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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： yujia Liu xue Han yan Su yiming Zhou Minhui xu Jiyan xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Tsallis agegraphic dark energy model with the sign-changeable interaction

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Communications in Theoretical Physics 2020年第1期72卷 96-101页

作者： y D xu School of Science Jiangsu Ocean UniversityLianyungang 222005China

In this paper,we study the evolution of a spatially flat universe composed of Tsallis agegraphic dark energy(TADE)and a pressureless dark matter(DM),by assuming that there is a signchangeable interaction between TADE and *** density,deceleration parameter and the equation of state parameters(EoS)show satisfactory behaviors in the *** analysis we find that the accelerated expansion of the universe can be achieved at the late time if model parametersδ>2 and-2/3y means of statefinder diagnostic and w–w’analysis.

关键词： Tsallis agegraphic dark energy cosmological evolution statefinder w–w’analysis

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Poststroke seizure:optimising its management

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Stroke & Vascular Neurology 2019年第1期4卷 48-56页

作者： Michael y xu Department of Neurology OSF Illinois Neurological InstituteUniversity of Illinois College of MedicinePeoriaIllinoisUSA

Seizure after stroke or poststroke seizure (PSS) is a common and very important complication of stroke. It can be divided into early seizure and late seizure, depending on seizure onset time after the stroke. It has been reported that ischaemic and haemorrhagic stroke accounts for about 11% of all adult epilepsy cases and 45% of epilepsy cases over 60 years of age. However, there are no reliable guidelines in clinical practice regarding most of the fundamental issues of PSS management. In recent years there has been an increased interest in the study of PSS which may give clinical practitioners a better picture of how to optimise PSS management. Studies have indicated two peaks in PSS occurrence-the first day and 6-12 months after a stroke. Haemorrhagic stroke, cortical involvement, severity of initial neurological deficit, younger patients (years of age), family history of seizures and certain genetic factors carry a higher risk of PSS. The use of continuous electroencephalogram has demonstrated significant benefits in capturing interictal or ictal abnormalities, especially in cases of non-convulsive seizures and non-convulsive status epilepticus. Current available data indicated that there was no significant difference in antiepileptic efficacy among most of the antiepileptic drugs (AEDs) in PSS. Levetiracetam and lamotrigine are the most studied newer generation AEDs and have the best drug tolerance. The purpose of this review is to summarise the recent advances in PSS research and focus on the most important practice issues of PSS management.

关键词： seizure epilepsy involvement

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Fluctuation theorem for entropy production at strong coupling

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Chinese Physics B 2020年第1期29卷 175-180页

作者： y y xu J Liu M Feng Faculty of Science Kunming University of Science and TechnologyKunming 650500China Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Fluctuation theorems have been applied successfully to any system away from thermal equilibrium,which are helpful for understanding the thermodynamic state *** investigate fluctuation theorems for strong coupling between a system and its reservoir,by path-dependent definition of work and heat satisfying the first law of *** present the fluctuation theorems for two kinds of entropy *** is the informational entropy production,which is always non-negative and can be employed in either strong or weak coupling *** other is the thermodynamic entropy production,which differs from the informational entropy production at strong coupling by the effects regarding the *** find that,it is the negative work on the reservoir,rather than the nonequilibrium of the thermal reservoir,which invalidates the thermodynamic entropy production at strong *** results indicate that the effects from the reservoir are essential to understanding thermodynamic processes at strong coupling.

关键词： fluctuation theorem entropy production strong coupling

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Diffusion of Hydrogen in Amorphous NiCrFeSiB Alloy

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Journal of Materials Science & Technology 1996年第1期12卷 15-18页

作者： Zuo, y yang, B xu, RS Dept. of Applied Chemistry Beijing University of Chemical Technology Beijing 100029 China

The diffusion of hydrogen in amorphous NiCrFeSiB alloy has been studied by electrochemical method. In the temperature range of 20 similar to 50 degrees C, diffusion coefficient of hydrogen in the alloy follows the equation: D(cm(2)/s) = 9.27x10(-8) exp(-53.4 kJ/RT). At room temperature the diffusion coefficient D and the solubility C-0 are 6.125 x 10(-12) cm(2)/s and 0.007 mol/cm(3), respectively. When As2O3 is added into the cathodic solution or the charging current density is increased, the diffusion coefficient and solubility increase, and the diffusion activation energy decreases. The influence of amorphous structure on diffusion and solution of hydrogen is discussed.

关键词： Nickel alloys

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A narrative review on inhibitory effects of edible mushrooms against malaria and tuberculosis-the world’s deadliest diseases

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Food Science and Human Wellness 2023年第4期12卷 942-958页

作者： Ashaimaa y.Moussa Baojun xu Department of Pharmacognosy Faculty of PharmacyAin Shams UniversityCairo 11566Egypt Food Science and Technology Program BNU-HKBU United International CollegeZhuhai 519087China

The isolated secondary metabolites from 39 edible mushrooms are reported,among which 107 compounds were active,61 demonstrated antitubercular activities with IC_(50) range of 0.2-50μg/mL and 46 manifested antimalarial effects with IC_(50) range of 0.061-36μg/*** more than 2000 strains of edible mushrooms are identified,this review shows the paucity of research in these rich organisms featuring a vital culinary ingredient worldwide.A thorough search was conducted on basidiomycetes to discuss the chemistry and biology of the isolated compounds,structure activity relationships(SAR)as well as the cytotoxicity profiles of,primarily,the active anti-plasmodial and antitubercular *** a safe cellular profile,lanostane triterpenoids were found to be the only molecules with combined activities against both *** correlations reviewed here indicated the significance of 3β-and 7α-hydroxylation in the anti-tuberculosis activity and the terminal unsaturated moiety between C-4 and C-28 in the antimalarial activity in the same terpene *** review will attract the attention of medicinal chemists,and food scientists to optimize and rationalize the use of mushrooms both as unexploited sources of novel molecules and as nutraceuticals to treat two of the deadliest infectious diseases,malaria,and tuberculosis.

关键词： Antituberculosis Antiplasmodial Macrofungi Mushrooms Structure activity relationship

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Studies on monodispersed colloidal particles of doped yttrium compounds

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Chinese Journal of Chemistry 1995年第3期13卷 199-206页

作者： DENG, HM xu, y GU, yD FUDAN UNIV ANAL & MEASUREMENT RES CTRSHANGHAI 200433PEOPLES R CHINA FUDAN UNIV DEPT CHEMSHANGHAI 200433PEOPLES R CHINA

Monodispersed particles of doped yttrium basic carbonates were prepared at aging at elevated temperature corresponding salts solutions in the presence of urea. Coprecipitation in mixed solutions of yttrium, lanthanum and neodymium salts under similar experimental conditions yielded composite particles of basic carbonates. The content of the three metals in the solids followed closely the initial composition of the reacting solutions. On calcination all prepared solids converted to their corresponding oxides while retaining their particle morphology. The so-prepared powders were characterized by various techniques.

关键词： yTTRIUM COMPOUNDS MONODISPERSED PARTICLES UREA DECOMPOSITION

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Studies on the energy transfer system of terbium-norfloxacin chelate and its interaction with serum albumins

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Chinese Journal of Chemistry 1997年第2期15卷 138-143页

作者： xu, y Shen, HX Huang, HG NANKAI UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA HEBEI INST TECHNOL DEPT CHEM ENGNTANGSHAN 063009HEBEIPEOPLES R CHINA

The energy absorbed by norfloxacin could be transferred to terbium(III) through chelation of norfloxacin with terbium(III), then the characteristic fluorescence emission could be observed. The interaction of serum albumins with norfloxacin have been investigated in this paper. The results showed that HSA could inhibit the energy transfer between norfloxacin and terbium(III). But, BSA could not. It was shown that the binding properties of norfloxacin to HSA and BSA were totally different.

关键词： norfloxacin terbium(III) energy transfer HSA BSA

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