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国际医学放射学杂志 2024年第3期 373-374页

作者： S.Lee y.y.kim J.Shin y.H.Roh J.y.Choi V.Chernyak 吴玉平

摘要目的该项更新的Meta分析旨在确定使用肝脏影像报告和数据系统（LI-RADS）2018版本（v2018）的LI-RADS LR-5类对肝细胞癌（HCC）的诊断能力，并通过评估成像方

关键词：

肝脏影像报告与数据系统用于CT/MRI诊断时需要解决的缺陷与问题

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国际医学放射学杂志 2019年第3期 367-368页

作者：于子川 y.y.kim J.y.Choi C.B.Sirlin C.An M.J.kim Department of Radiology Severance HospitalResearch Institute of Radiological ScienceYonsei University College of Medicine

摘要 2017年CT/MRI肝脏影像报告与数据系统(LIRADS)的研究核心就是为CT/MRI诊断算法提供清晰的定义和简明的解释。然而,至今仍有一些放射科医生在使用这套

关键词：数据系统 MRI

比较超分辨超声与对比增强超声对局灶性结节增生病人辐轮征的检测价值

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国际医学放射学杂志 2021年第2期44卷 228-229页

作者： T.W.Kang W.K.Jeong y.y.kim y.K.kim S.H.kim J.H.Min 王泽文郭邦俊

摘要超声诊断局灶性结节增生(FNH)通常需要使用对比剂。目前,超分辨超声对FNH诊断的效果尚不清楚。目的通过比较肿瘤血管分布模式,探讨超分辨超声成像和造影

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Focal Nodular Hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 182-190页

作者： Jaimy Villavicencio kim George y.Wu Division of Gastroenterology-Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Focal nodular hyperplasia is a benign tumor of the liver that is often found incidentally with *** purpose of this review is to discuss the pathophysiology,rare complications that can occur due to these lesions,and management options.A literature review was performed on clinical trials and case reports involving focal nodular hyperplasia complications and management of these,as well as the proposed pathogenesis underlying these *** exposure to oral contraceptive pills and endogenous hormones have been thought to play a role in the development of these lesions,this has not been *** recently,they are thought to arise as a consequence of a vascular anomaly causing alterations in the expression of angiopoietin *** are rare,but previous cases have reported associated pain,rupture and compression of nearby structures(hepatic vein,stomach,biliary system).Resection of focal nodular hyperplasia is not usually ***,if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk of causing a complication,then surgical resection,radiofrequency ablation or arterial embolization should be considered.

关键词： Focal nodular hyperplasia Oral contraceptives Liver lesion

前瞻性将肝脏影像报告和数据管理系统(LI-RADS)应用于钆塞酸二钠增强MR成像的诊断准确性

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国际医学放射学杂志 2018年第4期 490-490页

作者： y.y.kim C.An S.kim M.J.kim 郑孝飞 Department of Radiology and Research Institute of Radiological Science Severance HospitalYonsei University College of Medicine

目的前瞻性评价LI-RADS(2014版)分类标准在钆塞酸二钠增强MRI临床应用中的诊断效能。方法回顾性分析2014年1月—12月行肝脏钆增强MRI检查的143例初治高危病人的前瞻性影像报告,并对202例肝脏病灶进行了LI-RADS分类。统计分析了LI-RADS... 详细信息

目的前瞻性评价LI-RADS(2014版)分类标准在钆塞酸二钠增强MRI临床应用中的诊断效能。方法回顾性分析2014年1月—12月行肝脏钆增强MRI检查的143例初治高危病人的前瞻性影像报告,并对202例肝脏病灶进行了LI-RADS分类。统计分析了LI-RADS分类对肝细胞癌(HCC)和肝脏恶性肿瘤的诊断效能。结果 29例LR-4中20例(69.0%),75例LR-5中73例(97.3%)以及全部5例LR-5V(100%)病灶病理结果为HCC,剩余2例(2.7%)LR-5病灶为混合性肝细胞胆管细胞癌,13例LR-M病灶中10例(76.9%)为HCC。LR-5/5V对HCC的敏感度和特异度分别为60.5%和97.3%,纳入LR-M后敏感度增加(68.2%,P=0.002),但特异度降低,其差异无统计学意义(93.2%,P=0.154)。LR-5/5V/M对诊断肝脏恶性肿瘤的敏感度为68.9%,特异度为100.0%。结论 LI-RADS(2014版)成功应用于临床钆塞酸二钠增强MRI。LR-5/5V对诊断HCC特异性最高,但多数LR-M观察结果也为HCC,并有相当一部分非HCC恶性肿瘤被分为LR-4或LR-5。

关键词：钆塞酸二钠 MRI LR HCC MR LI-RADS

肝硬化病人的肝细胞癌与其他肝脏恶性肿瘤:2018版LI-RADS的评估能力

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国际医学放射学杂志 2019年第3期 362-362页

作者：景瑞 y.y.kim M.J.kim E.H.kim y.H.Roh C.An Department of Radiology Severance HospitalYonsei University College of Medicine

摘要目的评估2018版肝脏影像报告和数据系统(LIRADS)对肝硬化病人发生肝细胞癌(HCC)与发生其他肝脏恶性肿瘤(OM)的鉴别能力。材料与方法从2008—2017年,

关键词：肝脏恶性肿瘤肝细胞癌 LI-RADS 肝硬化

LI-RADS分类中的CT和MRI算法评估肝细胞癌的百分比：系统综述和Meta分析

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国际医学放射学杂志 2023年第3期 358-358页

作者： S.Lee y.y.kim J.Shin W.J.Son y.H.Roh J.y.Choi 杨思雨

摘要肝脏成像报告和数据系统（LI-RADS）中的CT和MRI算法同样适用于CT、使用细胞外对比剂的MRI (ECAMRI)和使用钆对比剂的MRI(Gx-MRI)的检查。目的通过

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Multiphase cooperation for multilevel strain accommodation in a single-crystalline BiFeO3 thin film

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Chinese Physics B 2024年第9期33卷 57-66页

作者： Wooseon Choi Bumsu Park Jaejin Hwang Gyeongtak Han Sang-Hyeok yang Hyeon Jun Lee Sung Su Lee Ji young Jo Albina y.Borisevich Hu young Jeong Sang Ho Oh Jaekwang Lee young-Min kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Samsung Electronics Hwaseong 18448Republic of Korea Department of Physics Pusan National UniversityBusan 46241Republic of Korea LG Energy Solution Daejeon 34122Republic of Korea Department of Materials Science and Engineering Kangwon National UniversityRepublic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Center for Nanophase Materials Sciences Oak Ridge National LaboratoryTN 37831USA Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Energy Engineering KENTECH Institute for Energy Materials and DevicesKorea Institute of Energy Technology(KENTECH)Naju 58330Republic of Korea

The functionalities and diverse metastable phases of multiferroic BiFeO3(BFO)thin films depend on the misfit *** mixed phase-induced strain relaxation in multiphase BFO thin films is well known,it is unclear whether a singlecrystalline BFO thin film can accommodate misfit strain without the involvement of its ***,understanding the strain relaxation behavior is key to elucidating the lattice strain–property *** this study,a correlative strain analysis based on dark-field inline electron holography(DIH)and quantitative scanning transmission electron microscopy(STEM)was performed to reveal the structural mechanism for strain accommodation of a single-crystalline BFO thin *** nanoscale DIH strain analysis results indicated a random combination of multiple strain states that acted as a primary strain relief,forming irregularly strained *** STEM-based bond length measurement of the corresponding strained nanodomains revealed a unique strain accommodation behavior achieved by a statistical combination of multiple modes of distorted structures on the unit-cell *** globally integrated strain for each nanodomain was estimated to be close to􀀀1.5%,irrespective of the nanoscale strain states,which was consistent with the fully strained BFO film on the SrTiO3 *** functional theory calculations suggested that strain accommodation by the combination of metastable phases was energetically favored compared to single-phase-mediated *** discovery allows a comprehensive understanding of strain accommodation behavior in ferroelectric oxide films,such as BFO,with various low-symmetry polymorphs.

关键词： BiFeO_(3) scanning transmission electron microscopy electron holography multiferroic material strain mapping

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RUFy4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong kim Hyunil Ha Taesoo kim Myeong Seon Jeong Suree kim Taesoo kim Han Sung kim Dongmin Kang Hyunbo Shim Soo young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FyVE domain-containing protein 4(RUFy4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFy4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFy4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Self-supported VO_(2)on polydopamine-derived pyroprotein-based fibers for ultrastable and flexible aqueous zinc-ion batteries

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Carbon Energy 2024年第7期6卷 1-13页

作者： Jeong Seok yeon Sul Ki Park Shinik kim Santosh VMohite Won Il kim Gun Jang Hyun-Seok Jang Jiyoung Bae Sang Moon Lee Won GHong Byung Hoon kim yeonho kim Ho Seok Park School of Chemical Engineering College of EngineeringSungkyunkwan UniversityGyeonggi-doRepublic of Korea Department of Engineering University of CambridgeCambridgeUK Department of Applied Chemistry Konkuk UniversityChungjuRepublic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)College of Natural SciencesUlsanRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Intelligent Sensor Convergence Research Center Incheon National UniversityIncheonRepublic of Korea Institute of Basic Science Incheon National UniversityIncheonRepublic of Korea Division of Material Analysis and Research Korea Basic Science InstituteDaejeonRepublic of Korea

A conventional electrode composite for rechargeable zinc-ion batteries(ZIBs)includes a binder for strong adhesion between the electrode material and the current ***,the introduction of a binder leads to electrochemical inactivity and low electrical conductivity,resulting in the decay of the capacity and a low rate *** present a binder-and conducting agent-free VO_(2)composite electrode using in situ polymerization of dopamine on a flexible current collector of pyroprotein-based *** as-fabricated composite electrode was used as a substrate for the direct growth of VO_(2)as a self-supported form on polydopamine-derived pyroprotein-based fibers(pp-fibers@VO_(2)(B)).It has a high conductivity and flexible nature as a current collector and moderate binding without conventional binders and conducting agents for the VO_(2)(B)*** addition,their electrochemical mechanism was *** energy storage is induced by Zn^(2+)/H^(+)coinsertion during discharging,which can be confirmed by the lattice expansion,the formation of by-products including Zn_(x)(OTf)_(y)(OH)_(2x−y)·nH_(2)O,and the reduction of V^(4+)to V^(3+).Furthermore,the assembled Zn//pp-fibers@VO_(2)(B)pouch cells have excellent flexibility and stable electrochemical performance under various bending states,showing application possibilities for portable and wearable power sources.

关键词： aqueous battery binder free conducting agent‐free flexible electrode zinc‐ion battery