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Identification of Potential Key Genes,miRNAs,and Pathways Involved in Pituitary Tumor Sphenoid Sinus Invasion:Bioinformatic Analysis and Machine Learning

Identification of Potential Key Genes,miRNAs,and Pathways In...

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第十六届中国医师协会神经外科医师年会

作者： Xiang-Ming Cai Feng yuan Jun-Hao Zhu Jin Yang Chao Tang Zi-Xiang Cong chi-yuan Ma School of Medicine Southeast University Department of Neurosurgery Affiliated Jinling HospitalSchool of MedicineNanjing University School of Medicine Nanjing Medical University

Background:The molecular basis of pituitary adenomas(PA) invading sphenoid sinus is largely *** study aims to identify key genes,miRNAs,and pathways and explore PA sphenoid sinus invasion’s molecular ***:E-MTAB-7768 and E-MTAB-7969,involving sphenoid sinus-invasive pituitary adenomas and nonsphenoid sinus-invasive pituitary adenomas,were extracted from *** the differential expression analysis of m RNAs and miRNAs using the EdgeR package,we performed functional enrichment analyses for differentially expressed genes(DEGs).We used protein-protein interaction network and correlation analysis to evaluate the relationship between enriched terms and ***-target regulatory network construction was performed using the multiMiR package and visualized by ***,we developed predictive models for sphenoid sinus invasion according to the key genes *** performance was mainly evaluated based on the area under the receiver operating characteristic curve(AUC).Results:A total of 396 DEGs and 24 differentially expressed miRNAs were *** analyses revealed that DEGs were mainly enriched in 8 pathways,including osteoclast differentiation and PI3K-Akt pathway,and 266 biological process terms like negative regulation of biomineral tissue development and negative regulation of cell ***3,SRGN,and CCR1 from negative regulation of biomineral tissue development and PTPN22,LILRB2,and IL1RN from negative regulation of cell adhesion were analyzed by PPI and correlation *** regulation of biomineral tissue development was found to have tight relationship with osteoclast ***,negative regulation of cell adhesion correlated with the PI3K-Akt ***,miR-1-3p regulates the highest number of DEGs in the miRNA-target regulation *** regression model yielded the best predictive performance(AUC=0.83).Conclusions:Osteoclast differentiation and negative regulati

关键词： bioinformatic analysis cell adhesion MiRNAs osteoclast differentiation pituitary adenomas sphenoid sinus invasion

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Effect of Top Slag Basicity on Quality of Steel Treated by Exothermic Agent SiFe and SiCaBa during Chemical Heating

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Journal of Iron and Steel Research(International) 2002年第1期9卷 12-15页

作者： WANG Hai-chuan ZHOU Yun WANG Shi-jun YUE Ke-xiang DONG yuan-chi Anhui University of Technology

The effect of top slag basicity on quality of steel treated with SiFe and SiCaBa alloy as exothermic agent in chemical heating was *** experiments were carried out in MoSi_2 laboratory furnace with 0.2 kg molten steel for equilibrium test and 2 kg molten steel for simulation test *** results showed that the adjusting basicity of top slag with CaO is effective to prevent rephosphorization and resulphurization,and it is possible to dephosphorize and desulphurize and remove the inclusions from molten steel when basicity R of the top slag is adjusted to 2.0 — 3.10,and SiCaBa alloy is better than SiFe alloy in this relation.

关键词： chemical heating top slag basicity SiFe SiCaBa exothermic agent

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Thermodynamic Properties of Fe-C-N and Fe-C-B-N Melts

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Journal of Iron and Steel Research(International) 2007年第1期14卷 21-24页

作者： CHEN Er-bac WANG Shi-jun DONG yuan-chi WU Bao-guo ZHOU Yun School of Metallurgy and Materials Anhui University of Technology Ma＇anshan 243002 Anhui China

The saturated solubility of carbon and nitrogen in Fe-C-N and Fe-C-B-N melts was measured experimentally at 1 485℃ to obtain the activity interaction coefficients between components in these melts. A new method was used to treat experimental results. Using thermodynamic derivation and calculation, some important interac- tion coefficients between components in these melts were obtained.

关键词： Fe-C-N melt Fe-C-B-N melt Fe-C-B melt interaction coefficient thermodynamic property

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Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AIDS Dementia Complex

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Biomedical and Environmental Sciences 2014年第2期27卷 111-117页

作者： ZHAO Li PU Shuang Shuang GAO Wen Hua chi yuan yuan WEN Hong Ling WANG Zhi Yu SONG Yan Yan YU Xue Jie Department of Laboratory Microbiology School of Public Health Shandong University Clinical Laboratory Affiliated Hospital of Shandong Traditional Chinese Medicine University Hospital of Shandong University Department of Pathology University of Texas Medical Branch

Objective To explore the role of HIV-1 tat gene variations in AIDS dementia complex （ADC） pathogenesis. Methods HIV-1 tat genes derived from peripheral spleen and central basal ganglia of an AIDS patient with ADC and an AIDS patient without ADC were cloned for sequence analysis. HIV-1 tat gene sequence alignment was performed by using CLUSTAL W and the phylogentic analysis was conducted by using Neighbor-joining with MEGA4 software. All tat genes were used to construct recombinant retroviral expressing vector MSCV-IRES-GFP/tat. The MSCV-IRES-GFP/tat was cotransfected into 293T cells with pCMV-VSV-G and pUMVC vectors to assemble the recombinant retrovirus. After infection of gliomas U87 cells with equal amount of the recombinant retrovirus, TNF-α, and IL-1β concentrations in the supernatant of U87 cells were determined with ELISA. Results HIV-1 tat genes derived from peripheral spleen and central basal ganglia of the AIDS patient with ADC and the other one without ADC exhibited genetic variations. Tat variations and amino acid mutation sites existed mainly at Tat protein core functional area （38-47aa）. All Tat proteins could induce ug7 cells to produce TNF-α and IL-1β, but the level of IL-1β production was different among Tat proteins derived from the ADC patient＇s spleen, basal ganglia, and the non-ADC patient＇s spleen. The level of Tat proteins derived from the ADC patient＇s spleen, basal ganglia, and the non-ADC patient＇s spleen were obviously higher than that from the non-ADC patient＇s basal ganglia. Conclusion Tat protein core functional area （38-47aa） may serve as the key area of enhancing the secretion of IL-1β. This may be related with the neurotoxicity of HIV-1 Tat.

关键词： Key words: HIV-1 tat gene AIDS dementia complex Cytokines TNF-α IL-1β Neurotoxicity

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Predictive factors of visual function recovery after pituitary adenoma resection： a literature review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1742-1750页

作者： Min Sun Zhi-Qiang Zhang chi-yuan Ma Sui-Hua Chen Xin-Jian Chen School of Electronic and Information Engineering Soochow University Suzhou 215006 Jiangsu Province China Department of Electronic Engineering Huaian College of Information Technology Huaian 223003 Jiangsu Province China Department of Medical Imaging Nanjing General Hospitalof Nanjing Military Command Nanjing 210002 JiangsuProvince China Department of Neurosurgery Nanjing General Hospitalof Nanjing Military Command Nanjing 210002 JiangsuProvince China Department of Ophthalmology Nanjing General Hospitalof Nanjing Military Command Nanjing 210002 JiangsuProvince China

AIM：To determine the dominant predictive factors of postoperative visual recovery for patients with pituitary ***：Pub Med,Google Scholar,Web of Science and Cochrane Library were searched for relevant human studies,which investigated the prediction of the postoperative visual recovery of patients with pituitary adenoma,from January2000 to May ***-analyses were performed on the primary *** the related data were extracted by two independent investigators,pooled weighted mean difference（WMD）and odds ratio（OR）with 95%confidence interval（CI）were estimated using a random-effects or a fixed-effects ***：Nineteen studies were included in the literature review,and nine trials were included in the Metaanalysis,which comprised 530 patients（975 eyes）with pituitary *** the primary outcomes,there was a significant difference between preoperative and postoperative mean deviation（MD）values of the visual field（WMD-5.85;95%CI：-8.19 to-3.51;P〈0.00001）.Predictivecharacteristics of four factors were revealed in this Metaanalysis by assigning the patients to sufficient and insufficient groups according to postoperative visual field improvements,including preoperative visual field defect（WMD 10.09;95%CI：6.17 to 14.02;P〈0.00001）,patient age（WMD-12.32;95%CI：-18.42 to-6.22;P〈0.0001）,symptom duration（WMD-5.04;95%CI：-9.71 to-0.37;P=0.03）,and preoperative peripapillary retinal nerve fiber layer（p RNFL）thickness（OR 0.1;95%CI：0.04 to 0.23;P〈0.00001）.CONCLUSION：Preoperative visual field defect,symptom duration,patient age,and preoperative p RNFL thickness are the dominant predictive factors of the postoperative recovery of the visual field for patients with pituitary adenoma.

关键词： pituitary adenoma retinal thickness visual field defect visual function recovery prediction

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鸡蛋壳膜分选装置相似设计及设计程序开发

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农业机械学报 2023年第10期54卷 381-389,415页

作者：迟媛陈博超刘聪王海岭赵梓为迟玉杰东北农业大学工程学院哈尔滨150030 吉林大学机械与航空航天工程学院长春130025 东北农业大学食品学院哈尔滨150030

鸡蛋壳膜分选装置用来分选分离后的鸡蛋壳膜混合物,目前在实验室中已经完成了壳膜分选装置的研究和设计,达到了很好的分选效果。为了使研究结果具有普遍适用性,便于工厂化应用,缩短设计周期,基于相似理论,以已研制的鸡蛋壳膜分选装置为... 详细信息

鸡蛋壳膜分选装置用来分选分离后的鸡蛋壳膜混合物,目前在实验室中已经完成了壳膜分选装置的研究和设计,达到了很好的分选效果。为了使研究结果具有普遍适用性,便于工厂化应用,缩短设计周期,基于相似理论,以已研制的鸡蛋壳膜分选装置为模型,提出一种鸡蛋壳膜分选装置的相似设计方法。当固体负荷率分别为6、12、18、24 kg/s时,对根据该方法设计的装置进行仿真,同时进行了比例尺为1.2倍的原型试验,验证了相似设计方法的正确性和可行性。运用Visual Basic 6.0对CATIA、AutoCAD进行二次开发,编写程序,可直接获得三维模型、二维图纸及工作参数,提高了鸡蛋壳膜分选装置的设计效率,降低了成本,实现了分选装置的快速设计。

关键词：蛋壳膜分选相似设计模拟仿真软件二次开发

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不同处理方法对蛋清蛋白免疫原性及结构的影响

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食品科学 2022年第15期43卷 93-100页

作者：王晨马艳秋张梓湘张龙媛迟玉杰迟媛东北农业大学食品学院黑龙江哈尔滨150030 东北农业大学工程学院黑龙江哈尔滨150030

为研究降低蛋清蛋白免疫原性的有效方法,分别采用微波、酶解、微波协同酶解对蛋清蛋白进行处理,采用酶联免疫吸附试验测定蛋清蛋白的免疫原性,并利用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、傅里叶变换红外光谱、荧光光谱及紫外光谱等对蛋... 详细信息

为研究降低蛋清蛋白免疫原性的有效方法,分别采用微波、酶解、微波协同酶解对蛋清蛋白进行处理,采用酶联免疫吸附试验测定蛋清蛋白的免疫原性,并利用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、傅里叶变换红外光谱、荧光光谱及紫外光谱等对蛋清蛋白结构进行表征。结果表明,微波700 W/20 s处理和碱性蛋白酶水解后蛋清蛋白免疫原性分别降低了50.81%和55.83%,而微波协同酶解后免疫原性进一步降低,最高降低了67.48%。经不同方法处理后十二烷基硫酸钠-聚丙烯酰胺凝胶电泳条带均发生变化;荧光光谱分析结果表明,3种方法处理使氨基酸微环境发生改变;利用傅里叶变换红外光谱进一步分析发现,不同方法处理的蛋清蛋白二级结构向无序方向转变,蛋白的二、三级结构均发生改变;此外,蛋清蛋白的表面疏水性均有所升高。说明蛋清蛋白免疫原性降低与不同方法处理改变蛋白质原有的结构特性相关。综上,微波协同酶解更有效地降低了蛋清蛋白致敏性,蛋清蛋白结构的变化与其免疫原性有关。

关键词：蛋清蛋白微波协同酶解免疫原性结构

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Thermodynamic Model for Calculating Activity of Nitrogen and Boron in Fe-C-B-N Molten Metal

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Journal of Iron and Steel Research(International) 2009年第3期16卷 15-19页

作者： WANG Shi-jun PENG Jun DONG yuan-chi LIU Li-xia ZHOU Yun CHEN Er-bao School of Metallurgy and Resource Anhui University of Technology Maranshan 243002 Anhui China School ofMetallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

The solubility of nitrogen in Fe-C-B-N system was measured at 1 758 K,and the computational model on activity （action concentration） of nitrogen and boron was established based on phase diagram and the coexistence theory about metal melt structure model. Comparing the computed results with the experimental results,satisfactory conclusion can be obtained. The result shows that BN and B4C can exist in Fe-C-B-N molten metal at high temperature,which consequently restrains the nitrogen removal from the melt. However,B4C content is extremely low. Before graphite is precipitated,the influence of carbon on activity of nitrogen in melt is higher in ternary system than in binary system; however,this effect is contrary to that after graphite is precipitated.

关键词： molten metal coexistence theory action concentration activity

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动力差速转向机构履带车辆载荷比与转向系数的关系

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农业工程学报 2012年第18期28卷 44-48页

作者：迟媛东北农业大学工程学院哈尔滨150030

为了研究采用动力差速转向机构的液压机械双流驱动系统履带车辆转向时的功率增长程度,该文对其载荷比和转向系数进行理论研究,并获得了两者之间的关系,与其他转向机构的载荷比-转向系数射线比较,分析了载荷比的增长情况。通过样机试验... 详细信息

为了研究采用动力差速转向机构的液压机械双流驱动系统履带车辆转向时的功率增长程度,该文对其载荷比和转向系数进行理论研究,并获得了两者之间的关系,与其他转向机构的载荷比-转向系数射线比较,分析了载荷比的增长情况。通过样机试验和计算获得了载荷比和转向系数的数值和关系,并绘制了载荷比-转向系数射线。载荷比与转向系数的关系可用来评价动力差速转向机构的转向性能。该文为进一步分析采用动力差速式转向机构的液压机械双流驱动系统的转向性能提供了参考。

关键词：车辆转向载荷系数差速转向

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Model of Calculating Activity of Nitrogen and Vanadium in Fe-C-V-N Molten Metal

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Journal of Iron and Steel Research(International) 2008年第5期15卷 19-23页

作者： PENG Jun WANG Shi-jun DONG yuan-chi LIU Li-xia ZHOU Yun CHEN Er-bao School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 Beijing China School of Metallurgy and Resource Anhui University of Technology Ma＇anshan 243002 Anhui China

The solubility of nitrogen in the Fe-C-V-N system was measured at 1 708 K and the model of calculating activity （action concentration） of nitrogen （N） and vanadium （V） was derived according to the phase diagram and the coexistence theory of the metal melt structure. The solubility expression of nitrogen in the Fe-C-V-N system at 1 708 K was ωN =0. 058 194-0. 010 367ωc＋0. 005 543 4ωv. Comparing the computing results with the experimental resuits, a satisfactory conclusion could be obtained. The analysis of the Fe-C-V-N system using this model showed that VN was present in a high temperature metal melt, which would reduce the action concentration of nitrogen obviously. It was consequently disadvantageous to the removal of nitrogen from hot metal.

关键词： metal melt coexistence theory action concentration activity

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