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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 73-77页

作者： Zhi-Jiang Sun ya-yi xia Orthopaedics Key Laboratory of Gansu Province The Second Hospital of Lanzhou University

Objective: To study the adverse effects of advanced glycation end products(AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery. AGEs were administered during chondrocytes culture. The rapamycin was used to induce autophagy. The cell viability was determined by 3-[4,5-dimethylthiazol2-yl]-2,5-diphenyl tetrazolium bromide(MTT) *** expression of tumor necrosis factor-α(TNF-α) and nuclear factor-κ B(NF-κ B) was detected by quantitative real-time polymerase chain reaction. The reactive oxygen species(ROS) production and apoptosis of the chondrocytes were determined by fluorescent probe and flow cytometer, respectively. Results: The chondrocytes viability was significantly reduced after 12 h incubation with AGEs(P<0.01)). In contrast, rapamycin pretreatment increased the chondrocytes viability through autophagy. AGEs increased TNF-α and NF-κ B mRNA expression of chondrocytes and autophagy receded or proceeded the change. AGEs increased intracellular ROS accumulation and autophagy reversed the change. AGEs accelerated chondrocytes apoptosis and autophagy suspended apoptosis. Conclusions: Accumulation of AGEs may have an adverse role for chondrocytes by increasing TNF-α and NF-κB expression, ROS accumulation and apoptosis; meanwhile, autophagy ameliorates the AGEsinduced adverse effects.

关键词： Advanced glycation end products Autophagy Tumor necrosis factor-α Nuclear factor-κ B Reactive oxygen species Apoptosis Chondrocytes

Narrow Intercondylar Notch and Anterior Cruciate Ligament Injury in Female Nonathletes with Knee Osteoarthritis Aged 41-65 Years in Plateau Region

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Chinese Medical Journal 2016年第21期129卷 2540-2545页

作者： Bin Geng Jing Wang Jing-Lin Ma Bo Zhang Jin Jiang xiao-yi Tan ya-yi xia Department of Orthopaedics The Second Hospital of Lanzhou University Lanzhou Gansu 730000 China Orthopaedics Key Laboratory of Gansu Province Lanzhou Gansu 730000 China

Background：Few data are available concerning intercondylar notch dimensions in female nonathletes with knee osteoarthritis （OA） in plateau *** aim of this study was to assess the relation of intercondylar notch morphology to anterior cruciate ligament （ACL） injuries in female nonathletes with knee OA aged 41-65 years from the Chinese Loess ***：The study was conducted on 330 patients with ACL injury （aged 31-65 years;159 males,171 females）,141 patients with OA （aged 31-55 years;59 males,82 females）,and 89 female healthy controls （aged 41-65 years）,and this evaluation included identifying the distribution of patients with OA or ACL injury and measuring the intercondylar notch width indexes （NWIs）.Results：There was a significant rising trend in patients with OA （the Kellgren and Lawrence grade =3） with ACL injury （OA-S ＋ ACL） aged 41-65 years,especially in *** found that the notches of OA-S ＋ ACL had a smaller NWI compared with control and OA without ACL injury （OA-S-only,P =0.000,95% confidence interval [CI] =-0.059--0.030;P =0.000,95% CI =-0.049--0.016）.A similar trend was found in notch shape index （NSI）,but not in notch depth index and the cross-sectional *** cutoff of NWI and NSI value was 0.26,and 0.65,and area under the receiver operating characteristic curve was 0.82,and 0.79,*** study displayed a significant correlation between a reduced NWI and NSI and OA-S ＋ ACL （P =0.000,χ^2 =14.012;P =0.000,χ^2 =14.286）.Conclusion：A narrower intercondylar notch and a plateau environment are risk factors of predisposing female nonathletes with knee OA to ACL injury aged 41-65 years.

关键词： Anterior Cruciate Ligament lntercondylar Notch Magnetic Resonance Imaging Osteoarthritis Plateau

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CoTCPP integrates with BiOBr microspheres for improved solar-driven CO_(2)reduction performance

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Green Energy & Environment 2025年第1期10卷 193-202页

作者： Lina Li yi Zhang Gaopeng Liu Tiange Wei Junze Zhao Bin Wang Mengxia Ji Yuanbin She Jiexiang xia Huaming Li School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu University301 Xuefu RoadZhenjiang212013China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

CO_(2) photoreduction into carbon-based chemicals has been considered as an appropriate way to alleviate the energy issue and greenhouse ***,the 5,10,15,20-tetra(4-carboxyphenyl)porphyrin cobalt(II)(CoTCPP)has been integrated with BiOBr microspheres and formed the CoTCPP/BiOBr *** as-prepared CoTCPP/BiOBr-2 composite shows optimized photocatalytic performance for CO_(2) conversion into CO and CH_(4) upon irradiation with 300 W Xe lamp,which is 2.03 and 2.58 times compared to that of BiOBr,*** introduced CoTCPP significantly enhanced light absorption properties,promoted rapid separation of photogenerated carriers and boosted the chemisorption of CO_(2) *** metal Co^(2+) at the center of the porphyrin molecules also acts as adsorption center for CO_(2) molecules,accelerating the CO_(2) conversion into CO and *** possible mechanism of CO_(2) photoreduction was explored by in-situ FT-IR *** work offers a new possibility for the preparation of advanced photocatalysts.

关键词： BiOBr CoTCPP CO_(2)photoreduction Carriers transfer CO_(2)adsorption-activation

Soliton Solutions of a Coupled KdV System via Backlund Transformation

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应用数学 2025年第1期38卷 211-216页

作者： CAO Xifang WU yiheng LU yi XU Wenjing xia Yutong School of Mathematical Sciences Yangzhou UniversityYangzhou 225002China

In this paper we use Böcklund transformation to construct soliton solutions for a coupled KdV *** system was first proposed by Wang in *** we generalize the well-known Bäcklund transformation for the KdV equation to such coupled KdV *** from a trivial seed solution,we construct soliton *** also give a nonlinear superposition formula,which allows us to generate multi-soliton solutions.

关键词： KdV equation Coupled KdV system B¨acklund transformation Soliton

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu xia Wenting Ye yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun xia Biao yang Ronghao Wang yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期68卷 21-25页

作者： Leyu Liu Zhaoming xia Zeyu Wang yinjuan Chen Hai xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

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Science China(Information Sciences) 2025年第1期68卷 219-237页

作者： xia JIANG yanyan FANG xianlin ZENG Jian SUN Jie CHEN National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

关键词： proximal operator random reshuffling inexact computation compressed sensing nonsmooth optimization

下肢力学轴线改变与膝关节骨性关节炎的关系(英文)

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中国临床康复 2003年第20期7卷 2832-2833页

作者：夏亚一孙正义王天民黑扳昌弘水野耕作兰州大学物理学院甘肃省兰州市730000 兰州医学院第二附属医院骨科甘肃省兰州市730030 日本神户大学医学部整形外科教室

目的探讨下肢力学轴线改变与膝关节骨性关节炎关系。方法选择健康人群56例(112只下肢,年龄13～40岁,平均24.8岁)和膝关节骨性关节炎患者50例(87只下肢,年龄54～83岁,平均67岁),根据FTA角的不同,将膝关节骨性关节炎分成4组。拍摄下肢全长... 详细信息

目的探讨下肢力学轴线改变与膝关节骨性关节炎关系。方法选择健康人群56例(112只下肢,年龄13～40岁,平均24.8岁)和膝关节骨性关节炎患者50例(87只下肢,年龄54～83岁,平均67岁),根据FTA角的不同,将膝关节骨性关节炎分成4组。拍摄下肢全长X线片,测定FTA角、颈干角、股骨干倾斜角、胫骨干倾斜角、关节间隙角和股骨力学轴偏位角。结果正常人群组FTA角、颈干角和关节间隙角与OA第1组比较有差异(P<0.01),股骨干倾斜角与OA第一组比较有差异(P<0.05)。胫骨干倾斜角和颈干角与OA第2组比较有差异(P<0.05)。结论初期OA人群组颈干角、关节间隙角和股骨干倾斜角发生了明显的改变,OA中后期的改变主要是关节间隙角和胫骨倾斜角减少。

关键词：下肢力学轴线膝关节骨性关节炎 FTA角测定

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Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts

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Science China Chemistry 2025年第1期68卷 181-185页

作者： yanping xia Luyang Sun Jiajia Cheng Sibo Wang Meifang Zheng Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols. Mechanistic studies support that boron carbonitrides(BCN) promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation, which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols, respectively. The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples) with reusability and scale-up experiments, verifying the complementary synthetic utility of this method to the homogeneous catalysts.

关键词： aliphatic ketones ketyl radical intermolecular cross-coupling tertiary alcohols