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Protective eff ect and mechanism of nanoantimicrobial peptide ND-C14 against Streptococcus pneumoniae infection

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World Journal of Emergency Medicine 2024年第1期15卷 28-34页

作者： Yangyang Guo Yaqi Sun Hongxia Wu Jian Lu yuan lin Jiaqing Zhu Meihong Lai Meiqi Zhang Jun Wang Jungang Zheng Department of Intensive Care Medicine Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China National Children’s Regional Medical Center National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Spleen and Stomach Diseases Hangzhou Traditional Chinese Medicine Hospital Affi liated to Zhejiang Chinese Medical UniversityHangzhou 310021China Department of Ultrasonic Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Zhejiang University School of Medicine Hangzhou 310058China The First People’s Hospital of Yuexi County Yuexi 616650China

BACKGROUND:Streptococcus pneumoniae(***)is a common pathogen that causes bacterial ***,with increasing bacterial resistance,there is an urgent need to develop new drugs to treat *** *** with a 14-carbon saturated fatty acid(ND-C14)is a novel nanoantimicrobial peptide designed by modifying myristic acid at the C-terminus of humanα-defensin 5(HD5)via an amide ***,it is unclear whether ND-C14 is effective against lung infections caused by ***:In vitro,three groups were established,including the control group,and the HD5 and ND-C14 treatment groups.A virtual colony-count assay was used to evaluate the antibacterial activity of HD5 and ND-C14 against *** morphological changes of *** treated with HD5 or ND-C14 were observed by scanning electron *** vivo,mice were divided into sham,vehicle,and ND-C14 treatment *** in the sham group were treated with 25μL of phosphate-buffered saline(PBS).Mice in the vehicle and ND-C14 treatment groups were treated with intratracheal instillation of 25μL of bacterial suspension with 2×108 CFU/mL(total bacterial count:5×10^(6) CFU),and then the mice were given 25μL PBS or intratracheally injected with 25μL of ND-C14(including 20μg or 50μg),*** rates were evaluated in the vehicle and ND-C14 treatment *** burden in the blood and bronchoalveolar lavage fluid were *** lung histology of the mice was assessed.A propidium iodide uptake assay was used to clarify the destructive eff ect of ND-C14 against ***:Compared with HD5,ND-C14 had a better bactericidal eff ect against *** because of its stronger ability to destroy the membrane structure of *** in *** vivo,ND-C14 significantly delayed the death time and improved the survival rate of mice infected with ***-C14 reduced bacterial burden and lung tissue ***,ND-C14 had a membrane per

关键词： Streptococcus pneumoniae Antimicrobial peptides Humanα-defensin 5 Infection

Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

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Chinese Chemical Letters 2024年第8期35卷 205-210页

作者： Zhe Li Ping-Zhao Liang Li Xu Fei-Yu Yang Tian-Bing Ren lin yuan Xia Yin Xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Photodynamic therapy(PDT)has emerged as a significant cancer therapy ***,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after ***,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some ***,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor ***,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor ***,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.

关键词： Water-soluble Three positive charge Photosensitizer Nonapoptotic Tumor therapy

Shared diagnostic genes and potential mechanisms between COVID-19 and sepsis revealed by bioinformatics analysis

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World Journal of Emergency Medicine 2024年第5期15卷 410-412页

作者： Weifei Wang Zhong Chen Wenyuan Zhang yuan lin Yaqi Sun Qi Yao Jian Lu Jungang Zheng Department of Gerontology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Anesthesiology Beilun District People’s HospitalNingbo 315800China Meigu County People’s Hospital Meigu 616450China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China Department of Ultrasound in Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China The First People’s Hospital of Yuexi County Yuexi 616650China Zhejiang University School of Medicine Hangzhou 310058China

The coronavirus disease 2019(COVID-19)pandemic,triggered by the novel coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has ravaged the globe,resulting in a staggering loss of life and wreaking havoc on the worldwide economy.[1,2]Sepsis is a cascade of abnormal responses provoked by infection,leading to a critical deterioration in organ function that poses a life-threatening risk.[3]However,it is unclear from published reports whether COVID-19 and sepsis are commonly aff ected by molecular ***,we performed a bioinformatics analysis to uncover shared diagnostic genes and potential mechanisms between COVID-19 and sepsis.

关键词： sepsis acute respiratory

Design of advanced porous silver powder with high-sintering activity to improve silicon solar cells

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Nano Research 2024年第4期17卷 3189-3197页

作者： Yongsheng Li Ziwei Chen Rui Zhou Wenguang Zhao Mu Li Jun Chen Zhongyuan Huang Jian Liu Yuhang Li Maolin Yang Minghan Yu Dong Zhou yuan lin Feng Pan School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055China Institute of Advanced Science Facilities Shenzhen 518107China Institute of Zhejiang University-Quzhou Quzhou 324000China Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China Institute of Materials Research(IMR) Tsinghua UniversityTsinghua Shenzhen International Graduate SchoolShenzhen 518055China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Silver(Ag)paste is widely used in semiconductor metallization,especially in silicon solar *** powder is the material with the highest proportion in Ag *** morphology and structure of Ag powder are crucial which determine its characteristics,especially for the sintering *** this work,a simple method was developed to synthesize a type of microcrystalline spherical Ag particles(SP-A)with internal pores and the structural changes and sintering behavior were thoroughly studied by combining ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),in-situ heating X-ray diffraction(XRD),focused ion beam(FIB),and thermal analysis *** to the unique internal pores,the grain size of SP-A is smaller,and the coefficient of thermal expansion(CTE)is higher than that of traditional solid Ag *** a result,the sintering activity of SP-A is excellent,which can form a denser sintered body and form silver nanoparticles at the Ag–Si interface to improve silver silicon *** silicon solar cell built with SP-A obtained a low series resistance(Rs)and a high photoelectric conversion efficiency(PCE)of 19.26%.These fill a gap in Ag particle structure research,which is significant for the development of high-performance electronic Ag particles and efficient semiconductor devices.

关键词： silver particles small angle X-ray scattering(SAXS) pore size distribution in-situ heating X-ray diffraction(XRD) sintering silicon solar cells

Transfer learning and neural networks in predicting quadrupole deformation

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Chinese Physics C 2024年第6期48卷 162-168页

作者：原林李佳星张鸿飞 School of Science Xi'an Polytechnic UniversityXi'an 710048China Engineering Research Center of Flexible Radiation Protection Technology Universities of Shaanxi ProvinceXi'an 710048China Xi'an Key Laboratory of Nuclear Protection Textile Equipment Technology Xi'an 710048China School of Physics Xi'an Jiaotong UniversityXi'an 710049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Accurately determining the quadrupole deformation parameters of atomic nuclei is crucial for understanding their structural and dynamic *** study introduces an innovative approach that combines transfer learning techniques with neural networks to predict the quadrupole deformation parameters of even-even *** the application of this innovative technique,the quadrupole deformation parameters of 2331 even-even nuclei are successfully predicted within the nuclear region defined by proton numbers 8≤Z≤134 and neutron numbers N≥***,we discuss the impact of nuclear quadrupole deformation parameters on the capture cross-sections in heavy-ion fusion reactions,reconstructing the capture cross-sections for the reactions ^(48)Ca+^(244)Pu and ^(48)Ca+^(248)*** research offers new insights into the application of neural networks in nuclear physics and highlights the potential of merging advanced machine learning techniques with both theoretical and experimental data,particularly in fields where experimental data are limited.

关键词： nuclear deformation neural networks transfer learning heavy-ion fusion reactions

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论20世纪五六十年代政治抒情诗的审美风格

华中师范大学学报（人文社会科学版） 2024年第2期63卷 137-143页

作者：袁琳华中农业大学文法学院湖北武汉430070

20世纪五六十年代的政治抒情诗忠实记录了新中国成立后的社会变革与公共生活的面貌,整体呈现出三种审美风格:宏大叙事中雄伟壮丽的崇高美、日常叙事中清新宁静的优美、异化情境中社会不良风气造成的荒诞感。无论是抒发社会主义建设革命... 详细信息

20世纪五六十年代的政治抒情诗忠实记录了新中国成立后的社会变革与公共生活的面貌,整体呈现出三种审美风格:宏大叙事中雄伟壮丽的崇高美、日常叙事中清新宁静的优美、异化情境中社会不良风气造成的荒诞感。无论是抒发社会主义建设革命豪情的壮美、表达日常生活幸福之感的优美,还是讽喻社会异化情境中的荒诞感,诗歌的价值内核仍然指向对真、善、美的追求。

关键词：政治抒情诗崇高优美荒诞感

女性歌者与城市声音景观的再造——上海广播电台“歌唱社现象”研究(1931-1949)

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中国音乐 2024年第4期 174-182,190页

作者：林媛哈尔滨音乐学院

20世纪30年代,大量歌唱社团进入上海广播电台演唱,先后成立的几百个歌唱社团为时代曲和抗战歌曲的大众化传播提供“歌唱源”。歌唱社的演唱者以女性居多,留下来的经典唱片也鲜明地将那个时期的声音指向女性。上海广播电台里的“歌唱社... 详细信息

20世纪30年代,大量歌唱社团进入上海广播电台演唱,先后成立的几百个歌唱社团为时代曲和抗战歌曲的大众化传播提供“歌唱源”。歌唱社的演唱者以女性居多,留下来的经典唱片也鲜明地将那个时期的声音指向女性。上海广播电台里的“歌唱社现象”持续了十余年。歌唱社团在歌唱资源、慈善资源和抗战资源之间不断转换,持续性的演唱形成了笼罩性的听觉刺激,从广播电台里传出的歌声塑造了城市的声音景观,改变了以传统演艺类型为主的上海广播电台娱乐节目的版图。一种女性化、标志性、象征性,具有隐喻功能的歌声重新绘制了上海的声音图景。

关键词：女性歌者广播电台歌唱社时代曲抗战歌曲

Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第3期21卷 349-358页

作者： Hui-Hui LIU Meng ZHANG yuan-lin GUO Cheng-Gang ZHU Na-Qiong WU Ying GAO Rui-Xia XU Jie QIAN Ke-Fei DOU Jian-Jun LI Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are ***,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with *** In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were *** admission,ABG,SHR,and GG were assessed and all participants were classified according to their ***-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term *** During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were ***-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and *** adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term ***,we observed similar associations of these acute glycemic parameters with 30-day *** Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.

关键词： admitted infarction shaped

Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： Jingyi Tan Jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang Jia Dan Zexin Zeng Jun Hu Wenbo Zhu Jiankai Liang Jing Cai Ying Liu Guangmei Yan yuan lin Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China Department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical Technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer