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Interparticle energy transfer between NaNdF_(4) and NaYbF_(4) in self-assembled nanostructures

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Journal of Rare Earths 2024年第6期42卷 1029-1035,I0001页

作者： Xinyu chen Haoze yang Yuyang Gu chenqing wen Yishuo Sun Jiaming Ke Wei Feng Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai200433China

Forster resonance energy transfer(FRET)is a widely used spectroscopic *** development of donor-acceptor combinations is essential to advance this *** make the energy transfer efficiency independent of the external environment,we explored the potential of constructing donor—acceptor combinations with lanthanide ion-doped nanoparticles(LNPs),in which the 4f electrons of the lanthanide ions are shielded by the 5s and 6p ***-radiative energy transfer between LNPs was demonstrated in self-assembled nanostructures and core-shell structure of LNPs was used to control the distance between donor and acceptor in self-assembled *** emission intensity ratio of donor and acceptor illustrates that the energy transfer efficiency decreases significantly with increasing distance and the effective energy transfer distance is 8.5 nm,showing the potential of using LNPs as donor-acceptor pairs in the construction of distance-dependent energy transfer system.

关键词： Lanthanide nanoparticles Self-assembly Energy transfer Distance Epitaxialgrowth Rare earths

Purification performance on molten steel of novel Al_(2)O_(3)-based ceramic filter prepared from microporous powder and nano-Al_(2)O_(3) powder

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Journal of Iron and Steel Research International 2024年第6期31卷 1535-1546页

作者： Zhe chen wen yan Ying Liu Guang-qiang Li Shao-song Hong Nan Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Jiangsu Shengnai New Materials Co. Ltd.Taizhou 225534JiangsuChina

Reticulated ceramic foam filters provide an effective way to purify molten steel by removing non-metallic *** proposed a novel strategy to improve the purification performance of Al_(2)O_(3)-based ceramic filters by using microporous corundum-spinel raw materials to replace dense raw *** kinds of Al_(2)O_(3)-based ceramic filters fabricated from dense α-Al_(2)O_(3) micro-powder or microporous corundum-spinel powder were selected to carry out the immersion tests with molten *** the one hand,the higher surface roughness of the filter skeleton prepared from microporous raw materials increased the adsorption capacity of skeleton surface on inclusions in molten *** the other hand,the higher apparent porosity and larger pore size of the filter skeleton were more beneficial to the penetration of molten steel in the micropores of *** reaction process at the solid-liquid interface also improved the wettability of the interface between skeleton and molten steel,resulting in a larger penetration depth and a better adsorption effect on the *** summary,the novel Al_(2)O_(3)-based ceramic filter prepared with microporous corundum-spinel powder and addition of 5 wt.% nano-Al_(2)O_(3) powder reduced the total oxygen content of the steel from 40.2×10^(-4) to 12.7×10^(-4) wt.% by 68.4% and the Al content from 0.46 to 0.18 wt.% by 60.9% after immersion test,presenting the most excellent purification performance on molten steel.

关键词： Al_(2)O_(3)-based ceramic filter Microporous corundum-spinel powder Non-metallic inclusion-Microstructure Molten steel purification

N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 659-669页

作者： yan-Rong wen Xia-wen Lin Yu-wen Zhou Lei Xu Jun-Li Zhang Cui-Ying chen Jian He Department of Nuclear Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Research and Development Sysdiagno(Nanjing)Biotech Co.LtdNanjing 210008Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage *** detection of pancreatic cancer(PC)can significantly increase survival *** To identify the serum biomarker signatures associated with early-stage PDAC by serum N-glycan *** An extensive patient cohort was used to determine a biomarker signature,in-cluding patients with PDAC that was well-defined at an early stage(stages I and II).The biomarker signature was derived from a case-control study using a case-cohort design consisting of 29 patients with stage I,22 with stage II,4 with stage III,16 with stage IV PDAC,and 88 *** used multiparametric analysis to identify early-stage PDAC N-glycan signatures and developed an N-glycan sig-nature-based diagnosis model called the“Glyco-model”.RESULTS The biomarker signature was created to discriminate samples derived from patients with PC from those of controls,with a receiver operating characteristic area under the curve of *** addition,the biomarker signature combined with cancer antigen 19-9 could discriminate patients with PDAC from controls,with a receiver operating characteristic area under the curve of ***-model demonstrated favorable diagnostic performance in all stages of *** diagnostic sensitivity for stage I PDAC was 89.66%.Core Tip:This study employed a patient cohort to investigate the N-glycan signature of early-stage pancreatic cancer(PC).Serum N-glycans analysis was conducted to identify the serum biomarker signature associated with early-stage pancreatic ductal adenocarcinoma(PDAC),resulting in the identification of nine early-stage PDAC N-glycan ***,utilizing these biosignatures,a diagnostic model named the“Glyco-model”was developed,demonstrating promising diagnostic performance across all stages of *** study revealed that the diagnostic sensitivity for stage I PDAC was determined to be 89.66%.Co

关键词： Glycomics N-glycans Biomarkers Pancreatic cancer Predictive modeling

Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1045-1055页

作者： LIU Gui-hong yaO Ze-qin chen Guo-qiang LI ya-lang LIANG Bing Department of Urology Sanya Central Hospital (The Third People's Hospital of Hainan Province) Department of Urology Yuzhou People's Hospital

Prostate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment strategies. Green tea, a well-known beverage derived from the Camellia sinensis plant, contains bioactive compounds with potential health benefits, including catechins and polyphenols. This comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing literature. Green tea possesses antioxidant, anti-inflammatory, and anti-carcinogenic properties attributed to its catechins, particularly epigallocatechin gallate. Epidemiological studies have reported an inverse association between green tea consumption and prostate cancer risk, with potential protection against aggressive forms of the disease. Laboratory studies demonstrate that green tea components inhibit tumor growth, induce apoptosis, and modulate signaling pathways critical to prostate cancer development and progression. Clinical trials and human studies further support the potential benefits of green tea. Green tea consumption has been found to be associated with a reduction in prostate-specific antigen levels, tumor markers, and played a potential role in slowing disease progression. However, challenges remain, including optimal dosage determination, formulation standardization, and conducting large-scale, long-term clinical trials. The review suggests future research should focus on combinatorial approaches with conventional therapies and personalized medicine strategies to identify patient subgroups most likely to benefit from green tea interventions.

关键词： epigallocatechin gallate green tea prevention prostate cancer review treatment

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 498-507页

作者： Bojian chen Tao Jiang Jing wen Guangdong yang Tangxia Yu Fengxiang Zhu Peng Hu School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China State key laboratory of vanadium and titanium resources comprehensive utilization Panzhihua 617000China

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be *** allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the *** referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux *** results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting *** comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was *** melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 *** permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently *** acid pellets played a role in withstanding load during the softening *** flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting *** slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single *** segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

关键词： high-chromium vanadium-titanium magnetite softening-melting properties all pellets integrated burden flux pellets

Irreducible Representations of GL_(n)(C)of Minimal Gelfand-Kirillov Dimension

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Acta Mathematica Sinica,English Series 2024年第3期40卷 639-657页

作者： Zhan Qiang BAI yang yang chen Dong wen LIU Bin Yong SUN School of Mathematical Sciences Soochow UniversitySuzhou 215006P.R.China School of Sciences JiangnanUniversityWui214122P.R.China School of Mathematical Sciences Zhejiang UniversityHangzhou 310058P.R.China Institute for Advanced Study in Mathematics Zhejiang UniversityHangzhou 310058P.R.China

In this article,by studying the Bernstein degrees and Goldie rank polynomials,we es-tablish a comparison between the irreducible representations of G=GL_(n)(C)possessing the minimal Gelfand-Kirillov dimension and those induced from finite-dimensional representations of the maximal parabolic subgroup of G of type(n-1,1).We give the transition matrix between the two bases for the corresponding coherent families.

关键词： Bernstein degree coherent continuation Gelfand-Kirillov dimension

Simulation of fire emergency evacuation in a large-passenger-flow subway station based on the on-site measured data of Shenzhen Metro

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Transportation Safety and Environment 2024年第1期6卷 47-55页

作者： Hua chen chenyang Zhang Jieyu Zhang ya Shu Xinjian Qi Chaozhe Jiang Sichuan FAST Fire Safety Assessment Co. LTD.Chengdu 610036SichuanChina School of Transportation and Logistics Southwest Jiaotong UniversityChengdu 611756SichuanChina Sichuan Fire Research Institute of MEM Chengdu 610036SichuanChina Shenzhen Metro Group Co. LTD.Shenzhen 518026GuangdongChina

Because of its large capacity,high efficiency and energy savings,the subway has gradually become the primary mode of transportation for citizens.A high density of passengers exists within a large-passenger-flow subway station,and the number of casualties and injuries during a fire emergency is *** this paper,Pathfinder software and on-site measured data of Pingzhou station in Shenzhen(China)were utilized to simulate a fire emergency evacuation in a large-passenger-flow subway *** Required Safe Egress Time(RSET),number of passengers and flow rates of stairs and escalators were analysed for three fire evacuation scenarios:train fire,platform fire and hall *** evacuation time of the train fire,which was 1173 s,was the longest,and 3621 occupants needed to evacuate when the train was fully *** could not complete the evacuation within 6 mins in all three fire evacuation scenarios,which does not meet the current standard requirements and *** changing the number of passengers and the number of stairs for evacuation,the flow rate capacity and evacuation time were explored,which have reference values for safety management and emergency evacuation plan optimization during peak hours of subway operation.

关键词： fire emergency evacuation large-passenger-flow subway station on-site measured data Pathfinder

MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer

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Cancer Innovation 2024年第3期3卷 33-48页

作者： Jing chen Jing yang Yufang Liu Xu Zhao Juanjuan Zhao Lin Tang Mengmeng Guo ya Zhou Chao chen Dongmei Li Zhenke wen Guiyou Liang Lin Xu Special Key Laboratory of Gene Detection&Therapy of Guizhou Province ZunyiGuizhouChina Department of Immunology Zunyi Medical UniversityZunyiGuizhouChina Department of Medical Physics Zunyi Medical UniversityZunyiGuizhouChina Institute of Biomedical Soochow UniversitySuzhouJiangsuChina Department of Cardiovascular Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouChina

Background:Angiogenesis plays an important role in the occurrence and development of non-small cell lung cancer(NSCLC).The atypical mitogen-activated protein kinase 4(MAPK4)has been shown to be involved in the pathogenesis of various ***,the potential role of MAPK4 in the tumor angiogenesis of NSCLC remains ***:Adult male C57BL/6 wild-type mice were randomly divided into the control group and p-siMAPK4 intervention group,*** cell proliferation was analyzed with flow cytometry and immunofluorescence *** vascular density in tumor mass was analyzed by immuno-fluorescence *** expressions of MAPK4 and related signaling molecules were detected by western blot analysis and immunofluorescence staining,and so ***:We found that the expression of MAPK4,which was dominantly expressed in local endothelial cells(ECs),was correlated with tumor angiogenesis of ***,MAPK4 silencing inhibited the proliferation and migration abilities of human umbilical vein ECs(HUVECs).QKHZC-2020-4Y156,QKH-JC-2018-1428,QKH-RC-2019-5612;Collaborative Innovation Center of Chinese Ministry of Education,Grant/Award Number:2020-39;Program for Science and Technology Joint Fund Project in Zunyi Science and Technology Bureau and Zunyi Medical University,Grant/Award Numbers:ZSKH-RPT-2020-6,ZSKH-HZ-2021-193;Graduate Research Fund of Zunyi Medical University,Grant/Award Number:2023-ZYK-171 Global gene analysis showed that MAPK4 silencing altered the expression of multiple genes related to cell cycle and angiogenesis pathways,and that MAPK4 silencing increased transduction of the extracellular regulated protein kinases 1/2(ERK1/2)pathway but not Akt and c-Jun n-terminal kinase *** analysis showed that MAPK4 silencing inhibited the proliferation and migration abilities of HUVECs cultured in tumor cell supernatant,which was accompanied with increased transduction of the ERK1/2 *** data analysis suggested that the

关键词： angiogenesis endothelial cell MAPK4 NSCLC p-ERK1/2

Sustained remission of Cronkhite-Canada syndrome after corticosteroid and mesalazine treatment: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2431-2437页

作者： ya-Lan chen Rui-yao Wang Ling Mei Ran Duan Department of Gastroenterology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Thoracic Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Medical Imageology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease of unknown *** optimal treatment for CCS remains *** with corticosteroids is considered the mainstay treatment because of its high efficacy,but the therapeutic strategy for steroid-resistant CCS is not yet *** SUMMARY This is the case of an 81-year-old woman who was diagnosed with *** her severe diarrhea,nausea,vomiting,and hypoproteinemia,hormone therapy(40 mg/d)was administered,and the symptoms improved within 1 *** 3 mo,the patient had no obvious *** polyps were significantly reduced on review gastroscopy and colonoscopy,thus hormone reduction gradually *** hormone level was maintained at 10 mg/d after 6 *** the age of the patient and the side effects of hormones,the patient had no obvious ***,hormone drugs were discontinued,and mesalazine was administered orally at 3 g/*** patient's symptoms continued to improve after a follow-up of 5 *** Corticosteroids and mesalazine are potential treatment options for CCS.

关键词： Cronkhite-Canada syndrome Corticosteroids Mesalazine Gastrointestinal polyposis Case report