检索结果-南通市图书馆

Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis

引用

Journal of Geriatric Cardiology 2024年第4期21卷 407-420页

作者： Jian-Guo CUI Feng TIAN Yu-Hao MIAO Qin-Hua JIN ya-jun shi Li LI Meng-jun SHEN Xiao-Ming XIE Shu-Lin ZHANG Yun-Dai CHEN School of Medicine Nankai UniversityTianjinChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Joint Laboratory of Bioimaging Technology and Applications SAS-SIM-IT&MEDIShanghaiChina Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghaiChina

OBJECTIVE To evalu ate the role of resting magnetocardiography in identifying seve re coronary artery stenosis in patients with suspected coronary artery *** A total of 513 patients with angina symptoms were included and divided into two groups based on the extent of coronary artery disease determined by angiography:the non-severe coronary stenusis group(<70% stenosis) and the severe coronary stenosis group(≥70% stenosis).The diagnostic model was constructed using magnetic field map(MFM) parameters,either individually or in combination with clinical *** performance of the models was evaluated using receiver operating characteristic curves,accuracy,sensitivity,specificity,positive predictive value(PPV) and ne gative predictive value(NPV).Calibration plots and decision curve analysis were performed to investigate the clinical utility and performance of the models,*** In the severe coronary stenosis group,QR_MCTDd,S_MDp,and TT_(MA)C_(50) were significantly higher than those in the non-severe coronary stenosis group(10,46±10.66 vs,5.11±6.07,P <0.001;7.2±8.64 vs.4.68±6.95,P=0.003;0.32±57.29 vs.0.26±57.29,P <0.001).While,QR_MV_(amp),R_(MA),and T_(MA) in the severe coronary stenosis group were lower(0.23±0.16 vs.0.28±0.16,P<0.001;55.06±48.68 vs.59.24±53.01,P<0.001;51.67±39.32 vs. 60.45±51.33,P <0.001).Seven MFM parameters were integrated into the model,resulting in an area under the curve of 0.810(95% CI:0.765-0.855).The sensitivity,specificity,PPV,NPV,and accurecy were 71.7%,80.4%,93.3%,42.8 %,and 73.5%;*** combined model exhibited an area under the curve of 0.845(95% CI:0.798-0.892).The sensitivity,specificity,PPV,NPV,and accuracy were 84.3%,73.8%,92.6%,54.6%,and 82.1%;*** curves demonstrate d excellent agreement between the nomogram prediction and actual *** decision curve analysis showed that the c ombine d model provided greater net benefit compared to the magnetocardingraphy model.C

关键词： coronary stenosis specificity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boswellic acids: a review on its pharmacological properties, molecular mechanism and bioavailability

引用

Traditional Medicine Research 2024年第10期9卷 64-74页

作者： Na Cui Ming-Jie Li Yi-Wen Wang Qian Meng ya-jun shi Yi Ding Department of Pharmacy 3201 HospitalHanzhong 723000China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Pharmacy Shaanxi University of Traditional Chinese medicineXianyang 712046China

Boswellic acids is a general term for a series of pentacyclic triterpenoid compounds that are isolated from the oleogin resin of the Boswellia genus and serve as the main active *** exhibits a wide range of biological activities,such as anti-inflammatory,anti-cancer,antibacterial,antiviral,hepatoprotective,neuroprotective,anti-diabetic,and anti-thrombotic *** a result,it has gained significant recognition among practitioners of traditional Chinese and Indian *** biological effects may be associated with multiple molecular targets and signal transduction ***,the poor pharmacokinetic properties of the substance lead to lower bioavailability,which affects its *** address this issue,scientists have proposed a number of strategies,such as solid dispersions,phytosome®technologies,and novel drug delivery *** article aims to provide a comprehensive overview for boswellic acids on the phytochemistry,molecular mechanisms,potential therapeutic applications,and strategies to improve bioavailability.

关键词： boswellic acids molecular mechanism pharmacological properties bioavailability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on the mechanism of SND in the treatment of anxiety disorders based on network pharmacology, molecular docking and experiment validation

引用

Pharmacology Discovery 2024年第2期4卷 10-23页

作者： Fei-yan Wang Ping Yuan Mei-Ling Zheng Xiao-Di Guo Long Li Jin Wang Shan Miao ya-jun shi Shan-Bo Ma Xiao-Peng shi College of pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Department of Pharmacy Xijing HospitalAir Force Medical UniversityXi’an 710032China Outpatient Department of University Hospital Northwestern Polytechnical University HospitalXi’an 710072China The College of Life Sciences Northwest UniversityXi’an 710127China

Background:Sini decoction(SND)is a classic traditional Chinese medicine(TCM)formulation that can be used to treat anxiety-related disorders,but the active substance and underlying molecular mechanism of its anxiolytic effects are *** this study,network pharmacology,molecular docking research and experimental verification methods were used to preliminarily explore the bioactive compounds and potential target mechanisms of SND ***:The active components and corresponding targets of SND were collected by ***,OMIM,PharmGkb,TTD and Drugbank were used to search for the targets of anxiety *** core target of SND in the treatment of anxiety was screened by PPI.R language was used to analyze the intersection targets of SND in the treatment of anxiety disorders by GO and KEGG enrichment *** Vina was used for molecular docking,and Discovery Studio was used for visual conformation analysis after *** anti-anxiety effect and molecular mechanism of SND were studied by in vivo ***:Based on network pharmacological analysis,we obtained 112 active ingredients and 350 effective targets related to anxiety from *** PPI analysis,26 targets such as STAT3,MAPK3,MAPK1,MAPK14,SRC,HSP90AA1,TP53 and PIK3CA were identified as core *** and KEGG analysis showed that the anxiolytic mechanism of SND may be related to the neuroactive ligand-receptor interaction pathway and inflammatory *** docking showed that quercetin,naringenin,licochalcone A had high affinity with JAK2,MAPK14 and *** experiments have shown that SND reverses the upregulation of GluN2B(NMDAR)and GluA1(AMPAR)proteins,and SND improves anxiety disorders by regulating glutamate transmitter levels,which may be related to neuroactive ligand-receptor interaction pathways,particularly glutamate ***:This study shows that SND can improve FS-induced behavioral changes in mice and can modulate hippocampal synapse-asso

关键词： SND anxiety disorders network pharmacology molecular docking pharmacological mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical research on slamming characteristics of aircraft landing on water

引用

Journal of Hydrodynamics 2023年第1期35卷 171-184页

作者： Dao-sheng Ning ya-jun shi Gui-yong Zhang Heng Wang Huan Hu Zhi-fan Zhang State Key Laboratory of Structural Analysis for Industrial Equipment School of Naval Architecture EngineeringDalian University of TechnologyDalian116024China China ship Scientific Research Center Wuxi200136China Collaborative Innovation Center for Advanced ship and Deep-Sea Exploration Shanghai200240China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

In order to investigate the impact characteristic of an aircraft landing on water,a computational fluid dynamics(CFD)simulation is conducted to explore the slamming characteristics of the NACA TN 2929 A *** flow around the model is solved by using Reynolds-averaged Navier-Stokes equations with the shear stress transport(SST)k—ωturbulence model,based on finite volume method(FVM).The free surface is captured by using the volume of fluid(VOF)method,and the aircraft impact process is realized with help of overset mesh ***,the effects of horizontal and vertical velocities and initial pitch angle on the slamming load,attitude change,impact pressure and flow field evolution are *** results reveal that the horizontal velocity has a considerable influence on whether the aircraft’s horizontal tail hits the water,and further affects the maximum vertical load as well as the maximum pitch angle throughout the impact *** vertical velocity determines the slamming load before the horizontal tail strikes the water,while the horizontal velocity has a significant effect on the load after the horizontal tail hits the water.A smaller initial pitch angle results in not only a heavier slamming load but also a more dramatic change of the posture after the aircraft impacts the *** impact pressure of the aircraft is maximized at the junction of the approaching surface of the fuselage and the free *** some cases,the pressure is also concentrated on the undersurface of the horizontal tail.

关键词： Computational fluid dynamics(CFD) aircraft landing water entry slamming load motion attitude change

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploration of the efficacy and mechanism of treating head wind disease with the combination change of ginger volatile oil and gingerol by using content-weighted network pharmacology technology

引用

TMR Modern Herbal Medicine 2024年第1期7卷 43-56页

作者： Wei-Xiang Wang Fei yan Fei Luan ya-jun shi Xiao-Fei Zhang Dong-yan Guo Bing-Tao Zhai jun-Bo Zou Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research College of PharmacyShaanxi University of Chinese MedicineXianyang 712046China

Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content ***:The experimental groups were divided into:0:10,1:4,1:2,1:1,2:1,4:1,10:*** relative content(Ri)of the chemical constituents of ginger's volatile oil was determined using gas chromatography-mass spectrometry(GC-MS).Additionally,the physicochemical and biological property parameters(LogP,MDCK,PPB,MW)of the components were *** assess the quantitative effect of the components,a grading score was performed,and the quantitative effect index(Ki)was ***,the target effect index(Ti)was calculated by combining the component-target matching score(Fit score).Using these calculations,the target effect score A was determined under the influence of multiple components targeting different *** targets with A≥1000 were *** predict the targets related to head wind disease,the Comparative Toxicogenomics Database(https://***/),Gene Cards(https://***/),and Disgenet database(https://***/)were *** key targets,obtained from different proportions of ginger's volatile oil and gingerol,were intersected with the predicted *** facilitated network pharmacological analysis and verification of the ***:The content of volatile oil in ginger demonstrated an impact on key targets associated with the volatile oil *** specific combination of volatile oil consistently activated distinct pathways,with variations stemming from changes in *** testing revealed that different combinations of ginger's volatile oil and gingerol effectively alleviated migraine symptoms in ***:Through the application of content-weighted network pharmacology technology and pharmacodynamic verification,it was determined that altering the ratio between ginge

关键词： network pharmacology volatile oil of ginger weight of content head wind disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predictors of adherence to home-based cardiac rehabilitation program among coronary artery disease outpatients in China

引用

Journal of Geriatric Cardiology 2019年第10期16卷 749-755页

作者： Cheng GE Jing MA Yong XU ya-jun shi Cheng-Hui ZHAO Ling GAO Jing BAI Yu WANG Zhi-jun SUN jun GUO Yun-Dai CHEN Department of Cardiology the First Medical Center of Chinese PLA General Hospital

Background Cardiac rehabilitation (CR) has proven beneficial for patients with coronary artery disease. However, adherence to CR programs is the key to the health improvement in those patients. Identifying predictors for adherence, which is very much unknown in China, would be valuable for effective rehabilitation. This study aims to determine the adherence to home-based CR programs in Chinese coronary artery disease patients and determine predictors of adherence. Methods The current study included 1033 outpatients with coronary heart disease in the First Medical Center of Chinese PLA General Hospital in Beijing from July 2015 to june 2017. Participants were given an exercise prescription and took part in home-based exercise training lasting for 3–24 months. A questionnaire was used to evaluate the completion of the CR program, understanding of the program, motivation of the patients, and family/peer support. Results Two thirds of the patients adhered well to the home-based CR program. Elder patients (≥ 65-year-old) adhere to the program better, while men adhered better than women. Patients who used to exercise (B = 6.756, P < 0.001), understood the program (B = 0.078, P = 0.002), with stronger motivation to participate (B = 0.376, P < 0.001), and received better family support (B = 0.487, P < 0.001) also adhere better to the program. Conclusions Understanding the program, self-motivation of patients, and family support help to keep patients engaged in a home-based CR program. Improvement of family support by educating both patients and families may be helpful in improving adherence to home-based CR programs.

关键词： Adherence Cardiac rehabilitation Coronary artery disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Subsurface multi-physical characterization of mountain excavation and city construction in loess plateau with a fiber-optic sensing system

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 2935-2946页

作者： Jie Liu Bin shi Kai Gu Meng-ya Sun jun-Cheng yao He-Ming Han School of Earth Sciences and Engineering Nanjing UniversityNanjingJiangsu210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing210023China School of Earth Sciences and Engineering Hohai UniversityNanjing210098China

Mountain excavation and city construction(MECC)projects being launched in the Loess Plateau in China involve the creation of large-scale artificial *** the subsurface evolution characteristics of the artificial land is essential,yet ***,we use an improved fiber-optic monitoring system for its subsurface multi-physical *** system enables us to gather spatiotemporal distribution of various parameters,including strata deformation,temperature,and ***’an New District was selected as a case study to conduct refined in-situ monitoring through a 77 m-deep borehole and a 30 m-long *** reveal that the ground settlement involves both the deformation of the filling loess and the underlying intact ***,the filling loess exhibits a stronger creep capability compared to underlying intact *** deformation along the profile is unevenly distributed,with a positive correlation with soil *** accumulation has been observed at the interface between the filling loess and the underlying intact loess,leading to a significant ***,the temperature and moisture in the filling loess have reached a new equilibrium state,with their depths influenced by atmospheric conditions measuring at 31 m and 26 m,*** refined investigation allows us to identify critical layers that matter the sustainable development of newly created urban areas,and provide improved insights into the evolution mechanisms of land creation.

关键词： Mountain excavation and city construction Fiber-optic monitoring Multi-physical characterization Compacted loess

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Armarium facilitating angina management post myocardial infarction concomitant with coronavirus disease 2019

引用

Journal of Geriatric Cardiology 2020年第4期17卷 217-220页

作者： Xiao-Qing CAI Pi-Qi JIAO Tao WU Fu-Ming CHEN Bao-shi HAN Jiu-Cong ZHANG Yong-Jiu XIAO Zhi-Feng CHEN jun LI Yu-Ying ZHAO Ling MA yan LIU ya-jun shi Pei-jun DAI Yun-Dai CHEN Department of Cardiology the 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouChina Department of Cardiology the First Medical Center of Chinese PLA General HospitalBeijingChina Department of Cardiology the 980th Hospital of Joint Logistics Support Force of Chinese PLAShijiazhuangChina Department of Infectious Diseases Huoshenshan HospitalWuhanChina

The outbreak and spread of coronavirus disease 2019(COVID-19)are not only a disaster of people’s life and health over the world,[1–3]but also the challenge for medical practitioner in clinical *** to many diagnostic instruments are not suitable or convenient to use any more in contagious ward considering the risk of cross infections,such as traditional stethoscope or electrocardiogram(ECG).In this scenarios,wireless and digital equipment are optimal choices for epidemic management in order to exert rapid diagnosis and disease ***,we reported a case of the patient suffering both COVID-19 and myocardial infarction,for which the tele-ECG and wireless stethoscope facilitated the accurate diagnosis and instant management.

关键词： Acute myocardial infarction Angina Coronavirus disease 2019 Electrocardiogram Stethoscope

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distributed Optimal Formation Control for Unmanned Surface Vessels by a Regularized Game-Based Approach

引用

IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 276-278页

作者： jun shi Maojiao Ye the School of Automation Nanjing University of Science and TechnologyNanjing 210094China IEEE

Dear Editor,This letter explores optimal formation control for a network of unmanned surface vessels(USVs).By designing an individual objective function for each USV,the optimal formation problem is transformed into a noncooperative *** this game theoretic framework,the optimal formation is achieved by seeking the Nash equilibrium of the regularized game.A modular structure consisting of a distributed Nash equilibrium seeker and a regulator is proposed.

关键词： Regular seeking optimal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Survey on performance of vertical slot and nature-like fishways at Angu hydropower station, Southwest China

引用

Water Science and Engineering 2024年第1期17卷 83-91页

作者： jun-jian Sun Jia-yue shi Qi Zhang Xiao-tao shi jun-jun Tan PowerChina Huadong Engineering Corporation Limited Hangzhou 311122China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang 443002China

To restore dam-blocked natural fish migratory passages,a growing number of artificial fishways have been built in water conservancy and hydropower projects in *** Angu hydropower station involved diverse important fish habitats in the lower reaches of the Daduhe River in Southwest ***,a vertical slot fishway(VSF)and a nature-like fishway(NLF)were built near the backwater area of the reservoir to connect the upstream and downstream *** and aquatic ecological surveys were conducted after the completion of the project to estimate the fish passing effect of the two *** results indicated that both fishways were in effective operation and could maintain the desired hydrodynamic conditions and be used by several local fish *** the survey,149 fish from 15 species and 111 fish from 17 species were captured by the traps in the VSF and NLF,respectively,while 1263 fish from 27 species were found in the downstream *** species captured in the VSF were not found in the NLF,and vice versa,which implied the different preferences of ***,3789 signals including 2099 upward ones and 1690 downward ones were monitored with an ultrasonic fish detector at the inlet of the *** findings revealed the characteristics of fish species observed in and near the fishways and provided valuable insights into the different fish passing capabilities of VSFandNLF.

关键词： Vertical slot fishway Nature-like fishway Aguatic ecological survey Fishwaymonitoring Statistical analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：