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uPlC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： yuE yin-zi lI Ming-xuan WANG Xiao-hui QIN yuan-yuan WANG ya-hui TAN Jin-hua Su lian-lin yAN Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57Bl/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(l-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(l-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by cal.ulating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(uPlC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(Puppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(Pl group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

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Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

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Chinese Chemical letters 2024年第6期35卷 433-438页

作者： Boran Cheng lei Cao Chen li Fang-yi Huo Qian-Fang Meng Ganglin Tong xuan Wu lin-lin Bu lang Rao Shubin Wang Department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(lOD)as low as 15.4 nmol/l,indicating the high sensitivity of F-CDs to ClO^(-).In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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CPl-active hybrid copper(Ⅰ)halides enabled by cation inclusion with chiral crown-ether

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Science China Chemistry 2024年第10期67卷 3283-3290页

作者： Peng Fan li-xuan Cai Xiao-Fang Duan Fan yin Chen-Chen li Zhong-Hua Deng Xiao-Zhen li Qing-Fu Sun College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Strait Institute of Flexible Electronics(Future Technologies) Fujian Key Laboratory of Flexible ElectronicsFujian Normal University and Strait Laboratory of Flexible ElectronicsFuzhou 350117China State Key laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian College University of Chinese Academy of SciencesFuzhou 350002China

Chiral hybrid metal halides with high photoluminescence quantum yield(PlQy)and superior dissymmetry factor(g_(lum))are promising candidates for circularly polarized luminescence(CPl)emitting ***,it is a great challenge to achieve both high g_(lum)and large ***,we report a new supramolecular strategy to fabricate chiral hybrid Cu(Ⅰ)-halides with nearunity quantum yields and intense CPl *** dissymmetry factor can be dramatically modulated by tuning the hostguest *** to the chirality and variable conformations of the host-guest complexes,a series of chiral[G@l^(R/S)]_(2)Cu_(4)I_(6)have been *** incorporation of different cations within the chiral l^(R/S)hosts leads to variations of packing modes along the c-axis and different extent of distortions in the[Cu_(4)I_(6)]_(2)-*** them,[H_(3)O@l^(R/S)]+cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in[H_(3)O@l^(R/S)]_(2)Cu_(4)I_(6),which results in a high g_(lum)of-7×10^(-3)and a large PlQy of 96.92%.Notably,[G@l^(R/S)]_(2)Cu_(4)I_(6)shows promising applications in single-component white light emitting diodes(WlEDs),exhibiting a maximum dissymmetry factor of-1.2×10^(-3).The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPl materials.

关键词： host-guest interaction circularly polarized luminescence copper iodide cluster hierarchical self-assembly chirality

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An Analysis of the Fragmentation of Observing Time At the Muztagh-Ata Site

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Research in Astronomy and Astrophysics 2024年第3期24卷 29-33页

作者： Wen-Bo Gu Jing Xu Guo-Jie Feng xuan Zhang le-Tian Wang Xin-liang Wang Ali Esamdin li-Xian Shen Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 83001lChina School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Cl.ud cover plays a pivotal role in assessing observational conditions for astronomical *** for the fraction of observing time,its fragmentation also wields a significant influence on the quality of nighttime sky *** this article,we introduce the functionΓ∈[0,1],designed to comprehensively capture both the fraction of available observing time and its *** in situ measurement data gathered at the Muztagh-Ata site between 2017 and 2021,we showcase the effectiveness of our *** statistical result il.ustrates that the Muztagh-Ata site affords approximately 122 nights that were absolutely clear and 205 very good nights annually,corresponding toΓ≥0.9 andΓ≥0.36 respectively.

关键词： site testing-atmospheric effects-methods statistical

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From bibliometric analysis: 3D printing design strategies and battery applications with a focus on zinc‐ion batteries

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SmartMat 2024年第1期5卷 59-82页

作者： xuan Gao Kejiang l.u Chang Su Wei Zhang yuhang Dai Ivan P.Parkin Claire J.Carmalt Guanjie He Christopher Ingold laboratory Department of ChemistryUniversity College LondonLondonUK Electrochemical Innovation lab(EIl) Department of Chemical EngineeringUniversity College LondonLondonUK Department of Physics Hong Kong Baptist UniversityHong KongChina Nanyang Technopreneurship Center Nanyang Technological UniversitySingaporeSingapore

Three‐dimensional(3D)printing has the potential to revolutionize the way energy storage devices are designed and *** this paper,we explore the use of 3D printing in the design and production of energy storage devices,especially zinc‐ion batteries(ZIBs)and examine its potential advantages over traditional manufacturing methods.3D printing could significantly improve the customization of ZIBs,making it a promising strategy for the future of energy *** particular,3D printing allows for the creation of complex,customized geometries,and designs that can optimize the energy density,power density,and overall performance of ***,we discuss and compare the impact of 3D printing design strategies based on different configurations of film,interdigitation,and framework on energy storage devices with a focus on ***,3D printing enables the rapid prototyping and production of batteries,reducing leading times and costs compared with traditional manufacturing ***,there are also challenges and limitations to consider,such as the need for further development of suitable 3D printing materials and processes for energy storage applications.

关键词： 3D printing battery commercialization bibliometric analysis electrode configurations zinc‐ion battery

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Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the yAP pathway

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2992-3008页

作者： Shicheng Fan yue Gao Pengfei Zhao Guomin Xie yanying Zhou Xiao yang xuan li Shuaishuai Zhang Frank JGonzalez Aijuan Qu Min Huangb Huichang Bi NMPA Key laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint laboratory for New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA The State Key laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyShenzhen Graduate School of Peking UniversityShenzhen 518055China

Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia *** studies also showed that it has therapeutic potential in various liver ***,its effects on hepatomegaly and liver regeneration and the involved mechanisms remain ***,the study showed that fenofibrate significantly promoted liver enlargement and regeneration post-partial hepatectomy in mice,which was dependent on hepatocyteexpressed PPARα.yes-associated protein(yAP)is pivotal in manipulating liver growth and *** further identified that fenofibrate activated yAP signaling by suppressing its K48-linked ubiquitination,promoting its K63-linked ubiquitination,and enhancing the interaction and transcriptional activity of the yAP-TEAD *** inhibition of yAP-TEAD interaction using verteporfin or suppression of yAP using AAV yap shRNA in mice significantly attenuated fenofibrate-induced *** factors,such as MyC,KRT23,RAS,and RHOA,might also participate in fenofibrate-promoted hepatomegaly and liver *** studies demonstrate that fenofibratepromoted liver enlargement and regeneration are PPARα-dependent and partially through activating the yAP signaling,with clinical implications of fenofibrate as a novel therapeutic agent for promoting liver regeneration.

关键词： Fenofibrate PPARa Hepatomegaly Partial hepatectomy liver regeneration yAP TEAD ubiquitination

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Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocel.ular carcinoma and meta-analysis

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World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： yu-Zhe Cao Guang-lei Zheng Tian-Qi Zhang Hong-yan Shao Jia-yu Pan Zi-lin Huang Meng-xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROuND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocel.ular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-l1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-l1 blockades(AIPB)at Sun yat-sen university Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,PluSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： unresectable hepatocel.ular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

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补肾活血方对复发性流产患者血清VEGF、HIF-1α、TGF-β_(1)、sflt-1影响研究

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时珍国医国药 2024年第1期35卷 72-74页

作者：韩永梅吕宣宣河南中医药大学河南郑州450000 河南大学淮河医院河南开封475000

目的研究补肾活血方对APl阳性RSA患者外周血VEGF、HIF-1α、TGF-β_(1)、sflt-1、miR-423-5p蛋白表达量影响。方法选取APl阳性RSA患者60例,分别于孕前给予药物调理。其中观察组服用补肾活血方,对照组服用肠溶阿司匹林,均治疗3个月。... 详细信息

目的研究补肾活血方对APl阳性RSA患者外周血VEGF、HIF-1α、TGF-β_(1)、sflt-1、miR-423-5p蛋白表达量影响。方法选取APl阳性RSA患者60例,分别于孕前给予药物调理。其中观察组服用补肾活血方,对照组服用肠溶阿司匹林,均治疗3个月。两组治疗前后分别检测血清VEGF、HIF-1α、TGF-β_(1)、sflt-1、miR-423-5p蛋白表达及中医证候积分。结果两组治疗后VEGF蛋白表达均显著升高;与对照组比较,观察组VEGF蛋白表达量显著高于对照组;两组治疗前后,HIF-1α蛋白表达量均无显著性差异;治疗后两组TGF-β1蛋白表达显著升高,与对照组比较,观察组TGF-β1蛋白表达显著升高;治疗后两组sflt-1蛋白表达显著降低;与对照组比较,观察组sflt-1蛋白表达显著降低。两组治疗后miR-423-5p相对表达量均降低,观察组优于对照组(Plt-1、miR-423-5p蛋白表达等途径,改善APl对子宫内膜的不良影响;同时可有效降低中医证候积分,从而降低再次妊娠后流产的发生率。

关键词：补肾活血方抗磷脂抗体复发性流产血清VEGF HIF-1 TGF-β sflt-1 miR-423-5p

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-lobato Mariam Masmudi-Martín Manuel F.lópez-Aranda Juan F.lópez-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Corrigendum to"Cel.ular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression"[Genes&Diseases 11(2024)952-963]

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Genes & Diseases 2024年第3期11卷 491-492页

作者： Zhenhao Zhang Doudou Jing Baijun xuan Zhicai Zhang Wei Wu Zengwu Shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Orthopedics The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

The authors regret that some data errors were made in"Cel.ular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression"at Figure 5F for the colony formation of MNNG/HOS cells with si-NOTCH3 and 5G for the tranwell assay of u2OS cells with *** and supplementation to Figure *** author used confusing experimental data and did not notice these errors when submitting the original ***,the authors made the latest corrections to the data of the batch of u2OS cells and MNNG/HOS cells transfected with *** authors confirm that this correction will not alter the conclusions in the original manuscript.

关键词： PI3K/AKT osteosarcoma submit

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