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Investigating m.ller glia reprogram.ing in m.ce: a retrospective of the last decade, and a look to the future

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Dam.ge and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

m.ller glia,as prom.nent glial cells within the retina,plays a significant role in m.intaining retinal hom.ostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assum. responsibility for spontaneous retinal regeneration,wherein endogenous m.ller glia undergo proliferation,transform.into m.ller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,m.ller glia in the m.use and hum.n retina exhibit lim.ted neural reprogram.ing.m.ller glia reprogram.ing is thus a prom.sing strategy for treating neurodegenerative ocular disorders.m.ller glia reprogram.ing in m.ce has been accom.lished with rem.rkable success,through various *** in m.lecular,genetic,epigenetic,m.rphological,and physiological evaluations have m.de it easier to docum.nt and investigate the m.ller glia program.ing process in ***,there rem.in issues that hinder im.roving reprogram.ing efficiency and ***,understanding the reprogram.ing m.chanism.is crucial toward exploring factors that will im.rove m.ller glia reprogram.ing efficiency,and for developing novel m.ller glia reprogram.ing *** review describes recent progress in relatively successful m.ller glia reprogram.ing *** also provides a basis for developing new m.ller glia reprogram.ing strategies in m.ce,including epigenetic rem.deling,m.tabolic m.dulation,im.une regulation,chem.cal sm.ll-m.lecules regulation,extracellular m.trix rem.deling,and cell-cell fusion,to achieve m.ller glia reprogram.ing in m.ce.

关键词： cell fusion chem.cal sm.ll-m.lecules epigenetic extracellular m.trix im.une m.tabolic m.ce m.ller glia neurodegenerative diseases reprogram.ing retina regeneration

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Unraveling the significance of cobalt on transform.tion kinetics,crystallography and im.act toughness in high-strength steels

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International Journal of m.nerals,m.tallurgy and m.terials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao Zhao Xuelin Wang hui Guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of m.terials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced m.tals and m.terials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the m.crostructure and im.act toughness of as-quenched highstrength steels by experim.ntal characterizations and therm.-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition tem.erature than the steel without ***,the Co-bearing steel reveals higher transform.tion rates at the interm.diate stage with bainite volum. fraction ranging from.around 0.1 to *** im.roved im.act toughness of the Co-bearing steel results from.the higher dense block boundaries dom.nated by the V1/V2 variant ***,the addition of Co induces a larger transform.tion driving force and a lower bainite start tem.erature(BS),thereby contributing to the refinem.nt of blocks and the increase of the V1/V2 variant *** findings would be instructive for the com.osition,m.crostructure design,and property optim.zation of high-strength steels.

关键词： high-strength steel cobalt transform.tion kinetics crystallography im.act toughness

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m.tal-organic fram.works with dinuclear m.tal centers for synergistically boosting CO2 photoreduction

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Science China Chem.stry 2025年第1期68卷 201-208页

作者： hui-Feng Wang Wen-Jie Shi Yu-Xin yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chem.stry and Chem.cal Engineering Yangzhou University Institute for New Energy m.terials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear m.tal synergistic catalysis （Dm.C） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of m.tal catalytic centers into an indium.based m.tal-organic fram.work （m.F）,obtained a series of isostructural In-m.Fs,including three m.Fs with m.nonuclear m.tal catalytic center （m.In）,three m.Fs with dinuclear hom.m.tallic catalytic centers （m.-In）,and three m.Fs with dinuclear heterom.tallic catalytic centers (m.’-In,m.m.=Co（II）,Ni（II）,Zn（II）).It was found that all these m.Fs can serve as catalysts for photochem.cal CO2reduction to *** with m.In,the catalytic activities of m.-In were obviously enhanced,and that of m.’-In was further significantly *** exam.le,the CO yield of Co Zn-In reaches a record value of 12,700μm.l g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear hom.m.tallic and m.nonuclear m.tallic *** results of control experim.nts and theoretical calculation reveal that the higher catalytic activities of m.-In over m.In can be ascribed to the Dm.C effect,and the higher catalytic activity of m.’-In over m.-In can be ascribed to the strengthened Dm.C *** work reveals the relationship between Dm.C effect and bim.tal centers in CO2reduction,which provides new insights into the Dm.C and paves a new way to design highly active catalysts for photochem.cal CO2reduction.

关键词： m.tal-organic fram.works dinuclear m.tal centers synergistic catalysis CO2 reduction photocatalysis

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GPS: graph contrastive learning via m.lti-scale augm.nted views from.adversarial pooling

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Science China(Inform.tion Sciences) 2025年第1期68卷 145-158页

作者： Wei JU Yiyang GU Zhengyang m.O Ziyue QIAO Yifang QIN Xiao LUO hui XIONG m.ng ZHANG School of Com.uter Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Departm.nt of Com.uter Science University of California

Self-supervised graph representation learning has recently shown considerable prom.se in a range of fields, including bioinform.tics and social networks. A large num.er of graph contrastive learning approaches have shown prom.sing perform.nce for representation learning on graphs, which train m.dels by m.xim.zing agreem.nt between original graphs and their augm.nted views(i.e., positive views). Unfortunately, these m.thods usually involve pre-defined augm.ntation strategies based on the knowledge of hum.n experts. m.reover, these strategies m.y fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach nam.d graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the rem.val of redundancy, we rethink graph pooling and leverage it to autom.tically generate m.lti-scale positive views with varying em.hasis on providing challenging positives and preserving sem.ntics, i.e., strongly-augm.nted view and weakly-augm.nted view. Then, we incorporate both views into a joint contrastive learning fram.work with sim.larity learning and consistency learning, where our pooling m.dule is adversarially trained with respect to the encoder for adversarial robustness. Experim.nts on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed m.thod over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augm.ntations graph pooling

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isom.rization study, and lasing application

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Science China Chem.stry 2025年第1期68卷 233-240页

作者： Peipei Liu yantong Li m.ng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang ya Cheng Hai-Bo yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum.m.lecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polym.r Optoelectronic m.terials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isom.rization process and lasing application is presented. 1 was synthesized by a sim.le protocol involving the form.tion of a 6,6′-bipentacene as the key interm.diate. It is worth noting that1 existed as two diastereom.rs 1-PP/m. and 1-Pm. which were successfully isolated and unam.iguously confirm.d by Xray crystallography. The optical resolution of the racem.c 1-PP/m. was successfully achieved by chiral-phase highperform.nce liquid chrom.tography（HPLC）, and 1-PP and 1-m. were characterized by circular dichroism. Interestingly, it was found that 1-PP/m. could be com.letely isom.rized to 1-Pm.upon heating, and the detailed therm.dynam.cs and kinetics of the isom.rization process were system.tically investigated. 1-Pm.exhibited deep-red lum.nescence with em.ssion m.xim.m.at 723 nm.and fluorescence quantum.yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-Pm.by doping with epoxy resin to assem.le a bottle m.crolaser spontaneously, which the lasing wavelength is 796.6 nm.at a threshold of 0.8 m.J cm.2. We believe that our studies, including the facile synthesis m.thodology, detailed isom.rization studies, and lasing application, will shed som. light on the design and synthesis of novel carbohelical system. with m.re functions.

关键词： double carbohelicene optical resolution organic laser isom.rization X-ray diffraction

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Genesis of geotherm.l water in the hinterland of Guanzhong Basin， China: Insight from.hydrochem.cal and isotopic analysis

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Journal of Earth Science 2025年

作者： Jiangxia Wang Panpan Xu hui Qian Yongqi Zang Qim.ng Wang Zhiyuan m. School of Water and Environm.nt， Chang'an University Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of the m.nistry of Education， Chang'an University Key Laboratory of Eco-hydrology and Water Security in Arid and Sem.-arid Regions of m.nistry of Water Resources， Chang'an University

The Guanzhong Basin， located in Shaanxi Province， China， has abundant geotherm.l resources in its hinterland. Focusing on typical therm.l reservoir structural units， nam.ly the Xianli fault-step (XL) and Xi'an depression (XA)， this study reveals the genesis of geotherm.l water by com.ining hydrochem.stry and environm.ntal isotopes. The geotherm.l waters of XL uniform.y correspond to the Na-Cl type with high contents of m.jor ions， while the geotherm.l water of XA has com.lex hydrochem.cal types. The quartz geotherm.m.ter (with m.xim.m.steam.loss) and Na-K-Ca geotherm.m.ter are recom.ended for XL and the quartz geotherm.m.ter (with no and m.xim.m.steam.loss) and Na-K geotherm.m.ter for XA. Their tem.erature ranges are 99-159℃ and 93-146℃， respectively. The circulation depth of geofluids in XL and XA range from.2579 to 4766 m.and from.2541 to 4330 m. with m.an apparent ages of 21543 and 20345 yr B.P.， respectively. The geotherm.l water in XL originates from.a m.xture of sedim.ntary water and ancient infiltration water， and its form.tion m.de was the vertical heat conduction with cooling process. In contrast， the geotherm.l water in XA originates from.the dual process of cooling and m.xing， with the process being dom.nated by ancient infiltration water and supplem.ntation by m.dern infiltration water.

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflam.ation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei Quan Xinyu Qiao Chun Cui Chenm.ng Qiao Weijiang Zhao yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate im.une ***,whether interferon regulatory factor 7-m.diated signaling contributes to Parkinson's disease rem.ins *** we report that interferon regulatory factor 7 is m.rkedly up-regulated in a 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced m.use m.del of Parkinson's disease and co-localizes with m.croglial *** the selective cyclic guanosine m.nophosphate adenosine m.nophosphate synthase inhibitor RU.521 and the stim.lator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 m.croglia exposed to 1-m.thyl-4-phenylpyridinium.and inhibited transform.tion of m.use BV2 m.croglia into the neurotoxic m. *** addition,si RNA-m.diated knockdown of interferon regulatory factor 7 expression in BV2 m.croglia reduced the expression of inducible nitric oxide synthase,tum.r necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflam.atory m.rkers ARG1 and *** together,our findings indicate that the cyclic guanosine m.nophosphate adenosine m.nophosphate synthase-stim.lator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine m.nophosphate adenosine m.nophosphate synthase H151 interferon regulatory factor 7 m. phenotype neurodegenerative disease neuroinflam.ation Parkinson’s disease RU521 STING type I interferon

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Estim.ting energy release perform.nce of oxidizer-activated alum.num.fuel particles under ultrafast stim.lus

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Defence Technology（防务技术） 2023年第5期23卷 92-99页

作者： ya-ru Li hui Ren Xin-zhou Wu hui-xin Wang Xi-long Yu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China State Key Laboratory of High Tem.erature Gas Dynam.cs Institute of MechanicsChinese Academy of SciencesBeijing100190China

Alum.num.Al) particles are good fuel additives to im.rove the energy output perform.nces of explosives. Under detonation environm.nt, reaction delay of Al particles plays a key role in the energy release efficiency. Up to date, reaction delay of Al particles is still lim.ted by the efficiency of m.ss and heat transfer from.oxidizers to Al particles. To address this issue, a hom.geneous fuel-oxidizer assem.ly has recently becom. a prom.sing strategy. In this work, oxidizer-activated Al fuel particles(ALG) were prepared with glycidyl azide polym.r(GAP) as the oxidizer. The ALG was in uniform.spherical shape and core-shell structure with shell layer of around 5 nm.which was observed by scanning electron m.croscope and transm.ssion electron m.croscope. The localized nanoscale m.d-IR m.asurem.nt detected the uniform.distribution of characteristic absorption bond of GAP in the shell layer which confirm.d the hom.genous fuel-oxidizer structure of ALG. A therm.l gravim.tric analysis of ALG at ultrafast heating rate of 1000℃/m.n under argon atm.sphere was conducted. The decom.osition of GAP finished m.ch earlier than that of GAP at heating rate of 10℃/m.n. Under ultrafast high laser fluence, the reaction response of ALG was characterized and com.ared with that of m.cro-sized Al(μAl). With the increase of laser energy, the propagation distance of the shock wave increased. However, the velocity histories were nearly the sam. when energies were lower than 299 m. or higher than 706 m.. The propagation distance of the shock wave for ALG was 0.5 m. larger than that for μAl at 2.1 μs. The underwater explosion showed the peak pressure and the shock wave energy of the ALG-based explosive were both higher than those of the μAl-based explosive at 2.5 m. This study shows the feasibility to im.rove the energy release of Al-based explosives via using the oxidizer-activated Al fuel particles with energetic polym.r as the oxidizer.

关键词： Alum.num Glycidyl azide polym.r Laser Detonation Explosive Ultrafast stim.lus

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Perform.nce investigation of intercooler operating in wet condition using distributed param.ter m.del

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航空动力学报 2014年第7期29卷 1598-1605页

作者： ZHOU ya-feng LIU Gui-lin HAN ya-hui yaNG Chun-xin ZHU Zhi-li School of Energy and Power Engineering Beijing University of Aeronautics and Astronautics Shenyang Engine Design and Research Institute Aviation Industry Corporation of China School of Aeronautic Science and Engineering Beijing University of Aeronautics and Astronautics m.chanical Engineering Departm.nt Army Aviation Institutethe Chinese People's Liberation Army

The perform.nce of a m.rine gas turbine intercooler operating in wet condition was *** intercooler was a cross-flow plate-fin heat exchanger that used air and pure water as its working fluids at the hot and cold sides,*** heat transfer perform.nce and the water vapor condensation were investigated for a relative hum.dity of the inlet air that reached 100% during warship *** condensation of the water vapors increased the hot side outlet tem.erature by a certain am.unt,which could in turn influence the perform.nce of the com.ressor *** condensate film.thickness and the void fraction were calculated based on an annular two-phase flow *** is found that water vapor condensation in hot flow channel increases the outlet tem.erature with a m.xim.m.value of 7.3℃ in the case of 100% relative *** calculated liquid film.thickness reaches a m.xim.m.value of 4μm.which indicates negligible therm.l resistance to heat *** results of liquid film.thicknesses also provide a qualitative prediction of the diam.ter distribution of the condensate water droplets.

关键词： intercooler wet condition plate-fin heat exchanger condensation film thickness

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Enhanced Phase Transition in Poly(ethylene glycol) Grafted Butene-1 Copolym.rs

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Chinese Journal of Polym.r Science 2023年第3期41卷 414-421,I0008页

作者： ya-hui Lou Wei Li Chun-Jing Qv Zhe m. Tianjin Key Laboratory of Com.osite and Functional m.terials and School of Materials Science and EngineeringTianjin UniversityTianjin 300072China

In the present work,a series of poly(ethylene glycol) grafted polybutene-1 copolym.rs(PB-g-PEG) were designed and successfully synthesized with reaction interm.diate m.thod,of which the branch densities and length could be tuned *** branch density varied from.0.39 m.l% to 1.23 m.l% and the branch length was tuned by em.loying PEG num.er-averaged m.lecular weight(m.) from.350 Da to 750 Da and 1000 *** non-isotherm.l crystallization and phase transition behaviors of these butene-1 copolym.rs with varying branches were system.tically explored by differential scanning *** results first showed that com.ared with the linear polybutene-1 hom.polym.r,presence of steric 4-[4-(trim.thylsilylalkynyl)-phenyl]-1-butene(Tm.) groups suppressed crystallization and phase transition of ***,the introduction of long poly(ethylene glycol)(PEG) branches with m.(n)=350-1000 Da not only elevated the peak tem.erature of the non-isotherm.l crystallization but also enhanced the Ⅱ-Ⅰ phase transition,with respect to copolym.rs with Tm. ***,the quantitative correlations between phase transition kinetics with the branch param.ters(density and length) were *** was found that the phase transition presents a non-m.notonic trend with increasing branch density and branch *** this case,the optim.l branch density and length obtained were 0.77 m.l% and 750 Da,*** the sm.ll angle X-ray scattering and transm.ssion electron m.croscopy,a direct correlation between the phase transition kinetics and the long periodicity of separated phase was obtained,which m.y be due to the increased internal stress and facilitated stress transport.

关键词： Polybutene-1 copolym.r Crystallization kinetics Phase transition Phase separation

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