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N^(6)-methyladenosine on the natural antisense transcript of NIA1 stabilizes its mRNA to boost NO biosynthesis and modulate stomatal movement

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Molecular Plant 2025年第1期18卷 151-165页

作者： Jie Li Wen Tian Ting Chen Qing-yan Liu Hua-Wei Wu Chuan-Hui Liu Yuan-Yuan fang Hui-Shan guo Jian-Hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

Nitric oxide(NO)is a crucial signaling molecule that regulates a wide range of metabolic pathways in different strata of *** plants,nitrate reductase(NR)is a key enzyme for NO *** are two NR-encoding genes in Arabidopsis genome,NIA1 and NIA2,which are precisely regulated and expressed in a tissue-specific *** this study,we found that the natural antisense transcript as-NIA1,transcribed from the 30 UTR of NIA1,stabilizes NIA1 mRNA to maintain its circadian oscillation in plants grown under the light/dark ***,as-NIA1-dependent NIA1 mRNA stability is indispensable for NIA1-mediated NO biosynthesis in guard cells and natural stomatal ***,we revealed that polypyrimidine tract-binding 3(PTB3)regulates the stabilization of NIA1 mRNA by directly binding to UC-rich elements of *** further found that MTA deposits N^(6)-methyladenosine(m6 A)on as-NIA1,facilitating the as-NIA1-PTB3 interaction in vivo,in agreement with RNA structure prediction in that m6 Amediated structural alterations expose the UC-rich elements to enhance the accessibility of *** together,these findings reveal a novel molecular mechanism by which plants precisely manipulate NO biosynthesis to modulate light/dark-regulated stomatal movement,highlighting the coupling of RNA epigenetic modifications and structures shaping RNA-protein interactions in the regulation of hormone biosynthesis.

关键词： natural antisense transcript,NO biosynthesis,N^(6)-methyladenosine,NIA1,stomatal movement

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新质生产力生态内涵的唯物史观阐释

中国地质大学学报(社会科学版) 2025年第1期25卷 11-19页

作者：郭飞方伟浙江工商大学马克思主义学院浙江杭州310018

新质生产力本质上是一种绿色生产力。生态向度是把握新质生产力理论深刻内涵及理论创新的重要视角。绿色发展是新质生产力的内在要求,也是高质量发展的底色。《1844年经济学哲学手稿》中关于人与自然和解的论断,为理解新质生产力的生态... 详细信息

新质生产力本质上是一种绿色生产力。生态向度是把握新质生产力理论深刻内涵及理论创新的重要视角。绿色发展是新质生产力的内在要求,也是高质量发展的底色。《1844年经济学哲学手稿》中关于人与自然和解的论断,为理解新质生产力的生态向度奠定了理论基础。新质生产力以新发展理念为理念先导,以绿色科技创新为动力支撑,以绿色发展为实现路径,以生态制度为可靠保障。探讨新质生产力的生态向度,有助于奠定新质生产力的马克思主义理论基础,彰显新质生产力理论对马克思主义的自然观、生产力理论、财富理论及社会发展理论的继承和发展,阐明新质生产力理论是对马克思主义政治经济学及中国特色社会主义政治经济学的开拓和创新。

关键词：新质生产力自然力生产力生态向度《1844年经济学哲学手稿》

主体结构荷载可控的新型组合式防护结构(Ⅱ):影响因素及设计理念

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爆炸与冲击 2025年第1期45卷 16-27页

作者：方秦高矗孔祥振杨亚陆军工程大学爆炸冲击防灾减灾国家重点实验室江苏南京210007 内蒙古财经大学财政税务学院内蒙古呼和浩特010070

为明确泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,充分发挥和合理利用泡沫混凝土良好的消波特性,首先通过试验及数值模拟探讨不同泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,并分析分层梯度泡沫混凝土在爆炸波作... 详细信息

为明确泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,充分发挥和合理利用泡沫混凝土良好的消波特性,首先通过试验及数值模拟探讨不同泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,并分析分层梯度泡沫混凝土在爆炸波作用下的消波特性。然后将组合式防护结构与采用中粗砂为分配层的传统成层式结构进行对比分析验证其优越性,在此基础上,总结凝练出组合式防护结构的主体结构荷载可控的设计理念。结果表明,利用泡沫混凝土材料较长的屈服平台和较低的波阻抗,以泡沫混凝土作为能量调控层,通过设计泡沫混凝土强度等级(密度等级)和厚度以及采用多层梯度泡沫混凝土,可使得作用于主体结构上的爆炸荷载峰值恰为泡沫混凝土屈服强度,实现对主体结构上荷载的可控设计,有效解决了中粗砂为分配层的传统成层式结构不易控制作用于主体结构上荷载的问题。研究结果可为抗新型钻地弹的防护设计提供重要参考。

关键词：泡沫混凝土组合式防护结构可控设计爆炸波消波

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai guo ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude

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Science China Life Sciences 2025年第03期 859-870页

作者： Xing-Hui Hou Yong-Chao Xu Tian-Shu Sun yan-Bo Gong Xin-Tong Li Guang-Teng Jin Yu-Tao Bian Yi-Ni Liu Juan Jiang Xiao-Min Niu Hong-ya Gu ya-Long guo State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences China National Botanical Garden State Key Laboratory for Protein and Plant Gene Research School of Life Sciences Peking University College of Life Sciences University of Chinese Academy of Sciences

To elucidate the process of adaptation, particularly the traits subject to natural selection and the molecular mechanisms underlying their natural variation, is one of the primary objectives of evolutionary biology. The uplifted landscape offers an excellent framework for understanding how organisms adapt to dramatic climatic gradients. To investigate the genetic basis of plant adaptation to the extremely high altitude, we first compared the genomic and phenotypic variations of two closely related Arabidopsis thaliana accessions from high altitude(Xizang, also known as “Tibet”) and low altitude(Yunnan), respectively. The Xizang population represents a relict group characterized by a small effective population size. Notably, the Xizang genome has more transposable elements(TEs) and more gene loss-offunction(LoF) mutations. Differentially expressed genes were enriched in biological processes of cellular response to oxygen-containing compound, regulation of defense response, and response to light intensity. Intriguingly, the phenotypic selection analysis revealed that silique density was under natural selection. Furthermore, we genetically mapped and validated that the LoF mutation of GA20ox1, the homologous gene of green revolution in rice, resulted in a higher silique density in Xizang Arabidopsis. Given that GA20ox1 is linked to Arabidopsis adaptation to the Alps Mountains, its parallel evolution plays an important role in the adaptation to Alpine habitats. Overall,our results highlight that identifying adaptive traits and elucidating the molecular mechanisms underlying natural variation of these traits is crucial for unraveling the mystery of adaptive evolution and has significant implications for crop breeding.

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肝脏巨噬细胞在慢性乙型肝炎病毒感染中的研究进展

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中华检验医学杂志 2025年第1期48卷 153-158页

作者：郭鸿燕傅亚欧启水福建医科大学附属第一医院检验科、福建省检验医学重点实验室、福建医科大学附属第一医院滨海院区国家区域医疗中心、福建医科大学基因诊断研究中心福州350005

肝脏巨噬细胞是肝脏固有免疫的关键成员,其在慢性乙型肝炎病毒(HBV)感染中发挥重要作用。受肝脏微环境影响,肝脏巨噬细胞可表现出不同的免疫表型和功能,具有抑制HBV感染和介导免疫耐受的双重作用。HBV也可主动调控肝脏巨噬细胞表型,从... 详细信息

肝脏巨噬细胞是肝脏固有免疫的关键成员,其在慢性乙型肝炎病毒(HBV)感染中发挥重要作用。受肝脏微环境影响,肝脏巨噬细胞可表现出不同的免疫表型和功能,具有抑制HBV感染和介导免疫耐受的双重作用。HBV也可主动调控肝脏巨噬细胞表型,从而有利于病毒持续感染。鉴于肝脏巨噬细胞和HBV间的相互作用直接影响HBV感染的结局,并且靶向巨噬细胞的标志物具有潜在的临床实践价值,因此,该文将从肝脏巨噬细胞的来源与异质性、肝脏巨噬细胞与HBV之间的相互作用,以及巨噬细胞相关的HBV感染潜在免疫学血清标志物三个方面,阐述肝脏巨噬细胞在HBV感染中的研究进展。

关键词：乙型肝炎病毒肝巨噬细胞免疫微环境免疫学血清标志物

养老基金助推金融高质量发展:基于金融五篇大文章的协同视角分析

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华中科技大学学报(社会科学版) 2025年第1期39卷 47-54,91页

作者：房连泉郭娟中国社会科学院中国式现代化研究院中国社会科学院大学政府管理学院

养老基金是重要的长期机构投资者。在人口老龄化加速发展的背景下,做好养老金融大文章,激发养老基金的潜力,不仅是积极应对人口老龄化国家战略的重要内容,还是推动金融高质量发展的重要议题。基于部分OECD国家的经验,探讨养老基金在现... 详细信息

养老基金是重要的长期机构投资者。在人口老龄化加速发展的背景下,做好养老金融大文章,激发养老基金的潜力,不仅是积极应对人口老龄化国家战略的重要内容,还是推动金融高质量发展的重要议题。基于部分OECD国家的经验,探讨养老基金在现代金融市场体系中的重要地位,分析养老基金与科技金融、绿色金融、普惠金融、数字金融的良性互动关系,就壮大中国养老金融提出如下建议:一是活跃资本市场与提振投资信心,二是加大养老基金投入科创企业的力度,三是引导养老保险基金关注绿色投资与社会责任,四是加快培育发展普惠型养老金融,五是推动养老基金与数字金融的协同发展。

关键词：养老保险基金金融高质量发展现代金融市场体系

Effect of heat treatment on microstructure and mechanical properties of a novel Al-Zn-Mg-Cu alloy

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China Foundry 2025年

作者： yan-mei yang Xin-chen Tang Ye-fei Li Xue-wei fang Da-wei Yi Zhi-yun Zhang Qiao-ling Zheng Zhi-xi Wang guo-yu Zhang Su Zhang Hao Cheng yang He Yi-bo Liu Zi-han Wu ya-nan Chen Yi-min Gao State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an Aerospace Precision Electromechanical Institute

Effects of solution and aging treatment on the microstructure and mechanical properties of a novel Al-Zn-Mg-Cu alloy by microalloying rare elements Sc and Er were studied. The results show that solution time has a visible influence on the microstructure and mechanical properties of the alloy. Specifically, as the solution time increases, the area fraction of the residual phase in the alloy decreases, and the shape of the grain becomes more spheroidal and coarser, leading to a decrease in hardness. This is attributed to the dissolution of strengthening phases during the solution treatment, which weakens the solid solution strengthening *** single-stage aging treatment shows an initial increase in strength and hardness of the alloy, followed by a decrease as the aging time is extended, until a steady state is achieved. The optimal single-aging conditions are found to be at 120 ℃ for 24 h, where the alloy exhibits an excellent combination of high strength and good ductility, with an ultimate tensile strength(UTS) of 523 MPa, yield strength(YS) of 482 MPa, and elongation(El)of 1.75%, respectively. Compared to single-stage aging, double-stage aging(120 ℃ for 24 h and then 150 ℃ for 52 h) significantly increases the elongation of the alloy(4.17%), but the UTS reduces to 465.29 MPa, and YS reduces to 410.64 MPa. Transmission electron microscopy(TEM) observations disclose that the grain size, the distribution spacing of precipitates along the grain boundary, and the width of the precipitation-free zone(PFZ) all undergo augmentation as the duration of the second stage aging process elongates.

关键词：

g-C_(3)N_(4)负载双金属Rh@Ru催化氨硼烷析氢反应机理研究

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原子与分子物理学报 2025年第5期42卷 17-21页

作者：郭雅琼武警警官学院成都610213

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、... 详细信息

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、Ⅱ所需活化能较高,反应路径Ⅲ更容易进行,Ⅰ为最优析氢路径.从微观角度揭示双贵金属Rh@Ru负载g-C_(3)N_(4)催化氨硼烷析氢的三条机理,希望为氨硼烷析氢催化剂的优化和设计提供理论信息.

关键词：双金属催化剂 g-C_(3)N_(4) NH_(3)BH_(3) 密度泛函理论反应机理