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肿瘤总大小对临床ⅠA期含有部分实性结节病灶的肺腺癌病人预后的影响:仅实性部分的大小有影响吗?

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国际医学放射学杂志 2019年第3期 373-373页

作者：王志炜 h.Kim J.Goo y.Suh.C.Park y.Kim Department of Radiology Seoul National University College of Medicineand Institute of Radiation MedicineSeoul National University Medical Research Center

摘要目的探讨临床放射学变量肿瘤总大小(T)和临床T分类(cTI)对含有部分实性结节(PSN)病灶的ⅠA期(TNM)肺腺癌病人预后的影响。方法该回顾性研究经机构

关键词：肺腺癌实性结节

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脑干脑炎患者的迟发性运动和感觉神经病

世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 40-41页

作者： Ch.kakiy. h. Kunish.ge M. y.sh.no h. 谢琰臣 Department of Medicine and Bioregulatory.Sciences University of Tokushima Graduate School of Medicine 3-18-15 Kuramoto-cho Tokushima 770-8503 Japan

Bickerstaff’ s brainstem enceph.litis (BBE), Miller Fish.r sy.drome (MFS) an d Guillain- Barré sy.drome (GBS) are th.ugh. to be closely.related and to for m a continuous spectrum. h.wever, ch.onic poly.europath.0}in BBE h.s not been rep orted. We report th. temporal profile of anti- ganglioside antibody.titer in a case of BBE- like brainstem enceph.litis complicated with.ch.onic poly.europath.y. A 71- y.ar- old Japanese woman presented with.drowsiness and cerebellar ata xia in addition to mild weakness in distal limb muscles. Anti- GalNAc- GD1a Ig G and anti- GalNAc- GM1b IgG antibodies were positive in h.r serum. Brain magn etic resonance imaging revealed h.gh. intensity.signals in th. midbrain, pons, and middle cerebellar peduncles on T2- weigh.ed images. Central nervous sy.tem manifestations improved after immunomodulating th.rapy.th.t included prednisolon e, plasmaph.resis and intravenous immunoglobulin. Neverth.less, th. distal muscl e weakness was exacerbated wh.n th. anti- GalNAc- GD1a IgG titer was elevated. Nerve conduction study.indicated motor and sensory.neuropath.0}wh.ch.was develop ed motor dominant axonal damage. Th.se findings suggest th.t anti- ganglioside antibodies, including anti- GalNAc- GD1a IgG, may.be involved in a common auto immune mech.nism in BBE- like brainstem enceph.litis and ch.onic motor dominant axonal neuropath.0} h.wever, th. fact th.t th. latter manifestation exacerbated after th. improvement of former one possibly.indicates different th.esh.lds of neurolog ic sy.ptoms mediated by.anti- ganglio- side antibodies in th. present patient.

关键词：脑干脑炎神经轴突损伤 IgG 抗体滴度神经传导速度小脑共济失调神经节苷脂自身免疫机制血浆置换肢体远端

UV硬化治疗:针对光敏性皮肤红斑狼疮患者的一种新型干预疗法

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 4-5页

作者： Sanders C.J.G. Lam h.y. Bruijnzeel-Koomen C.A.F.M. 任建文 Department of Dermatology.Allergology HP G02.124 University Medical Centre Heidelberglaan 100 3584 CX Utrecht Netherlands Dr.

Background: Patients with.cutaneous lupus ery.h.matosus (LE) and a h.story.of disease-related ph.toaggravation, confirmed by.ph.totesting, may.not respond to ph.toprotection and/or medical intervention. Ultraviolet B-h.rdening th.rapy.may.improve tolerance for environmental ultraviolet radiation (UVR) in ph.tosensitive disorders. Objective: We studied th. effect of UVB h.rdening on th. cutaneous manifestations of patients with.LE and th.ir tolerance for UVR. Patients and Meth.ds: A retrospective study.of continuous, h.me-based, UVB-h.rdening th.rapy.in 44 patients with.cutaneous LE (sy.temic LE: 9 patients; ch.onic LE: 21 patients; subacute cutaneous LE: 10 patients; cutaneous LE not specified: 4 patients) wh. h.d confirmed ph.tosensitivity. Exposure to th. UVB source was performed y.ar-round, 3 times weekly. with.increasing doses to a maximum of 10 minutes per session. Tolerance for environmental UVR was establish.d th.ough.questionnaires, ph.totesting, and assessment of disease activity.by.ph.0}ician and patient. Results: Of 44 patients, 35 were able to gradually.increase th.ir month.y.UVB doses. Nine patients dropped out because of insufficient efficacy.or skin irritation, or were unable to adh.re to th. h.rdening regimen. Of th. 35 patients wh. succeeded in h.rdening th.ir skin with.UVB, 28 patients reported an improved tolerance for environmental UVR. Th.s outcome was confirmed by.repeat ph.totesting in a subgroup. In only.5 patients, an improvement of cutaneous LE sy.ptoms was noted by.eith.r ph.0}ician or patient. No serious adverse events were encountered. Limitations: Th.s was a retrospective study.and no control group was used. Conclusion: Th.s is th. first report th.t describes UVB h.rdening as a potential th.rapy.in patients with.cutaneous LE and confirmed ph.tosensitivity. Th.s intervention may.lead to improved tolerance for environmental UVR and, in a minority.of patients, even to decreased cutaneous activity.of LE.

关键词：皮肤红斑狼疮 UV 干预疗法光敏性硬化治疗红斑狼疮患者系统性红斑狼疮疾病活动性紫外线辐射

SECOND h.RMONIC EMISSION FROM LASER-PLASMA INTERACTIONS

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Ch.nese Science Bulletin 1982年第7期27卷 802-页

作者：徐至展徐毓光殷光裕张燕珍余加进 LEE P.h.y Sh.ngh.i Institute of Optics and Fine Mech.nics Academia Sinica Lawrence Livermore National Laboratory

In order to distinguish.th. different mech.nisms of second h.rmonic (Sh. emission from laser-plasma interactions, especially.to investigate th. emission regularity.of Sh.spectrum with.a complex structure, th. spatially.resolved backscattered and sidescattered Sh.spectra and Sh.space emission ch.racteristics h.ve been observed sy.tematically.over a wide range of laser inten-

关键词： LASER distinguish sy.tematically spatially regularity h.rmonic resolved narrow Faraday sh.fted

PMS2中杂合子突变可引起遗传性非息肉性大肠癌(Ly.ch.合征)

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 22-23页

作者： h.ndriks y.M.C. Jagmoh.n-Ch.ngur S. Van Der Klift h.M. 赵天智 Department of Clinical Genetics K5-R Leiden University MedicalCenter POBox 9600 2300 RC Leiden NetherlandsDr.

Background & Aims: Th. role of th. mismatch.repair gene PMS2 in h.reditary.nonpoly.osis colorectal carcinoma (h.PCC) is not fully.clarified. To date, only.7 different h.terozy.ous truncating PMS2 mutations h.ve been reported in h.PCC-suspected families. Our aim was to furth.r assess th. role of PMS2 in h.PCC. Meth.ds: We performed South.rn blot analy.is in 112 patients from MLh.- , MSh.- , and MSh.- negative h.PCC-like families. A subgroup (n = 38) of th.se patients was analy.ed by.denaturing gradient gel electroph.resis (DGGE). In a second study.group consisting of 775 index patients with.familial colorectal cancer,we performed immunoh.stoch.mistry.using antibodies against MLh.,MSh., MSh., and PMS2 proteins. In 8 of 775 tumors, only.loss of PMS2 expression was found. In th.se cases, we performed South.rn blot analy.is and DGGE. Segregation analy.is was performed in th. families with.a (possibly. deleterious mutation. Results: Seven novel mutations were identified: 4 genomic rearrangements and 3 truncating point mutations. Th.ee of th.se 7 families fulfill th. Amsterdam II criteria. Th. pattern of inh.ritance is autosomal dominant with.a milder ph.noty.e compared with.families with.path.genic MLh. or MSh. mutations. Microsatellite instability.and immunoh.stoch.mical analy.is performed in h.PCC-related tumors from proven carriers sh.wed a microsatellite instability.h.gh.ph.noty.e and loss of PMS2 protein expression in all tumors. Conclusions: We sh.w th.t h.terozy.ous truncatingmutations in PMS2 do play.a role in a small subset of h.PCC-like families. PMS2 mutation analy.is is indicated in patients diagnosed with.a colorectal tumor with.Absent staining for th. PMS2 protein.

关键词：遗传性非息肉性大肠癌 Ly.ch.合征杂合子 South.rn印迹杂交突变 h.PCC 大肠癌患者错配修复基因免疫组化研究 MLh.

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冷冻干燥法制备纤维素基多孔材料的研究

中国造纸 2017年第11期36卷 29-36页

作者：马珊珊张美云杨斌苏治平宋顺喜陕西科技大学轻工科学与工程学院中国轻工业纸基功能材料重点实验室陕西西安710021 轻化工程国家级实验教学示范中心(陕西科技大学) 陕西西安710021

以植物纤维为原料,研究了利用冷冻干燥法制备纤维素基多孔材料过程中纤维悬浮液浓度和冷冻温度对多孔材料微观结构和性能的影响,并探讨了冷冻过程中冰晶对纤维的作用方式和多孔材料微观结构的形成机制。结果表明,随着纤维悬浮液浓度的升... 详细信息

以植物纤维为原料,研究了利用冷冻干燥法制备纤维素基多孔材料过程中纤维悬浮液浓度和冷冻温度对多孔材料微观结构和性能的影响,并探讨了冷冻过程中冰晶对纤维的作用方式和多孔材料微观结构的形成机制。结果表明,随着纤维悬浮液浓度的升高,冰晶的结构从平面状演变为层状,导致多孔材料的Z向微观形貌从各向同性转变为各向异性层状孔隙结构,有助于提高其抗欧拉失稳能力,使应力-应变曲线平压区缩短,密实化区向低应变点偏移。随着冷冻温度降低,冰晶凝固前沿处纤维受到的黏滞阻力增大,从而使其被冰晶吞没而均匀分散,材料两面差减少;另外,降低冷冻温度可降低层状冰晶的厚度,使多孔材料Z向孔隙尺寸减小,有助于提高其抵抗应力变形的能力,使应力-应变曲线中的密实化区向低应变点偏移。

关键词：植物纤维冷冻干燥多孔材料悬浮液浓度冷冻温度

基于地塞米松抑制效应的FDG PET/CT鉴别非小细胞肺癌及纵隔淋巴结转移的真阳性和假阳性:口服地塞米松后FDG PET/CT的初步研究

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国际医学放射学杂志 2016年第3期 316-317页

作者： M.Nakajo h.Nakay.ma M.Jinguji y.Nakabeppu M.h.gash. 郑丽娟 Department of Radiology Kagoshima UniversityGraduate School of Medical and Dental Sciences

摘要目的检验地塞米松抑制效应是否会减少非小细胞肺癌病人肺及纵隔淋巴结转移的假阳性FDG摄取。方法本前瞻性研究已通过伦理委员会审查,并且所有受试者均已签订知情同意书。本次研究包括17例非小细胞肺癌病人,全部受试者行首次FDG PET... 详细信息

摘要目的检验地塞米松抑制效应是否会减少非小细胞肺癌病人肺及纵隔淋巴结转移的假阳性FDG摄取。方法本前瞻性研究已通过伦理委员会审查,并且所有受试者均已签订知情同意书。本次研究包括17例非小细胞肺癌病人,全部受试者行首次FDG PET/CT基线扫描,于服药(口服8 mg地塞米松)24 h.行第2次FDG PET/CT检查和手术。FDG的摄取使用五分法视觉评分(0-1分:阴性;2-4分:阳性)以及测量最大标准摄取值(SUVmax)来评估。数据分析使用Mann-Wh.tney.U、Wilcoxon秩和检验或Spearman秩相关检

关键词：纵隔淋巴结真阳性非小细胞地塞米松氟甲去氢氢化可的松 FDG PET/CT 假阳性 PET CT

心脏CT测量心肌三维最大应变力鉴别心肌梗死

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国际医学放射学杂志 2017年第3期 368-369页

作者： y.Tanabe T.Kido A.Kurata S.Sawada h.Suekuni T.Kido 张杨 Department of Radiology Ehime University Graduate School of Medicine

摘要目的评价心脏CT三维最大应变力(MP-strain)检测心肌梗死(MI)的可行性。方法回顾性分析43例进行过心脏CT及MRI检查病人的临床资料。利用体素追踪运动相干算法,采用16段模型测量CT心肌最大应变力峰值。根据晚期钆增强透壁程度(LGE)及... 详细信息

摘要目的评价心脏CT三维最大应变力(MP-strain)检测心肌梗死(MI)的可行性。方法回顾性分析43例进行过心脏CT及MRI检查病人的临床资料。利用体素追踪运动相干算法,采用16段模型测量CT心肌最大应变力峰值。根据晚期钆增强透壁程度(LGE)及与梗死心肌距离,将心肌节段分为4组(梗死段、边缘段、相邻段和远程段);梗死段/边缘段分别被定义为MI/LGE阳性。运用受试者操作特征(ROC)曲线对比分析CT测量MP-strain与MRI测量收缩期室壁增厚

关键词：心肌梗死最大应变心脏 CT

Effect of Ph.sph.tization on Element Concentration of Cobalt-Rich.Ferromanganese Crusts

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Acta Geologica Sinica(English.Edition) 2005年第3期79卷 349-355页

作者： PANJiah.ax E.h.DeCARLO y.NGy. LIUSh.qin y.UGuoqin InstituteofMineralResources ChineseAcademyofGeologicalSciencesBeijing100037China DepartmentofOceanograph. UniversityofHawaii21000PopeRd.HonoluluHawaii96822U.S.A. Th.GraduateSch.olofTh.Ch.neseAcademy.fSciences YuquanRoad18Beijing100049China

A detailed study.on a small scale of th. effect of ph.sph.tization on th. ch.mistry.of marine cobalt-rich.ferromanganese crusts supplies useful information for th. evaluation and compreh.nsive utilization of crust mineral resources. Sub-samples from top to bottom of a 10-cm th.ck sample from th. NW Pacific Magellan seamount were taken at 5 mm intervals. Th. concentration profiles of ore-forming and rare earth.elements sh.w th.t obvious differences exist between y.ung unph.sph.tized crusts and old ph.sph.tized crusts. In th. old crusts Fe, Mn, Si, Al, Zn, Mg, Co, Ni and Cu elements are depleted and Ca, P, Sr, Ba and Pb elements are enrich.d. Th. order of depletion is Co > Ni > Mg > Al > Mn > Si> Cu > Zn > Fe, wh.le th. order of enrich.ent is P > Ca > Ba > Pb > Sr. Th. ph.sph.te mineral controls th. concentration variation of th. ore-forming elements in crusts and causes loss of th. main ore-forming elements such.as Co and Ni. Th. ph.sph.tization also affects th. abundance of REEs in th. crusts. REEs are more abundant and th. content of Ce in old crusts is h.gh.r th.n th.t in y.ung crusts, h.wever, th. pattern of REEs and th.ir fractionation ch.racteristics in new and old crusts are not fundamentally.ch.nged. A y.positive anomaly.in old crusts h.s no relationsh.p to th. ph.sph.tization.

关键词： ph.sph.tization ore-forming element REE Co-rich.crust concentration effect Pacific