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PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cy.okine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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oncology Research 2024年第10期32卷 1575-1587页

作者： EGoR V.BAToRoV ALISA D.INESHINA TATIANA A.ARISToVA VERA V.DENISoVA SVETLANA A.SIZIKoVA DARIA S.BAToRoVA GALINA y.USHAKoVA EKATERINA y.SHEVELA ELENA R.CHERNyKH Laboratory.of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia V.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,previous studies showed the possibility.of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cy.okines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cy.okine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EoMES)was comparatively assessed with flow cy.ometry in PD-1-and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positive T lymphocytes expressed commonγ-chain cy.okine receptors and *** of cy.okine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negative and positive CD8+T cells express EoMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EoMES in CD4+T cells were mutually exclusive regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cy.okines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negative T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cy.okine *** in commonγ-chain cy.okine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity.of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EoMES) Homeostatic proliferation

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Towards an ultrafast 3D imaging scanning LiDAR system:a review

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Photonics Research 2024年第8期12卷 1709-1729页

作者： ZHI LI yAQI HAN LICAN WU ZIHAN ZAng MAoLIN DAI SZE yUN SET SHINJI yAMASHITA QIAN LI H.y.FU Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-8656Japan Research Center for Advanced Science and Technology The University of TokyoTokyo 153-8904Japan School of Electronic and Computer Engineering Peking UniversityShenzhen 518055China

Light detection and ranging(LiDAR),as a hot imaging technology in both industry and academia,has undergone rapid innovation and *** current mainstream direction is towards system miniaturization and *** are many metrics that can be used to evaluate the performance of a LiDAR system,such as lateral resolution,ranging accuracy,stability,size,and *** recently,with the continuous enrichment of LiDAR application scenarios,the pursuit of imaging speed has attracted tremendous research ***,for autonomous vehicles running on motorways or industrial automation applications,the imaging speed of LiDAR systems is a critical *** this review,we will focus on discussing the upper speed limit of the LiDAR *** on the working mechanism,the limitation of optical parts on the maximum imaging speed is *** beam scanner has the greatest impact on imaging *** provide the working principle of current popular beam scanners used in LiDAR systems and summarize the main constraints on the scanning ***,we highlight the spectral scanning LiDAR as a new paradigm of ultrafast ***,to further improve the imaging speed,we then review the parallel detection methods,which include multiple-detector schemes and multiplexing ***,we summarize the LiDAR systems with the fastest point acquisition rate reported *** the outlook,we address the current technical challenges for ultrafast LiDAR systems from different aspects and give a brief analysis of the feasibility.of different approaches.

关键词： LiDAR scanner system

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Addressing poxvirus challenges in the Middle East to enhance biosafety and biosecurity measures

Journal of Biosafety and Biosecurity

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Journal of Biosafety and Biosecurity 2024年第3期6卷 142-156页

作者： Laith N.AL-Eitan Haneen o.Ali Hana S.Abu Kharmah Maryam K.Alasmar Iliya y.Khair Ahmad H.Mihyar Department of Applied Biological Sciences Jordan University of Science and Technology22110 IrbidJordan Department of Biotechnology and Genetic Engineering Jordan University of Science and Technology22110 IrbidJordan

The emergence and zoonotic transmission of poxviruses in the Middle East have been recognized as complex public health ***,a vast family.of DNA viruses,can infect many hosts,including animals and *** Middle East has had multiple epidemics of poxvirus infections(e.g.,Monkey.ox,Smallpox,and Camelpox)that have raised concerns owing to their detrimental effects on livestock,wildlife,and sporadic human *** review aims to thoroughly examine the complexity.of the epidemiological patterns,intricate genetic diversity,and several contributing factors that support the emergence and zoonotic transmission of poxviruses in the Middle *** aspects of poxviruses contribute to the emergence of endemics and zoonotic breakouts,such as the complex nature of human-animal interactions,environmental changes,and their subtle capacity for viral *** review was compiled in the hopes of contributing to the current understanding of poxvirus biology and its implications for human and animal health in the Middle *** provide a comprehensive overview of the most common poxviruses in the Middle East,including their classification,structure,replication cycle,pathogenesis,route of transmissions,and of how the Middle East has developed ways to mitigate these biological threats.

关键词： Pox viruses Middle East Emergence Zoonotic Transmission

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Childhood opportunity and appropriate use of child safety restraints in motor vehicle collisions

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World Journal of Pediatric Surgery 2024年第2期7卷 142-149页

作者： Stephanie y Chen Iris Garcia Shadassa ourshalimian Chantel Lowery Pradip P Chaudhari Ryan G Spurrier Pediatric Surgery Children's Hospital Los AngelesLos AngelesCaliforniaUSA Injury Prevention Program Children's Hospital Los AngelesLos AngelesCaliforniaUSA Emergency and Transport Medicine Children's Hospital Los AngelesLos AngelesCaliforniaUSA Pediatrics University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA Surgery University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA

objectives Safety restraints reduce injuries from motor vehicle collisions(MVCs)but are often improperly applied or not *** Childhood opportunity Index(CoI)reflects social determinants of health and its study in pediatric trauma is *** hy.othesized that MVC patients from low-opportunity neighborhoods are less likely to be appropriately *** A retrospective cross-sectional study was performed on children/adolescents≤18 years old in MVCs between January 1,2011 and December 31,*** were identified from the Children's Hospital Los Angeles trauma *** outcome was safety restraint use(appropriately restrained,not appropriately restrained).CoI levels by home zip codes were stratified as very low,low,moderate,high,and very *** regression controlling for age identified factors associated with safety restraint *** of 337 patients,73.9%were appropriately restrained and 26.1%were not appropriately *** with appropriately restrained patients,more not appropriately restrained patients were from low-CoI(26.1%vs 20.9%),high-CoI(14.8%vs 10.8%)and very high-CoI(10.2%vs 3.6%)*** analysis demonstrated no significant associations in appropriate restraint use and *** was a non-significant trend that children/adolescents from moderate-CoI neighborhoods were more likely than those from very low-CoI neighborhoods to be appropriately restrained(oR=1.82,95%CI 0.78,4.28).Conclusion Injury prevention initiatives focused on safety restraints should target families of children from all neighborhood types.

关键词： MVC restrained neighborhood

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Game Theory based optimal Defensive Resources Allocation with Incomplete Information in Cyber-physical Power Systems against False Data Injection Attacks

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Protection and Control of Modern Power Systems 2024年第2期9卷 115-127页

作者： Bingjing yan Zhenze Jiang Pengchao y.o Qiang y.ng Wei Li Albert y.Zomaya College of Electrical Engineering Zhejiang University College of Control Science and Engineering Zhejiang University College of Electrical Engineering Zhejiang UniversityHangzhou 310027China School of Information Technologies at The University.of Sydney School of Information Technologies

Modern power grid is fast emerging as a complex cyber-physical power system(CPPS)integrating physical current-carry.ng components and processes with cyber-embedded computing,which faces increasing cy-berspace security threats and *** this paper,the state(i.e.,voltage)offsets resulting from false data injection(FDI)attacks and the bus safety characterization are applied to quantify the attack *** state offsets are obtained by the state estimation method,and the bus safety characterization considers the power net-work topology as well as the vulnerability and connection relationship of *** the indeterminacy.of attacker’s resource consumption and reward,a zero-sum game-theoretical model from the defender’s perspective with incomplete information is explored for the optimal allocation of limited defensive *** attacker aims to falsify measurements without triggering threshold alarms to break through the protection,leading to load shedding,over-voltage or *** defender attempts to ensure the estimation results to be as close to the actual states as possible,and guarantee the system’s safety and efficient defensive resource *** proposed solution is extensively evaluated through simu-lations using the IEEE 33-bus test network and real-time digital simulator(RTDS)based testbed experiments of the IEEE 14-bus *** results demonstrate the effec-tiveness of the proposed game-theoretical approach for optimal defensive resource allocation in CPPS when lim-ited resources are available when under FDI *** Terms—optimal strategy,game theory,Nash equilibrium,CPPS,FDI attack.

关键词： optimal strategy game theory Nash equilibrium CPPS FDI attack

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Effects of Moringa oleifera aqueous extract on the growth performance,blood characteristics,and histological features of gills and livers in Nile tilapia

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Aquaculture and Fisheries 2024年第1期9卷 85-92页

作者： Mahamoud A.Emam Ramy M.Shourbela Waleed N.El-Hawarry Seham y.Abo-Kora Fatma Abdel-Monem Gad Ashraf M.Abd El-latif Mahmoud A.o.Dawood Histology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Animal Husbandry and Animal Wealth Development Faculty of Veterinary MedicineAlexandria UniversityAlexandria22758Egypt Pharmacology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Clinical Pathology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Aquatic Animal Diseases and Management Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Animal Production Department Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33511Egypt The Center for Applied Research on the Environment and Sustainability The American University in CairoCairo11835Egypt

Moringa oleifera is well known as a highly nutritious plant and a water purifier in fish *** fish has many impressive qualities making them very suitable for ***,this study aimed to evaluate the effect of supplementation of Moringa oleifera aqueous extract(MoAE)at vary.ng concentrations(0,100,200,and 400 mg/kg diet for 90 days)on growth performance,hematological,and some biochemical parameters of Nile ***,histological changes and immunohistochemical expression of caspase 3 in gills and livers were *** enhancements(Powth rate,red blood cells,hemoglobin,packed cell volume,white blood cells,and total serum protein were observed in fish fed 200 mg MoAE/kg diet compared with other ***,a significant reduction(Pof liver and kidney function tests and non-significant changes in lipid profile were *** the other hand,fish fed 400 mg MoAE/kg diet revealed disturbance in the corresponding *** histological degenerative changes were detected in the gills and liver of fish fed 400 mg MoAE/kg *** comparison,fish fed 200 mg MoAE/kg diet showed the best histo-architectures of these organs compared with other *** immune expressions of caspase 3 were determined where gills and liver of fish fed 400 mg MoAE/kg diet revealed extensive number of positive caspase 3 cells indicating severe apoptotic ***,a dietary MoAE at 200 mg/kg diet is recommended to improve the growth performance,hematological parameters,liver and kidney functions in Nile ***,caution must be considered when using MoAE at a concentration over 200 mg/kg diet.

关键词： Growth performance Liver Gills Moringa oleifera Nile tilapia

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Mindfulness Facets and Psychological Well-Being among Meditators:Serenity as a Mediating Process

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International Journal of Mental Health Promotion 2024年第3期26卷 177-187页

作者： Rebecca y.M.Cheung Iris yili Wang Elsa ngar-Sze Lau School of Psychology and Clinical Language Sciences University of ReadingReadingUK Department of Special Education and Counselling The Education University of Hong KongHong KongChina Department of Educational Administration and Policy The Chinese University of Hong KongHong KongChina

Guided by the theoretical processes of mindfulness and psychological well-being,this study examined serenity as a mediator between mindfulness facets and psychological well-being,as indexed by depressive symptoms and life *** were 133 mindfulness practitioners who took part in a 3-day transnational meditation event in Hong *** informed consent,participants completed a self-report *** findings from structural equation modeling showed that serenity mediated the relation between two facets of mindfulness,including describing and nonreacting to inner experience,and life *** also mediated the relation between the mindfulness facet of describing and depressive *** associations were indicated between two mindfulness facets,including observing and nonjudging of inner experience,and depressive *** together,the findings revealed mindfulness facets as major correlates of serenity and psychological outcomes among Chinese meditation *** foster psychological well-being,researchers,educators,and practitioners should pay attention to the role of serenity,describing,and nonreacting to inner experience in mental health.

关键词： Depressive symptoms mindfulness mindfulness practitioners satisfaction with life serenity

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加权加标网络的稳定与平衡

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逻辑学研究 2024年第4期17卷 35-53页

作者：王轶董惠敏中山大学哲学系(珠海) 维也纳工业大学逻辑与计算研究所

经典结构平衡理论对不带权重的加标网络有较为完善的研究。Morrissette(1958)将结构平衡理论推广到加权加标网络并加以经验研究。近年来出现了基于时态逻辑CTL的结构平衡逻辑研究,但所探讨的社会网络局限于不带权重的加标网络。本文将... 详细信息

经典结构平衡理论对不带权重的加标网络有较为完善的研究。Morrissette(1958)将结构平衡理论推广到加权加标网络并加以经验研究。近年来出现了基于时态逻辑CTL的结构平衡逻辑研究,但所探讨的社会网络局限于不带权重的加标网络。本文将结构平衡逻辑推广到带权重的加标网络,引入几种适用的形式语言和语义,探讨由此得到的几个逻辑的表达能力,并给出证明系统。

关键词：加权加标网络结构平衡理论稳定性平衡性分支时间逻辑

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Prenatal Diagnosis of an Apically Located Congenital Left Ventricular Aneurysm: A Rare Case

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Congenital Heart Disease 2024年第1期19卷 123-129页

作者： yücel Kaya And yavuz Hasan Berkan Sayal Büşra Tsakir Gökalp Kabacaoğlu Kadriye NilayÖzcan Department of Perinatology Antalya Education and Research HospitalUniversity of Health SciencesAntalyaTurkey Department of Perinatology Faculty of MedicineSüleyman Demirel UniversityIspartaTurkey

Congenital ventricular aneurysm is a very rare cardiac anomaly.A diagnosis can be made during the prenatal period using fetal *** study presents a very rare apically located left ventricular aneurysm case,and the relevant literature was reviewed and *** this case,a 35-year-old,gravida 2,parity 1 preg-nant woman at 24 weeks of gestation,displayed a wide aneurysmal image in the left ventricular apical wall on fetal *** was a 1.79 mm muscular ventricular septal defect at the apical region of the interven-tricular *** the course of the color Doppler ultrasonography examination,an aberrantﬁbrous band within the left ventricle and consequent turbulentﬂow during systole were *** baby,born via cesarean section at 37 weeks of gestation,is now in its postnatal seventh ***,during echocardiographic follow-ups,changes have been observed,including mild to moderate mitral insufﬁciency and a decrease in systolic *** theseﬁndings,the clinical condition remains *** is of great importance to use a multidis-ciplinary approach in managing these rare cases that could lead to potential adverse outcomes during the antena-tal or postnatal periods.

关键词： Heart aneurysm prenatal diagnosis echocardiography congenital heart defects left ventricle

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