检索结果-南通市图书馆

Poststroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from local cerebral ischemia in rats

引用

Neural Regeneration Research 2007年第2期2卷 65-69页

作者： Xingbao Zhu Jasmine Lee Jill Wong Wan loo Tan Zhongtang Feng Tinghua Wang Zhicheng Xiao Ivan Ng Department of Neurosurgery Kunming General Hospital of Chinese PLA Kunming 650032 Yunnan Province China Brain Injury Research Laboratory Department of Neurosurgery National Neuroscience Institute Singapore 408433 Institute of Neuroscience Kunming Medical College Kunming 650031 Yunnan Province China Institute of Molecular and Cell Biology Singapore 117608 Department of Anatomy Faculty of Medicine National University of Singapore Singapore 119074 Department of Clinical Research Singapore General Hospital Singapore 169608

BACKGROUND： Inhibitory.s.gnals, i.e. neurite growth inhibitors （NGIs）, presenting on central nervous system （CNs） myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the body.s.immune repair mechanisms. OBJECTIVE： To evaluate the effect of poststroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of local cerebral ischemia. DEsIGN： Completely randomized grouping design, and controlled experiment. sETTING： Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, singapore. MATERIALs： sixty adult male sprague-Dawley rats ranging in age from 45 to 120 days and in weight from 180 to 250 grams were provided by Animal Center of Department of Anatomy, Faculty of Medicine, National University of singapore. pcDNA3.1（＋）-neurite growth inhibitors （pcDNA-NGIs） a gift was provided by Dr. Xiao from Department of Clinical Research, singapore General Hospital, singapore. METHODs： The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, singapore from August 2003 to April 2005. （1）The involved rats were randomized into 3 groups： pcDNA-NGIs group （group A）, pcDNA3.1 （＋） group （group B） and model group （group C）, with 20 rats in each group. Left focal cerebral ischemia （FCI） was permanently induced through middle cerebral artery occlusion （MCAO） with the assistance of an operating microscope. successful MCAO was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline （PBs） was intramuscularly injected into the tibial muscle once a week after MCAO for 6 weeks in group A. As control, pcDNA3.1 （＋） was also administrated in the sam

关键词： stroke(TCM) growth inhibitors, cerebral ischemia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

引用

World Journal of Gastroenterology 2014年第47期20卷 17851-17862页

作者： Katharine M Irvine Richard skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy loo Brian Gabrielli Michelle M Hill Matthew J sweet Andrew D Clouston Elizabeth E Powell Centre for Liver Disease Research School of MedicineThe University of QueenslandTranslational Research InstituteBrisbane 4102Australia Institute for Molecular Bio-science The University of QueenslandBrisbane 4067Australia The University of Queensland Diamantina Institute The University of Queensland Translational Research InstituteBrisbane 4102Australia Department of Gastroenterology and Hepatology Princess Alexandra HospitalBrisbane 4102Australia

AIM: To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype (sAsP).

关键词： Cell aging Chemokines Hepatocytes Inflammation Liver diseases Macrophages

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Connecting the Belt and Road through sea-rail collaboration

引用

Frontiers of Engineering Management 2017年第3期4卷 315-324页

作者： Chenhao ZHOU Haobin LI Wencheng WANG loo Hay LEE Ek Peng CHEW Industrial systems Engineering and Management National University of Singapore school of Management shanghai University

As part of China's "the Belt and Road"strategy, China Railway Express provides alternative shipping routes and transportation modes from Asia to Europe and creates new opportunities for intermodal transportation in the shipping industry. A time–distancebased cost(time cost) function was proposed to compare China Railway Express with traditional transportation modes. Time cost was related to different types of cargoes,which exhibit distinct sensitivity to time. Using the proposed cost function as basis, we identified the cost indifference area where total costs are equal. Further analysis was performed for selecting the transportation mode and supply area for a specific cargo. This study provides various parties, such as business owners, the government, and the shipping industry, with many valuable insights.

关键词： China Railway Express the Belt and Road shipping industry combined transportation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of biscuit-type feeding supplementation on the neurocognitive outcomes of HIV-affected school-age children:a randomized,double-blind,controlled intervention trial in Kenya

引用

Family Medicine and Community Health 2017年第4期5卷 245-258页

作者： Kek Khee loo shemra Rizzo Qiaolin Chen Robert E.Weiss Catherine A.sugar Grace Ettyang Judith Ernst Goleen samari Charlotte G.Neumann Kaiser Permanente Los Angeles Medical Center Department of Pediatrics1526 Edgemont Street5th FloorLos AngelesCAUSA Department of statistics University of CaliforniaRiverside1438 Olmsted Hall900 University AvenueRiversideCAUSA Novartis Pharmaceuticals Corporation One Health Plaza337/A03.3CEast HanoverNJUSA Department of Biostatistics UCLA Fielding School of Public Health650 Charles Young Drive SouthLos AngelesCAUSA Department of Psychiatry and Biobehavioral sciences David Geffen School of Medicine at UCLALos AngelesCAUSA school of Public Health Moi UniversityP.O.Box 4606EldoretKenya Department of Nutrition and Dietetics Indiana University School of Health and RehabilitationColeman HallCF 2241140 W.Michigan StreetIndianapolisINUSA Population Research Center University of Texas at Austin305 E.23rd StreetStop G1800AustinTXUSA Department of Community Health sciences UCLA Fielding School of Public Health650 Charles Young Drive SouthLos AngelesCAUSA

Objective:To determine if meat or soy protein dietary.s.pplementation will enhance the neuro-cognitive performance of HIV-affected children at-risk of malnutrition and food ***:A randomized,double-blind,controlled intervention trial evaluated the effect of nu-tritional supplementation on the neurocognitive outcomes of 49 HIV-affected school-age children in western *** intervention consisted in providing the mother,target child,and siblings with one of three isocaloric biscuit-type supplements-soy,wheat,or beef-on 5 days per week for 18 *** outcomes of the target children were assessed by a battery of eight measures and followed up longitudinally for up to 24 ***:Mixed effects modeling demonstrated significant differences in the rates of increase over time among all three groups(F test degrees of freedom of 2,Ps progressive matrices performance,but not for verbal meaning,arithmetic,digit span backward,forward,and total,embedded figure test,and Beery visual-motor integration ***:HIV-affected school-age children provided with soy protein supplementation showed greater improvement in nonverbal cognitive(fluid intelligence)performance compared with peers who received isocaloric beef or wheat *** nutrients may have an enhancing effect on neurocognitive skills in HIV-affected school-age children.

关键词： Neurocognition neurodevelopment malnutrition HIV nutrition Africa animal source foods meat soy proteins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factors early in life associated with hepatic steatosis

引用

World Journal of Hepatology 2022年第6期14卷 1235-1247页

作者： sabrina Xin Zi Quek Eunice Xiang-Xuan Tan yi Ping Ren Mark Muthiah Evelyn Xiu Ling loo Elizabeth Huiwen Tham Kewin Tien Ho siah Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingapore 119228Singapore National University Centre for Organ Transplantation National University Health SystemSingapore 119228Singapore yong loo Lin school of Medicine National University of SingaporeSingapore 117597Singapore Department of Medicine National University HospitalSingapore 119228Singapore Department of Paediatrics Yong Loo Lin School of MedicineNational University of SingaporeKhoo Teck Puat-National University Children's Medical InstituteNational University HospitalNational University Health SystemSingapore 119228Singapore singapore Institute for Clinical sciences Agency for ScienceTechnology and ResearchSingapore 117609Singapore

BACKGROUND The rise in prevalence of non-alcoholic fatty liver disease(NAFLD)mirrors the obesity *** is insidious but may gradually progress from simple steatosis to steatohepatitis,fibrosis and cirrhosis and/or hepatocellular *** strategies to ameliorate developmental programming of NAFLD may be more efficacious during critical windows of developmental *** To review the early developmental factors associated with *** Databases MEDLINE via PubMed,and EMBAsE and Reference Citation Analysis were searched and relevant publications up to April 30,2021 were *** research studies that included risk factors associated with early development of NAFLD in human subjects were *** factors include:Maternal factors,intrauterine and prenatal factors,post-natal factors,genetic and ethnic predisposition,childhood and adolescence environmental *** were excluded if they were review articles or animal studies,case reports or conference abstracts,or if NAFLD was not clearly defined and assessed *** Of 1530 citations identified by electronic search,420 duplicates were *** the 1110 citations screened from title and abstract,80 articles were included in the final *** polymorphisms such as patatin-like phospholipase domain-containing protein 3(PNPLA3)and membrane-bound O-acyltransferase domain-containing protein 7(MBOAT7)were associated with increased risk of *** factors such as maternal obesogenic environment and parental history of hepatic steatosis was associated with offspring *** duration of exclusive breastfeeding in infancy was associated with a lower risk of developing NAFLD later in life while metabolic dysfunction and/or obesity in adolescence was associated with increased risk of *** relating to socioeconomic factors and its association with NAFLD reported confounding *** Maternal metabolic dysfunction during pr

关键词： Epidemiology Natural history Obesity Fatty liver Developmental

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国养老政策的演进及智慧社会下居家养老的发展

引用

科技导报 2019年第6期37卷 6-12页

作者：王波卢佩莹曹彦芹甄峰香港大学社会科学学院地理系香港999077 香港大学深圳研究院深圳518000 深圳市铁汉生态环境股份有限公司深圳518000 南京大学建筑与城市规划学院南京210093 江苏省智慧城市设计仿真与可视化工程实验室南京210093

人口老龄化已经成为世界各国、各地区社会经济发展面临的重要问题。中国从2001年步入老龄化社会,提升老龄群体生活质量对于全面实现小康社会意义重大,也是促进中国城镇化健康发展的需要。梳理了中国20世纪80年代以来养老政策和实践的演... 详细信息

人口老龄化已经成为世界各国、各地区社会经济发展面临的重要问题。中国从2001年步入老龄化社会,提升老龄群体生活质量对于全面实现小康社会意义重大,也是促进中国城镇化健康发展的需要。梳理了中国20世纪80年代以来养老政策和实践的演进路径,强调了居家养老既要符合中国社会经济发展的特征,也要满足老龄群体的生活需求;鉴于中国社区的养老服务设施供给仍然滞后于老龄化发展的现状,探讨了在智慧社会下,通过信息化策略(虚拟空间)与可步行邻里环境(实体空间),提升已有养老服务设施的服务覆盖面和质量、构建老龄群体的智慧社区生活模式、促进居家养老服务的时空匹配、提升居家养老服务的质量水平等策略。

关键词：养老政策居家养老智慧社会智慧社区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aberrant methylation of Glutathione s-transferase P1 and E-cadherin in invasive ductal breast carcinoma and fibroadenoma

引用

中华乳腺病杂志（电子版） 2010年第5期4卷 14-19页

作者： Wings Tjing yung loo Mary Ngan Bing Cheung Louis Wing Cheong Chow UNIMED Medical Institute Organisation for Oncology and Translational Research Hong Kong school of Chinese Medicine The University of Hong Kong Clinical Trial Centre Li Ka Shing Faculty of MedicineThe University of Hong Kong

Objective To investigate the hypermethylation status of glutathione transferase P1(GsTP1)and E-cadherin(ECAD),TsGs(tumor suppressor genes)in our breast cancer samples and explore their correlation with clinicopathological features of corresponding cancer *** One hundred and thirty.s.x IDC(invasive ductal carcinoma)patients were recruited for analysis and 16 fibroadenoma patients acted as *** extraction and methylation-specific PCR(MsP)were subsequently performed preceded by pathological *** The percentage of hypermethylated GsTP1 in carcinoma and fibroadenoma groups was 34.92% and 15.79% respectively and the percentage of hypermethylated ECAD in carcinomas and fibroadenomas was 18.00% and 0.00% *** had the highest percentage of c-erbB2 overexpression being 54.55% among the clinicopathological *** Hypermethylation patterns are frequent in IDC and seem to relate to c-erbB2 overexpression,and such epigenetic change should not be neglected in *** methylation status in cancer patients can be determined at early.s.age and it may be a reference for better treatment planning.

关键词：乳腺癌临床治疗疗效

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

术前口服依他昔布对妇科手术后病人自控镇痛的影响

引用

中国临床药理学与治疗学 2005年第9期10卷 984-987页

作者：刘薇 loo CC 秦晓涛黄宇光中国医学科学院中国协和医科大学北京协和医院麻醉科 Anesthesia Department (O&G) Singapore KK Women's and Children's Hospital Singapore 229899 Singapore

目的:观察妇科开腹手术患者术前给予依他昔布120mg对术后自控镇痛(PCA)吗啡用量的影响及其副作用。方法:随机选取全麻下接受妇科开腹全子宫(双附件)切除患者40例,术前分别给予安慰剂或依他昔布120mg口服。在手术后观察24h患者PCA吗啡用... 详细信息

目的:观察妇科开腹手术患者术前给予依他昔布120mg对术后自控镇痛(PCA)吗啡用量的影响及其副作用。方法:随机选取全麻下接受妇科开腹全子宫(双附件)切除患者40例,术前分别给予安慰剂或依他昔布120mg口服。在手术后观察24h患者PCA吗啡用量,同时记录患者的疼痛评分和满意度评分,并观察不良反应。结果:术后PCA吗啡24h消耗量在依他昔布组为9.4±7.6mg,显著低于安慰剂组15.7±8.9mg。两组患者24h内对PCA的按压次数依他昔布组也低于安慰剂组(P<0.05)。其中术后3、6、8和12hPCA吗啡消耗量在两组间无显著差异。两组患者术后24h疼痛评分和对镇痛治疗的满意度也无差异。两组患者不良反应的发生率亦无差别。结论:在妇科开腹手术患者术前应用依他昔布120mg可使患者术后PCA吗啡消耗量降低,且在术后12h后下降明显。未发现与依他昔布应用相关的副作用。

关键词：依他昔布病人自控镇痛 COX-2抑制剂吗啡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

黄斑色素光学密度、中央黄斑厚度与体重指数的关系（英文）

引用

国际眼科杂志 2019年第5期19卷 709-713页

作者： Lee Hong Nien Fazliana Ismail Rafidah sudarno Angela loo Voon Pei Visvaraja subrayan 马来西亚大学医疗中心眼科马来西亚吉隆坡59100 Tunku Abdul Rahman大学医学部马来西亚吉隆坡蕉赖43000

目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用sD Cirrus OCT测... 详细信息

目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用sD Cirrus OCT测量中央黄斑厚度。记录所有眼MPOD和OCT信息。使用Microsoft~?Excel,sPss和R进行数据分析。结果:MPOD和中央黄斑厚度之间呈明显正相关(r=0.42,P<0.01)。同时,MPOD和BMI之间呈明显负相关(r=-0.23,P<0.01)。结论:研究得出,MPOD和中央黄斑厚度之间呈明显正相关。还需要进一步研究中央凹的详细结构及其与MPOD的关系。研究发现了MPOD与BMI之间呈明显正相关,且得出BMI的降低可能会增加黄斑色素的密度,这有助于预防年龄相关性黄斑变性(ARMD)。

关键词：黄斑色素光学密度体重指数中央黄斑厚度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ON ЛАВРЕНТЬЕВ’s PARTIAL DIFFENTIAL EQUATION OF THE MIXED TyPE

引用

science in China,ser.A 1964年第11期 1755-1762页

作者：华罗庚 Institute of Mathematics Academia sinica

During the investigation of the theo汀of partial differential equationstype of n variables,the author found some imProvements in BH叩及se,s月朋详HT邸,5 equation:of the mixedtreatment ofaZUOxZ十sgnyaZUayZ0 Let D be the... 详细信息

关键词： ON s PARTIAL DIFFENTIAL EQUATION OF THE MIXED TyPE

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：