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Chinese Science Bulletin 2011年第32期56卷 3394-3397页

作者： LUI Simon S y SHAM Pak CHAN Raymond C K CHEUng Eric F C Neuropsychology and Applied Cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Castle Peak Hospital Department of Psychiatry the University of Hong Kong

The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.

关键词：精神病患者稳定家庭早期原理预计香港面部表情识别

Rectal-prolapse repair in men is safe,but outcomes are not well understood

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Gastroenterology Report 2019年第4期7卷 279-282,I0002页

作者： Vitaliy y.Poylin Jennifer L.Irani Reza Rahbar Muneera R.Kapadia Beth Israel Deaconess Medical Center BostonMAUSA Brigham and Woman’s Hospital BostonMAUSA UNC Health Care RaleighNCUSA University of Iowa Iowa CityIAUSA

Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this *** purpose of this study was to evaluate the surgical approach and outcomes of rectal-prolapse repair in ***:A retrospective multicenter review was conducted of consecutive men who underwent rectal-prolapse repair between 2004 and *** approaches and outcomes,including erectile function and fecal continence,were ***:During the study period,58 men underwent rectal-prolapse repair and the mean age of repair was 52.7624.1 *** mean follow-up was 13.2 months(range,0.5–117 months).The majority of patients underwent endoscopic evaluation(78%),but few patients underwent anal manometry(16%),defecography(9%)or ultrasound(3%).Ten patients(17%)underwent biofeedback/pelvic-floor physical therapy prior to *** patients(33%)underwent a perineal approach(most were perineal proctosigmoidectomy).Thirty-nine patients(67%)underwent repair using an abdominal approach(all were suture rectopexy)and,of these,77%were completed using a minimally invasive *** overall complication rate was 26%including urinary retention(16%),which was more common in patients undergoing the perineal approach(32%vs.8%,P=0.028),urinary-tract infection(7%)and wound infection(3%).The overall recurrence rate was 9%,with no difference between abdominal and perineal *** on sexual function was missing in the majority of patients both before and after surgery(76%and 78%,respectively).Conclusion:Rectal-prolapse repair in men is safe and has a low recurrence rate;however,sexual function was poorly recorded across all *** studies are needed to evaluate to best approach to and functional outcomes of rectal-prolapse repair in men.

关键词： Rectal prolapse surgical procedure sexual function men

A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice

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World Journal of Gastroenterology 2006年第2期12卷 306-312页

作者： yuan-Xiang Zhou Maggie yuk-Ting Lee James Ming-Him ng Mee-Len Chye Wing-Kin yip Sze-yong Zee Eric Lam Department of Botany The University of Hong Kong PokfulamRoad Hong Kong China Biotech Center Rutgers University 59 Dudley RoadNew Brunswick NJ 08901-8520 United States

AIM： To cost-effectively express the 23-ku pE2, the most promising subunit vaccine encoded by the E2 fragment comprising of the 3＇-portion of hepatitis E virus （HEV） open reading frame 2 （ORF2） in plastids of tobacco （Nicotiana tabacum cv. SR1）, to investigate the transgene expression and pE2 accumulation in plastids, and to evaluate the antigenic effect of the plastid-derived pE2 in mice. METHODS： Plastid-targeting vector pRB94-E2 containing the E2 fragment driven by rice psbA promoter was constructed. Upon delivery into tobacco plastids, this construct could initiate homologous recombination in psaB-trnfM and trng-psbC fragments in plastid genome, and result in transgene inserted between the two fragments. The pRB94-E2 was delivered with a biolistic particle bombardment method, and the plastid-transformed plants were obtained following the regeneration of the bombarded leaf tissues on a spectinomycin-supplemented medium. Transplastomic status of the regenerated plants was confirmed by PCR and Southern blot analysis, transgene expression was investigated by Northern blot analysis, and accumulation of pE2 was measured by ELISA. Furthermore, protein extracts were used to immunize mice, and the presence of the pE2-reactive antibodies in serum samples of the immunized mice was studied by ELISA. RESULTS： Transplastomic lines confirmed by PCR and Southern blot analysis could actively transcribe the E2 mRNA. The pE2 polypeptide was accumulated to a level as high as 13.27 μg/g fresh leaves. The pE2 could stimulate the immunized mice to generate pE2-specific antibodies. CONCLUSION： HEV-E2 fragment can be inserted into the plastid genome and the recombinant pE2 antigen derived is antigenic in mice. Hence, plastids may be a novel source for cost-effective production of HEV vaccines.

关键词： Hepatitis E virus E2 Plastid transformation Vaccine Tobacco

Data-driven nonlinear control of a solid oxide fuel cell system

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Journal of Central South University 2012年第7期19卷 1892-1901页

作者：李益国沈炯 K.y.Lee 刘西陲费文哲 Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education(School of Energy and Environment Southeast University) Department of Electrical and Computer Engineering Baylor UniversityWacoTX 76798-7356USA

Solid oxide fuel cells (SOFCs) are considered to be one of the most important clean,distributed resources. However,SOFCs present a challenging control problem owing to their slow dynamics,nonlinearity and tight operating constraints. A novel data-driven nonlinear control strategy was proposed to solve the SOFC control problem by combining a virtual reference feedback tuning (VRFT) method and support vector machine. In order to fulfill the requirement for fuel utilization and control constraints,a dynamic constraints unit and an anti-windup scheme were adopted. In addition,a feedforward loop was designed to deal with the current disturbance. Detailed simulations demonstrate that the fast response of fuel flow for the current demand disturbance and zero steady error of the output voltage are both achieved. Meanwhile,fuel utilization is kept almost within the safe region.

关键词： solid oxide fuel cell (SOFC) data-driven method virtual reference feedback tuning (VRFT) support vector machine(SVM) anti-windup

Surveillance of emerging SARS-CoV-2 variants by nanopore technology-based genome sequencing

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 313-320页

作者： J.I.Abeynayake G.P.Chathuranga M.A.y.Fernando M.K.Sahoo Department of Virology Medical Research InstituteP.O.Box:527Baseline RoadColombo 08Sri Lanka Department of Pathology Stanford University School of MedicinePalo AltoCaliforniaUnited States of America

Objective:To surveill emerging variants by nanopore technology-based genome sequencing in different COVID-19 waves in Sri Lanka and to examine the association with the sample characteristics,and vaccination ***:The study analyzed 207 RNA positive swab samples received to sequence laboratory during different *** N gene cut-off threshold of less than 30 was considered as the major inclusion *** RNA was extracted,and elutes were subjected to nanopore *** the sequencing data were uploaded in the publicly accessible database,***:The Omicron,Delta and Alpha variants accounted for 58%,22%and 4%of the variants throughout the *** than 1%were Kappa variant and 16%of the study samples remained *** variant was circulated among all age groups and in all the *** value and variants assigned percentage was 100%in Ct values of 10-15 while only 45%assigned Ct value over ***:The present study examined the emergence,prevalence,and distribution of SARS-CoV-2 variants locally and has shown that nanopore technology-based genome sequencing enables whole genome sequencing in a low resource setting country.

关键词： Emerging SARS-CoV-2 variants Laboratory surveillance Nanopore technology Genome sequencing Bioinformatics analysis and phylogeny Sociodemographic and sample cutoff(Ct)threshold Global sharing of genomic data/GISAID

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现代汉语与越南语存在句语用比较研究

海外华文教育 2013年第2期 165-178页

作者： Hoàng T■ nguyên 胡志明市人文与社会科学大学中国语文系越南胡志明市70000

存在句是存现句最典型的一种。对于这种特殊的句子,至今已有不少学者深入研究并在此方面获得了相当大的成果。本文力图将现代汉语与越南语"存在句"(C■U T■N T■I)的语用进行比较分析。

关键词：现代汉语存在句越南语CAU TON TAI 语用比较

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撞击坑研究进展与展望

中国科学：地球科学 2023年第11期53卷 2482-2493页

作者：岳宗玉史珂邸凯昌林杨挺芶盛中国科学院地质与地球物理研究所地球与行星物理重点实验室北京100029 中国科学院空天信息创新研究院遥感科学国家重点实验室北京100101 中国科学院比较行星学卓越创新中心合肥230026

撞击坑是超高速运动的小天体撞击固态天体(包括类地行星及其卫星、小行星等)表面形成的地质结构,而强烈的撞击是这些天体形成与演化的重要动力,因此撞击过程的研究是行星科学的重要研究领域.文章对撞击坑的遥感观测、撞击坑的形成机制研... 详细信息

撞击坑是超高速运动的小天体撞击固态天体(包括类地行星及其卫星、小行星等)表面形成的地质结构,而强烈的撞击是这些天体形成与演化的重要动力,因此撞击过程的研究是行星科学的重要研究领域.文章对撞击坑的遥感观测、撞击坑的形成机制研究,以及撞击坑研究的意义等进行了总结.文章描述了微坑、简单坑、复杂坑、撞击盆地等四类撞击坑的形貌特征,介绍了撞击坑形貌研究中常用到的特征参数,分析了撞击挖掘过程导致的撞击坑周围矿物岩石分布特征.基于遥感观测数据,总结了撞击坑的识别方法,以及月球、火星、谷神星、灶神星等天体表面的撞击坑数据库.在撞击坑的形成机制研究方面,描述了撞击坑形成的一般过程,介绍了撞击坑形成机制研究的常用方法,讨论了撞击坑研究中经验公式的重要性.在撞击坑研究的科学应用方面,介绍了撞击坑统计定年法的原理及其应用现状,描述了撞击坑在月壤形成过程以及推测月壤与玄武岩厚度中的应用.文章最后就撞击坑的形成机制等方面的研究进行了探讨与展望.

关键词：行星撞击坑遥感观测数值模拟统计定年

面向电动车窗/天窗应用的集成嵌入式功率半导体

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电子产品世界 2008年第12期15卷 73-75页

作者： ng Jit Keah David 英飞凌科技亚太有限公司汽车工业及多元化电子市场部

如今,电动车窗已成为汽车标准功能之一。即使在成本至上的新兴市场,它也是影响购车者决定的最重要因素之一。多数购车者都将电动车窗视为必备的舒适功能,因此汽车厂商都将其作为一种基本功能。

关键词：电动车窗 TLE7810G ECU 功率半导体

Influence of Solid Fraction on Gravity Segregation of Sn in A1-20Sn Alloy Casting

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Journal of Materials Science & Technology 2000年第6期16卷 577-580页

作者： Zhang P. Du y.H. Zeng D.B. Cui J.Z. Ba L.M. Dep. of Mechanical Eng. Tsinghua Univ. Beijing 100084 China

The influence of solid fraction of Al-20Sn alloy mushy on gravity segregation of Sn in casting was studied . The relationship between solid fraction and the temperature of alloy mushy and that between solid fraction of alloy mushy and size of Sn particle in ingot were determined. The results show that the relationship between solid fraction and the temperature of alloy mushy was fs=1683-4.86t+0.003 5t2. The extent of gravity segregation of Sn in casting reduced gradually with the increase of solid fraction of alloy mushy. When solid fraction of alloy mushy was larger than 40%, the gravity segregation of Sn in casting could be removed basically, and the relationship between solid fraction of alloy mushy and size of Sn particle in ingot was s=-0.64fs+70.8.

关键词： Metal casting

High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross- sectional survey

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General Psychiatry 2021年第5期34卷 31-41,I0006-I0025页

作者： Natasha Smallwood Leila Karimi Marie Bismark Mark Putland Douglas Johnson Shyamali Chandrika Dharmage Elizabeth Barson Nicola Atkin Claire Long Irene ng Anne Holland Jane E Munro Irani Thevarajan Cara Moore Anthony McGillion Debra Sandford Karen Willis Department of Respiratory Medicine Alfred HospitalPrahranVictoriaAustralia Department of Allergy Immunology and Respiratory MedicineCentral Clinical SchoolAlfred HospitalMonash UniversityMelbourneVictoriaAustralia School of Psychology and Public Health La Trobe UniversityMelbourneVictoriaAustralia School of Medicine and Healthcare Management Caucasus UniversityTbilisiGeorgia Department of Psychiatry The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Public Health Law Melbourne School of Population and Global HealthThe University of MelbourneParkvilleVictoriaAustralia Department of Emergency Services The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Critical Care Faculty of MedicineDentistry and Health SciencesThe University of MelbourneMelbourneVictoriaAustralia Departments of General Medicine and Infectious diseases The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Medicine The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Allergy and Lung Health Unit School of Population and Global HealthThe University of MelbourneParkvilleVictoriaAustralia Department of Allied Health The Royal Melbourne HospitalParkvilleVictoriaAustralia Parkville Integrated Palliative Care Service The Royal Melbourne HospitalParkvilleVictoriaAustralia Sir Peter MacCallum Department of Oncology The University of MelbourneParkvilleVictoriaAustralia Department of Geriatric Medicine Western HealthFootscrayVictoriaAustralia Department of Anaesthesia and Pain Management The Royal Melbourne HospitalParkvilleVictoriaAustralia Centre for Integrated Critical Care Melbourne Medical SchoolThe University of MelbourneParkvilleVictoriaAustralia Department of Physiotherapy Alfred HealthMelbourneVictoriaAustralia Rheumatology Unit Royal Children's HospitalParkvilleVictoriaAustralia Arthritis and Rheumatology Murdoch Children's Research InstituteParkvilleVictoriaAustralia Department of Infectious diseases T

Background The coronavirus disease 2019(COVID-19)pandemic has had a profound and prolonged impact on healthcare services and healthcare *** The Australian COVID-19 Frontline Healthcare Workers Study aimed to investigate the severity and prevalence of mental health issues,as well as the social,workplace and financial disruptions experienced by Australian healthcare workers during the COVID-19 *** A nationwide,voluntary,anonymous,single timepoint,online survey was conducted between 27 August and 23 October *** self-identifying as frontline healthcare workers in secondary or primary care were invited to *** were recruited through health organisations,professional associations or colleges,universities,government contacts and national ***,home and work situation,health and psychological well-being data were *** A total of 9518 survey responses were received;of the 9518 participants,7846(82.4%)participants reported complete *** regard to age,4110(52.4%)participants were younger than 40 years;6344(80.9%)participants were *** were nurses(n=3088,39.4%),doctors(n=2436,31.1%),allied health staff(n=1314,16.7%)or in other roles(n=523,6.7%).In addition,1250(15.9%)participants worked in primary *** measured mental health symptoms were common:mild to severe anxiety(n=4694,59.8%),moderate to severe burnout(n=5458,70.9%)and mild to severe depression(n=4495,57.3%).Participants were highly resilient(mean(SD)=3.2(0.66)).Predictors for worse outcomes on all scales included female gender;younger age;pre-existing psychiatric condition;experiencing relationship problems;nursing,allied health or other roles;frontline area;being worried about being blamed by colleagues and working with patients with *** The COVID-19 pandemic is associated with significant mental health symptoms in frontline healthcare *** preparedness together with policies and pra

关键词： distress nurse workers