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World Journal of Clinical Cases 2021年第23期9卷 6810-6815页

作者： Lei Tian li-ya he Hong-Zhen Zhang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Syndrome of inappropriate secretion of antidiuretic hormone(SIADH)is relatively common in several cancers,such as small cell lung ***,nedaplatin-induced SIADH is *** describe a case of SIADH mediated by *** SUMMARY A 54-year-old female with nasopharyngeal carcinoma was treated with nedaplatin and developed severe hyponatremia due to *** side effects were successfully treated by fluid restriction and sodium *** This case report highlights the importance of cautiously treating life-threatening hyponatremia in patients treated with nedaplatin.

关键词： Nedaplatin Syndrome of inappropriate secretion of antidiuretic hormone Hyponatremia Fluid restriction Sodium supplementation Case report

Inflammatory cutaneous metastases originating from gastric cancer: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8411-8415页

作者： Lei Tian Zhi-Bin Ye Yun-Lei Du Qiao-Fang li li-ya he Hong-Zhen Zhang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Gastrointestinal Surgery Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Emergency Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Cutaneous metastasis with gastric cancer(GC)origin is extremely rare and associated with poor *** type is the most common type,while other forms are extremely *** SUMMARY This study describes severe skin redness,swelling,pain,and fever in a 65-year-old man diagnosed with GC,whose left chest wall,left upper limb,and left back were mainly ***,the patient was diagnosed with“lymphangitis”and treated to promote lymphatic ***,the symptoms were constantly deteriorating,and skin thickening and scattered small nodules gradually ***,the skin biopsy confirmed cutaneous metastases,and the patient died 7 d *** Our case highlights that cutaneous metastasis should be considered when skin lesions appear in patients with GC.

关键词： Cutaneous metastasis Gastric cancer Inflammatory Sclerodermoid Nodular Case report

Combination therapy(toripalimab and lenvatinib)-associated toxic epidermal necrolysis in a patient with metastatic liver cancer:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3478-3484页

作者： Kai-Kai Huang Shan-Shan Han li-ya he lin-lin yang Bao-Ying liang Qing-Yu Zhen Zi-Bo Zhu Cai-Yun Zhang Hong-Yi li Ying lin Department of Dermatology the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Dermatology the Second Clinical Medical College of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510120Guangdong ProvinceChina

BACKGROUND Both programmed cell death-1(PD-1)inhibitors and lenvatinib,which have a synergistic effect,are promising drugs for tumor *** is generally believed that combination therapy with a PD-1 inhibitor and lenvatinib is safe and ***,we report a case of toxic epidermal necrolysis(TEN),a grade 4 toxicity,after this combination *** SUMMARY A 39-year-old male presented with erythema,blisters and erosions on the face,neck,trunk and limbs 1 wk after receiving combination therapy with lenvatinib and toripalimab,a PD-1 *** skin injury covered more than 70%of the body surface *** was previously diagnosed with liver cancer with cervical vertebra ***,prominent necrotic keratinocytes,hyperkeratosis,liquefaction of basal cells and acantholytic bullae were observed in the *** vessels in the dermis were infiltrated by lymphocytes and *** immunofluorescence staining was ***,the diagnosis was confirmed to be TEN(associated with combination therapy with toripalimab and lenvatinib).Full-dose and long-term corticosteroids,high-dose intravenous immunoglobulin and targeted antibiotic drugs were *** rashes gradually faded;however,as expected,the tumor ***, sorafenib and regorafenib were given in succession, and the patient was still alive at the10-mo *** attention should be given to rashes that develop after combination therapy with PD-1inhibitors and lenvatinib. Large-dose and long-course glucocorticoids may be crucial for thetreatment of TEN associated with this combination treatment.

关键词： Toxic epidermal necrolysis Toripalimab Lenvatinib Programmed cell death-1 inhibitor liver cancer Case report

The application of computer technology in digital museum

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通讯和计算机（中英文版） 2009年第9期6卷 58-61页

作者： JI ya-li liU he-bing HU Xiao-hong College of lnformation and Management Henan Agricultural University Zhengzhou 450002 China

TWO NEW INDOLE ALKALOIDS FROM MELODINUS MORSEI

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Chinese Chemical Letters 1992年第9期3卷 715-718页

作者： ya li he Wei Ming CheN Xiao Zhang FENG Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050

Two new indole alkaloids named 152-hydroxy-14,15-dihydro-vindo- linine and 152-hydroxy-14,15-dihydro-16-epi-vindolinine were isolated from Melodinus *** structures were established by spectroscopic means and compariso... 详细信息

关键词： NOE TWO NEW INDOLE ALKALOIDS FROM MELODINUS MORSEI ppm

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song he li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

IDSSCNN-XgBoost:Improved Dual-Stream Shallow Convolutional Neural Network Based on Extreme Gradient Boosting Algorithm for Micro Expression Recognition

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Computers, Materials & Continua 2025年第1期82卷 729-749页

作者： Adnan Ahmad Zhao li Irfan Tariq Zhengran he School of Information Science and Engineering Southeast UniversityNanjing210016China

Micro-expressions(ME)recognition is a complex task that requires advanced techniques to extract informative features fromfacial *** deep neural networks(DNNs)with convolutional structures have been ***,unlike DNNs,shallow convolutional neural networks often outperform deeper models in mitigating overfitting,particularly with small ***,many of these methods rely on a single feature for recognition,resulting in an insufficient ability to extract highly effective *** address this limitation,in this paper,an Improved Dual-stream Shallow Convolutional Neural Network based on an Extreme Gradient Boosting Algorithm(IDSSCNN-XgBoost)is introduced for ME *** proposed method utilizes a dual-stream architecture where motion vectors(temporal features)are extracted using Optical Flow TV-L1 and amplify subtle changes(spatial features)via EulerianVideoMagnification(EVM).These features are processed by IDSSCNN,with an attention mechanism applied to refine the extracted effective *** outputs are then fused,concatenated,and classified using the XgBoost *** comprehensive approach significantly improves recognition accuracy by leveraging the strengths of both temporal and spatial information,supported by the robust classification power of *** proposed method is evaluated on three publicly available ME databases named Chinese Academy of Sciences Micro-expression Database(CASMEII),Spontaneous Micro-Expression Database(SMICHS),and Spontaneous Actions and Micro-Movements(SAMM).Experimental results indicate that the proposed model can achieve outstanding results compared to recent *** accuracy results are 79.01%,69.22%,and 68.99%on CASMEII,SMIC-HS,and SAMM,and the F1-score are 75.47%,68.91%,and 63.84%,*** proposed method has the advantage of operational efficiency and less computational time.

关键词： ME recognition dual stream shallow convolutional neural network euler video magnification TV-L1 XgBoost

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing li Zixuan he Weitai Chai Meng Tian Huali Yu Xiaoxiao he Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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Effect of Progressive Substitution of Cement and lime by Powdered Shells Used as a Curing Agent for Dredged Soil in a Port Area

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 88-102页

作者： SUN yang WANG Faxin SU yaying li Yiwei he Feng College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Huai'an Research Institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment Corp.Ltd. Lianyungang 210098China

This study aimed to address the challenges of solid waste utilization,cost reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was collected by conducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement content had a positive effect on *** high-strength solidified soil,the recommended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the recommended ratio was 100:5.4:2.4:***,under appropriate conditions,improved short-term strength by promoting the formation of expansive ettringite minerals that contributed to cementation and *** findings suggest that the combination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** recommended ratios provide practical guidance for achieving desired strength levels while considering factors such as cost and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** conclusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and cost-effective *** recommended ratios for different str

关键词： carbon reduction and solidification dredged soil abandoned shells orthogonal test chemical additives(lime and cement) unconfined compressive strength(UCS)

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang he lingzi Shi Ran Sun lianfei Ding Mukun he Jiaming li Hua Guo Tiande Gao Panbo liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

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