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Chinese Medical Journal 2017年第8期130卷 993-996页

作者： ya-guang peng Xiao-Lu Nie Jing-Jing Feng Xiao-Xia peng Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children's Hospital Capital Medical University Beijing 100045 China Key Laboratory of Major Diseases in Children Ministry of Education Beijing 100045 China Center for Medical Safety and Risk Administration National Institute of Hospital Administration Beijing 100091 China

Different from trials for regulatory approvals of new interventions aimed to test the efficacy, comparative effectiveness research （CER） is the direct comparison of existing health-care interventions （compared with... 详细信息

关键词： Comparative Effectiveness Research Postrandomization Confounding Randomized Clinical Trials

Age-dependent changes of total and differential white blood cell counts in children

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Chinese Medical Journal 2020年第16期133卷 1900-1907页

作者： Kun Li ya-guang peng Ruo-Hua yan Wen-Qi Song Xiao-Xia peng Xin Ni Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children HealthBeijing 100045China Department of Epidemiology and Health Statistics School of Public HealthCapital Medical UniversityBeijing 100069China Department of Clinical Laboratory Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children HealthBeijing 100045China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and NeckSurgeryBeijing Children’s HospitalCapital Medical UniversityNational Center for Children HealthBeijing 100045China

Background:Total and differential white blood cell counts are important for the diagnostic evaluation of suspected *** facilitate the interpretation of total and differential white blood cell counts in pediatric patients,the present study investigated agedependent changes in total and differential white blood cell counts in healthy reference ***:Data were obtained from the Pediatric Reference Intervals in China study(PRINCE),which aims to establish and verify pediatric reference intervals for Chinese children based on a nationwide multicenter cross-sectional study from January 2017 to December *** curves were calculated using the generalized additive models for location,shape,and scale *** 2.5th,50th,and 97.5th quantile curves were calculated for both total and differential white blood *** of stacked area charts were used to demonstrate the proportions of differential white blood *** statistical analyses were performed using R ***:Both 50th and 97.5th quantiles of total white blood cell count and monocyte count were highest at birth,then rapidly decreased in the first 6 months of life;relatively slow reduction continued until 2 years of *** lymphocyte count was low during infancy and increased to its highest level at 6 months of age;it then exhibited moderate and continuous reduction until approximately 9 years of *** pattern of neutrophil count changed with age in a manner opposite to that of lymphocyte ***,there were two inter-sections of lymphocyte count and neutrophil count during infancy and at approximately 5 years of age,based on locally weighted regression(LOESS)*** were no apparent age-related changes in eosinophil or basophil ***:These data regarding age-related changes in total and differential white blood cell counts can be used to assess the health of pediatric patients and guide clinical decisions.

关键词： Leukocyte count Trends Pediatrics Development Growth

Cosinor-rhythmometry for 24-h urinary sodium,potassium,creatinine excretion in the Chinese adult population

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Chinese Medical Journal 2021年第5期134卷 539-545页

作者： ya-guang peng Jing-Jing Feng Ying Zhang Kun Li Si-Yu Cai Ruo-Hua yan Xiao-Xia peng Center for Clinical Epidemiology&Evidence-based Medicine National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China department of Nursing Administration and Rehabilitation Research National Institute of Hospital AdministrationBeijing 100044China Department of Diseases Prevention and Control Third HospitalPeking UniversityBeijing 100191China Center for Endocrine Metabolism and Immune Diseases Beijing Luhe HospitalCapital Medical UniversityBeijing 101149China

Background:The low accuracy of equations predicting 24-h urinary sodium excretion using a single spot urine sample contributed to the misclassification of individual sodium intake *** application of single spot urine sample is limited by a lack of representativity of urinary sodium excretion,possibly due to the circadian rhythm in urinary *** study aimed to explore the circadian rhythm,characteristics,and parameters in a healthy young adult Chinese population as a theoretical foundation for developing new ***:Eighty-five participants(mean age 32.4 years)completed the 24-h urine ollction by sccessively cllecing each of the single-voided specimens within 24 *** concentrations of the urinary sodium,potassium,and creatinine for cach voided specimen were *** analysis was applied to explore the circadian rhythm of the urinary sodium,potassium,and creatinine *** excretion per hour was computed for analyzing the change over time with repeated-measures analysis of variance and a cubic spline ***:The metabolism of urinary sodium,potassium,and creatinine showed different patterns of circadian rhythm,although the urinary sodiurm excretion showed non-significant parameters in the cosinor model.A significant circadian rhythm of urinary creatinine excretion was observed,while the circadian rhythm of sodium was less significant than that of *** circadian rhythm of urinary sodium and creatinine excretion showed synchronization to some extent,which had a nocturnal peak and fell to the lowest around noon to *** contrast,the peak of potassium was observed in the morning and dropped to the lowest point in the *** hourly urinary excretion followed a similar circadian ***:It is necessary to consider the circadian rhythm of urinary sodium,potassium,and creatinine excretion in adults while exploring the estimation model for 24-h urinary sodium excretion using spot urine.

关键词： Circadian rhythm Sodium urinary excretion Cosinor analysis Spot urine 24-h urine

Efficacy and safety of human chorionic gonadotropin combined with human menopausal gonadotropin and a gonadotropin-releasing hormone pump for male adolescents with congenital hypogonadotropic hypogonadism

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Chinese Medical Journal 2021年第10期134卷 1152-1159页

作者： Ying Liu Xiao-ya Ren ya-guang peng Shao-Ke Chen Xin-Ran Cheng Miao Qin Xiao-Ling Wang yan-Ning Song Li-Jun Fan Chun-Xiu Gong Department of Pharmacy Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Endocrinology Genetics and MetabolismBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Maternal and Child Health Hospital of guangxi Zhuang Autonomous Region NanningGuangxi 530003China Department of Endocrinology Chengdu Women’s and Children’s Central HospitalChengduSichuan 610091China Beijing Key Laboratory for Genetics of Birth Defects Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

Background:Compared to adult studies,studies which involve the treatment of pediatric congenital hypogonadotropic hypogonadism(CHH)are limited and no universal treatment regimen is *** aim of this study was to evaluate the feasibility of human chorionic gonadotropin(hCG)/human menopausal gonadotropin(hMG)therapy for treating male adolescents with ***:Male adolescent CHH patients were treated with hCG/hMG(n=20)or a gonadotropin-releasing hormone(GnRH)pump(n=21).The treatment was divided into a study phase(0-3 months)and a follow-up phase(3-12 months).The testicular volume(TV),penile length(PL),penis diameter(PD),and sex hormone levels were compared between the two *** TV and other indicators between the groups were analyzed using a t-test(equal variance)or a rank sum test(unequal variance).Results:Before treatment,there was no statistical difference between the two groups in terms of the biochemistry,hormones,and other demographic *** 3 months of treatment,the TV of the hCG/hMG and GnRH groups increased to 5.1±2.3 mL and 4.1±1.8 mL,respectively;however,the difference was not statistically significant(P>0.05,t=1.394).The PL reached 6.9±1.8 cm and 5.1±1.6 cm(P0.05,t=0.314).After 9 to 12 months of treatment,the T level was higher in the hCG/hMG *** parameters did not exhibit a statistical ***:The hCG/hMG regimen is feasible and effective for treating male adolescents with *** initial 3 months of treatment may be a window to optimally observe the strongest effects of ***,results

关键词： Congenital hypogonadotropic hypogonadism Gonadotropin-releasing hormone Human chorionic gonadotropin Human menopausal gonadotropin Treatment regime

Catalytic reduction of SO_2 by CO over CeO_2-TiO_2 mixed oxides

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Transactions of Nonferrous Metals Society of China 2016年第11期26卷 2960-2965页

作者：张丽秦毅红陈白珍彭亚光何汉兵袁依中南大学冶金与环境学院长沙410083

The structure and catalytic desulfurization characteristics of CeO2-TiO2 mixed oxides were investigated by means ofX-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS） and catalytic activity tests. According to the results, a CeO2-TiO2solid solution is formed when the mole ratio of cerium to titanium n（Ce）：n（Ti） is 5：5 or greater, and the most suitable n（Ce）：n（Ti） isdetermined as 7：3, over which the conversion rate of SO2 and the yield of sulfur at 500℃ reach 93% and 99%, *** to the activity testing curve, Ce0.7Ti0.3O2 （n（Ce）：n（Ti）=7：3） without any pretreatment can be gradually activated by reagentgas after about 10 min, and reaches a steady activation status 60 min later. The XPS results of Ce0.7Ti0.3O2 after different time ofSO2＋CO reaction show that CeO2 is the active component that offers the redox couple Ce4＋/Ce3＋ and the labile oxygen vacancies, andTiO2 only functions as a catalyst structure stabilizer during the catalytic reaction process. After 48 h of catalytic reaction at 500℃,Ce0.7Ti0.3O2 still maintains a stable structure without being vulcanized, demonstrating its good anti-sulfur poisoning performance.

关键词： CeO2-TiO2 mixed oxides solid solution catalytic reduction carbon monoxide sulfur dioxide

Symmetry energy of strange quark matter and tidal deformability of strange quark stars

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Nuclear Science and Techniques 2022年第11期33卷 89-100页

作者： Jian-Feng Xu Cheng-Jun Xia Zhen-yan Lu guang-Xiong peng ya-peng Zhao College of Information Engineering Suqian UniversitySuqian 223800China School of Physics and Electrical Engineering AnYang Normal UniversityAnyang 455000China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and ElectronicsHunan University of Science and TechnologyXiangtan 411201China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Institute of High-Energy Physics Chinese Academy of SciencesBeijing 100049China School of Mathematics and Physics Henan Urban Construction UniversityPingdingshan 467036China

Research performed during the past decade revealed an important role of symmetry energy in the equation of state(EOS)of strange quark matter(SQM).By introducing an isospin-dependent term into the quark mass scaling,the SQM stability window in the equivparticle model was *** results show that a sufficiently strong isospin dependence C_(I)can significantly widen the SQM region of absolute stability,yielding results that simultaneously satisfy the constraints of the astrophysical observations of PSR J1614-2230 with 1.928±0.017 Mand tidal deformability 70≤Λ_(1:4)≤580 measured in the event *** increasing C_(I),the difference between the u,d,and s quark fractions for the SQM inβ-equilibrium becomes inconspicuous for C>0,leading to small isospin asymmetryδ,and further resulting in similar EOS and structures of strange quark stars(SQSs).Moreover,unlike the behavior of the maximum mass of ud QSs,which varies with C_(I)depending on the sign of the parameter C,the maximum mass of the SQSs decreases monotonously with increasing CI.

关键词： Symmetry energy Strange quark matter Strange stars Tidal deformability

Molecular simulation study of the microstructures and properties of pyridinium ionic liquid[HPy][BF_(4)]mixed with acetonitrile

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原子与分子物理学报 2025年第4期42卷 27-32页

作者： XU Jian-Qiang MA Zhao-peng CHENG Si LIU Zhi-Cong ZHU guang-Lai Department of Physics School of Physics and Electronic InformationAnhui Normal UniversityWuhu 241002China

The microstructures and thermodynamic properties of mixed systems comprising pyridinium ionic liquid[HPy][BF_(4)]and acetonitrile at different mole fractions were studied using molecular dynamics simulation in this *** following properties were determined:density,self-diffusion coefficient,excess molar volume,and radial distribution *** results show that with an increase in the mole fraction of[HPy][BF_(4)],the self-diffusion coefficient ***,the excess molar volume initially decreases,reaches a minimum,and then *** rules of radial distribution functions(RDFs)of characteristic atoms are *** increasing the mole fraction of[HPy][BF_(4)],the first peak of the RDFs of HA1-F decreases,while that of CT6-CT6 rises at first and then *** indicates that the solvent molecules affect the polar and non-polar regions of[HPy][BF_(4)]differently.

关键词： Pyridinium ionic liquids Thermodynamic properties Molecular dynamics simulation Radial distribution functions

Reaction between Ti–6Al–4V and Y_2O_3–SiO_2 based face shell for investment casting

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Rare Metals 2016年第12期35卷 901-908页

作者： ya-Meng Wei Zhi-Gang Lu guang-peng Wu Xing-Quan Long Department of Mechanical Engineering Tsinghua University State Key Laboratory of Tribology Tsinghua University Guizhou Anji Aviation Investment Casting Co. Ltd.

The pH value and viscosity of Y2O3-SiO2 （Y-Si） slurry made by Y2O3 powders and silica sol for the face coat of Ti-6Al-4V investment casting were measured. The thermal behavior of the shell made by the Y-Si face coat system was investigated by differential scanning calorimeter （DSC）, thermal gravimetric （TG） analysis combined with mass spectrometry （MS）, and the phase transformations were determined by X-ray diffraction （XRD）. Hot strength, residual strength, linear expansion coefficient, and wearing resistance performance of the shell were also tested. The microstructure and elements distri- bution of the interaction layer were studied by scanning electron microscope （SEM） and energy-dispersive spectrometer （EDS）, respectively. The microhardness tester was applied for the microhardness. The results showed that the slurry was stable for at least 60 h. A very small amount of YZrO3 was formed below 1050℃ and Y2SiO5 was formed around 1450℃. The shell made by Y-Si system had good mechanical property which could reduce cracks during the procedure of dewaxing and inclusions during pouring. Some Al volatilized from the melt, permeated the surface of the face coat shell, and formed the black reaction layer, which blocked the permeation of O so that O penetration was limited to 5μm. The depth of Si penetration was about 60 μm. The hard layer was also around 60 μm.

关键词： Investment casting Titanium alloy Silica sol Yttrium oxide Interface reaction

Synthesis and Crystal Structure of a Ternary Complex:[Ni(phen)_2(pmal)]·8H_2O

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1265-1269页

作者： SNN ya-guang Laboratory of Coordination Chemistry Shenyang Institute of Chemical TechnologyShenyang 110142 China

A new ternary complex [Ni（phen）（pmal）]·8H2O （phen = 1,10-phenanthroline, pmal^2- = phenethyl malonic acid） has been synthesized by the reaction of nickel acetate, phen and phenethyl malonic acid. Elemental analysis, IR spectra and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure. Crystal data for this complex： triclinic system, space group PI^-, a = 10.387（5）, b = 13.112（6）, c = 14.229（6） °A, α= 76.176（7）, β = 83.778（8）, γ = 71.770（6）°, C35H42N4O12Ni, Mr= 769.44, Z = 2, F（000） = 808, V = 1786.1°A^3, Dc = 1.431 g/cm^3,μ= 0.612 mm^-1, the final R = 0.0653 and wR = 0.1033 for 9379 （Rint = 0.0244） independent reflections and 4730 observed reflections （I〉 2σ（I））. Structural analysis shows that the coordination geometry of Ni（Ⅱ） is a distorted octahedron. A novel two-dimensional structure is constructed from （H2O）4 and （H2O）12 water clusters, and the complex forms a 3-D network supramolecular structure by hydrogen bonds and π-π stacking of neighboring phens.

关键词： Ni(Ⅱ) phenethyl malonic acid crystal structure water cluster

绿原酸对中性粒细胞功能及胞外诱捕网形成的影响及机制

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中国药理学通报 2025年第1期41卷 101-107页

作者：杨运刘娅王翠彭春红贵州中医药大学第二临床医学院贵州贵阳550025 七星关区中医妇幼集团医院贵州毕节551700 毕节市中医医院贵州毕节551700 贵州医科大学临床医学院贵州贵阳550025 贵州省人民医院呼吸与危重医学科贵州贵阳550002 国家卫健委肺脏免疫性疾病重点实验室贵州贵阳550002

目的探究绿原酸(chlorogenic acid,CGA)对中性粒细胞(neutrophil,NEU)功能及中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)形成的影响及机制。方法从小鼠骨髓中分离并纯化NEU;将NEU与CGA共培养,通过CCK-8法筛选共培养适合的干预浓度;检测NEU迁移能力、髓过氧化物酶(MPO)以及脱颗粒弹性蛋白酶(NE)、基质金属蛋白酶9(MMP-9)的水平观察CGA对NEU功能的影响;免疫荧光法观察NETs的主要结构组蛋白H3及DNA骨架,以及检测NEU释放的游离DNA(cf-DNA)含量,观察NETs的形成情况;检测NEU产生的活性氧(ROS)水平,以确定CGA是否影响NEU释放NETs过程中的ROS的生成。结果CGA在浓度为100、200、400μmol·L^(-1)时对NEU活性有明显抑制作用(P<0.01)。与空白组(Blank)相比,CGA(100、200、400μmol·L^(-1))干预后,细胞迁移能力及MPO、NE、MMP-9分泌量增加(P<0.05),组蛋白H3及DNA骨架、cf-DNA的释放量明显增加(P<0.01),细胞产生的ROS也明显增加(P<0.01),上述作用在一定范围内具有浓度依赖性。结论CGA能够增强NEU功能及促进NETs的形成,可能与促进细胞内ROS水平增加有关。

关键词：绿原酸中性粒细胞胞外诱捕网免疫抗菌活性氧