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FpR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUAng E LIAO Jun-qun LIAO ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:premature rupture of membranes(pROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FpR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FpR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between pROM,FpR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,pCR,Masson staining,and ELISA ***(LpS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LpS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,pCR and Masson staining indicated that the expression of FpR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LpS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FpR1 in the fetal membrane of pROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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Retinitis pigmentosa and stem cell therapy

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1363-1369页

作者： Xin-ya Qi Chen-Hui Mi De-Rui Cao Xie-qun Chen p.ng Zhang School of Medicine Department of Life Sciences and MedicineNorthwest UniversityXi’an 710069Shaanxi ProvinceChina The Third Hospital of Xi’an Affiliated Hospital of Northwest UniversityXi’an 710021Shaanxi ProvinceChina

Retinitis pigmentosa(Rp)is a group of genetic disorders characterized by progressive degeneration of photoreceptors and retinal pigment epithelium(RpE)*** main clinical manifestations include night blindness and progressive loss of peripheral vision,making it a prevalent debilitating eye disease that significantly impacts patients’quality of *** exhibits significant phenotypic and genetic *** instance,numerous abnormal genes are implicated in Rp,resulting in varying clinical presentations,disease progression rates,and pathological characteristics among different ***,gene therapy for Rp poses challenges due to these ***,stem cells have garnered considerable attention in the field of RpE therapy since both RpE cells and photoreceptors can be derived from stem *** recent years,a large number of animal experiments and clinical trials based on stem cell transplantation attempts,especially cord blood mesenchymal stem cell(MSC)transplantation and bone marrow-derived MSC transplantation,have confirmed that stem cell therapy can effectively and safely improve the outer retinal function of the Rp-affected ***,stem cell therapy also has certain limitations,such as the fact that Rp patients may involve multiple types of retinal cytopathia,which brings great challenges to stem cell transplantation therapy,and further research is needed to solve various problems faced by this approach in the *** comprehensive analysis of the etiology and histopathological changes associated with Rp,this study substantiates the efficacy and safety of stem cell therapy based on rigorous animal experimentation and clinical trials,while also highlighting the existing limitations that warrant further investigation.

关键词： retinitis pigmentosa photoreceptor stem cell therapy

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Light-responsive Self-Immolative L-glutamic Acid-based polyester Nanoparticles for Controlled Drug Release via passerini Three-Component polymerization

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Chinese Journal of polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-Fei Sun Xu Zhang Shu-p.ng Song ya-qun yao yan Zhang Cheng-Liang Wang Jing-Jiang Sun Qing-Fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of passerini three-component polymerization(p-3Cp)for the straightforward preparation of LA-based light-responsive polyesters(pLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of pLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse pLTD-based doxorubicin-loaded nanoparticles(pLTD-DOX-Np)(size=193 nm,pDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the pLTD-DOX-Np undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the pLTD-Np possesses adequate biosafety,both before and after ***,the incorporation of p-3Cp with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid passerini three-component polymerization Light-responsive polyester Nanoparticles

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Oxidation behavior of 4774DD1 Ni-based single-crystal superalloy at 980℃ in air

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China Foundry 2024年第2期21卷 116-124页

作者： Yu Fang ya-zhou Li Qiang yang qun-gong He Xiu-fang Gong Qian Duan Hai-yang Song Fu Wang Qiong-yuan Zhang Hong Zeng State Key Laboratory of Long-Life High Temperature Materials Dongfang Turbine Co.Ltd.Deyang 618000SichuanChina State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain *** phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and *** show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this *** the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 ***,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 *** internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture *** two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 *** internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)***,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.

关键词： nickel-base single crystal superalloy oxidation kinetics oxide film microstructure mechanism

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Research progress in CALpHAD assisted metal additive manufacturing

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China Foundry 2024年第4期21卷 295-310页

作者： ya-qing Hou Xiao-qun Li Wei-dong Cai Qing Chen Wei-ce Gao Du-p.ng He Xue-hui Chen Hang Su China Iron&Steel Research Institute Group Beijing 100081China Thermo-Calc Software AB SolnaSE-169Sweden KTH Royal Institute of Technology StockholmSE-100Sweden Central Iron and Steel Research Institute Beijing 100081China

Metal additive manufacturing(MAM)technology has experienced rapid development in recent *** both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of *** calculation of phase diagrams(CALpHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple *** combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal *** development of CALpHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural *** endeavor carries considerable theoretical and practical *** paper summarizes the important achievements of CALpHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties ***,the limitations of applying CALpHAD technology to MAM technology are discussed,along with prospective research directions.

关键词： metal additive manufacturing CALpHAD integrated computational material engineering powder bed fusion material design microstructure simulation

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Bioinspired Double-stranded yarn with Alternating Hydrophobic/Hydrophilic patterns for High-efficiency Fog Collection

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Chinese Journal of polymer Science 2024年第7期42卷 968-975,I0008页

作者： Lan-Lan Hou Meng-Na Qiu ya-Qiong Wang Tong-Hua Bai Zhi-Min Cui Jing-Chong Liu Ying-qun Qi Nü Wang Yong Li Yong Zhao Beijing Institute of Graphic Communication Beijing102600China Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing100191China Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Beijing Key Laboratory for Bioengineering and Sensing TechnologyDaxing Research InstituteSchool of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing100083China

Efforts to develop innovative water harvesting strategies offer powerful solutions to alleviate the water crisis,especially in remote and arid *** by the hydrophobic/hydrophilic pattern of desert beetles and water self-propulsion property of spider silks,a double-strand hydrophobic pVDF-HFp/hydrophilic pAN nanofibers yarn is proposed by electrospinning and twisting *** double-strand cooperation approach allows for water deposition on hydrophobic pVDF-HFp segment and transport under the asymmetric capillary driving force of hydrophilic pAN segment,thus speeded up the aggregation and growth of *** effects of the composition and the diameter ratio of the two primary yarns were studied and optimized for boosting fog collection *** double-strand anisotropic yarn not only provide an effective method for water harvesting,but also hold the potential to inspire innovative design concepts for fog collection materials in challenging environments.

关键词： Fog collection Wettability Electrospinning Nanofibers Spider silk

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Two aquaporins,pIp1;1 and pIp2;1,mediate the uptake of neonicotinoid pesticides in plants

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plant Communications 2024年第5期5卷 176-188页

作者： qun Wan Yixin Li Jinjin Cheng ya Wang Jing Ge Tingli Liu Liya Ma Yong Li Jianan Liu Chunli Zhou Haocong Li Xing Sun Xiaolong Chen Qing X.Li Xiangyang Yu Key Laboratory of Food Quality and Safety of Jiangsu province State Key Laboratory Breeding BaseNanjing 210014China Institute of Food Safety and Nutrition Jiangsu Academy of Agricultural Sciences50 Zhongling StreetNanjing 210014China Jiangsu provincial Key Construction Laboratory of Special Biomass Resource Utilization Nanjing Xiaozhuang University3601 Hongjin AvenueNanjing 211171China Department of Molecular Biosciences and Bioengineering University of Hawaii at ManoaHonoluluHI 96822USA

Neonicotinoids(NEOs),a large class of organic compounds,are a type of commonly used pesticide for crop *** uptake and accumulation in plants are prerequisites for their intra-and intercellular move-ments,transformation,and *** the molecular mechanisms that underpin NEO uptake by plants is crucial for effective application,which remains ***,we demonstrate that NEOs enter plant cells primarily through the transmembrane symplastic pathway and accumulate mainly in the *** plasma membrane intrinsic proteins discovered in Brassica rapa,BrapIp1;1 and BrapIp2;1,were found to encode aquaporins(AQps)that are highly permeable to NEOs in different plant species and facilitate NEO subcellular diffusion and *** conserved transport function was further demonstrated in Xenopus laevis oocyte and yeast ***1;1 and BrapIp2;1 gene knockouts and interaction as-says suggested that their proteins can form functional *** of the potential of mean force indicated a negative correlation between NEO uptake and the energy barrier of BrapIp1;1 *** study shows that AQps transport organic compounds with greater osmolarity than previously thought,providing new insight into the molecular mechanisms of organic compound uptake and facilitating innovations in systemic pesticides.

关键词： neonicotinoid aquaporin Brassica rapa plasma membrane uptake systemic pesticide

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Intratumoural microorganism can affect the progression of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4232-4243页

作者： Bao-qun Liu Yi Bai Da-p.ng Chen ya-Min Zhang Tian-Ze Wang Jing-Rui Chen Xiang-Yu Liu Bin Zheng Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Tianjin First Central Hospital Clinic Institute School of MedicineNankai UniversityTianjin 300192China School of Medicine Tianjin UniversityTianjin 300072China

BACKGROUND Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma(HCC);however,their role in tumor progression remains ***,there is a need for further research on the role of intratumoural microorganisms in *** To investigate the changes in intratumoural microorganisms in HCC and the effect of propionibacterium on HCC *** HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization(FISH).After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two *** was cocultured with HCC cells in *** in cell proliferation and migration capacity were *** expression of NF-κB pathway related proteins in tumor cells was *** orthotopic liver implantation model and the subcutaneous xenograft model were *** tissues and subcutaneous tumors were collected 2 weeks *** FISH demonstrated the presence of microorganisms in HCC and normal liver tissues.16S rRNA sequencing revealed an abundance of Lysobacter,Lachnospiraceae,pseudomonas,and Lactobacillus in HCC *** distribution and abundance of propionibacterium showed differences between HCC and peritumoral tissues(ppropionibacterium and its metabolite propionic acid(pA)inhibited the proliferation and migration of HCC cells(ppression of the proteins in NF-κB signaling pathway also decreased in HCC cells(pplayed significant *** pA-producing bacterium propionibacterium in HCC exerts an effect on the NF-κB pathway,thereby affecting the biological behavior of HCC.

关键词： Hepatocellular carcinoma Intratumoural microbiome 16S rRNA sequencing propionibacterium

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Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4427-4433页

作者： ya-Xin Xu Xiao-Xuan Niu Bei-Li Xu Yuan Ji qun-yan yao Department of General practice Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of pathology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-normal-glutamyl *** episodes may persist for weeks to months before spontaneously resolving,with patients typically remaining asymptomatic between *** entails the evaluation of clinical symptoms and targeted genetic *** BRIC is recognized as a benign genetic disorder,the triggers,particularly psychosocial factors,remain poorly *** SUMMARY An 18-year-old Chinese man presented with recurrent jaundice and pruritus after a cold,which was exacerbated by self-medication involving vitamin B and *** and laboratory evaluations revealed elevated levels of bilirubin and liver enzymes,in the absence of viral or autoimmune liver *** excluded biliary and pancreatic abnormalities,and liver biopsy demonstrated centrilobular cholestasis,culminating in a BRIC diagnosis confirmed by the identification of a novel ATp8B1 gene *** assessment of the patient unveiled stress attributable to academic and familial pressures,regarded as potential triggers for *** relief was observed with ursodeoxycholic acid and cetirizine,followed by an adjustment of the treatment regimen in response to elevated liver *** patient's condition significantly improved following a stress-related episode,thanks to a comprehensive management approach that included psychosocial support and medical *** Our research highlights genetic and psychosocial influences on BRIC,emphasizing integrated diagnostic and management strategies.

关键词： Benign recurrent intrahepatic cholestasis Genetic testing psychosocial factors ATp8B1 gene mutation Cholestasis Jaundice pruritus Case report

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Clinicopathological Features and Long-Term prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KOng Zi Qing LIU Li qun HUAng De Qin WAng Yu Tong LI Jing Jie ZHAng Zheng WAng Xi Xi LIU Chuan Ling ZHAng ya Di SHAO Jia Kang ZHU Yi Min CHEN Yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese pLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(pgR)positivity than HER2-IHC0 BC group(png ER expression levels(Mantel-Haenszelχ^(2)test,ppearson’s R=0.159,pnger overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(p=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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