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胎儿主动脉缩窄超声心动图诊断指标的综合评估

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岭南心血管病杂志 2024年第2期30卷 167-175页

作者：黄雨申俊君杨柳青庞程程石子桢潘微广东省心血管病研究所心儿科广东省人民医院(广东省医学科学院) 广州510080 广东省心血管病研究所心儿科南方医科大学附属广东省人民医院(广东省医学科学院) 广州510080

目的本研究旨在综合分析胎儿主动脉缩窄(coarctation of the aorta,CoA)的相关超声心动图指标。方法回顾性分析2018年1月至2023年5月广东省人民医院产前超声心动图检查疑诊CoA存活胎儿204例的临床资料,提取产前超声心动图数据和患者资... 详细信息

目的本研究旨在综合分析胎儿主动脉缩窄(coarctation of the aorta,CoA)的相关超声心动图指标。方法回顾性分析2018年1月至2023年5月广东省人民医院产前超声心动图检查疑诊CoA存活胎儿204例的临床资料,提取产前超声心动图数据和患者资料。根据生后随访结果将研究对象分为真阳性组(A组)和假阳性组(B组)。通过Logistic回归分析筛选预测指标并建立确诊CoA列线图预测模型,按6:4随机将患者分为训练集和测试集,进行模型内部验证及效果评价。结果204例胎儿被纳入研究,其中A组95例(46.5%),B组109例(53.43%)。最终确定4个指标组成列线图模型,包括左心室Z值、主动脉远端横弓Z值、肺动脉主干与升主动脉比值、是否合并室间隔缺损。该模型具有一定预测能力和实用价值[曲线下面积(area under the curve,AUC)=0.888],在验证集中亦取得了良好的诊断效能(AUC=0.825),内部验证显示模型具有良好的预测能力和应用价值。结论本研究建立的列线图模型可作为应用简单且有效的工具,提高CoA的产前诊断准确性,促进围产期及生后的分层管理。

关键词：主动脉缩窄先天性心脏病产前诊断超声心动图胎儿

基于GC-MS和主成分分析法的蛋卷风味物质研究

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中国食品添加剂 2024年第6期35卷 203-214页

作者：张岩朱荣安陈思云杨祥敏彭海明杨柳青金健王储炎合肥学院生物食品与环境学院合肥230601 安徽柏兆记食品股份有限公司合肥231200

本论文采用固相微萃取技术,结合气相色谱-质谱联用法开展蛋卷风味物质检测,进而通过主成分分析法探究蛋卷风味中关键化合物,希望能为蛋卷的加工提供借鉴。研究结果表明,从蛋卷中检测出71种香气成分,其中醛类16种,醇类12种,酮类10种;借... 详细信息

本论文采用固相微萃取技术,结合气相色谱-质谱联用法开展蛋卷风味物质检测,进而通过主成分分析法探究蛋卷风味中关键化合物,希望能为蛋卷的加工提供借鉴。研究结果表明,从蛋卷中检测出71种香气成分,其中醛类16种,醇类12种,酮类10种;借助峰面积归一化法计算风味化合物相对含量,得出蛋卷最佳烘烤工艺为200℃、300 s;进而确定出蛋卷中具有贡献作用的风味物质有14种,分别为2,5-二甲基吡嗪、乙酸乙酯、2-庚酮、2-壬酮、庚醛、己醛、苯乙醛、2-十一酮、2-十三酮、安息香醛、γ-辛内酯、δ-十二内酯、2-戊基呋喃、萘。

关键词：蛋卷风味物质气相色谱-质谱联用主成分分析

川芎嗪及相关制剂联合用药在脑血管病中的应用进展

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中华中医药学刊 2024年第8期42卷 157-162页

作者：冯科冉吴娅丽杨柳青泥文娟李琨纪秋如汪彬唐进法李伟霞河南中医药大学第一附属医院药学部河南郑州450003 河南省中药临床应用、评价与转化工程研究中心河南省中药临床药学中医药重点实验室河南省中药安全评价与风险防控工程研究中心河南郑州450000 河南中医药大学药学院河南郑州450046

随着脑血管疾病发病率的不断升高,活血化瘀类中药在保护脑血管作用方面日益成为研究热点,川芎嗪(tetramethylpyrazine,TMP)是从中药川芎中提取出来的吡嗪类活性成分,具有抗炎、免疫调节、扩张血管等多重作用。大量的体内外研究证实TMP... 详细信息

随着脑血管疾病发病率的不断升高,活血化瘀类中药在保护脑血管作用方面日益成为研究热点,川芎嗪(tetramethylpyrazine,TMP)是从中药川芎中提取出来的吡嗪类活性成分,具有抗炎、免疫调节、扩张血管等多重作用。大量的体内外研究证实TMP通过保护血管内皮细胞、保护神经元、抗炎抗氧化、抗血小板聚集等方式对脑血管疾病发挥良好的保护作用。对TMP的脑血管病保护作用及其机制进行综述,并针对目前有关TMP的联合用药进行分析,以更好地明确TMP的治疗途径和作用机理,进而促进TMP研究的开展以及临床上更好地应用。

关键词：川芎嗪吡嗪类生物碱联合用药脑血管疾病

ANALYSIS OF AN EPIDEMIC MODEL WITH CROWLEY-MARTIN INCIDENCE RATE AND HOLLING TYPE Ⅱ TREATMENT

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Annals of Applied Mathematics 2020年第2期36卷 204-220页

作者： liuqing yang Fengying Wei College of Mathematics and Computer Science Fuzhou UniversityFuzhou 350108FujianPR China Key Laboratory of Operations Research and Control of Universities in Fujian Fuzhou UniversityFuzhou 350108FujianPR China

We propose an epidemic model consisting five compartments within a total population with Crowley-Martin incidence rate and Holling type Ⅱ treatment,where total population is separated by the susceptible, the vaccinated, the exposed, the infected and the removed in this paper. We firstly prove that the epidemic model admits a unique global positive solution by contradiction. We then find out that diseases tend to extinction provided that the basic reproduction number is less than one. Moreover, the sufficient conditions of persistence for infectious diseases are obtained by constructing suitable Lyapunov functions.

关键词： epidemic model Crowley-Martin incidence rate extinction persistence

通关藤注射液逆转乳腺癌多柔比星耐药的作用机制

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中草药 2024年第15期55卷 5112-5124页

作者：张小帅杨柳青王晓艳汪彬孟高全孟伟亭李伟霞陈小菲张明亮张辉吴娅丽唐进法河南中医药大学第一附属医院药学部河南郑州450003 河南中医药大学药学院河南郑州450046 河南省中药临床应用、评价与转化工程研究中心河南省中药临床药学中医药重点实验室河南省中药安全评价与风险防控工程研究中心河南郑州450003 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南郑州450046

目的探究通关藤注射液(Tongguanteng Injection,TGT)对乳腺癌多柔比星(doxorubicin,DOX)耐药的逆转作用及潜在作用机制。方法分别用DOX、TGT、DOX+TGT干预人乳腺癌DOX耐药MCF-7/DOX细胞株,采用CCK-8法、克隆形成实验检测细胞增殖;Comb... 详细信息

目的探究通关藤注射液(Tongguanteng Injection,TGT)对乳腺癌多柔比星(doxorubicin,DOX)耐药的逆转作用及潜在作用机制。方法分别用DOX、TGT、DOX+TGT干预人乳腺癌DOX耐药MCF-7/DOX细胞株,采用CCK-8法、克隆形成实验检测细胞增殖;Combenefit软件定量分析药物联合作用指数;Transwell实验观察细胞迁移能力;TUNEL染色检测细胞凋亡率;利用罗丹明外排实验检测TGT对MCF-7/DOX细胞外排功能的影响;采用生物信息学手段预测TGT逆转乳腺癌DOX耐药的作用机制,并采用Western blotting实验检测TGT对MCF-7/DOX细胞中耐药相关蛋白表达的调控作用。结果 TGT可逆转MCF-7/DOX细胞的耐药性,且能够协同DOX抑制MCF-7/DOX细胞的增殖、迁移,促进细胞凋亡;此外,TGT增加细胞内Rho-123的蓄积(P<0.001)。TGT成分靶标的基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)富集分析结果表明其主要参与调控磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)、丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、凋亡等信号通路。GEO数据库筛选得到MCF-7和MCF-7/DOX细胞差异表达基因823个,KEGG富集分析表明乳腺癌DOX耐药主要与PI3K/Akt、Ras相关蛋白1(Ras-proximate-1,Rap1)、凋亡等信号通路相关。TGT联合DOX显著下调MCF-7/DOX细胞中p-PI3K、p-Akt、B细胞淋巴瘤-2(B-cell lymphoma-2,Bcl-2)、三磷酸腺苷结合转运蛋白B1(adenosine triphosphate-binding cassette transporter B1,ABCB1)、ABCG2蛋白表达(P<0.05、0.01),且上调Bcl-2相关X蛋白(Bcl-2 associated X protein,Bax)表达(P<0.05)。结论基于生物信息学结合细胞实验验证TGT联合DOX可通过抑制PI3K/Akt介导的凋亡相关信号通路,同时下调ABCB1、ABCG2蛋白表达逆转乳腺癌DOX耐药。为临床TGT与DOX联合用药提供了实验依据,为乳腺癌耐药的治疗提供新的思路。

关键词：通关藤注射液多柔比星乳腺癌耐药性 PI3K/Akt信号通路

Plant Landscape Design in River Renovation Based on Site Characte-ristics——A Case Study of Plant Landscape Design in Renovation of Longwanggang River

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Journal of Landscape Research 2013年第Z1期5卷 53-56,60页

作者： yang liuqing CHEN Hu Central South University of Forestry and Technology Zhuzhou Institute of Planning and Design

Plant landscape design in the renovation of Longwanggang River was taken for example to elaborate that plant landscape designs based on site characteristics are mainly demonstrated as "respecting original landforms, considering original plant species, communities and landscapes, exploring proper indigenous plant species". Plant landscapes of Longwanggang River were oriented as riverfront landscape belt with multiple textures, urban portal and ecological corridor, aiming at returning to the nature, integrating environmental resources, achieving large scales and multiple forms. Considering properties of the neighboring plots, functional areas are divided according to different community types and eco-community structure of the plant landscapes, so as to form landscape nodes, highlight overall plant landscape effects, regional characteristics and low maintenance cost.

关键词： Site characteristics River renovation Plant landscapes Planning and design

Dangua Fang(丹瓜方)regulating tricarboxylic acid cycle and respiratory chain and its mechanism in diabetic rats

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1150-1159页

作者： HENG Xianpei WANG Zhita yang liuqing LI Liang HUANG Suping Department of Endocrinology People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China Academy of Integrative Medicine Fujian Fujian University of Traditional Chinese MedicineFuzhou 350122China

OBJECTIVE:To investigate the influence and possible targets of Dangua Fang(丹瓜方)on tricarboxylic acid(TCA)cycle and respiratory chain to enrich the prescription’s mechanism of effective intervention on glycolipid metabolic diseases such as type 2 ***:After interventional rats were fed with high glucose and high fat diet ad libitum for 4 weeks,intraperitoneally injected streptozotocin to induce diabetic *** to blood glucose level,28 diabetic rats were selected and continued to be fed with high glucose and high fat diet,were stratified by body weight,and divided randomly by blood glucose into Model group(was given sterile water by gastric perfusion and injected aquae pro injection intraperitoneally),Dangua group[Dangua liquor(丹瓜方液)20.5 g·kg^(-1)·d^(-1) by perfusion and aquae pro injection intraperitoneally],Inhibitor group[sterile water by perfusion and nicotinamide phosphoribosyl transferase(Nampt)specific blocker GEN-6171.25 mg/kg intraperitoneally],DanInhit group(Dangua liquor and GEN-617 synchronously).Control group were continuously fed with ordinary *** intervention was last for 10 *** weight(BW),liver index(LI),glycosylated hemoglobin(HbA1c),TC,TG,free fatty acids(FFA),creatinine(Cr),and A-ketoglutarate(α-KG),Iso-citric acid(ICA),oxaloacetic acid(OAA)were *** cytochrome C oxidase(COX)and Succinate dehydrogenase(SDH)were evaluated by Colorimetry;Nampt protein,Adenosine triphosphate(ATP)synthase(ATPs),Nicotinamide adenine dinucleotide(NAD^(+))and its reduced(NADH)in liver were measured by enzyme linked immunosorbent *** expressions of Nampt and mitochondrialnadhdehydrogenase-1(mt-ND1)gene in liver was assessed by real-time polymerase chain *** tissue staining was also ***:The levels of BW,ICA,α-KG and Nampt-mRNA in the Model group are lower than that in the Normal group(P<0.05),conversely,liver weight,LI,TC,HbA1c,SDH and ATPs,mt-ND1-mRNA,and Nampt protein in the Model group are higher(P<0

关键词： Dangua Fang diabetes mellitus citric acid cycle electron transport nicotinamide phosphoribosyltransferase

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补骨脂肝毒性及其减毒方法的研究进展

中华中医药学刊 2024年第7期42卷 162-165页

作者：冯科冉吴娅丽李伟霞王晓艳张辉杨柳青韩冰汪彬唐进法河南中医药大学第一附属医院药学部河南郑州450003 河南省中药临床应用、评价与转化工程研究中心河南省中药临床药学中医药重点实验室河南省中药安全评价与风险防控工程研究中心河南郑州450000 河南中医药大学药学院河南郑州450046

补骨脂因含香豆素类、黄酮类和单萜酚类等化学成分,具有抗肿瘤、抗氧化、抗菌、抗炎、调节雌激素水平、促进骨生长、神经保护等作用而广泛用于肾部疾病、脾胃病、肢体经络病、妇科病的治疗,是临床常用的传统“无毒”的补益类中药,但近年... 详细信息

补骨脂因含香豆素类、黄酮类和单萜酚类等化学成分,具有抗肿瘤、抗氧化、抗菌、抗炎、调节雌激素水平、促进骨生长、神经保护等作用而广泛用于肾部疾病、脾胃病、肢体经络病、妇科病的治疗,是临床常用的传统“无毒”的补益类中药,但近年来,国家药品不良反应监测中心多次通报警示补骨脂相关制剂(如壮骨关节丸、仙灵骨葆胶囊、致康胶囊)引发的肝损伤问题,更有单味补骨脂引发肝损伤的临床病例报道,其肝损伤现象已成为当前行业研究的热点及难点,为补骨脂的临床安全用药带来极大挑战。课题组前期基于脂多糖模型证实了补骨脂具有特异质肝损伤的属性,并从体内外角度相互验证了补骨脂甲素、补骨脂乙素、补骨脂酚、补骨脂定或可通过调控PI3K-Akt信号通路、NF-κB信号通路、NLRP3信号通路等引发肝损伤。通过对近年来补骨脂肝毒性的相关文献进行整理、归纳,探讨引起补骨脂肝毒性的主要毒理机制,并总结了配伍减毒和炮制减毒对减轻补骨脂肝毒性的重要意义,为补骨脂的临床安全用药提供数据支撑。

关键词：补骨脂肝毒性作用机制配伍减毒炮制减毒

Coordinated Path Planning for UAVs Based on Sheep Optimization

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Transactions of Nanjing University of Aeronautics and Astronautics 2020年第5期37卷 816-830页

作者： yang liuqing WANG Pengfei ZHANG Yong Research Institute of Pilotless Aircraft Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Key Laboratory of Advanced Technology for Small and Medium-Sized UAV Ministry of Industry and Information TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China

Using the traditional swarm intelligence algorithm to solve the cooperative path planning problem for multi-UAVs is easy to incur the problems of local optimization and a slow convergence rate.A cooperative path planning method for multi-UAVs based on the improved sheep optimization is proposed to tackle ***,based on the three-dimensional planning space,a multi-UAV cooperative cost function model is established according to the path planning requirements,and an initial track set is constructed by combining multiple-population *** an improved sheep optimization is proposed and used to solve the path planning problem and obtain multiple cooperative *** simulation results show that the sheep optimization can meet the requirements of path planning and realize the cooperative path planning of *** with grey wolf optimizer(GWO),improved gray wolf optimizer(IGWO),chaotic gray wolf optimizer(CGWO),differential evolution(DE)algorithm,and particle swam optimization(PSO),the convergence speed and search accuracy of the improved sheep optimization are significantly improved.

关键词： multi-UAV cooperation path planning swarm intelligence algorithm multi-population improved sheep optimization(ISO)