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Complexation Induced by Weak Interaction between DNA and PEO-b-P4VP below the CMC of the Polymer

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Chinese Journal of Polymer Science 2017年第1期35卷 46-53页

作者： han miao ya-fen wang hai-yan dong 陈道勇 The State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200433 China

The complexation between circular DNA and individual chains of PEO-b-P4VP with a relatively long PEO block and a short P4VP block is highly controllable when the interaction between DNA and the polymer is weak enough. When one circular DNA chain is taken into consideration, and the polymer concentration is far below its critical micelle concentration （CMC）, polymer chains are absorbed by DNA chain due to the interaction between the negatively charged DNA chain and the slightly positively charged P4VP block chains. After the adsorption/complexation, the DNA chain is converted into a nanoring （type 1）. In the nanoring, the DNA chain is sufficiently wrapped by the polymer and adopts a fully stretched conformation, so that the DNA compact ratio in the nanorings is close to 1. When the polymer concentration is close to but lower than the CMC, the free polymer chains in the solution are adsorbed not only by the DNA chain but also by the polymer chains that have already been adsorbed on the DNA chain. As a result, the circular DNA chain adsorbs more polymer chains, and thus the resultant nanoring （type 2） has a larger width. In the type 2 nanoring, the DNA chain is slightly compressed; the DNA compact ratio is only about 2-3. Therefore, complexation induced by the weak interaction between DNA and PEO-b-P4VP below the CMC can produce narrow-disperse and large nanorings with a perimeter of micrometers, which are difficult to prepare by existing methods.

关键词： Weak interaction DNA Individual polymer chains Block copolymer Critical micelle concentration

Pneumocystis jirovecii diagnosed by next-generation sequencing of bronchoscopic alveolar lavage fluid: A case report and review of literature

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World Journal of Clinical Cases 2023年第4期11卷 866-873页

作者： Qing-Wei Cheng Hong-Li Shen Zhi-Hui Dong Qian-Qian Zhang ya-fen wang Jin yan Yu-Sheng wang Ning-Gang Zhang Department of Oncology The Sixth Division HospitalXinjiang Production and Construction CorpsWujiaqu 831300Xinjiang Uygur Autonomous RegionsChina Department of Gastrointestinal Oncology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina

BACKGROUND The advent of molecular targeted agents and immune checkpoint inhibitors has greatly improved the treatment of advanced renal cell carcinoma(RCC), thus significantly improving patient survival. The incidence of rare drug-related adverse events has gained increased *** SUMMARY We report a patient with advanced RCC treated with multiple lines of molecular targeted agents and immune checkpoint inhibitors, who developed a pulmonary infection after treatment with everolimus in combination with lenvatinib. Determining the pathogenic organism was difficult, but it was eventually identified as Pneumocystis jirovecii by next-generation sequencing(NGS) of bronchoscopic alveolar lavage fluid(BALF) and successfully treated with *** Rare pulmonary infections caused by molecular targeted agents are not uncommon in clinical practice, but their diagnosis is difficult. Evaluating BALF with NGS is a good method for rapid diagnosis of such infections.

关键词： Renal cell carcinoma Everolimus Pneumocystis jirovecii pneumonia Next-generation sequencing Bronchoscopic alveolar lavage fluid Case report

A modified laser-induced choroidal neovascularization animal model with intravitreal oxidized low-density lipoprotein

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1187-1194页

作者： Tong Wu Kuan-Rong Dang ya-fen wang Bao-Zhen Lyu Wen-Qin Xu Guo-Rui Dou Jian Zhou yan-Nian Hui Hong-Jun Du Department of Ophthalmology Xijing HospitalEye Institute of Chinese PLAFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Anatomy and Histology and Embryology Xi’an Health SchoolXi’an 710032Shaanxi ProvinceChina The Orbital Disease Institute of the Third Medical Center of PLA General Hospital Beijing100039China

AIM: To investigate whether intravitreal injection of oxidized low-density lipoprotein(OxLDL) can promote laserinduced choroidal neovascularization(CNV) formation in mice and the mechanism involved, thereby to develop a better animal ***: C57BL6/J mice were randomized into three groups. Immediately after CNV induction with 532 nm laser photocoagulation, 1.0 μL of OxLDL [100 μg/m L in phosphate-buffered saline(PBS)] was intravitreally injected, whereas PBS and the same volume low-density lipoprotein(LDL;100 μg/m L in PBS) were injected into the vitreous as controls. Angiogenic and inflammatory cytokines were measured by quantitative real-time polymerase chain reaction(q RT-PCR) and Western blotting(WB) after 5 d, and CNV severity was analyzed by choroid flat mount and immunofluorescence staining after 1wk. In vitro, retinal pigment epithelial(RPE) cell line(ARPE19) were treated with OxLDL(LDL as control) for 8 h. Angiogenic and inflammatory cytokine levels were measured. A specific inhibitor of lectin-like oxidized low-density lipoprotein receptor 1(LOX1) was used to evaluate the role of LOX1 in this ***: At 7 d after intravitreal injection of 1 μL(100 μg/mL) OxLDL, T15-labeled OxLDL was mainly deposited around the CNV area, and the F4/80-labeled macrophages, the CD31-labeled vascular endothelial cells number and CNV area were increased. Meanwhile, WB and qR T-PCR results showed that vascular endothelial growth factor(VEGF), CC chemokine receptor 2(CCR2), interleukin-6(IL-6), IL-1β, and matrix metalloproteinase 9(MMP9) expressions were increased, which was supported by in vitro experiments in RPE cells. LOX1 inhibitors significantly reduced expressions of inflammatory factors IL-1β and VEGF. CONCLUSION: A modified laser-induced CNV animal model is established with intravitreal injection of 1 μL(100 μg/mL) of OxLDL at 7 d, which at least partially through LOX1. This animal model can be used as a simple model for studying the role of OxLDL in age-

关键词： age-related macular degeneration choroidal neovascularization oxidized low-density lipoprotein animal model

Quality of life and symptom distress after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2022年第32期10卷 11775-11788页

作者： ya-fen wang Ting-yao wang Tzu-Ting Liao Meng-Hung Lin Tzu-Hao Huang Meng-Chiao Hsieh Vincent Chin-Hung Chen Li-Wen Lee Wen-Shih Huang Chao-Yu Chen Cancer Center Chang Gung Memorial HospitalChiayiTaiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayiTaiwan Division of Case Management Cancer CenterChang Gung Memorial HospitalChiayiTaiwan Health Information and Epidemiology Laboratory Chang Gung Memorial HospitalChiayiTaiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayiTaiwan Division of Colorectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayiTaiwan Department of Psychiatry Chang Gung Memorial HospitalChiayi and Chang Gung UniversityTaoyuanTaiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayiTaiwanCollege of MedicineChang Gung UniversityTaoyuanTaiwan Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayiTaiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiungTaiwanDepartment of Early Childhood Care and EducationShu-Zen Junior College of Medicine and ManagementKaohsiungTaiwan

BACKGROUND Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy(CRS/HIPEC)for peritoneal surface malignancy can effectively control the disease,however it is also associated with adverse effects which may affect quality of life(QoL).AIM To investigate early perioperative QoL after CRS/HIPEC,which has not been discussed in *** This single institution,observational cohort study enrolled patients who received CRS/*** assessed QoL using the Taiwan residents version of the MD Anderson Symptom Inventory(MDASI-T)and European Organization Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30).Participants completed the questionnaires before CRS/HIPEC(S1),at the first outpatient follow-up(S2),and 3 mo after CRS/HIPEC(S3).RESULTS Fifty-eight patients were *** was no significant perioperative difference in global health *** changes in physical and role functioning scores decreased at S2,and fatigue and pain scores increased at S2 but returned to baseline at *** regression analysis showed that age and performance status were significantly correlated with *** the MDASI-T questionnaire,distress/feeling upset and lack of appetite had the highest scores at S1,compared to fatigue and distress/feeling upset at S2,and fatigue and lack of appetite at *** leading interference items were working at S1 and S2 and activity at ***-T scores were significantly negatively correlated with the EORTC QLQ-C30 *** QoL and symptom severity improved or returned to baseline in most categories within 3 mo after CRS/*** findings can help with preoperative consultation and perioperative care.

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Quality of life Symptom distress Perioperative care

Kinsenoside:A Promising Bioactive Compound from Anoectochilus Species

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 11-18页

作者： Chang-xing QI Qun ZHOU Yuan ZHOU Zeng-wei LUO Chong DAI Hu-cheng ZHU Chun-mei CHEN Yong-bo XUE Jian-ping wang ya-fen wang ya-ping LIU Ming XIANG Wei-guang SUN Jin-wen ZHANG Yong-hui ZHANG Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 China

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus,and exhibits many biological activities and pharmacological effects,including hepatoprotective,anti-hyperglycemic,anti-hyperliposis,anti-inflammatory,vascular protective and anti-osteoporosis effects and so on,which is contributing to its promising potency in disease *** review aims to recapitulate the pharmacological functions of kinsenoside,as well as its source,extraction,identification,quantitative analysis,pharmacokinetics,synthesis and patent *** data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

关键词： Anoectochilus roxburghii kinsenoside bioactivity synthesis review

Bifurcations and Spatiotemporal Patterns in the Diffusive Nutrient-Microor ganism Model

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 162-178页

作者： ya-di wang Hai-long YUAN yan-ling LI School of Arts and Sciences Shaanxi University of Science and TechnologyXi'an 710021China School of Mathematics and Statistics Xi'an Jiaotong UniversityXi'an 710049China School of Mathematics and Information Science Shaanxi Normal UniversityXi'an 710062China

In this paper,the diffusive nutrient-microorganism model subject to Neumann boundary conditions is *** Hopf bifurcations and steady state bifurcations which bifurcate from the positive constant equilibrium of the system are investigated in *** addition,the formulae to determine the direction of Hopf and steady state bifurcations are *** results show the existence of spatially homogeneous/nonhomogeneous periodic orbits and steady state solutions,which indicates the spatiotemporal dynamics of the *** numerical simulations are also presented to support the analytical results.

关键词： nutrient-microorganism model Hopf bifurcation steady state bifurcation simulations

Bi Modified Bi2MoO6 Microspheres by Photo-reduction With Enhanced Visible Light Photocatalytic Activity for Degradation of NOx

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Bi Modified Bi2MoO6 Microspheres by Photo-reduction With Enh...

Nitrogen-doped Carbon Quantum Dots Decorated Zn Sn（OH）6 Nanocomposite with Enhanced Visible Light Photocatalytic Oxidation Activity for NO Removal

第十八届中国科协年会——分12 大气雾霾及PM2.5控制先进技术研讨会

作者： Huichi CHUANG Shengjie YOU ya fen wang Yu HUANG Junji CAO Qian ZHANG DepartmentofenvironmentalEngineering ChungYuanChristianUniversity KeyLaboratoryofAerosolChemistryandPhysics InstituteofEarthEnvironmentChineseAcademyofSciences

The problem of environmental pollution and energy shortage has become the two major problems faced by the sustainable development of human beings. Therefore, the development of friendly new energy has

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Nitrogen-doped Carbon Quantum Dots Decorated Zn Sn（OH）6 Na...

Research progress on piperidine-containing compounds as agrochemicals

第十八届中国科协年会——分12 大气雾霾及PM2.5控制先进技术研讨会

作者： Jinjie HE Shengjie YOU ya fen wang Yu HUANG Junji CAO yanfeng LU DepartmentofenvironmentalEngineering ChungYuanChristianUniversity KeyLaboratoryofAerosolChemistryandPhysics InstituteofEarthEnvironmentChineseAcademyofSciences

Indoor nitrogen oxides can enter the body through breathing, and it cause irritation of the respiratory tract, lungs, and the corrosion damage of organs. So, it is importance to remove these pollutant

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Chinese Chemical Letters 2025年第1期36卷 58-67页

作者： Wei Sun Anjing Liao Li Lei Xu Tang ya wang Jian Wu State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China

Piperidine is a crucial pharmacophore and a special scaffold in the realm of drug *** flexibility increases the molecule’s capability to bind to the *** piperidine-containing compounds are distinguished by their remarkable activity,and are increasingly becoming a vital category of *** this review,the research progress of piperidines in the discovery of pesticides was updated according to their active *** structure-activity relationships(SARs),and mechanisms of action of piperidine-containing compounds were also *** article is meant to enable readers to quickly understand piperidines,while providing ideas for creating piperidines with novel structures and unique mechanisms of action.

关键词： Piperidine Agrochemicals Biological activity Structure-activity relationships Mechanism of action