classified by postoperative pathology, as there are no specific clinical presentations, serological indicators or imaging modalities for preoperative diagnosis. Complete surgical resection is necessary for BMCNs, and the postoperative prognosis is favorable.

关键词： Biliary mucinous cystic neoplasms Low-grade intraepithelial neoplasms High-grade intraepithelial neoplasms Overall survival Recurrence-free survival

Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

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Food Science and Human Wellness 2024年第1期13卷 225-240页

作者： Linzi Li Xueying Lei Lin Chen ya Ma jun Luo Xuebo liu Xinglian Xu Guanghong Zhou Xianchao Feng College of Food Science and Engineering Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Synergetic Innovation Center of Food Safety and Nutrition Key Laboratory of Meat Processing and Quality ControlMinistry of EducationCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological *** exposure to acrylamide(AA)can cause liver injury and endanger human ***,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not ***,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in *** vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated *** vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced ***,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant *** conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.

关键词： Quercetin compounds Acrylamide Protection mechanism Oxidative stress Antioxidant activity

Posterior Reduction and Monosegmental Fusion with Intraoperative Three-dimensional Navigation System in the Treatment of High-grade Developmental Spondylolisthesis

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Chinese Medical Journal 2015年第7期128卷 865-870页

作者： Wei Tian Xiao-Guang Han Bo liu ya-jun liu Da He Qiang Yuan Yun-Feng Xu Department of Spine Surgery Beijing Jishuitan Hospital Beijing 100035 China

Background： The treatment of high-grade developmental spondylolisthesis （HGDS） is still challenging and controversial. In this study, we investigated the efficacy of the posterior reduction and monosegmental fusion assisted by intraoperative three-dimensional （3D） navigation system in managing the HGDS. Methods： Thirteen consecutive HGDS patients were treated with posterior decompression, reduction and monosegmental fusion ofL5/S1, assisted by intraoperative 3D navigation system. The clinical and radiographic outcomes were evaluated, with a minimum follow-up of 2 years. The differences between the pre- and post-operative measures were statistically analyzed using a two-tailed, paired t-test. Results： At most recent follow-up, 12 patients were pain-free. Only l patient had moderate pain, There were no permanent neurological complications or pseudarthrosis. The magnetic resonance imaging showed that there was no obvious disc degeneration in the adjacent segment. All radiographic parameters were improved. Mean slippage improved from 63.2% before surgery to 12.2% after surgery and 11.0% at latest follow-up. Lumbar lordosis changed from preoperative 34.9 ± 13.3° to postoperative 50.4 ±9.9°, and 49.3 ± 7.8° at last follow-up. L5 incidence improved from 71.0 ± 11.3° to 54.0 ± 1 1.9° and did not change significantly at the last follow-up 53.±1 15.4°. While pelvic incidence remained unchanged, sacral slip significantly decreased from preoperative 32.7± 12.5° to postoperative 42.6 ± 9.8°and remained constant to the last follow-up 44.4 ± 6.9°. Pelvic tilt significantly decreased from 38.4±12.5° to 30.9± 8.1° and remained unchanged at the last fbllow-up 28.1± 11.2°. Conclusions： Posterior reduction and monosegmental fusion of L5/S1 assisted by intraoperative 3D navigation are an effective technique for managing high-grade dysplastic spondylolisthesis. A complete reduction of local deformity and excellent correction of overall sagittal balance can be achieved.

关键词： High-grade Developmental Spondylolisthesis Intraoperative Three-dimensional Navigation Neurological Complication Reduction: Spondylolisthesis

The Proton-Coupled Electron Transfer Reaction of Lumiflavin with Oxygen: Revealing the Oxygenation Mechanism in Bacterial Bioluminescence

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The Proton-Coupled Electron Transfer Reaction of Lumiflavin ...

Robust textile-based spoof plasmonic frequency scanning antenna for on-body IoT applications

第十三届全国量子化学会议

作者： yanling Luo ya-jun liu Key Laboratory of Theoretical and Computational Photochemistry Ministry of Education College of ChemistryBeijing Normal University

Flavoproteins are kinds of proteins containing flavins as a prosthetic group, which play vital roles in a wide array of biological pr *** can be divided into oxidases and monooxygenases based on their reactivity with oxygen and the corresponding products. The bacterial luciferase is a peculiar flavoprotein monooxygenase involving the amazing bioluminescence phenomenon. The entire bacterial bioluminescence process is initiated by the oxygenation reaction of reduced flavin mononucleotide(FMNH2) in the luciferase. Furthermore,the oxidation of reduced flavin by oxygen is one of the most fascinating reactions in biochemist ry. To interpret the spin-forbidden oxygenation reaction and provide clues for bacterial bioluminescence mechanism, the reaction of lumiflavin with oxygen was studied under vacuum. The results reveal that the oxygenation carries out in accordance with the proton-coupled electron transfer mechanism.

关键词： Oxygenation Flavin Bacterial bioluminescence

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Science China(Information Sciences) 2024年第8期67卷 269-284页

作者： Zhao-Min CHEN jun-Lin ZHAN Hao CHEN ya LI Hongjun HE Wu yaNG Zhen-Guo liu Wei-Bing LU State Key Lab of Millimeter Waves School of Information Science and EngineeringSoutheast University Center for Flexible RF Technology Frontiers Science Center for Mobile Information Communication and SecuritySoutheast University Future Research Laboratory China Mobile Research Institute Purple Mountain Laboratories

Securing a comfortable, wearable compact frequency beam scanning antenna(FBSA) with robustness to deformation, low specific absorption rate(SAR), and good coverage of the surrounding environment for Internet of Things(IoT) applications, such as on-body navigation and wireless communication is an emerging challenge. In this work, a robust textile-based spoof plasmonic frequency scanning antenna utilizing higher-order modes is presented, which is also robust to deformation caused by the activities of the human body. The innovative design of the element ensures the high-efficiency transmission of the fundamental mode of spoof surface plasmon polaritons(SSPP) structure, providing the potential of being a multifunctional composite device in the compact on-body network. Besides, an artificial magnetic conductor(AMC) is designed underneath the SSPP structure, obtaining a low SAR value(0.113 W/kg), which ensures the safety of users. As a practical realization of this concept, a textile-based spoof plasmonic antenna was fabricated in the microwave regime and the performed experimental results show the proposed antenna has a single-beam radiation characteristic with a 70° beam scanning angle range when the frequency is 4.7–6.0 GHz with a high average realized gain of 13.15 dBi. And it still maintains a steady performance when faced with structure deformation, which proves its robustness. Wireless communication quality experiments are performed to demonstrate the proposed antenna can measure the angles of targets and realize wireless signal transmission to specific targets as the frequency varies, it may find great potential in the field of on-body IoT applications.

关键词： frequency beam scanning antenna (FBSA) Internet of Things (IoT) on-body communication spoof surface plasmon polaritons (SSPP) textile-based antenna

Theoretical Studies on the Influence of Substituents on the Fluorescence of the Coelenteramide

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Theoretical Studies on the Influence of Substituents on the ...

Solution-processed rare-earth thulium oxide with high permittivity for low-voltage transistor and inverters applications

第十三届全国量子化学会议

作者： Meng Gao ya-jun liu Key Laboratory of Theoretical and Computational Photochemistry Ministry of Education College of ChemistryBeijing Normal University

Coelenterazine(CTZ) is a widespread light-emitting subst rate found in marine bioluminescent organisms. In order to expand the biological application for real-time non-invasive visualization of intracellular calcium concentration dynamics in cel ls and whole organisms, numerous coelenterazine analogues with modification of the substitution at the C,C, C and C positions of the imidazopyrazinone core are summarized as luminescent substrates. Ca-discharged obelin is a known fluorescent protein including coelenteramide(CTD), which is produced from the bioluminescence of CTZ. The photoluminescence of CTD gives green light. The fluorescence of CTD with different substitutions has been comprehensively investigated in gas, solvent, and protein environment by the time-dependent density functional theory and the hybrid quantum mechanics/molecular mechanics(QM/MM) method. Key geometrical parameters, different protonation states, and substituent effects are considered.

关键词： Coeleterazine Coeleteramide Fluorescence

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Journal of Rare Earths 2024年第8期42卷 1604-1609,I0007页

作者： Daiming liu Fei Wang Yongtao Zhang ya'nan Ding Shandong Engineering Laboratory for Preparation and Application of High-performance Carbon-Materials College of Electromechanical EngineeringQingdao University of Science&TechnologyQingdao266061China College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao266590China

The use of high-permittivity(high-k) thin films as gate dielectrics is essential in the development of lowpower electronics,In this work,rare-earth thulium oxide(Tm_(2)O_(3)) thin films were prepared by a facile solution process and annealed at various temperatures from 400 to 700℃.The evolution of the physical and dielectric properties of Tm_(2)O_(3) thin film with annealing temperature was *** is demonstrated that the Tm_(2)O_(3) thin film annealed at 600℃ exhibits the optimal performance,including a low leakage current of 3×10^(-10) A/cm^(2),a large areal capacitance of 250 nF/cm^(2) at 100 Hz,and a high permittivity value of *** Tm_(2)O_(3) thin film as a gate insulator was integrated into the thin film transistor(TFT) employing In_(2)O_(3)-based semiconducting *** In_(2)O_(3) TFT with 600℃-annealed Tm_(2)O_(3) dielectric exhibits the superior perfo rmance,with a high I_(on)/I_(off) of 1.65×10^(7),a small subthre shold swing(SS) value of 0.2 V/dec,a V_(TH) of+1.8 V,and a mobility of 1.68 cm^(2)/(V·s).Furthermore,an inverter constructed by connecting the TFT with a resistor exhibits full-swing *** work provides a facile and appealing method for preparing the high-k Tm_(2)O_(3) thin films as alternative gate dielectrics with the potential for use in low-power electronics and logic circuit applications.

关键词： Rare earths Tm_(2)O_(3) Dielectric Transistor Inverter

Time-history performance optimization of flapping wing motion using a deep learning based prediction model

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Chinese Journal of Aeronautics 2024年第5期37卷 317-331页

作者： Tianqi WANG liu liu jun LI Lifang ZENG School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310027China Huanjiang Laboratory Zhuji 311800China

Flapping Wing Micro Aerial Vehicles(FWMAVs)have caused great concern in various fields because of their high efficiency and *** wing motion is a very important factor that affects the performance of the aircraft,and previous works have always focused on the time-averaged performance ***,the time-history performance is equally important in the design of motion mechanism and flight control *** this paper,a time-history performance optimization framework based on deep learning and multi-island genetic algorithm is presented,which is designed in order to obtain the optimal two-dimensional flapping wing ***,the training dataset for deep learning neural network is constructed based on a validated computational fluid dynamics *** aerodynamic surrogate model for flapping wing is obtained after the convergence of *** surrogate model is tested and proved to be able to accurately and quickly predict the time-history curves of lift,thrust and ***,the optimization framework is used to optimize the flapping wing motion in two specific cases,in which the optimized propulsive efficiencies have been improved by over 40%compared with the ***,a dimensionless parameter C_(variation)is proposed to describe the variation of the time-history characteristics,and it is found that C_(variation)of lift varies significantly even under close time-averaged *** the importance of time-history performance in practical applications,the optimization that integrates the propulsion efficiency as well as C_(variation)is carried *** final optimal flapping wing motion balances good time-averaged and time-history performance.

关键词： FWMAV Flapping wing motion Deep learning Unsteady aerodynamic performance Optimization Time-history curve