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非离子聚丙烯酰胺絮凝剂对减水剂分散性能的影响

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铁道建筑技术 2024年第8期 1-4页

作者：檀军锋杨雷 Serina ng 李想东宋欣罗鑫陈福现中铁京诚工程检测有限公司北京104442 石家庄市长安育才建材有限公司河北石家庄051430 四川砼道科技有限公司四川成都610200 中铁二十二局集团有限公司北京100043

本文选用非离子聚丙烯酰胺絮凝剂和不同侧链长度、酸醚比的聚羧酸减水剂、萘系减水剂,通过试验研究聚丙烯酰胺与减水剂之间的相互作用及对减水剂分散性能的影响。研究结果:随聚丙烯酰胺含量增加,减水剂的初始分散性能和保持性能均随之下... 详细信息

本文选用非离子聚丙烯酰胺絮凝剂和不同侧链长度、酸醚比的聚羧酸减水剂、萘系减水剂,通过试验研究聚丙烯酰胺与减水剂之间的相互作用及对减水剂分散性能的影响。研究结果:随聚丙烯酰胺含量增加,减水剂的初始分散性能和保持性能均随之下降,而萘系减水剂所受影响较小;随聚羧酸侧链长度增加,聚羧酸减水剂的初始分散性能和保持性能下降严重;随聚羧酸酸醚比增加,各种聚羧酸减水剂的初始分散性能和保持性能受聚丙烯酰胺的影响差距不大;聚羧酸减水剂先吸附于水泥颗粒上,侧链再与聚丙烯酰胺通过氢键相互作用、缠结,从而降低了减水剂的空间位阻效应,随水泥水化更易被水化产物覆盖。

关键词：非离子聚丙烯酰胺絮凝剂减水剂侧链长度酸醚比

政府多工具组合优惠对企业创新行为的影响研究

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中国管理科学 2024年第2期32卷 221-230页

作者：赵凯李磊青岛大学经济学院山东青岛266075 华侨大学统计学院福建厦门361021

为提高政府创新政策运作的协调性与实施的高效性,挖掘出能够有效激励企业创新的最优政策工具“组合拳”策略,本文基于2009—2019年我国沪深A股上市企业数据,着重考察和比较直接补贴、税收优惠和政府采购这三种创新政策工具及其组合对企... 详细信息

为提高政府创新政策运作的协调性与实施的高效性,挖掘出能够有效激励企业创新的最优政策工具“组合拳”策略,本文基于2009—2019年我国沪深A股上市企业数据,着重考察和比较直接补贴、税收优惠和政府采购这三种创新政策工具及其组合对企业创新行为的影响,揭示政府多工具组合优惠策略对异质性企业创新的效果差异。结果显示,由直接补贴、税收优惠和政府采购构成的多工具组合优惠策略,无论是在激励企业创新投入还是提升企业创新质量方面,皆为政府最优的实施策略,并且该策略对于激励国有企业创新的效果尤为明显。

关键词：多工具组合优惠多水平处理效应模型政府采购税收优惠实质性创新

Effects of dual antiplatelet therapy de-escalation on the prognosis of acute coronary syndrome patients at high risk of ischemia who underwent percutaneous coronary intervention

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Chinese Medical Journal 2024年第6期137卷 746-748页

作者： Jingyao Wang yachao Li Mengjie lei yanli y.ng Haiyan Gao Xiangjin Wang lei An Haili Zhou Xue Sun Cairong Li Zhigang Zhao Zengming Xue Department of Cardiology Langfang People’s HospitalHebei Medical UniversityLangfang Core Laboratory of Precision Treatment of Coronary Artery DiseaseLangfangHebei 065000China

To the Editor:Current guidelines recommend that for patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI),dual antiplatelet therapy(DAPT),preferably involving powerful P2y_(12) receptor inhibitors,including ticagrelor or prasugrel,should be used for at least 12 months.^([1–3])However,there is a lack of relevant evidence regarding the feasibility of de-escalation treatment and specific DAPT treatment regimens for ACS patient populations with high ischemic risk.

关键词： coronary patients acute

Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations

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Zoological Research 2024年第1期45卷 69-78页

作者： Shun Wang Peng Zhang Fan Fei Tiany.ng Tong Xiujuan Zhou yajie Zhou Jing Zhang Mengke Wei yanqi Zhang lei Zhang yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui 230032China Department of Mechanical and Aerospace Engineering University at BuffaloState University of New YorkBuffaloNY 14260 USA International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China

Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance *** species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same *** highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate ***,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly *** the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence ***,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic *** findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.

关键词： Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein

Efficient inhibition of SARS-CoV-2 emerging EG.5,EG.5.1 and BA.2.86 variants by fusion inhibitor Hy3000 peptide

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hLife 2024年第1期2卷 43-46页

作者： Lili Wu Anqi Zheng y.ngming Tang Xiaoyun Wang yue Gao Wenwen lei Guizhen Wu Qihui Wang George Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina University of the Chinese Academy of Sciences BeijingChina Hybio Pharmaceutical Co. Ltd.GuangdongChina College of Life Science Hebei UniversityHebeiChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and ***,the Omicron EG.5 linage,which was first detected in Indonesia on 17 February 2023,has raised concerns due to its increased prevalence and extended immune escape properties,according to the risk analysis by the World Health Organization(WHO)[1].As of 3 October 2023,EG.5 and its sub-linages have been reported in 83 countries with shared 49,008 genome sequences in GISAID database(https://***/hcov19-variants/).EG.5 has become the dominant strain in the United States according to Centers for Disease Control and Prevention(CDC),accounting for 29.4%of SARS-CoV-2 infections(https://***/covid-data-tracker/#variant-proportions).

关键词： acute respiratory variants

TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

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Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SOng Dong-lei SUN Chen-y.ng LI yu-xin LUO Qian LIU yue yAO Hong ZHAng Ting-ting y.ng Mei SOng Xin-li BAI Xiao-lan ZHAng Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1

Analysis of the Heavy Rainfall Process in Mangshi City on August 8, 2023

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Meteorological and Environmental Research 2024年第2期15卷 48-54,61页

作者： yan yU Bowen LIU Wan GOng Shuxuan HE lei WEI Dehong Meteorological Observatory Dehong 678400China yunnan Meteorological Observatory Kunming 650034China Key Laboratory of Heavy Rainfall in River Basins China Meteorological AdministrationWuhan 430205China Research Center for Disastrous Weather over Hengduan Mountains&Low-Latitude Plateau China Meteorological AdministrationKunming 650034China yunnan Institute of Geological Environment Monitoring Kunming 650216China

On August 7,2023,Mangshi City,Dehong Prefecture experienced a local heavy rainstorm,and the geological disaster caused by the heavy rainfall caused casualties and property *** on the real-time observation data of automatic stations,Doppler weather radar detection and meteorological risk warning products,the disaster situation,social impact,forecast and early warning service,causes of heavy precipitation and forecast and early warning inspection were summarized and *** results show that the heavy rainfall was prominent locally,lasted for a long time and accumulated a large amount of *** were biases in model products,and it was difficult for forecasters to make subjective corrections in complex *** analysis ideas and focus points of heavy rainfall forecast,the improvement ideas and technical schemes of forecast deviation,and the improvement ideas and suggestions of services were *** provides a reference for the forecast and early warning of severe weather in the future.

关键词： Heavy rainfall Low-pressure inverted trough Geological disaster Forecast deviation

Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1412-1427页

作者： Jianpei Xu yinzhe Sun y.ng you yuwen Zhang Dan Huang Songlei Zhou yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang lei Zhihua Wang Xiaoling Gao Jun Chen Shanghai Pudong Hospital&Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Emergency Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Institute of Science and Technology for Brain-Inspired Intelligence&Department of Neurology Fudan UniversityShanghai 201203China Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 201203China Daxing Research Institute University of Science and Technology BeijingBiomedical Industry BaseZhongguancun Science and Technology ParkBeijing 102600China Cellular Biomedicine Group Inc. Shanghai 201210China

Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical *** levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’*** on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC *** system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective *** this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for ***,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate *** engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 *** vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.

关键词： Ischemic stroke Mesenchymal stem cell Cell engineering Hormesis effect Bioorthogonal chemistry Microglia Reactive oxygen spices Proinflammatory cytokines

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun Zhang yue-Mei Zhao lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang Tom yuan yaozuo yuan Mei Zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identify.ng stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation