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Comparison of clinicopathological characteristics and survival outcomes between gallbladder mucinous adenocarcinoma and gallbladder adenocarcinoma:A propensity score-matched study

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1436-1450页

作者： Wen-Wei yang Yu-Ting Fang ya-ru niu Yong-Kun Sun Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer HospitalLangfang 065001Hebei ProvinceChina

BACKGROUND Gallbladder mucinous adenocarcinoma(GBMAC)is a rare subtype of gallbladder adenocarcinoma(GBAC),with limited knowledge of its survival outcomes from small case series and single-center retrospective *** To compare the clinicopathological characteristics of GBMAC with typical GBAC and its prognostic factors to gain insights into this *** This study was conducted using data from the Surveillance,Epidemiology,and End Results database,including cases of GBMAC and typical GBAC diagnosed from 2010 to *** Pearson chi-square test or Fisher exact test was used to examine the differences in clinicopathological features between these two *** addition,propensity score matching(PSM)analysis was performed to balance the selection *** and multivariate Cox hazards regression analyses were performed to determine independent prognostic factors for cancer-specic survival(CSS)and overall survival(OS).The Kaplan–Meier curves and log-rank tests were used to assess the OS and CSS of GBMAC and typical GBAC *** The clinicopathological and demographic characteristics of GBMAC were different from typical *** included a larger proportion of patients with unmarried status,advanced American Joint Committee on Cancer(AJCC)stage,higher T stage,higher N1 stage rate and lower N0 and N2 stage rates(P<0.05).Multivariate analyses demonstrated that surgery[OS:Hazard ratio(HR)=2.27,P=0.0037;CSS:HR=2.05,P=0.0151],chemotherapy(OS:HR=6.41,P<0.001;CSS:HR=5.24,P<0.001)and advanced AJCC stage(OS:Stage IV:HR=28.99,P=0.0046;CSS:Stage III:HR=12.31,P=0.015;stage IV:HR=32.69,P=0.0015)were independent prognostic indicators for OS and CSS of GBMAC ***,after PSM analysis,there was no significant difference between GBMAC and matched typical GBAC patients regarding OS(P=0.82)and CSS(P=0.69).CONCLUSION The biological behaviors of GBMAC are aggressive and significantly different from that of typical ***,they show similar

关键词： Gallbladder mucinous adenocarcinoma Gallbladder adenocarcinoma Surveillance,Epidemiology,and End Results Prognosis Risk factors

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Recent advances in targeted therapy for pancreatic adenocarcinoma

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 571-595页

作者： Yu-Ting Fang Wen-Wei yang ya-ru niu Yong-Kun Sun Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer HospitalChinese Academy of Medical SciencesLangfang 065001Hebei ProvinceChina

Pancreatic adenocarcinoma(PDAC)is a fatal disease with a 5-year survival rate of 8%and a median survival of 6 *** PDAC,several mutations in the genes are involved,with Kirsten rat sarcoma oncogene(90%),cyclin-dependent kinase inhibitor 2A(90%),and tumor suppressor 53(75%–90%)being the most *** against decapentaplegic homolog 4 represents 50%.In addition,the selfpreserving cancer stem cells,dense tumor microenvironment(fibrous accounting for 90%of the tumor volume),and suppressive and relatively depleted immune niche of PDAC are also constitutive and relevant elements of *** targeted therapy is widely utilized and effective in several solid *** PDAC,targeted therapy has been extensively evaluated;however,survival improvement of this aggressive disease using a targeted strategy has been *** is currently only one United States Food and Drug Administration-approved targeted therapy for PDAC–erlotinib,but the absolute benefit of erlotinib in combination with gemcitabine is also minimal(2 wk).In this review,we summarize current targeted therapies and clinical trials targeting dysregulated signaling pathways and components of the PDAC oncogenic process,analyze possible reasons for the lack of positive results in clinical trials,and suggest ways to improve *** also discuss emerging trends in targeted therapies for PDAC:combining targeted inhibitors of multiple *** PubMed database and National Center for Biotechnology Information clinical trial website(***)were queried to identify completed and published(PubMed)and ongoing(***)clinical trials(from 2003-2022)using the keywords pancreatic cancer and targeted *** PubMed database was also queried to search for information about the pathogenesis and molecular pathways of pancreatic cancer using the keywords pancreatic cancer and molecular pathways.

关键词： Pancreatic carcinoma Targeted therapy Cancer stem cell Monoclonal antibody Epigenetic modifier

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Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection inβcells

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World Journal of Diabetes 2020年第9期11卷 374-390页

作者： Li-Juan Cui Tao Bai Lin-Ping Zhi Zhi-Hong Liu Tao Liu Huan Xue Huan-Huan yang Xiao-Hua yang Min Zhang ya-ru niu Yun-Feng Liu Yi Zhang Department of Pharmacology Basic Medical CollegeShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Endocrinology The First Clinical Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Respiratory Medicine The First Clinical Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of General Surgery Shanxi Bethune HospitalTaiyuan 030006Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Long noncoding RNAs(lncRNAs)and mRNAs are widely involved in various physiological and pathological *** use of glucagon-like peptide-1 receptor agonists(GLP-1RAs)is a novel therapeutic strategy that could promote insulin secretion and decrease the rate ofβ-cell apoptosis in type 2 diabetes mellitus(T2DM)***,the specific lncRNAs and mRNAs and their functions in these processes have not been fully identified and *** To identify the lncRNAs and mRNAs that are involved in the protective effect of GLP-1RA inβcells,and their *** Rat gene microarray was used to screen differentially expressed(DE)lncRNAs and mRNAs inβcells treated with geniposide,a *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to assess the underlying functions of DE *** mRNAs were filtered using the STRING database and the Cytoscape plugin,*** order to reveal the regulatory relationship between lncRNAs and hub mRNAs,their co-expression network was constructed based on the Pearson coefficient of DE lncRNAs and mRNAs,and competing endogenous RNA(ceRNA)mechanism was explored through miRanda and TargetScan *** We identified 308 DE lncRNAs and 128 DE mRNAs with a fold change filter of≥1.5 and P value<*** and KEGG pathway enrichment analyses indicated that the most enriched terms were G-protein coupled receptor signaling pathway,inflammatory response,calcium signaling pathway,positive regulation of cell proliferation,and ERK1 and ERK2 ***,Htr2a,and Agtr1a were screened as hub mRNAs using the STRING database and the Cytoscape plugin,*** result was further verified using SwissTargetPrediction *** the co-expression network and competing endogenous(ceRNA)mechanism,we identified seven lncRNAs(NONRATT027738,NONRATT027888,NONRATT030038,etc.)co-expressed with the three hub mRNAs(Pomc,Htr2a,and Agtr1a)based on the Pearson coefficient of

关键词： Type 2 diabetes βcell Long noncoding RNA Competing endogenous RNA Co-expression analysis Glucagon-like peptide-1 receptor agonist

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Regulating the oxygen-atom configuration of carbon anode enabling extremely fast-charging potassium-ion hybrid capacitors

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Nano Research 2025年第1期18卷 373-381页

作者： Daping Qiu Yuehui Wang Lulu Zhang Hang Lei Haizhou Ying Jin niu Min Li Xuelin yang Feng Wang ru yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering and New EnergyChina Three Gorges UniversityYichang 443002China State Key Laboratory of Chemical Resource Engineering Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials and Chemical Engineering China Three Gorges UniversityYichang 443002China

Metal-ion hybrid capacitors,such as potassium-ion hybrid capacitors(PIHCs),are regarded as promising fast-charging energy storage ***,the kinetics mismatch between the battery anode and the capacitive cathode restricts their fastcharging *** constructing carbon anodes with enhanced kinetics is an innovative approach to address this ***,using epigallocatechin gallate with high oxygen content as the precursor,oxygen-enriched carbon materials(OEC)with tunable C=O content are successfully ***,the C=O content of OEC is regulated by adjusting the pyrolysis *** as an anode for PIHCs,OEC-600 with the highest C=O content exhibits an attractive fast-charging specific capacity of 135.2 mAh·g^(-1)at 20 A·g^(-1),along with a superior fast-charging cycling *** theoretical calculations,comprehensive kinetics analysis and in-situ Raman,the positive effects of C=O on the potassium storage capability and reversibility of OEC-600 are ***,PIHCs assembled based on an OEC-600 anode deliver impressive energy/power density of 145.1 Wh·kg^(-1)/45.9 kW·kg^(-1)and superior fast-charging cycling stability with 87.5%of capacity retention over 20,000 cycles at 5 A·g^(-1).This work is anticipated to provide an optional design concept toward the carbon anode for fast-charging PIHCs.

关键词： carbon anode oxygen epigallocatechin gallate potassium-ion hybrid capacitor

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Method of secure, scalable, and fine-grained data access control with efficient revocation in untrusted cloud

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The Journal of China Universities of Posts and Telecommunications 2015年第2期22卷 38-43页

作者： Song Lingwei Yu Fang Zhang ru niu Xinxin Information Security Center Beijing University of Posts and Telecommunications

Cloud computing is a developing computing paradigm in which resources of the computing infrastructure are provided as services over the network. Hopeful as it is, this paradigm also brings new challenges for data security and encryption storage when date owner stores sensitive data for sharing with untrusted cloud servers. When it comes to fine-grained data and scalable access control, a huge computation for key distribution and data management is required. In this article, we achieved this goal by exploiting and uniquely combining techniques of ciphertext-policy attribute-based encryption （CP-ABE）, linear secret sharing schemes （LSSS）, and counter （CTR） mode encryption. The proposed scheme is highly efficient by conducting the revocation on attribute level rather than on user level. The goals of data confidentiality and no collusion attack （even the cloud servers （CS） collude with users）, as well as ones of fine-grainedness and scalability, are also achieved in our access structure.

关键词： CP-ABE revocation fine-grained counter mode encryption cloud computing

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Applying System Thinking to Learn from Accident of Modern Automatic Control Systems

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Chinese Journal of Electronics 2014年第2期23卷 409-414页

作者： niu ru CAO Yuan GE Xiaocheng TANG Tao State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong University School of Electronics and Information Engineering National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University Department of Computer Science University of York

Modern societies increasingly rely on automatic control systems. These systems are hardly pure technical systems; instead they are complex socio-technical systems, which consist of technical elements and social components. It is necessary to have a systematic approach to analyze these systems because it is growing evidence that accidents from these systems usually have complex causal factors which form an interconnected network of events,rather than a simple cause-effect chain. We take railway Train control systems(TCS) as an example to demonstrate the importance of the socio-technical approach to analyze the system. The paper presents an investigation of recent high-speed railway accident by applying STAMP – one of the most notable socio-technical system analysis techniques, outlines improvements to the system which could avoid similar accidents in the future. We also provide our valuable feedback for the use of STAMP.

关键词： Socio-technical automatic system Railway safety Accident analysis Systems theoretic accident model and processes(STAMP)

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Color Image Super-Resolution and Enhancement with Inter-Channel Details at Trivial Cost

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Journal of Computer Science & Technology 2020年第4期35卷 889-899页

作者： Chuang-Ye Zhang yan niu Tie-ru Wu Xi-Ming Li College of Computer Science and Technology Jilin UniversityChangchun 130012China Key Laboratory of Symbolic Computer and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012China School of Mathematics Jilin UniversityChangchun 130012China

Image super-resolution is essential for a variety of applications such as medical imaging,surveillance imaging,and satellite imaging,among ***,the most popular color image super-resolution is performed in each color channel *** this paper,we show that the super-resolution quality can be further enhanced by exploiting the cross-channel *** by the High-Quality Linear Interpolation(HQLI)demosaicking algorithm by Malvar et al.,we design an image super-resolution scheme that integrates intra-channel interpolation with cross-channel details by isotropic linear *** its simplicity,our super-resolution method achieves the accuracy comparable with the existing fastest state-of-the-art super-resolution algorithm at 20 times faster *** is well applicable to applications that adopt traditional interpolations,for improved visual quality at trivial computation *** comparative study verifies the effectiveness and efficiency of the proposed super-resolution algorithm.

关键词： image super-resolution isotropic linear interpolation inter-channel detail enhancement low cost

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