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Structures and ion transport mechanisms of plant high-affinity potassium transporters

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Molecular Plant 2024年第3期17卷 409-422页

作者： Jiangqin Wang yanping Luo Fan ye Zhong Jie ding Shao Jian Zheng Shuai Qiao yong Wang Jiangtao Guo Wei yang Nannan Su international Institutes of Medicine the Fourth Affiliated HospitalZhejang University School of MedicineYiwuZhejiang 322000China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejang 310058China State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejang UniversityHangzhouZhejang 310058China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Science and Brain-machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310058China Nanhu Brain-computer Interface Institute Hangzhou.Zheiang 311100.China

Plant high-affinity K^(+) transporters(HKTs)mediate Na^(+) and K^(+) uptake,maintain Na^(+)/K^(+) homeostasis,and therefore play crucial roles in plant salt *** this study,we present cryoelectron microscopy structures of HKTs from two classes,classI HKT1;1 from Arabidopsis thaliana(AtHKT1;1)and class II HKT2;1 from Triticum aestivum(TaHKT2;1),in both Na^(+) -and K^(+) -bound states at 2.6-to 3.0-A ***1;1and TaHKT2;1function *** HKT subunit consists of four tan-dem domain units(D1-D4)with a repeated K^(+) -channel-like M-P-M *** each subunit,D1-D4 assemble into an ion conduction pore with a pseudo-four-fold *** both TaHKT2;1and AtHKT1;1 have only one putative Na^(+) ion bound in the selectivity filter with a similar coordination pattern,the two HKTs display different K^(+) binding modes in the ***2;1 has three K^(+) ions bound in the selec-tivity filter,but AtHKT1;1 has only two K^(+) ions bound in the filter,which has a narrowed external entrance due to the presence of a Ser residue in the first filter *** structures,along with compu-tational,mutational,and electrophysiological analyses,enable us to pinpoint key residues that are critical for the ion selectivity of *** findings provide new insights into the ion selectivity and ion transport mechanisms of plant HKTs and improve our understanding about how HKTs mediate plant salt tolerance and enhance crop growth.

关键词： HKTs structure ion selectivity mechanism salt tolerance

Cognitive impairment associated with individual and joint exposure to PM_(2.5)constituents in a Chinese national cohort

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 39-50页

作者： Boning Deng yachen Li Lifeng Zhu yuwei Zhou Aonan Sun Jingjing Zhang yixiang Wang yuxi Tan Jiajun Shen yalin Zhang Zan ding yunquan Zhang Institute of Social Development and Health Management Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of Public HealthWuhan University of Science and TechnologyWuhan 430065China Baoan Central Hospital of Shenzhen Shenzhen 518102China

Nationwide longitudinal evidence linking cognitive decline with exposure to fine particulate matter(PM_(2.5))constituents remains scarce in *** constructing a dynamic cohort based on the China Health and Retirement Longitudinal Study,we aimed to assess individual and joint associations of PM_(2.5)constituents with cognitive function among middle-aged and older adults in *** mixed-effects models incorporated with quantile-based g-computation were applied to investigate individual and joint associations of long-term exposures to PM_(2.5)constituents with cognitive *** 13,507 respondents,we evaluated 38,950 follow-up records of cognitive function *** in global cognitive score associated with an interquartile range(IQR)increase in exposure were−1.477(95%CI:−1.722,−1.232)for nitrate,followed by−1.331(−1.529,−1.133)for ammonium,−1.033(−1.184,−0.883)for sulfate,−0.988(−1.144,−0.832)for organic matter and−0.822(−0.946,−0.699)for black *** IQR-equivalent increase in joint exposure to these PM_(2.5)constituents was associated with a decline of−1.353(−1.659,−1.048)in global cognitive ***,younger,and well-educated individuals were at greater vulnerability to cognitive impairment related to individual and joint exposure to PM_(2.5)*** study suggested that later-life exposures to PM_(2.5)constituents were associated with cognitive decline in middle-aged and older adults in China.

关键词： Air pollution PM_(2.5)constituents Cognitive function Joint exposure Middle-aged and older adults

Spin-controlled generation of a complete polarization set with randomly-interleaved plasmonic metasurfaces

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Opto-Electronic Advances 2024年第8期7卷 16-24页

作者： Sören im Sande yadong Deng Sergey I.Bozhevolnyi Fei ding Centre for Nano Optics University of Southern DenmarkOdense 5230Denmark

Optical metasurfaces,comprising subwavelength quasi-planar nanostructures,constitute a universal platform for manipulating the amplitude,phase,and polarization of light,thus paving a way for the next generation of highly integrated multifunctional optical *** this work,we introduce a reflective metasurface for the generation of a complete(angularly resolved)polarization set by randomly interleaving anisotropic plasmonic meta-atoms acting as nanoscale wave *** the proof-of-concept demonstration,we achieve multidirectional beam-steering into different polarization channels forming a complete set of polarization states,which can also be dynamically altered by switching the spin of incident *** developed design concept represents a significant advancement in achieving flat polarization optics with advanced functionalities.

关键词： plasmonic metasurface randomly interleaved multidirectional beam-steering spin-controlled all-polarization generation

Factors affecting meibomian gland area loss in symptomatic adults

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1036-1041页

作者： Si-Cheng ding Jing-Jing Su Qing Zhan Jiao-Man Wang Fang Zheng Xu-Xuan Fang Dan Cheng Ping Guo The Second Clinical Medical College Jinan UniversityShenzhen 518000Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

AIM:To characterize the distribution of meibomian gland(MG)area loss(MGL)and its relationship with demographic characteristics,mites,and ***:This retrospective observational study included patients who visited the Dry Eye Clinic of Shenzhen Eye Hospital between June 2020 and August *** patient characteristics,ocular symptoms,Demodex test results of the eyelid edges,and the results of a comprehensive ocular surface analysis were *** was analyzed using Image J ***:This study enrolled 1204 outpatients aged 20-80(40.70±13.44)y,including 357 males(29.65%)and 847 females(70.35%).The patients were classified into mild(n=155;12.87%),moderate(n=795;66.03%),severe(n=206;17.11%),and extremely severe(n=48;3.99%)MGL *** was significantly larger in female than in male(P=0.006).The degree of MGL also significantly differed in age(Py(Pysis identified that female sex,older age,secretory symptoms,and a large number of mites were risk factors for MGL(Py to be older,female,more numbers of mites,and increased secretion.

关键词： meibomianglands aging sex symptomatology Demodex

Developing a CRISPR/FrCas9 system for core promoter editing in rice

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aBIOTECH 2024年第2期5卷 189-195页

作者： Hui Wang Jian ding Jingyan Zhu Xiaoshuang Liu Rongfang Xu Ruiying Qin Dongfang Gu Min Li Pengcheng Wei Juan Li College of Agronomy Anhui Agricultural UniversityHefei 230036China Key Laboratory of Rice Genetic Breeding of Anhui Province Rice Research InstituteAnhui Academy of Agricultural SciencesHefei 230031China Research Centre for Biological Breeding Technology Advance AcademyAnhui Agricultural UniversityHefei 230036China

Small mutations in the core promoter region of a gene may result in substantial changes in expression ***,targeting TA-rich sequences of core promoters may pose a challenge for Cas9 variants such as SpCas9 and other G-rich PAM-compatible *** this study,we engineered a unique FrCas9 system derived from Faecalibaculum rodentium for plant genome *** findings indicate that this system is efficient in rice when the TATA sequence is used as a *** addition,FrCas9 demonstrated activity against all 16 possible NNTA PAMs,achieving an efficiency of up to 35.3%in calli and generating homozygous or biallelic mutations in 31.3%of the T_(0)transgenic plants.A proof-ofconcept experiment to examine editing of the rice WX core promoter confirmed that FrCas9-induced mutations could modify gene expression and amylose *** mutations and deletions were produced by bidirectional editing,mediated by FrCas9,using a single palindromic TATA sequence as a ***,we developed FrCas9-derived base editors capable of programmable conversion between AT and GC pairs in *** study highlights a versatile FrCas9 toolset for plant core promoter editing,offering great potential for the fine-tuning of gene expression and creating of new germplasms.

关键词： Genome editing FrCas9 CRISPR Core promoter Base editing

Fault characteristics and their control on oil and gas accumulation in the southwestern Ordos Basin

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Energy Geoscience 2024年第1期5卷 162-171页

作者： yongtao Liu Shuanghe Dai yijun Zhou Fufeng ding Mingjie Li Xingyun Li yu Zhao Binhua Guo Tong Li Junan Han Research Institute of Oriental Geophysical Company CNPCXi'an710021China State Key Laboratory of Continental Dynamics Northwest UniversityXi'an710069China Exploration Department of PetroChina Changqing Oilfield Company Xi'an710018China

3D seismic data recently acquired from the Ordos Basin shows three sets of regularly distributed fault systems,which overrides previous understanding that no faults were developed in this *** interpretation suggests that the faults in the southwestern Ordos Basin have three basic characteristics,namely extreme micro-scale,distinct vertical stratification,and regularity of planar *** NS-,NW-,and NE-trending fault systems developed in the Meso-Neoproterozoic e Lower Ordovician *** these,the NS-trending fault system mainly consists of consequent and antithetic faults which show clear syndepositional *** fault systems in the Carboniferous e Middle-Lower Triassic strata are not clear on seismic reflection *** NW-and NE-trending fault systems are developed in the Upper Triassic e Middle Jurassic *** these,the NW-trending fault system appears as a negative flower structure in sectional view and in an en echelon pattern in plan-view;they show transtensional deformation.A NE-trending fault system that developed in the Lower Cretaceous e Cenozoic strata shows a y-shaped structural style and tension-shear properties.A comprehensive analysis of the regional stress fields at different geologic times is essential to determine the development,distribution direction,and intensity of the activity of fault systems in the Ordos *** exploration suggests three aspects in which the faults within the Ordos Basin are crucial to oil and gas ***,these faults serve as vertical barriers that cause the formation of two sets of relatively independent petroleum systems in the Paleozoic and Mesozoic strata respectively;this is the basis for the‘upper oil and lower gas’distribution ***,the vertical communication of these faults is favorable for oil and gas migration,thus contributing to the typical characteristics of multiple oil and gas fields within the basin,*** and gas reservoirs with multiple

关键词： Coherent attribute Strike-slip fault Flower structure Shale oil Ordos basin

Multidimensional regulation of Ti-Zr-Cr-Mn hydrogen storage alloys via y partial substitution

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Nano Research 2024年第5期17卷 4211-4220页

作者： Haixiang Xiu Wanqiang Liu Dongming yin Nan ding Wenfeng Qiao Shaolei Zhao Long Liang Cong Liu Shaohua Wang Qingshuang Wang Bingbing Chen Limin Wang yong Cheng School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China College of Life Science and Technology Changchun University of Science and TechnologyChangchun 130022China

High density and safe storage of hydrogen are the preconditions for the large-scale application of hydrogen ***,the hydrogen storage properties of Ti_(0.6)Zr_(0.4)Cr_(0.6)Mn_(1.4) alloys are systematically studied by introducing y element instead of Ti element through vacuum arc *** the partial substitution of y,a second phase of rare earth oxide is added in addition to the main suction hydrogen phase,C14 Laves *** to the unique properties of rare earth elements,the partial substitution of y can not only improve the activation properties and plateau pressure of the alloys,but also increase the effective hydrogen storage capacity of the *** comprehensive properties of hydrogen storage alloys are improved by multidimensional regulation of rare earth *** them,Ti_(0.552)y_(0.048)Zr_(0.4)Cr_(0.6)Mn_(1.4) has the best comprehensive *** alloy can absorb hydrogen without activation at room temperature and 5 MPa,with a maximum hydrogen storage capacity of 1.98 wt.%.At the same time,it reduces the stability of the hydride and the enthalpy change value,making it easier to release *** theoretical analysis and first-principle simulation,the results show that the substitution of y element reduces the migration energy barrier of hydrogen and the structural stability of the system,which is conducive to hydrogen *** alloy has superior durability compared to the original alloy,and the capacity retention rate was 96.79%after 100 hydrogen absorption/desorption cycles.

关键词： AB_(2)-type hydrogen storage alloy rare earth element first-principles simulation multidimensional regulation

Engineering fibrillar morphology for highly efficient organic solar cells

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Journal of Semiconductors 2024年第2期45卷 7-9页

作者： Chengcheng Xie Bin Zhang Menglan Lv Liming ding Engineering Research Center for Energy Conversion and Storage Technology of Guizhou School of Chemistry and Chemical EngineeringGuizhou UniversityGuiyang 550025China Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

The power conversion efficiency(PCE)for single-junction organic solar cells(OSCs),wherein the photoactive layer is a typical bulk-heterojunction containing donor and acceptor materials,has surpassed 19%[1−4].The advance is ascribed to the development of y-series non-fullerene acceptors(NFAs)[5,6]and polymer donors[7−13],and the refined control of the blend film morphology.

关键词： morphology refined donor

Efficacy and safety of Huzhang Granule,a compound Chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

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Journal of Integrative Medicine 2024年第3期22卷 270-278页

作者： Hao Wang Si-ting Chen Xiao-jie ding Le Kuai Liang Hua Xin Li yi-fei Wang Ming Zhang Bin Li Rui-ping Wang Mi Zhou Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Department of Dermatology the Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000Jiangxi ProvinceChina Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200443China Institute of Dermatology School of MedicineTongji UniversityShanghai 200443China

Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high *** medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse *** Granule(HZG),a compound Chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse ***,the efficacy and safety of HZG in AGA patients remains ***:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA ***,setting,participants and interventions:The current study was conducted as a noninferiority,randomized controlled clinical trial on 180 eligible enrolled *** were randomly assigned into the HZG and etoricoxib *** were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and placebo HZG in the same ratio(1:1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment *** pain level was measured via a visual analogue scale,ranging from 0 mm to 100 *** secondary outcomes comprised joint tenderness and swelling,reduction of inflammatory biomarkers,and the patient’s and investigator’s global evaluations of therapeutic ***:The mean reduction in pain was-51.22 mm(95%confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95%CI,[-54.06,-49.94]mm)for the etoricoxib *** mean difference between the two groups was 0.78 mm(95%CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of *** in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etoricoxib group(4.44%vs 13.33%;P≤0.05).Conclusion:HZG and etoricoxib groups demons

关键词： Acute gouty arthritis Huzhang Granule Randomized controlled trial Blind