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Chinese Journal of Polymer Science 2019年第7期37卷 664-673页

作者： ya-di liu Qiang Zhang Xin-Hong Yu Jian-Gang liu yan-Chun Han State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China

For poly(9,9-dioctylfluorene)(PFO),β phase (coplanar conformation with the intra-chain torsion angle of 165°) has a greater conjugation length and higher degree of order compared to those of α phase, which favors charge carrier transport. However, the highest content of β phase obtained so far is 45%. We propose to increase the content of β phase by promoting the solution aggregation of PFO molecules and extending film-forming time. For this purpose, 1,8-diiodooctane (diO) is added to PFO o-xylene solution, which enhances the interaction of PFO chains and improves the planarity of PFO backbone, resulting in the formation of ordered aggregation. The aggregates act as nucleation centers to promote the formation of β phase. The content of β phase increases with increasing diO concentration and reaches a platform of 39% as diO is more than 4 vol%. Furthermore, the film is kept in a sealed environment with oxylene atmosphere for 3 h, thus the PFO molecules have enough time to diffuse to the crystallization front and achieve disorder-order transition. As a result, the crystallinity of PFO is improved significantly and the content of β phase increases to 52%, reaching the highest value reported so far.

关键词： β Phase Ordered aggregation Film-forming time disorder-order transition

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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细胞凋亡与病毒感染

西南民族大学学报（自然科学版） 2005年第S1期31卷 42-45页

作者：孙小玲刘亚刚刘娣琴西南民族大学生命科学与技术学院成都610041

病毒感染细胞后通过其自身基因的表达或激活宿主细胞凋亡相关基因,启动或抑制细胞凋亡.研究病毒与细胞的相互关系,有助于深入理解病毒的致病机理,为病毒性疾病的预防、治疗和诊断提供相应对策.

关键词：细胞凋亡病毒感染

Organic geochemistry and petrology of source rocks from the Banqiao Sag, Bohai Bay Basin, China: Implications for petroleum exploration

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Petroleum Science 2022年第4期19卷 1505-1515页

作者： Xiang-Bai liu Guang-di liu Wen-ya Jiang Ze-Zhang Song Na Wang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China College of Geosciences China University of PetroleumBeijing102249China Exploration and Development Research Institute Dagang Oilfield CompanyPetroChinaTianjin300280China

The organic geochemistry and petrology of source rocks determine the hydrocarbon generation potential of the Banqiao Sag. In this study, organic geochemistry and petrology were used to determine the abundance of organic matter(OM), OM type, OM maturity, and sedimentary environments of the source rocks, collected from Cenozoic Shahejie Formation, Banqiao Sag, Bohai Bay Basin, China. Vitrinite and liptinite are the main maceral composition of the source rocks, and range from 18% to 81% and from 2% to82% on a mineral matter free(MMF) basis, respectively. The values of vitrinite reflectance(Ro)(0.36%-1.20%) and the Tmaxvalues(397-486.C) show that the thermal maturity range from low mature to peak-maturity. The abundance of OM varies between 0.22% and 4.37%, suggesting that the source rocks of the Shahejie(Es) Formation are mainly fair to good source rocks. The Rock-Eval pyrolysis results show that the source rocks have good petroleum generation potential. The amount of free hydrocarbons(S_1)and hydrocarbons generated from pyrolysis(S_(2)) range within 0.01-3.70 mg/g, and 0.04-29.17 mg/g. The hydrogen index(HI) varies between 18.18 and 741.13 mg HC/g TOC, with most of the samples appearing to be mainly Type II kerogen, and thereby exhibiting the ability to generate both oil and gas. The ratios of Pr/Ph, the cross plot of Pr/nC_(17)-Ph/nC_(18), the cross plot of C_(29)/C_(27)-Pr/Ph, and ternary of dibenzothiophene, dibenzofuran, and fluorene, indicate that the Shahejie Formation deposited in suboxic and weak reducing environments. The main biological source is from advanced plants. The maceral composition and rock pyrolysis data indicate the kerogen type is a humic type or mixed sapropelic-humic type. The source rocks of the Shahejie(Es) Formation occur in the oil window, and the abundant organic richness,humic kerogen demonstrate that these rocks are effective oil and gas source rocks. The mudstone rocks in the Shahejie Formation are the main source of oil and gas and re

关键词： Lacustrine source rocks Petrology Biomarkers Depositional environment Banqiao Sag

Quasicrystal dissolution and performance of isothermally heat-treated Mg–Zn–Y alloy

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Rare Metals 2015年第7期34卷 452-456页

作者： di-Qing Wan Xian Luo ya-Juan liu Tian Yu Key Laboratory of Ministry of Education for Conveyance and Equipment East China Jiaotong University State Key Laboratory of Solidification Processing Northwestern Polytechnical University School of Materials Science Northwestern Polytechnical University

Conventional casting method was employed to prepare Mg–Zn–Y alloy only with a-Mg+I-phase; however, the grain size of quasicrystal is quite large in the ascast ***, isothermal treatment was applied to refine the quasicrystal *** result shows that after the Mg–Zn–Y alloy was isothermally treated at 500 °C for several hours, the coarse quasicrystal can be gradually dissolved and thus ***, the dissolving processes of quasicrystal are slow first and then accelerate;after isothermally treated with 8 h at 500 °C, the quasicrystal is almost completely dissolved into the matrix only with 1–5 lm tiny quasicrystals *** of quasicrystal can markedly reduce the wear resistance, but increase the corrosion resistance.

关键词： Magnesium alloy Quasicrystal Isothermal treatment

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-ya Chai Pei-Sai Li yang liu Li-Xia liu Ying Xu Pan-Pan yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Arylazopyrazole-functionalized photoswitchable octanuclear Zn(Ⅱ)-silsesquioxane nanocage

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Science China Chemistry 2021年第3期64卷 419-425页

作者： Kai Sheng ya-Nan liu Rakesh Kumar Gupta Mohamedally Kurmoo di Sun School of Aeronautics Shandong Jiaotong UniversityJi'nan 250037China School of Chemistry and Chemical Engineering State Key Laboratory of Crystal MaterialsShandong UniversityJi'nan 250100China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engineering厶iaocheng UniversityLiaocheng 252000China Institut de Chimie de Strasbourg Universite de StrasbourgCNRS-L/MR 71774 rue Blaise PascalStrasbourg Cedex 67008France

Photoswitchable organic materials have shown significant advancement for photonic applications,however,the polynuclear metal clusters conjugated with photoswitching properties are still ***,a novel octanuclear Zn(Ⅱ) nanocage{[Zn_(8)-(Me_(4)Si_(4)O_(8))_(2)(azopz)_(8)]·4CH_(2)Cl_(2)·MeOH·MeCN}(SD/Zn8)(Hazopz=3,5-dimethyl-4-(phenyldiazenyl)-1H-pyrazole),based on multidentate silsesquioxane and pyrazole modified by photoisomerizable azo group has been designed and synthesized to realize the reversible photoswitching behavior.X-ray crystallographic study reveals that the unique metal core consists of two annular Me_(4)Si_(4)O_(8)^(4-)sandwiching a ring of eight Zn atoms where the pyrazole end of azopz-bridges them *** azopz-ligands diverge above and below the plane defined by eight Zn ***,SD/Zn8 shows quick trans-to-cis transformation upon 365 nm light irradiation,which can be easily changed back by 450 nm light,but slow cis-to-trans reversibility at room temperature as confirmed by UV-V is and 1H NMR *** process,which presumably regulates the spaces,acts like a pump and is completely *** such,it can be considered as a molecular pump energized by ***,the molecule is an energy reservoir where it absorbs the light energy and releases it slowly with time.

关键词： silsesquioxane metal-organic nanocage photochromism X-ray single-crystal structure

High efficient multipacket decoding approach for network coding in wireless networks

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The Journal of China Universities of Posts and Telecommunications 2013年第1期20卷 95-100页

作者： yaO Yu-kun WEN ya-di REN Zhi liu Zhi-hu Chongqing Key Laboratory of Mobile Communication Technology Chongqing University of Posts and Telecommunications

To improve the performance of transmission by reducing the number of transmission and network overhead of wireless single-hop networks, this paper presents a high efficient multipacket decoding approach for network coding （EMDNC） in wireless networks according to the idea of encoding packets which cannot be decoded and are stored in buffer by receiving nodes, the lost packets can be recovered from these encoded packets. Compared with the network coding wireless broadcasting retransmission （NCWBR）, EMDNC can improve the efficiency of decoding and reduce the number of retransmission and transmission delay. Simulation results reveal that EMDNC can effectively reduce the number of retransmission and network overhead.

关键词： wireless single-hop networks network coding number ofretransmission transmission delay network overhead

Combination of Quercetin, Hirudin and Cinnamaldehyde Promotes Schwann Cell differentiation and Myelination against High Glucose by Inhibiting ERK Signaling Pathway

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Chinese Journal of Integrative Medicine 2020年第8期26卷 591-598页

作者： liu di LIANG Xiao-chun SUN Ying WU ya-nan ZHANG Hong Department of Traditional Chinese Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Cell Resource Center Institute of Basic Medical SciencePeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China the Department of Nephrology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Objective:To investigate the therapeutic and synergistic effects of QHC(combination of quercetin(Q),hirudin(H)and cinnamaldehyd(C))on Schwann cell differentiation and myelination against high glucose(HG)induced ***:Primary-culture Schwann cells exposed to HG(50 mmol/L)for 72 h and Schwann cell–dorsal root ganglion(DRG)neuron cocultures exposed to HG(50 mmol/L)for 7 days were employed as in vitro model of diabetic *** cells were randomly divided into 10 groups:control(CON,25 mmol/L glucose),HG(50 mmol/L glucose),HG plus 10μmol/L quercetin(Q),HG plus 0.04 IU/mL hirudin(H),HG plus 100 nmol/L cinnamaldehyd(C),HG plus 10μmol/L quercetin and 0.04 IU/mL hirudin(QH),HG plus 10μmol/L quercetin and 50 nmol/L cinnamaldehyd(QC),HG plus 0.04 IU/mL hirudin and 50 nmol/L cinnamaldehyd(HC),HG plus 10μmol/L quercetin,0.04 IU/mL hirudin and 50 nmol/L cinnamaldehyd(QHC)or 10μmol/L *** differentiation was evaluated by periaxin immunofluorescence *** protein expression levels of myelin protein zero(P0),myelin basic protein(MBP),myelin-associated glycoprotein(MAG),extracellular signal-regulated kinase(ERK),p-ERK,p-c-Jun,c-Jun,notch intracellular domain(NICD)and the mRNA expression levels of P0,MBP,MAG,Krox-20,Notch1 and Jagged1 were detected by Western blotting and real-time quantitative PCR *** secretion of ciliary neurotrophic factor(CNTF)was determined by enzyme-linked immunosorbent assay(ELISA).The number and length of the myelin segments were evaluated by MBP immunofluorescence *** expression and the location of p-ERK in cocultures were detected by MAG and p-ERK immunofluorescence double ***:Co-treatment with Q,C,H and their combination promoted Schwann cell differentiation,increased CNTF secretion,up-regulated the protein and m RNA expressions of myelin,and increased the number and length of the myelin segments(P<0.01 or P<0.05).In particular,the combination therapy of Q,H and C was superior to the respective mono

关键词： diabetic peripheral neuropathy extracellular signal-regulated kinase pathway Schwann cells myelination Chinese medicine synergistic effect

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu ya-Xin Qin Xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin