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Characteristics and genetic mechanism of the Mesoproterozoic rift system,Ordos Basin,China

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Energy Geoscience 2024年第1期5卷 141-152页

作者： Meng Li Xiangbin Yan Wei Zhang yuanling Guo Chaoying Liu Lingling Fan Shuang Yang Petroleum Exploration and Production Research Institute SINOPECBeijing100083China Exploration and Development Research Institute SINOPEC North China CompanyZhengzhouHenan450006China

The Mesoproterozoic rifts are developed in the Ordos Basin located in the western margin of the North China *** on the latest 3D seismic data and previous research results,this study intends to discuss the zonal differential deformation characteristics and genetic mechanism of the Mesoproterozoic rifts in the Ordos ***-trending rifts are developed in the Mesoproterozoic in the south-central Ordos Basin,the main part of which are located near the western margin of the North China ***-trending rifts are developed in the north of the basin,while NW-NNW rifts in the Mesoproterozoic in Hangjinqi *** genetic mechanism of the Mesoproterozoic rifts is related to regional extensional stress field,plate boundary conditions and internal preexisting *** main extensional stress direction strikes NWW-SSE(120°)in the western margin of the North China Plate,based on the forward rift trend of the northern *** Hangjinqi area,the reactivation of the existing NWtrending Wulansu fault and NW-NW-trending Daolao fault,results in dextral shear stress *** boundary between the western margin of the North China Plate and its adjacent plates forms a nearly NS-trending preexisting basement tectonic belt,which intersects with the NWW-SSE(120°)extensional stress at an acute angle of 60°.Therefore,the western margin of the North China Plate is formed by oblique normal faults under oblique *** to the long time span of Columbia Supercontinent breakup(1.8e1.6 Ga),the oblique rift in the south-central Ordos Basin is formed under the continuous oblique extension at the western margin of the North China Plate.

关键词： Columbia Supercontinent Ordos Basin Rift system Mesoproterozoic Genetic mechanism

TP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer:a clinical next-generation sequencing study

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Precision Clinical Medicine 2024年第2期7卷 122-131页

作者： Yongsheng Huang Shuwei Ren Linxiaoxiao Ding yuanling jiang Jiahuan Luo Jjinghua Huang Xinke Yin Jianli Zhao Sha Fu Jianwei Liao Cellular&Molecular Diagnostics Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Laboratory The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangzhou Regenerative Medicine and Health Guangdong LaboratorySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Background:TP53 mutations and homologous recombination deficiency(HRD)occur frequently in breast ***,the characteristics of TP53 pathogenic mutations in breast cancer patients with/without HRD are not ***:Clinical next-generation sequencing(NGS)of both tumor and paired blood DNA from 119 breast cancer patients(BRCA-119 cohort)was performed with a 520-gene ***,tumor mutation burden(TMB),and genomic HRD scores were assessed from NGS *** data from 47 breast cancer patients in the HRD test cohort were analyzed for further ***:All TP53 pathogenic mutations in patients had somatic origin,which was associated with the protein expression of estrogen receptor and progestogen *** to patients without TP53 pathologic mutations,patients with TP53 pathologic mutations had higher levels of HRD scores and different genomic *** frequency of TP53 pathologic mutation was higher in the HRDhigh group(HRD score≥42)relative to that in the HRD-low group(HRD score<42).TP53 has different mutational characteristics between the HRD-low and HRD-high ***53-specific mutation subgroups had diverse genomic features and ***,TP53 pathogenic mutations predicted the HRD status of breast cancer patients with an area under the curve(AUC)of ***53-specific mutations,namely HRD-low mutation,HRD-high mutation,and HRD common mutation,predicted the HRD status of breast cancer patients with AUC values of 0.32,0.72,and 0.58,***,TP53 HRD-high mutation and HRD common mutation combinations showed the highest AUC values(0.80)in predicting HRD ***:TP53-specific mutation combinations predict the HRD status of patients,indicating that TP53 pathogenic mutations could serve as a potential biomarker for poly-ADP-ribose polymerase(PARP)inhibitors in breast cancer patients.

关键词： next-generation sequencing homologous recombination deficiency TP53 breast cancer

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity

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National Science Review 2024年第7期11卷 80-94页

作者： Pan Liu Can Yue Bo Meng Tianhe Xiao Sijie Yang Shuo Liu Fanchong Jian Qianhui Zhu yuanling Yu Yanyan Ren Peng Wang Yixin Li Jinyue Wang Xin Mao Fei Shao Youchun Wang Ravindra Kumar Gupta Yunlong Cao Xiangxi Wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences University of Chinese Academy of Sciences Cambridge Institute of Therapeutic Immunology&Infectious Disease(CITIID) University of Cambridge Biomedical Pioneering Innovation Center(BIOPIC) Peking University Changping Laboratory Joint Graduate Program of Peking-Tsinghua-NIBS Academy for Advanced Interdisciplinary Studies Peking University Peking-Tsinghua Center for Life Sciences Tsinghua University Chinese Academy of Medical Sciences&Peking Union Medical College

Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-binding domain(RBD). Details of how the acquisition of glycosylation impacts viral fitness and human adaptation are not clearly understood. Here, we dissected the role of N354-linked glycosylation, acquired by BA.2.86 sub-lineages, as a RBD conformational control element in attenuating viral infectivity. The reduced infectivity is recovered in the presence of heparin sulfate, which targets the‘N354 pocket’ to ease restrictions of conformational transition resulting in a ‘RBD-up’ state, thereby conferring an adjustable infectivity. Furthermore, N354 glycosylation improved spike cleavage and cell–cell fusion, and in particular escaped one subset of ADCC antibodies. Together with reduced immunogenicity in hybrid immunity background, these indicate a single spike amino acid glycosylation event provides selective advantage in humans through multiple mechanisms.

关键词： coronavirus glycosylation viral fitness adjustable infectivity co-factor usage viral evolution conformational modulator

A novel live attenuated vaccine candidate protects chickens against subtype B avian metapneumovirus

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Journal of Integrative Agriculture 2024年第5期23卷 1658-1670页

作者： Lingzhai Meng Mengmeng Yu Suyan Wang Yuntong Chen yuanling Bao Peng Liu Xiaoyan Feng Tana He Ru Guo Tao Zhang Mingxue Hu Changjun Liu Xiaole Qi Kai Li Li Gao Yanping Zhang Hongyu Cui Yulong Gao Avian Immunosuppressive Diseases Division State Key Laboratory for Animal Disease Control and PreventionHarbin Veterinary Research InstituteChineseAcademy of Agricultural SciencesHarbin150069China Avian ImmunosuppressiveDiseases DivisionStateKey LaboratoryforAnimal Disease Cont National Poultry Laboratory Animal Resource Center Harbin 150069China

Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by serial passaging in Vero cells and evaluated its safety and efficacy as a vaccine candidate. The safety test showed that after the 30th passage, the LN16-A strain was fully attenuated, as clinical signs of infection and histological lesions were absent after *** LN16-A strain did not revert to a virulent strain after five serial passages in chickens. The genomic sequence of LN16-A differed from that of the parent wild-type LN16(wtLN16) strain and had nine amino acid mutations. In chickens, a single immunization with LN16-A induced robust humoral and cellular immune responses, including the abundant production of neutralizing antibodies, CD4^(+) T lymphocytes, and the Th1(IFN-γ) and Th2(IL-4 and IL-6)cytokines. We also confirmed that LN16-A provided 100% protection against subtype B aMPV and significantly reduced viral shedding and turbinate inflammation. Our findings suggest that the LN16-A strain is a promising live attenuated vaccine candidate that can prevent infection with subtype B aMPV.

关键词： avian metapneumovirus attenuated protection vaccine candidate chickens

双液压马达驱动的甘蔗根切器刀盘转速同步控制方法

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农业工程学报 2024年第11期40卷 59-68页

作者：陈远玲覃良昊陈承宗廖国陆广西大学机械工程学院南宁530004

为简化双刀盘甘蔗根切器的传动链,提高传动系统对时变载荷的适应性,该研究提出用双液压马达直接驱动双刀盘,并将电液比例负载敏感技术应用于根切器的传动方案,通过建模仿真和试验探究双刀盘同步精度的控制方法。建立根切器电液比例阀控... 详细信息

为简化双刀盘甘蔗根切器的传动链,提高传动系统对时变载荷的适应性,该研究提出用双液压马达直接驱动双刀盘,并将电液比例负载敏感技术应用于根切器的传动方案,通过建模仿真和试验探究双刀盘同步精度的控制方法。建立根切器电液比例阀控马达闭环速度控制系统的传递函数,分析得到该系统的稳定裕度仅为16.5°,因此需要采用合适的控制算法提高系统的稳定性和控制精度。基于AMESim-MATLAB联合仿真,研究采用主从控制策略,主马达为PID控制,从马达分别采用PID、自适应模糊PID和滑模变结构控制算法时系统的稳定性和刀盘转速的控制精度。仿真结果为:不同控制算法下马达开启过程转速的动态调整时间分别为5.5、3.0、2.7 s,稳态阶段两个液压马达的速度差分别为20、8、5 r/min;最后搭建试验台,以实测载荷谱为负载输入,进行主从马达转速同步控制试验,得到PID、自适应模糊PID和滑模变结构控制系统启动阶段转速的动态调整时间分别为6.3、4.6、3.7 s,稳态阶段主从马达的转速差分别为47、23、13 r/min;仿真与试验结果均表明,基于滑模变结构算法的刀盘转速同步控制系统的各项指标均优于PID和自适应模糊PID控制。研究结果可为甘蔗收割机根切器传动与控制系统的优化设计提供理论参考。

关键词：农业机械试验甘蔗收获根切器双液压马达同步控制滑模变结构控制

Physiological Analysis of Drought Resistance of Seven Cultivars Spring Wheat in Northern Regions of China

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Journal of Northeast Agricultural University(English Edition) 2024年第2期31卷 1-12页

作者： Gao Fengmei Zhang Fuzhi Zhao yuanling Li Tie Li Dongmei Sun Minglong Zhang Qichang Liu Ningtao Sun Dan Tian Chao Sun Lianfa Institute of Crop Resources Heilongjiang Academy of Agricultural SciencesHarbin 150086China College of Art and Design Harbin Institute of Information EngineeringHarbin 150431China

In order to determine the physiological mechanism of drought resistance of northern wheat in China,six drought resistant wheat and one sensitivity to drought wheat were planted in *** were subjected to drought treatment and normal water when the plants grew to the 3-leaf *** were collected at 10,20,30,and 40 days after the drought treatment,*** electrical conductivity,photosynthetic parameters,chlorophyll fluorescence parameters,sugar content,proline content,protein content,and active oxygen scavenging enzyme activity of the plants were detected,and the agronomic traits of the wheat varieties were investigated at *** results indicated that the phenotype and yield-related factors of Darkhan 144 changed little under the drought *** relative electrical conductivity of Kefeng 6 and Darkhan 166 was lower under the drought stress,and their cell membrane was less *** Darkhan 144 and Darkhan 166 had higher drought resistance coefficients,and were the wheat varieties with stronger drought ***,the physiological mechanisms of drought resistance of these three wheat were different:Darkhan 144 maintained a higher photosynthetic activity under the drought stress;Darkhan 166 maintained a higher protein content,photosynthetic activity and active oxygen scavenging enzyme *** addition,other drought-resistant varieties Kefeng 6,Kefeng 10 and Longmai 26 had a higher content of osmoregulatory substances under the drought stress.

关键词： wheat tolerance drought physiological mechanism

中央文献翻译中的受众意识——以党的二十大报告俄文翻译为例

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天津外国语大学学报 2024年第4期31卷 101-109,F0003页

作者：宋元玲中央党史和文献研究院第六研究部

论文以党的二十大报告的中俄翻译为例探讨了受众意识对讲好新时代中国故事、做好中央文献翻译的重要意义,并以此为基础探索可行的翻译策略。作为译者,我们需要具备基本的受众意识,努力在作者和读者之间、文本和译本之间搭建桥梁、实现对... 详细信息

论文以党的二十大报告的中俄翻译为例探讨了受众意识对讲好新时代中国故事、做好中央文献翻译的重要意义,并以此为基础探索可行的翻译策略。作为译者,我们需要具备基本的受众意识,努力在作者和读者之间、文本和译本之间搭建桥梁、实现对接,提高译文的可读性,同时,更要坚守正确的政治立场和根本的翻译原则,守正创新,打造中央文献精品译文。

关键词：中央文献翻译受众意识对接

脑干听觉诱发电位在孤独症谱系障碍患儿中的特征分析

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中外医学研究 2024年第2期22卷 146-149页

作者：洪远玲厦门市仙岳医院(厦门医学院附属仙岳医院福建省精神医学中心福建省精神疾病临床医学研究中心)福建厦门361000

目的:分析脑干听觉诱发电位(BAEP)在孤独症谱系障碍(ASD)患儿中的特征。方法:选取2020年1月—2023年1月厦门市仙岳医院收治的100例ASD患儿为观察组,另取同期体检健康儿童26例为对照组,对其BAEP检测结果进行统计。对观察组实施听觉统合训... 详细信息

目的:分析脑干听觉诱发电位(BAEP)在孤独症谱系障碍(ASD)患儿中的特征。方法:选取2020年1月—2023年1月厦门市仙岳医院收治的100例ASD患儿为观察组,另取同期体检健康儿童26例为对照组,对其BAEP检测结果进行统计。对观察组实施听觉统合训练,观察干预效果。结果:两组Ⅰ波与Ⅲ波潜伏期比较,差异无统计学意义(P>0.05),观察组Ⅴ波潜伏期长于对照组,差异有统计学意义(P0.05),观察组Ⅲ波、Ⅴ波,Ⅰ波、Ⅴ波波间差均大于对照组,差异有统计学意义(P<0.05)。治疗后2周、1个月,异常组孤独症治疗评定量表(ATEC)评分均低于非异常组,差异有统计学意义(P<0.05)。治疗前和治疗后2周,异常组儿童孤独症评定量表(CARS)评分均低于非异常组,差异有统计学意义(P<0.05);异常组治疗前和治疗后2周CARS评分差值均大于非异常组,差异有统计学意义(P<0.05)。结论:BAEP检测能够为ASD患儿诊断提供依据,且听觉统合训练对于BAEP异常患儿症状改善更为显著。

关键词：孤独症谱系障碍脑干听觉诱发电位听觉统合训练

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基于熵产理论的航空柱塞泵涡轮增压系统优化

航空学报 2024年第4期45卷 280-292页

作者：陈远玲陈家文潘越洋闫明洋广西大学机械工程学院南宁530004

在航空柱塞泵的进油端集成涡轮增压系统,有利于提高航空液压系统的集成度,并解决柱塞泵在高转速下因吸油不足而产生的空化、脱靴等难题。针对涡轮增压系统中叶片和压水室流道的优化设计问题,基于熵产理论对增压系统中的能量损失及其空... 详细信息

在航空柱塞泵的进油端集成涡轮增压系统,有利于提高航空液压系统的集成度,并解决柱塞泵在高转速下因吸油不足而产生的空化、脱靴等难题。针对涡轮增压系统中叶片和压水室流道的优化设计问题,基于熵产理论对增压系统中的能量损失及其空间分布进行了研究,构建了涡轮自增压轴向柱塞泵的流体域模型,探究压水室形式、断面形状、进口宽度、断面面积变化规律以及涡轮叶片形式与熵产率的关系,以熵产最小为目标优化涡轮增压系统的结构:涡轮采用扭曲叶片,压水室采用螺旋形、断面形状采用圆弧形、压水室进口宽度采用8 mm、断面面积变化规律为U型时,增压系统的总熵产下降约0.032 W/K,较优化前降低了13%,增压值上升约0.22 bar,较优化前增加7%。最后采用试制的样机搭建试验系统,测试了直叶片形式和扭曲叶片形式的涡轮增压值,试验结果与仿真结果基本一致。

关键词：航空柱塞泵涡轮增压熵产理论能量损失结构优化