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Metal-decorated defective BN nanosheets as hydrogen storage materials

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Frontiers of physics 2011年第2期6卷 224-230页

作者： Ming li ya-fei li Zhen ZHOU Pan-wen SHEN College of Chemical Engineering and Biological Technology Hebei Polytechnic University Tangshan 063009 China Institute of New Energy Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry （Ministry of Education） Nankai University Tianjin 300071 China

Density functional theory computations were performed to investigate hydrogen adsorption in metaldecorated defective BN nanosheets. The binding energies of Ca and Sc on pristine BN nanosheets are much lower than the corresponding cohesive energies of the bulk metals; however, B vacancies in BN nanosheets enhance the binding of Ca and Sc atoms dramatically and avoid the clustering of the metal atoms on the surface of BN nanosheets. Ca and Sc strongly bind to defective BN nanosheets due to charge transfer between metal atoms and BN nanosheets. So-decorated BN nanosheets with B vacancies demonstrate promising hydrogen adsorption performances with a hydrogen adsorption energy of -0.19 - -0.35 eV/H2.

关键词： BN nanosheets hydrogen storage first principles

Research progress on myocardial regeneration: what is new?

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Chinese Medical Journal 2020年第6期133卷 716-723页

作者： Chong Du Yi Fan ya-fei li Tian-Wen Wei lian-Sheng Wang Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjingJiangsu 210029China

The regeneration capacity of cardiomyocytes(CMs)is retained in neonatal mouse hearts but is limited in adult mouse Myocardial infarction(MI)in adult hearts usually leads to the loss of large amounts of cardiac tissue,and then accelerates the process of cardiac remodeling and heart failure.Therefore,it is necessary to explore the potential mechanisms of CM regeneration in the neonates and develop potential therapies aimed at promoting CM regeneration and cardiac repair in adults.Currently,studies indicate that a number of mechanisms are involved in neonatal endogenous myocardial regeneration,including cell cycle regulators,transcription factors,non-coding RNA,signaling pathways,acute inflammation,hypoxia,protein kinases,and others.Understanding the mechanisms of regeneration in neonatal CMs after MI provides theoretical support for the studies related to the promotion of heart repair after MI in adult mammals.However,several difficulties in the study of CM regeneration still need to be overcome.This article reviews the potential mechanisms of endogenous CM regeneration in neonatal mouse hearts and discusses possible therapeutic targets and future research directions.

关键词： Myocardial infarction Cardiomyocyte Endogenous regeneration Mechanism

Wheat ear growth modeling based on a polygon

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Frontiers of Information Technology & Electronic Engineering 2019年第9期20卷 1175-1184页

作者： Jun-xiao XUE Chen-yang SUN Jun-jin CHENG Ming-liang XU ya-fei li Shui YU School of Software Zhengzhou UniversityZhengzhou 450000China School of Information Engineering Zhengzhou UniversityZhengzhou 450000China School of Software University of Technology SydneySydney 2007Australia

Visual inspection of wheat growth has been a useful tool for understanding and implementing agricultural techniques and a way to accurately predict the growth status of wheat yields for economists and policy decision makers.In this paper,we present a polygonal approach for modeling the growth process of wheat ears.The grain,lemma,and palea of wheat ears are represented as editable polygonal models,which can be re-polygonized to detect collision during the growth process.We then rotate and move the colliding grain to resolve the collision problem.A linear interpolation and a spherical interpolation are developed to simulate the growth of wheat grain,performed in the process of heading and growth of wheat grain.Experimental results show that the method has a good modeling effect and can realize the modeling of wheat ears at different growth stages.

关键词： Visual inspection Virtual crop Three-dimensional modeling

Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives

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Chinese Chemical Letters 2015年第10期26卷 1307-1310页

作者： Chi-Yu Sun yang-Sheng li Ai-Long Shi ya-fei li Rui-Fang Cao Huai-Wei Ding Qing-Qing Yin li-Juan Zhang Hua-Chuan Zheng Hong-Rui Song Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University The First Affiliated Hospital of liaoning Medical University

A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10 c showed promising inhibition of hedgehog（Hh） signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10 c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.

关键词： Aryl cycloaliphatic amine Antiproliferative activity Hedgehog signaling

Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women

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Science China(life Sciences) 2020年第4期63卷 582-591页

作者： Yue-Mei Hu Meng Guo Chang-Gui li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan li Hui Zhao Xiang-Hong Wu Bi-Zhen lin Zhi-Jie lin Xing-Mei yao ya-fei li fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009China The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesCollaborative Innovation Center of Biologic ProductsSchool of Public HealthXiamen UniversityXiamen 361102China National Institute for Food and Drug Control Beijing 102629China Sheyang Center for Disease Control and Prevention Sheyang 244300China Xiamen Innovax Biotech Company Xiamen 361022China

A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women.

关键词： immunobridging noninferiority human papillomavirus vaccine Escherichia coli girls

Changing Tendency Analysis of Chinese Normal Male's Semen Quality in Recent 25 Years:Samples from Chinese Documents

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Journal of Reproduction and Contraception 2010年第4期21卷 229-241页

作者： li-ping HUANG ya-fei li Hong-yan XIONG Jia CAO Department of Epidemiology College of Preventive Medicine Third Military Medical University Chongqing 400038 China Chongqing Shapingba Center for Disease Control and Prevention Chongqing 400038 China College of Preventive Medicine Third Military Medical University Chongqing 400038 China

Objective To analyze the trend of change in semen quality of Chinese healthy men over recent 25 years. Methods A total of 115 reports were collected on quality inspection of semen of healthy Chinese men between 1985-2009 through literature search, which involved 23 126 persons from 69 counties and cities. Trend of change in semen parameters was analyzed by linear regression model and rank sum test. Results Sperm concentration and non-progressive motility （c%） declined, and the linear equation was of statistics value. linear equations include y=2.968-0. 004x （P〈0.05） and y=3.204-0.026x （P〈0.05）. As the results of K-S rank sum test showed, the difference of sperm concentration and total sperm count in the three groups, i.e., the group for 1985-1989, the group for 1990-1999 and the group for 2000-2009 was of statistics value. Conclusion The semen concentration decline over recent 25 years （P〈0.05）. of healthy Chinese men appears a possible

关键词： semen parameter healthy men regression analysis

Metabolic heterogeneity of gastric cancer cell lines

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中国药理学与毒理学杂志 2018年第4期32卷 278-279页

作者： Xia-xia FAN Ying-li ZHU Bei-bei SHAO Lu-lu li ya-fei li Ao JIA Ai-feng WANG Yong-cheng MA Clinical Pharmacology Laboratory Pharmacy DepartmentZhengzhou University People's Hospital Clinical Pharmacology Laboratory Pharmacy DepartmentFuwai Centeral China Cardiovascular Hospital

OBJECTIVE Gastric cancer is one of the most common malignant tumors,and the incidence rate is the highest in all kinds of tumors in China.However,it remains unclear that how signifi.cantly gastric cells are dependent on glycolysis,and which type of gastric cells are sensitive to glycolysis inhibition.In this study,several kind of gastric cancer cell lines were used as the research object,and the metabolic characteristics of different cell lines were systematically analyzed to provide theoretical support for the accurate treatment of gastric cancer.METHODS We examined the energy metabolism of four gastric cancer cell lines(MGC-803,SGC-7901,HGC-27 and BGC-823) by using glycolysis inhibitor,2-deoxy-D-glucose(2-DG) and inhibitor of oxidative phosphorylation,oligomycin.Oxygen consumption rates(OCR) and L-lactate were also measured with an XF96 Analyzer(Seahorse Biosciences) to deter.mine the significance of metabolism of oxidative phosphorylation and aerobic glycolysisin gastric cells.In addition,western blot was used to detect the contribution of AMP-activated protein kinase(AMPK),and anti-apoptotic proteins(Bcl-2 and survivin) to clarify the mechanism of death or survival of gastric cancer cells treated by 2-DG or oligomycin.RESULTS In this study,it was shown that the growth of gastric cell lines were suppressed by 2-DG.However,the sensitivity to 2-DG was quite different among cell lines:IC 50 of 2-DG was from 3.28 mmol·L^(-1)(MGC-803) to 15.57 mmol·L^(-1)(BGC-823).MGC-803 was relatively sensitive to 2-DG(IC 50:3.28 mmol·L^(-1)),consumed more glucose and produced more lactate(waste product of glycolysis) than the three other cell lines.Consequently,MGC-803 could be more dependent on glycolysis than other cell lines,which was further confirmed by the fact that glucose(+) FCS(-) medium showed more growth and survival than glucose(-) FCS(+) medium.Alternatively,BGC-823,most resistant to 2-DG(IC50:15.57 mmol · L-1),was most sensitive to oligomycin,and showed more growth and survival in glucose(-) FCS(+) medium than in g

关键词：胃癌恶性肿瘤治疗方法临床分析

Pollution source identification methods and remediation technologies of groundwater: A review

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China Geology 2024年第1期7卷 125-137页

作者： ya-ci liu Yu-hong fei ya-song li Xi-lin Bao Peng-wei Zhang Fujian Provincial Key Laboratory of Water Cycling and Eco-Geological Processes Institute of Hydrogeology and Environmental GeologyChinese Academy of Geological SciencesXiamen 361000China Key Laboratory of Water and Soil Resources Conservation and Restoration in the Middle and Lower Reaches of Yellow River Basin MNRZhengzhou 450016China

Groundwater is an important source of drinking water.Groundwater pollution severely endangers drinking water safety and sustainable social development.In the case of groundwater pollution,the top priority is to identify pollution sources,and accurate information on pollution sources is the premise of efficient remediation.Then,an appropriate pollution remediation scheme should be developed according to information on pollution sources,site conditions,and economic costs.The methods for identifying pollution sources mainly include geophysical exploration,geochemistry,isotopic tracing,and numerical modeling.Among these identification methods,only the numerical modeling can recognize various information on pollution sources,while other methods can only identify a certain aspect of pollution sources.The remediation technologies of groundwater can be divided into in-situ and ex-situ remediation technologies according to the remediation location.The in-situ remediation technologies enjoy low costs and a wide remediation range,but their remediation performance is prone to be affected by environmental conditions and cause secondary pollution.The ex-situ remediation technologies boast high remediation efficiency,high processing capacity,and high treatment concentration but suffer high costs.Different methods for pollution source identification and remediation technologies are applicable to different conditions.To achieve the expected identification and remediation results,it is feasible to combine several methods and technologies according to the actual hydrogeological conditions of contaminated sites and the nature of pollutants.Additionally,detailed knowledge about the hydrogeological conditions and stratigraphic structure of the contaminated site is the basis of all work regardless of the adopted identification methods or remediation technologies.

关键词： Groundwater pollution Identification of pollution sources Geophysical exploration identification Geochemistry identification Isotopic tracing Numerical modeling Remediation technology Hydrogeological conditions Hydrogeological survey engineering

High critical current density in li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

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Rare Metals 2024年第2期43卷 692-701页

作者： Ying-Tong Lv Teng-fei Zhang Zhao-Tong Hu Guang-lin Xia Ze-ya Huang Zhen-Hua liu li-Hua Que Cai-Ting Yuan Fang-Qin Guo Takayuki Ichikawa Xue-Bin Yu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China Centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials Science Fudan UniversityShanghai200433China Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and safety.However,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical application.Herein,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable li/LLZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) Critical current density Solid-state electrolytes(SSEs) lithium-sulfur batteries