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Electrochemical behavior of tungsten in(NaCl–KCl–NaF–WO_3)molten salt

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Rare Metals 2013年第5期32卷 512-517页

作者： Jie Li Xin-Yu Zhang ya-bin liu Yun-Gang Li Ri-Ping liu Key Laboratory of Metastable Materials Science & Technology Yanshan University Key Laboratory of the Ministry of Education for Modern Metallurgy Technology College of Metallurgy & Energy Hebei United University

Abstract The electrochemical reaction mechanism and electrocrystaUization process of tungsten in the NaCl- KCl-NaF-WO3 molten salt were investigated at 973 K （700℃） by means of cyclic voltammetry, chronopotentiometry, and chronoamperometry techniques. The results show that the electrochemical reaction process of tungsten in the NaCl-KCl-NaF-WO3 molten salt system is a quasireversible process mix-controlled by ion diffusion rate and electron transport rate. Tungsten ion in this system is reduced to W（0） in two steps. The electrocrystallization process of tungsten is found to be an instantaneous, hemispheroid three-dimensional nucleation process and the tungsten ion diffusion coefficient of 2.361 × 10^-4 cm2.s^-1 is obtained at experimental conditions.

关键词： NaCl-KClNaF-WO3 Tungsten Electrochemical reduction mechanism Electrocrystallization process

Porcine Interleukin-2 Expression in Insect Cells and Its Enhancement of Pig Immunity to Swine Influenza Virus Inactivated Vaccine

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Agricultural Sciences in China 2010年第8期9卷 1211-1220页

作者： CHEN Hong-ying ZHANG Hong-ying HUANG yan-quan CUI Bao-an WANG Zhen-ya WANG yan-bin liu Jin-peng CHAO An-jun College of Animal Husbandry and Veterinary Henan Agricultural University Zhengzhou 450002 P.R.China

Mature porcine interleukin-2 （pIL-2） gene was amplified by PCR from the plasmid pGEM-T-pIL2 and cloned into the baculovirus pFastBacTM Dual vector of the Bac-to-Bac baculovirus expression system under the control of the PH promoter. Recombinant plL-2 （rpIL-2） expressed in Sf9 insect cells was detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunofluorescence assay. Western blot analysis confirmed that the rpIL-2 protein had a molecular mass of 20 kDa, which was larger than the molecular mass of the mature protein predicted based on its peptide sequence. The rpIL-2 protein induced in vitro proliferation of ConA-stimulated porcine splenocytes and enhanced in vivo protective immune responses induced by vaccinating the pigs with inactivated oil emulsion vaccine against swine influenza virus. The results showed that the rpIL-2 expressed in Sf9 insect cells has immunoenhancement effects; the finding lays the foundation for the preparation of a specific recombinant IL-2 protein and the development of a novel immune adjuvant of vaccines against various infectious porcine pathogens to increase the immunoprotective efficacy of vaccines.

关键词： porcine interleukin-2 Sf9 insect cells expression inactivated vaccine swine influenza virus

The As-surface of an iron-based superconductor CaKFe_(4)As_(4)

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Nano Research 2021年第11期14卷 3921-3925页

作者： Lu Cao yang Song ya-bin liu Qi Zheng Guangyuan Han Wenyao liu Meng Li Hui Chen Yuqing Xing Guang-Han Cao Hong Ding Xiao Lin Shixuan Du Yu-yang Zhang Geng Li Ziqiang Wang Hong-Jun Gao Institute of Physics Chinese Academy of SciencesBeijing100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing100049China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing100190China Songshan Lake Materials Laboratory Dongguan523808China Department of Physics Zhejiang UniversityHangzhou310027China Department of Physics Boston CollegeChestnut HillMassachusetts02467USA

As a new type of iron-based superconductor, CaKFe_(4)As_(4) has recently been demonstrated to be a promising platform for observing Majorana zero modes (MZMs). The surface of CaKFe_(4)As_(4) plays an important role in realizing the MZM since it hosts superconducting topological surface states. However, due to the complicated crystal structure, the terminal surface of CaKFe_(4)As_(4) has not been determined yet. Here, by using scanning tunneling microscopy/spectroscopy (STM/S), we find that there are two types of surface structure in CaKFe_(4)As_(4). Bias-dependent atomic resolution images show an evolvement from 2–√×2–√ superstructure with respect to the As lattice into 1 × 1 when the tip is brought close to the surface, revealing the sublattice of missing As atoms. Together with the first-principles calculations, we show that the surface As layer has a buckled structure. Our findings provide insight to future surface study of CaKFe_(4)As_(4) as well as other iron-pnictide superconductors.

关键词： CaKFe_(4)As_(4) scanning tunneling microscopy atomic resolution density functional theory

Retrospective Study on the Relation between the Level of Thyroid Hormone and Coronary Atherosclerotic Heart Disease

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Retrospective Study on the Relation between the Level of Thy...

Observation of Zero-Energy Modes with Possible Time-Reversal Symmetry Breaking on Step Edge of CaKFe_(4)As_(4)

中华医学会第十五次全国心血管病学大会

作者： Yingyan Ma yan-Xia Wang Wei Dong ya-bin liu ya-Ling Han Department of Cardiology Institute of Cardiovascular Research of People’s Liberation Army Shenyang Northern Hospital

Background To observe the changes of the level of thyroid hormone in the patients with coronary atherosclerotic heart disease (CHD). Methods According to the results of coronary artery angiography, 299 patients were divided into experimental group (n=208) and control group (n=91). And the experimental group were divided into three groups: the single vessel disease group(n=72), the double vessel disease group(n=87)and the triple vessel

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Chinese Physics Letters 2024年第11期41卷 114-127页

作者： Lu Cao Geng Li Wenyao liu ya-bin liu Hui Chen Yuqing Xing Lingyuan Kong Fazhi yang Quanxin Hu Meng Li Xingtai Zhou Zichao Chen Chenhang Ke Lunhui Hu Guang-Han Cao Congjun Wu Hong Ding Hong-Jun Gao Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Hefei National Laboratory Hefei 230088China Department of Physics Zhejiang UniversityHangzhou 310027China New Cornerstone Science Laboratory Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China Institute for Theoretical Sciences Westlake UniversityHangzhou 310024China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China Tsung-Dao Lee Institute and New Cornerstone Science LaboratoryShanghai Jiao Tong UniversityShanghai 201210China

Topologically nontrivial Fe-based superconductors attract extensive attentions due to their ability of hosting Majorana zero modes(MZMs)which could be used for topological quantum *** defects such as vortex lines are required to generate ***,we observe the robust edge states along the surface steps of CaKFe_(4)As_(4).Remarkably,the tunneling spectra show a sharp zero-bias peak(ZBP)with multiple integerquantized states at the step edge under zero magnetic *** propose that the increasing hole doping around step edges may drive the local superconductivity into a state with possible spontaneous time-reversal symmetry ***,the ZBP can be interpreted as an MZM in an effective vortex in the superconducting topological surface state by proximity to the center of a tri-junction with different superconducting order *** results provide new insights into the interplay between topology and unconventional superconductivity,and pave a new path to generate MZMs without magnetic field.

关键词： vortex Observation breaking

The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling

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The PAX6-ZEB2 axis promotes metastasis and cisplatin resista...

Synthesis and Structure of Ion-pairComplex［Mo （dtc）_4］［Sm （dtc）_4］

2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： Dong-ming Wu Ting Zhang ya-bin liu Shi-hua Deng Rong Han Teng liu Jing Li Ying Xu Clinical Laboratory The First Affiliated Hospital of Chengdu Medical College Radiology department The First Affiliated Hospital of Chengdu Medical College

Background: Paired-box 6(PAX6) is an important transcription factor required for the function of human neuroectodermal epithelial tissues. Previous studies have suggested that it is also expressed in several tumors and plays an oncogenic role. However, very little is known its role in non-small cell lung cancer(NSCLC). Methods: The immunohistochemistry was used to detect the PAX6 expression in human NSCLC tissue arrays(HLug-Ade050 CD-01) and the relationship between PAX6 with clinical outcome in a microarray dataset with clinical follow-up information(HLugA180 Su05). The effects of PAX6 on cell migration, invasion, epithelial-to-mesenchymal transition(EMT) and stem cell transformation were explored. Cisplatin resistance was assessed in vivo and in vitro. The RT2 Profiler PCR Array was used to analyze the molecular mechanism of *** pathway was assessed by western ***: We found that PAX6 expression levels are up-regulated in human lung cancer tissues and correlate with poor clinical outcomes. Meanwhile,overexpression of PAX6 significantly promotes NSCLC EMT and metastasis, whereas knockdown of PAX6 inhibits this process. Importantly, PAX6 was found to be commonly correlated with the EMT-mediated stem cell transformation, thereby inducing cisplatin resistance. Moreover, we found that PAX6 can directly bind the promoter region of ZEB2 and that the PAX6-ZEB2 axis modulates EMT through the PI3 K/AKT signaling pathway in NSCLC. Conclusions: These findings indicate that PAX6 might be a novel and reliable prognostic marker and a potential target to overcome metastasis and cisplatin resistance in NSCLC.

关键词： non-small cell lung cancer PAX6 EMT ZEB2 cisplatin resistance

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Chemical Research in Chinese Universities 1994年第3期10卷 236-239页

作者： SUN Chun-ting, ZHU ya-bin, liu Xiao-xun and YI Shuzhen(Chemistry Department , Jitin University , Changchun, 130023 )LI Li , ZHENG Xiao-feng and WANG Yue(Key Laboratory of Molecular Spectrum and Molecular Structure , .jilin Univiersity)

etra ( N, N-diethyldithiocarbamates ) Samarium (Ⅲ)tetra (N, N-di-ethyldithiocarbamates) Molybdenum (V)([Mo (dtc)][Sm (dtc)])was synthesizedby the reaction of [Mo(dtc)]Cl and Na[Sm(dtc)] in miethanol. The crystal struc-ture was determined using X-ray diffraction methods. The compound crystallizes inthe triclinic space group P1 with the lattice parameters: a =1. 1557(4) nm, b=1.5253(3) nm, c=1. 8670 (6) nm and a=97.001 (20)°, β=94. 506(24)°, γ=93. 419(20)°,Z=*** final R=*** spectroscopic and XPS studies werecarried out.

关键词： Crystal structure,Molybdenum(Ⅲ) Samarium(Ⅴ)

双膦酸盐预防中国妇女绝经后骨质疏松骨折的系统评价及药物经济学分析

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中国医院药学杂志 2017年第8期37卷 740-745页

作者：邹雅敏张斌刘丹杨浩杰西安交通大学医院陕西西安710049 西安市红会医院陕西西安710054 西安市第五医院陕西西安710082

目的:评估3种双膦酸盐预防中国妇女绝经后骨质疏松骨折的有效性、安全性和经济性。方法:计算机检索国内外常用文献数据库中使用阿仑膦酸、利塞膦酸、唑来膦酸预防中国妇女绝经后骨质疏松骨折的随机对照试验(RCT),提取资料后进行Meta分析... 详细信息

目的:评估3种双膦酸盐预防中国妇女绝经后骨质疏松骨折的有效性、安全性和经济性。方法:计算机检索国内外常用文献数据库中使用阿仑膦酸、利塞膦酸、唑来膦酸预防中国妇女绝经后骨质疏松骨折的随机对照试验(RCT),提取资料后进行Meta分析,并建立决策树模型进行成本-效果分析。结果:Meta分析结果显示,与单用钙剂/维生素D_3方案相比,联用双膦酸盐能显著减少中国妇女绝经后骨质疏松的椎体骨折[RR0.50,95%CI(0.33,0.74)]和非椎体骨折[RR0.36,95%CI(0.20,0.65)]的风险,差异有统计学意义(P<0.01)。亚组分析显示,唑来膦酸能显著减少中国妇女绝经后骨质疏松椎体骨折[RR0.44,95%CI(0.25,0.77)]风险,阿仑膦酸和利塞膦酸亦表现出减少绝经后骨质疏松非椎体骨折的风险的优势[RR0.16,95%CI(0.04,0.72)和RR0.28,95%CI(0.10,0.80)]。安全性方面,加用双膦酸盐期间不良事件的发生率与对照组比较差异无统计学意义。成本-效果分析显示,联用双膦酸盐较单用钙剂和维生素D_3方案经济性更优,阿仑膦酸联合钙剂/维生素D3方案为经济性最优方案。结论:联用双膦酸盐(尤其是阿仑膦酸)较单用钙剂/维生素D_3方案能显著地减少中国妇女绝经后骨质疏松骨折的风险,安全性较好,经济性更优。

关键词：双膦酸盐绝经期妇女骨质疏松系统评价药物经济学决策树模型

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein