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Effect of changing the proportion of C16:0 and cis-9 C18:1 in fat supplements on rumen fermentation,glucose and lipid metabolism,antioxidation capacity,and visceral fatty acid profile in finishing Angus bulls

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Animal Nutrition 2024年第3期18卷 39-48页

作者： Haixin Bai Lubo Wang Modinat Tolani Lambo yang li Yonggen Zhang College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030China

This study evaluated the effects of different proportions of palmitic(C16:0)and oleic(cis-9 C18:1)acids in fat supplements on rumen fermentation,glucose(GLU)and lipid metabolism,antioxidant function,and visceral fat fatty acid(FA)composition in Angus *** design of the experiment was a randomized block design with 3 treatments of 10 animals each.A total of 30 finishing Angus bulls(21±0.5 months)with an initial body weight of 626±69 kg were blocked by weight into 10 blocks,with 3 bulls per *** bulls in each block were randomly assigned to one of three experimental diets:(1)control diet without additional fat(CON),(2)CON+2.5%palmitic calcium salt(PA;90%C16:0),(3)CON+2.5%mixed FA calcium salts(MA;60%C16:0+30%cis-9 C18:1).Both fat supplements increased C18:0 and cis-9 C18:1 in visceral fat(Pliver FA transport protein 5(FATP5;Plin concentration(Pliver,the content of the C16:0 in visceral fat(P=0.004),and weight gain(P=0.032),and up-regulated the expression of liver diacylglycerol acyltransferase 2(DGAT2;Pliver,insulin resistance,and reduced antioxidant *** adverse effects were alleviated by partially replacing C16:0 with cis-9 C18:1.

关键词： Palmitic acid Oleic acid lipid metabolism lipotoxicity Finishing bull

Axial-torsional nonlinear vibration of bottom hole assembly in the air drilling technology

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Petroleum 2024年第3期10卷 446-461页

作者： Shujie Ding Pan Fang Gao li Junan Lu Yanmin Wang yang li Yutian Han Dong Xiao School of Mechanical Engineering Southwest Petroleum UniversityChengdu610500China Petroleum Engineering School Southwest Petroleum UniversityChengdu610500China Petrochina Tarim Oilfield CNPCKorla841000China PetroChina Huabei Oilfield Co CNPC834000China

The safety and efficiency of drilling engineering are greatly impeded by destructive vibrations of drill string in air drilling,such as stick-slip,bit-bounce and their coupled *** avoid or suppress these vibrations improving the stability of drilling operations,revealing the occurrence mechanisms of abovementioned harmful vibrations are indispensable by investigating dynamics characteristics of drill string *** this paper,an axial-torsional coupled dynamics model that can capture the motion behaviors of bottom hole assembly(BHA)is established adopting the lumped parameter ***,a rate of penetration(ROP)model appropriating for air drilling is obtained firstly by linear fitting ***,a novel discontinuous support model is established to describe the bitformation ***,BHA dynamics are discussed using numerical simulations under different vibration scenarios:normal operation;stick-slip;bit-bounce;bit-bounce and stick-slip ***,in two drilling modes:the continuous and intermittent drilling,the vibration mitigation strategies and dynamics sensibility study of BHA are carried out based on the parametric *** results show that increasing torsional stiffness of drill-pipes,appropriately adjusting rotation speed of top driven system and dynamic weight on bit(WOB)are deemed as an effective strategy suppressing or eliminating stick-slip and bit-bounce vibrations of *** that the rotation speed of top driven system and dynamic WOB are 5 rad/s and 3.5 kN,***,the constructed probability maps allow to driller to choose reasonable mechanical parameters,thereby realizing smooth drilling operation in the air drilling.

关键词： Drill string BHA Contact model ROP Stick-slip Bit-bounce

The BEL1-like transcription factor GhBLH5-A05 participates in cotton response to drought stress

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The Crop Journal 2024年第1期12卷 177-187页

作者： Jing-Bo Zhang Yao Wang Shi-Peng Zhang Fan Cheng Yong Zheng yang li Xue-Bao li Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina College of life Sciences Xinjiang Normal UniversityUrumqi 830017XinjiangChina

Drought stress impairs crop growth and ***1-like family transcription factors may be involved in plant response to drought stress,but little is known of the molecular mechanism by which these proteins regulate plant response and defense to drought *** we show that the BEL1-like transcription factor GhBLH5-A05 functions in cotton(Gossypium hirsutum)response and defense to drought *** of GhBLH5-A05 in cotton was induced by drought *** of GhBLH5-A05 in both Arabidopsis and cotton increased drought tolerance,whereas silencing GhBLH5-A05 in cotton resulted in elevated sensitivity to drought ***5-A05 binds to cis elements in the promoters of GhRD20-A09 and GhDREB2C-D05 to activate the expression of these ***5-A05 interacted with the KNOX transcription factor ***-expression of GhBLH5-A05 and GhKNAT6-A03 increased the transcription of GhRD20-A09 and *** conclude that GhBLH5-A05 acts as a regulatory factor with GhKNAT6-A03 functioning in cotton response to drought stress by activating the expression of the drought-responsive genes GhRD20-A09 and GhDREB2C-D05.

关键词： Cotton(Gossypium hirsutum) BEL1-like transcription factor Drought stress Transcriptional regulation Drought tolerance

Hydrogen Sulfide Promotes Platelet Autophagy via􀀳􀀧􀀪􀀩􀀵􀀐􀄮􀀒􀀳􀀬􀀖􀀮􀀒􀀤􀁎􀁗􀀃􀀶􀁌􀁊􀁑􀁄􀁏􀁌􀁑􀁊􀀃􀁌􀁑􀀃􀀦􀁌􀁕􀁕􀁋􀁒􀁗􀁌􀁆􀀃􀀷􀁋􀁕􀁒􀁐􀁅􀁒􀁆􀁜􀁗􀁒􀁓􀁈􀁑􀁌􀁄

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 625-633页

作者： Hua-Xiang yang yang-Jie li yang-Lan He Ke-Ke Jin ling-Na Lyu Hui-Guo Ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijingChina

Background and Aims:The role of platelet autophagy in cirrhotic thrombocytopenia(CTP)remains *** study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hydrogen sulfide(H_(2)S)on platelet ***:Platelets from 56 cirrhotic patients and 56 healthy individuals were isolated for in vitro *** markers(ATG7,BECN1,LC3,and SQSTM1)were quantified using enzyme-linked immunosorbent assay,while autophagosomes were visualized through electron *** blotting was used to assess the autophagy-related proteins and the PDGFR/PI3K/Akt/mTOR pathway following treatment with NaHS(an H_(2)S donor),hydroxocobalamin(an H_(2)S scavenger),or AG 1295(a selective PDGFR-α/inhibitor).A carbon terachloride-induced cirrhotic BALB/c mouse model was *** mice with thrombocytopenia were randomly treated with normal saline,NaHS,or hydroxocobalamin for 15 *** in platelet count and aggregation rate were observed every three ***:Cirrhotic patients with thrombocytopenia exhibited significantly decreased platelet autophagy markers and endogenous H_(2)S levels,alongside increased platelet aggregation,compared to healthy *** vitro,NaHS treatment of platelets from severe CTP patients elevated LC3-II levels,reduced SQSTM1 levels,and decreased platelet aggregation in a dose-dependent manner.H_(2)S treatment inhibited PDGFR,PI3K,Akt,and mTOR *** vivo,NaHS significantly increased LC3-II and decreased SQSTM1 expressions in platelets of cirrhotic mice,reducing platelet aggregation without affecting the platelet ***:Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients.H_(2)S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling pathway.

关键词： liver cirrhosis Thrombocytopenia Platelet Autophagy Hydrogen sulfide NaHS PDGFR-α PI3K/Akt/mTOR signaling

Complete genome assembly provides insights into the centromere architecture of pumpkin(Cucurbita maxima)

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Plant Communications 2024年第9期5卷 12-15页

作者： Qingguo Zeng Minghua Wei Shuai li Haiyan Wang Changjuan Mo li yang Xinzheng li Zhilong Bie Qiusheng Kong National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China School of Horticulture and Landscape Architecture Henan Institute of Science and TechnologyXinxiang 453003China

Dear Editor,Pumpkin(Cucurbita maxima)belongs to the Cucurbita genus of the Cucurbitaceae family and is a globally cultivated vegetable crop with great economic *** global production and planting area of pumpkin,includ... 详细信息

关键词： significance. insight globally

Promising dawn in tumor microenvironment therapy:engineering oral bacteria

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International Journal of Oral Science 2024年第2期16卷 208-224页

作者： Zifei Wang Wansu Sun Ruixue Hua Yuanyin Wang yang li Hengguo Zhang Key Laboratory of Oral Diseases Research of Anhui Province College&Hospital of StomatologyAnhui Medical UniversityHefeiChina Department of Stomatology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Genetics School of Life ScienceAnhui Medical UniversityHefeiChina

Despite decades of research,cancer continues to be a major global health *** human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via ***,the role of oral microbes in the development and progression of cancer has received increasing *** the same time,bioengineering technology and nanotechnology is growing rapidly,in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of *** engineered bacteria were transformed to achieve directed genetic reprogramming,selective functional reorganization and precise *** contrast to endotoxins produced by typical genetically modified bacteria,oral flora exhibits favorable biosafety *** outline the current cognitions upon oral microbes,engineered microbes and human cancers,related literatures were searched and reviewed based on the PubMed *** focused on a number of oral microbes and related mechanisms associated with the tumor microenvironment,which involve in cancer occurrence and *** engineering oral bacteria can be a possible application of cancer therapy is worth consideration.A deeper understanding of the relationship between engineered oral bacteria and cancer therapy may enhance our knowledge of tumor pathogenesis thus providing new insights and strategies for cancer prevention and treatment.

关键词： prevention organs precise

Safe Efficient Policy Optimization Algorithm for Unsignalized Intersection Navigation

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2011-2026页

作者： Xiaolong Chen Biao Xu Manjiang Hu Yougang Bian yang li Xin Xu State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body the College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body the College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082 Wuxi Intelligent Control Research Institute(WICRI)of Hunan University Wuxi 214115China College of Intelligence Science and Technology Institute of Unmanned SystemsNational University of Defense TechnologyChangsha 410073China

Unsignalized intersections pose a challenge for autonomous vehicles that must decide how to navigate them safely and *** paper proposes a reinforcement learning(RL)method for autonomous vehicles to navigate unsignalized intersections safely and *** method uses a semantic scene representation to handle variable numbers of vehicles and a universal reward function to facilitate stable learning.A collision risk function is designed to penalize unsafe actions and guide the agent to avoid them.A scalable policy optimization algorithm is introduced to improve data efficiency and safety for vehicle learning at *** algorithm employs experience replay to overcome the on-policy limitation of proximal policy optimization and incorporates the collision risk constraint into the policy optimization *** proposed safe RL algorithm can balance the trade-off between vehicle traffic safety and policy learning *** intersection scenarios with different traffic situations are used to test the algorithm and demonstrate its high success rates and low collision rates under different traffic *** algorithm shows the potential of RL for enhancing the safety and reliability of autonomous driving systems at unsignalized intersections.

关键词： Autonomous driving decision-making reinforcement learning(RL) unsignalized intersection

Multi-performance evaluation of high-throughput accelerated corrosion test for high-strength low-alloy 921A steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1260-1278页

作者： Cong-cong Du Ming-hua Qin Zhan-fang Wu Dong-ling li Lei Zhao Xiang-yang li Hai-zhou Wang Beijing Advanced Innovation Center for Materials Genome Engineering National Center for Materials Service SafetyUniversity of Science and Technology BeijingBeijing100083China China Iron and Steel Research Institute Group Co. Ltd.Beijing100081China Beijing Advanced Innovation Center for Materials Genome Engineering Central Iron and Steel Research InstituteBeijing100081China

The corrosion behavior of high-strength low-alloy 921A steel in a simulated marine atmospheric environment was studied using a high-throughput experimental *** corrosion behavior,corrosion morphology,and corrosion products of 921A steels were analyzed using various techniques,including corrosion mass loss method,polarization curve,white-light interferometry,scanning electron microscopy,energy-dispersive spectrometry,microbeam X-ray fluorescence spectrometry,X-ray diffraction technique,and X-ray photoelectron *** test results indicated that 921A steel exhibits better corrosion resistance than Q450NQR1 steel in simulated harsh atmospheric environments,as evidenced by a lower corrosion mass loss rate throughout the corrosion *** corrosion products of both steels consisted ofα-FeOOH,Fe_(3)O_(4),andγ-FeOOH,withα-FeOOH being more prevalent in the rust layer of 921A steel than in Q450NQR1 *** inner rust layer of 921A steel also exhibited an appositional enrichment region of Cr,Ni,Mo,and V,leading to its superior corrosion resistance compared to that of Q450NQR1 *** efficacy of high-throughput accelerated corrosion experimental methods was highlighted for evaluating the corrosion resistance of steel materials in harsh environmental *** findings suggest that 921A steel exhibits better corrosion resistance compared to Q450NQR1 steel and has the potential to be more suitable in harsh marine atmospheric *** characterization of the rust layer structures and composition reveals the parallel enrichment of certain elements in the inner rust layer of 921A steel,which enhances its corrosion resistance.

关键词： Atmospheric corrosion High-throughput experimental method High-strength low-alloy steel Corrosion characteristics Rust layer Element enrichment

Mitigation of black carbon emissions could immediately reduce 6.3% of glacier melting in the Qilian Mountains

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Advances in Climate Change Research 2024年第4期15卷 725-736页

作者： Ji-Zu CHEN Wen-Tao DU Shi-Chang KANG Xiang QIN Wei-Jun SUN li-Hui LUO yang li Jun-Hua yang You-Yan JIANG Qilian Shan Station of Glaciology and Eco-environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Geography and Environment Shandong Normal UniversityJinan 250014China Zhangye Meteorological Bureau Zhangye 734000China Lanzhou Regional Climate Center Lanzhou 730020China Institute of International Rivers and Eco-security Yunnan UniversityKunming 650500China Gansu Provincial Industry Technology Center of Inteligent Equipment and Big Data for Disaster Prevention Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China

Global warming in tandem with surface albedo reduction caused by black carbon(BC)deposition on glaciers accelerated glacier melting;however,their respective contributions remain *** in the Qilian Mountains are crucial for the development of oases in the Hexi Corridor;however,their area has decreased by more than 20%over the past ***,this study developed a dynamic deposition model for light-absorbing particles(LAPs),coupled with a surface energy and mass balance *** comprehensively assessed the effects of BC and warming on the melting of a typical glacier in the Qilian Mountains based on the coupled *** on the glacier surface caused 13.1%of annual glacier-wide melting,of which directly deposited atmospheric BC reduced the surface albedo by 0.02 and accounted for 9.1%of glacier *** air temperature during 2000-2010 has increased by 1.5°C relative to that during the 1950s,accounting for 51.9%of current glacier ***,BC emission have increased by 4.6 times compared to those of the early Industrial Revolution recorded in an ice core,accounting conservatively for 6.3%of current glacier *** BC emissions has a limited influence on current glacier melting;however,in the long-term,mitigation should exert a noteworthy impact on glacier melting through the self-purification of glaciers.

关键词： Glacier Melting Black carbon Simulation Qilian Mountains