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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Non-asymptotic Error Bound for Optimal Prediction of Function-on-Function Regression by RKHS Approach

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Acta Mathematica Sinica,English Series 2022年第4期38卷 777-796页

作者： Hong Zhi TOng Ling fang HU Michael ng School of Statistics University of International Business and EconomicsBeijing 100029P.R.China Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong KongP.R.China Department of Mathematics The University of Hong KongPokfulamHong KongP.R.China

In this paper,we study and analyze the regularized least squares for function-on-function regression *** our model,both the predictors(input data)and responses(output data)are multivariate functions(with d variables andd variables respectively),and the model coefficient lies in a reproducing kernel Hilbert space(RKHS).We show under mild condition on the reproducing kernel and input data statistics that the convergence rate of excess prediction risk by the regularized least squares is minimax *** examples based on medical image analysis and atmospheric point spread function estimation are considered and tested,and the results demonstrate that the performance of the proposed model is comparable with that of other testing methods.

关键词： Regularized least squares function-on-function regression non-asymptotic error bound reproducing kernel Hilbert space integral operator

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Kernel Density Estimation Based Multiphase Fuzzy Region Competition Method for Texture Image Segmentation

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Communications in Computational Physics 2010年第8期8卷 623-641页

作者： fang Li Michael K.ng Department of Mathematics East China Normal UniversityShanghai 200241China Centre for Mathematical Imaging and Vision and Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

In this paper,we propose a multiphase fuzzy region competition model for texture image *** the functional,each region is represented by a fuzzy membership function and a probability density function that is estimated by a nonparametric kernel density *** overall algorithm is very efficient as both the fuzzy membership function and the probability density function can be implemented *** apply the proposed method to synthetic and natural texture images,and synthetic aperture radar *** experimental results have shown that the proposed method is competitive with the other state-of-the-art segmentation methods.

关键词： Texture multiphase region competition kernel density estimation fuzzy membership function total variation

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Simultaneous optimization of phononic and electronic transport in two-dimensional Bi2O2Se by defect engineering

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Science China(Information Sciences) 2023年第6期66卷 87-93页

作者： fang y.ng Hong Kuan ng Jing WU yunshan ZHAO Junpeng LU School of Physics Southeast University Institute of Materials Research and Engineering Agency for ScienceTechnology and Research NNU-SULI Thermal Energy Research Center (NSTER) & Center for Quantum Transport and Thermal Energy Science (CQTES) School of Physics and TechnologyNanjing Normal University

Defect engineering represents one degree of freedom to tune the physical and chemical properties of two-dimensional (2D)***,we demonstrate that the thermal and electronic properties of 2D Bi2O2Se can be optimized simultaneously by introducing oxygen defects.2D Bi2O2Se and its oxygendeficient counterpart (Bi2Ox Se,xy synthesized by the chemical vapor deposition(CVD)*** introducing oxygen defects,the thermal conductivity of 2D Bi2O2Se is reduced by nearly three times,achieving an extremely low thermal conductivity of 0.68±0.06 W/mK at room temperature via the thermal bridge *** low thermal conductivity is enabled by the scattering of phonons by targeting of high-,mid-,and low-frequency phonons due to oxygen defects,strong anharmonicity,and nanostructure boundaries,***,the mobility is also improved to 260–500 cm2·V-1·s-1and the usual polar optical phonon scattering in 2D Bi2O2Se is weakened owing to the introduction of oxygen *** results promise potential applications for thermoelectric design,nanoelectronics,and thermal barrier coating devices based on emerging 2D materials.

关键词： 2D Bi$_2$O$_2$Se thermal conductivity oxygens defects phonon scattering mobility

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Design and analysis of Salisbury screens and Jaumann absorbers for solar radiation absorption

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Frontiers in Energy 2018年第1期12卷 158-168页

作者： Xing fang C. y. ZHAO Hua BAO Institute of Engineering Thermophysics Shanghai Jiao Tong UniversityShanghai 200240 China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong University Shanghai 200240 China

Two types of resonance absorbers, i.e., Salis- bury screens and Jaumann absorbers are systematically investigated in solar radiation absorption. Salisbury screen is a metal-dielectric-metal structure which overcomes the drawback of bulky thickness for solar spectrum. Such structures have a good spectral selective absorption property, which is also insensitive to incident angles and polarizations. To further broaden absorption bandwidth, more metal and dielectric films are taken in the structure to form Jaumann absorbers. To design optimized structural parameters, the admittance matching equations have been derived in this paper to give good initial structures, which are valuable for the following optimization. Moreover, the analysis of admittance loci has been conducted to directly show the effect of each layer on the spectral absorptivity, and then the effect of thin films is well understood. Since the fabrication of these layered absorbers is much easier than that of other nanostructured absorbers, Salisbury screen and Jaumann absorbers have a great potential in large-area applications.

关键词： thin films admittance loci solar absorber

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Interface defeat studies of long-rod projectile impacting on ceramic targets

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Defence Technology（防务技术） 2020年第1期16卷 50-68页

作者： y.X.Zhai H.Wu Q.fang Amy Engineering University of PLA Nanjing210007China Research Institute of Structural Engineering and Disaster Reduction College of Civil EngineeringTongji UniversityShanghai200092China

The interface defeat phenomenon always occurs when a long-rod projectile impacting on the ceramic target with certain velocity,i.e.,the projectile is forced to flow radially on the surface of ceramic plates for a period of time without significant *** defeat has a direct effect upon the ballistic performance of the armor piercing projectile,which is studied numerically and theoretically at ***,by modeling the projectiles and ceramic targets with the SPH(Smoothed Particle Hydrodynamics)particles and Lagrange finite elements,the systematic numerical simulations on interface defeat are performed with the commercial finite element program *** different responses,i.e.,complete interface defeat,dwell and direct penetration,are reproduced in different types of ceramic targets(bare,buffered,radially confined and oblique).Furthermore,by adopting the validated numerical algorithms,constitutive models and the corresponding material parameters,the influences of projectile(material,diameter,nose shape),constitutive models of ceramic(JH-1 and JH-2 models),buffer and cover plate(thickness,constraints,material),as well as the prestress acted on the target(radial and hydrostatic) on the interface defeat(transition velocity and dwell time) are syste matically ***,based on the energy conservation approach and taking the strain rate effect of ceramic material into account,a modified model for predicting the upper limit of transition velocity is proposed and *** present work and derived conclusions can provide helpful reference for the design and optimization of both the long-rod projectile and ceramic armor.

关键词： Interface defeat Ceramic Transition velocity Numerical simulation Parametric study

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Taxuchin B,a New Chlorine-Containing Taxoid

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Chinese Chemical Letters 1997年第3期8卷 231-232页

作者： fang, WS fang, QC Liang, XT Lu, y Wu, N Zheng, QT CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJIng UNION MED COLL BEIJING 100050PEOPLES R CHINA

A new taxoid, taxuchin B[1], has been isolated from twigs and needles of Taxus chinensis. It is the first chlorine-containing taxoid reported to date.

关键词： Zhang Chen

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FeCo alloy@N-doped graphitized carbon as an efficient cocatalyst for enhanced photocatalytic H2 evolution by inducing accelerated charge transfer

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Journal of Energy Chemistry 2021年第1期30卷 92-101,I0004页

作者： Sibo Chen yun Hau ng Jihai Liao Qiongzhi Gao Siyuan y.ng Feng Peng Xinhua Zhong yueping fang Shengsen Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510643GuangdongChina School of Energy and Environment City University of Hong KongHongkong 999077China Department of Physics South China University of TechnologyGuangzhou 510640GuangdongChina School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006GuangdongChina

Cocatalysts play important roles in improving the activity and stability of most *** is of great significance to develop economical,efficient and stable ***,using Na2CoFe(CN)6 complex as precursor,a novel noble-metal-free FeCo@ngC cocatalyst(nano-FeCo alloy@N-doped graphitized carbon) is fabricated by a simple pyrolysis *** with g-C3 N4, the optimal FeCo@ngC/g-C3N4 receives a boosted visible light driven photocatalytic H2 evolution rate of 42.2 μmol h-1, which is even higher than that of 1.0 wt% Pt modified g-C3N4 *** on the results of density functional theory(DFT) calculations and practical experiment measurements,such outstanding photocatalytic performance of FeCo@ngC/g-C3N4 is mainly attributed to two *** is the accelerated charge transfer behavior,induced by a photogene rated electrons secondary transfer performance on the surface of FeCo alloy *** other is related to the adjustment of H adsorption energy(approaching the standard hydrogen electrode potential) by the presence of external ngC thin *** factors play key roles in the H2 evolution *** outstanding performance highlights an enormous potential of developing noble-metal-free bimetallic nano-alloy as inexpensive and efficient cocatalysts for solar applications.

关键词： FeCo alloy nanoparticles Cocatalyst N-doped graphitized carbon g-C3N4 Visible light Hydrogen evolution

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Magnetite of Early Ordovician limestone in Tarim and implications for paleomagnetism

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Chinese Science Bulletin 1997年第13期42卷 1110-1113页

作者： Shen, Zy ye, y fang, DJ Department of Earth Sciences Zhejiang University Hangzhou 310027 China

THE Early Ordovician Baiy.ngang Formation limestone in Tarim is characterized by multiplemagnetic components including primary remanent magnetism (PRM) and late remagnetiza-tion. Considerable attention should be paid to its petromagnetic significance. Investigatingthe relationship between these components and the magnetic carriers is important to distin-

关键词： petromagnetism paleomagnetism Baiy.ngang Formation.

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