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Infectious Microbes & Diseases 2023年第3期5卷 120-126页

作者： Fei-Xiang Liu Zi-Bei Dong Min Zhao ya-hui gao Xiang Li ya-Nan Jiang Yi-Ming Li Yu-Xin Zheng Zhen Wang yan-Chen Feng ya-Li Liu Cerebropathy Hospital The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouChina The First Clinical Medical School Henan University of Chinese MedicineZhengzhouChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Research Units of Infectious Disease and Microecology Chinese Academy ofMedical SciencesHangzhouChina Traditional ChineseMedicine(Zhong Jing)School Henan University of Chinese MedicineZhengzhouChina.

Coronavirus disease 2019(COVID-19)has affected the quality of sleep for various populations,causing anxiety and depression ***-19–related insomnia(COVIDRI)appears to be more common in certain populations,including females,urban residents and other individuals who reside in high-risk COVID-19–related areas,lack higher socioeconomic and educational levels,have a history of underlying mental illness,have no access to social support and work,or have been mandated for *** vulnerable pop-ulations,pregnant women,adolescents and children are more likely to suffer from anxiety and depression,which leads to irregular sleep-wake cycles and significantly poor sleep *** in COVID-19 patients is associated with decreased immune levels,ex-cessive psychological stress and severe *** COVIDRI incidence and severity among frontline healthcare workers is high,espe-cially among females and those working in isolation wards and intensive care *** factors related to COVIDRI for college students during home study are stress from upcoming graduation,disharmonious family relationships and inadaptability to online *** military personnel,anxiety and depression are the main causes of poor sleep *** on the characteristics of different popula-tions,active Chinese and Western medications,non-drug therapy,psychological counseling and suitable sleep management are vital measures to strengthen immunity,alleviate insomnia and limit recurrence.

关键词： COVID-19 insomnia anxiety depression.

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我国微型硅藻类的新记录属——微壳藻属

植物分类学报 2008年第5期46卷 750-753页

作者：李扬高亚辉吕颂辉华南师范大学生命科学学院广东省植物发育生物工程重点实验室广州510631 厦门大学生命科学学院厦门361005 暨南大学赤潮与水环境研究中心

微型硅藻是海洋浮游植物的重要组成类群,由于其个体微小,在以往的研究中大多被忽略了。本文利用透射电镜(TEM)对若干采自我国沿海海域的样品进行观察,经鉴定,确认一个我国微型硅藻类的新记录属——微壳藻属Nanofrustulum Round,Hallstei... 详细信息

微型硅藻是海洋浮游植物的重要组成类群,由于其个体微小,在以往的研究中大多被忽略了。本文利用透射电镜(TEM)对若干采自我国沿海海域的样品进行观察,经鉴定,确认一个我国微型硅藻类的新记录属——微壳藻属Nanofrustulum Round,Hallsteinsen & Paasche1999。对该属及该属一个新记录种的主要形态学特征进行了描述,提供了透射电镜下的照片,并对相似属种进行了形态学比较研究。

关键词：微型硅藻微壳藻属新记录

Pelagodictyon Clarke,a newly recorded nanodiatom genus for China

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Journal of Systematics and Evolution 2009年第2期47卷 179-182页

作者： 1,2yang LI 2ya-hui gao 1(Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education,College of Life Science,South China Normal University,Guang-zhou 510631,China) 2(School of Life Sciences,Xiamen University,Xiamen 361005,China) Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education College of Life Science South China Normal University Guangzhou 510631 China School of Life Sciences Xiamen University Xiamen 361005 China

Marine nanoplanktonic diatoms have been frequently either underestimated or overlooked in phyto-plankton investigations due to their small size(2-20 μm),which allows most of them to pass through a regular phytoplankton net of 70-μm pore *** nanoplanktonic diatom classification,water samples(each 2000 mL) were collected from several representative sea areas of Chinese coast from May 2002 to May *** Clarke was identified as a newly recorded nanodiatom genus for China under transmission electron microscope(TEM).This genus is characterized by the delicate structure of the valve *** striae are seen to be formed by ribs with cross-ribs(frets) and the intervening spaces are occupied by polygonal cribra situated much close to the exterior face of the *** one species was found,i.e.,*** *** description of the taxonomic characteristics with TEM photographs of this species and its ecological habitat and distribution are given in this *** characteristics comparisons among several resembling genera were discussed.

关键词： China fret nanodiatom new record Pelagodictyon Stephanodiscaceae

First report of Protokeelia spinifera and Rhopalodia iriomotensis from China,with comments on their systematic positions

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Journal of Systematics and Evolution 2009年第2期47卷 173-178页

作者： 1,2yang LI 2ya-hui gao 1,3Song-hui LU 1(College of Life Sciences,South China Normal University,Guangdong Provincial Key Lab of Biotechnology for Plant Development,Guangzhou 510631,China) 2(Key Laboratory for Subtropical Wetland Ecosystem Research,Ministry of Education,School of Life Sciences,Xiamen University,Xiamen 361005,China) 3(Institute of Harmful Algae and Aquatic Environment,Jinan University,Guangzhou 510632,China) College of Life Sciences South China Normal University Guangdong Provincial Key Lab of Biotechnology for Plant Development Guangzhou 510631 China Key Laboratory for Subtropical Wetland Ecosystem Research Ministry of Education School of Life Sciences Xiamen University Xiamen 361005 China Institute of Harmful Algae and Aquatic Environment Jinan University Guangzhou 510632 China

Protokeelia is described as a new and rare pennate diatom genus in *** valve includes two parts:ventral valve and dorsal *** ventral valve is more or less convex or *** raphe runs in a distinct elevated and thickened siliceous *** the internal valve,beneath the raphe are fibulae or fibulae clusters which connect the ventral and dorsal *** species,*** Round & Basson,is observed in the water samples from a mangrove forest in Sai Kung,Hong Kong,*** main morphological features are described in this paper along with electron microscope(EM) *** comparisons are also made among several allied *** addition,a newly recorded species for China,Rhopalodia iriomotensis Kobayasi,Nagumo & Tanaka,is discussed *** several key features observed in this species resemble those of some Pro-tokeelia species,we suggest that it may actually represent a Protokeelia species.

关键词： China new genus record Protokeelia Rhopalodia iriomotensis

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng hui gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen gao Jing-Wen Li hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li hui-Min Xing Hai-Dong Qian Qiao gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-hui Zhang Zhi-Lai Zhan Guang-Lu Chang yan gao Xia Li Wen-Yuan gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation