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Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

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Neural Regeneration Research 2022年第12期17卷 2643-2648页

作者： Ling-Ping cen Tsz Kin ng Wai Kit Chu Chi Pui Pang Joint Shantou International Eye center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Both inflammation and anti-inflammation are involved in the protection of retinal *** of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic *** effects are also found in ocular inflammatory and neurologic injury *** experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental *** review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

关键词： neuroprotection ocular inflammation optic nerve injury retinal ganglion cells uveitis

An Efficient and Convenient Cyclization Method for the Synthesis of Flavans

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Chinese Chemical Letters 1998年第9期9卷 805-807页

作者： Hou, LM Huang, CS cen, W Li, y Li, yL Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China Qingdao Univ Dept Chem Qingdao 266071 Peoples R China

A convenient cyclization method for the flavans synthesis is described. BF3 was used for the first time as an efficient catalyst to effect the cyclization of 1,3-diarylpropan-1-ols.

关键词： flavans cyclization synthesis

A modified spontaneous emulsification solvent diffusion method for the preparation of curcumin-loaded PLGA nanoparticles with enhanced in vitro anti-tumor activity

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Frontiers of Materials Science 2014年第4期8卷 332-342页

作者： cen CHEN Institute of Biomaterials and Marine Biological Resources College of Life Sciences Zhejiang Sci-Tech University Hangzhou 310018 China Bio-X center Zhejiang Sci-Tech University Hangzhou 310018 China

To improve the anti-tumor activity of hydrophobic drug curcumin, we prepared curcumin-loaded PLGA nanoparticles （PLGA-Cur NPs） through a modified spontaneous emulsification solvent diffusion （modified-SESD） method. The influence of main preparation parameters was investigated, such as the volume ratio of binary organic solvents and the concentration of surfactant. Results indicated that the synthesized regular spherical PLGA NPs with the average diameter of 189.7 nm exhibited relatively higher yield （58.9%）, drug loading （11.0% （w/w）） and encapsulation efficiency （33.5%）, and also a controllable drug release profile. In order to evaluate the in vitro cytotoxicity of the prepared NPs, MTT assay was conducted, and results showed that the NPs could effectively inhibit HL60 and HepG2 cells with lower IC50 values compared with free curcumin. Furthermore, confocal microscopy together with flow cytometry analysis proved the enhanced apoptosis-inducing ability of PLGA-Cur NPs. Polymeric NP formulations are potential to be used for hydrophobic drug delivery systems in cancer therapy.

关键词： curcumin PLGA nanoparticle modified spontaneous emulsificationsolvent diffusion (modified-SESD) anti-tumor

Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth

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Neural Regeneration Research 2021年第6期16卷 1121-1126页

作者： Jia-Jian Liang yu-Fen Liu Tsz Kin ng Ci-yan Xu Mingzhi Zhang Chi Pui Pang Ling-Ping cen Joint Shantou International Eye center of Shantou University and the Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or ***,the effects and mechanisms of macrophage activation on neuronal survival remain *** the present study,we co-cultured adult Fischer rat retinas with primary peritoneal macrophages or zymosan-treated peritoneal macrophages for 7 *** analysis revealed that peritoneal macrophages reduced retinal ganglion cell survival and neurite outgrowth in the retinal explant compared with the control *** addition of zymosan to peritoneal macrophages attenuated the survival and neurite outgrowth of retinal ganglion *** media from peritoneal macrophages also reduced retinal ganglion cell survival and neurite *** result suggests that secretions from peritoneal macrophages mediate the inhibitory effects of these *** addition,increased inflammationand oxidation-related gene expression may be related to the enhanced retinal ganglion cell degeneration caused by zymosan *** summary,this study revealed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth,and that macrophage activation further aggravated retinal ganglion cell *** study was approved by the Animal Ethics Committee of the Joint Shantou International Eye center of Shantou University and the Chinese University of Hong Kong,Shantou,Guangdong Province,China,on March 11,2014(approval ***20140311(2)-P01).

关键词： in vitro inflammation macrophages model neurite outgrowth optic nerve retinal ganglion cells survival

NUMERICAL INVESTIGATION ON FLOW CHARACTERISTICS IN RIBBED BEND

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Journal of Hydrodynamics 2001年第2期13卷 111-120页

作者： yao, J. Fan, J.R. Zhang, X.y. cen, K.F. Dept. of Energy Engineering Zhejiang Univ. Hangzhou 310027 China

Previous research by the author has proved that ribbed bend technology is a simple and efficient anti-erosion method. The present paper is a further study to unveil the mechanism of the technology by using numerical method. The flow characteristics in ribbed bend were studied. A k-Ε turbulence model was used and the simulations were carried out in the body-fitted coordinates. This procedure was confirmed to be credible by showing the satisfactory agreement between the predications and experimental results. It is concluded that the character of the longitudinal flow in ribbed bend especially in the concave parts between ribs has a beneficial effect on increasing the anti-erosion ability of ribbed bend but the secondary flow has little effect on determining the particle trajectory.

关键词： Boundary conditions Differential equations Erosion Mathematical models Numerical methods Three dimensional

Synthesis and enhanced luminescence properties of double perovskite NaLa0.95-xyxEu0.05MgWO6 phosphors

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Rare Metals 2020年第8期39卷 895-901页

作者： Jing Zhang Jia-Lin Shen Nai-cen Xu Nanjing center China Geological SurveyNanjing 210016China Supervision and Testing center of East China Mineral Resources of the Ministry of Land and ResourcesNanjing 210016China

Double perovskite Na(La,y)MgWO6:Eu3+phosphors were obtained by the sol-gel method.X-ray diffractometer(XRD)patterns,scanning electron microscopy(SEM)images and photoluminescence properties were carried out to study the effect of polyethylene glycol(PEG).Enhanced optical properties were obtained by adding 3 wt%PEG under the excitation of 395 nm.y3+with smaller radius was selected to substitute La3+in this host to decrease the symmetry and further enhance the luminescence *** y3+concentration increasing,Na2WO4 and y30W8O69 phases came *** emission spectra showed different shapes,and the emission intensity was enhanced by doping y3+.Under the excitation of 395 and 465 nm,the emission intensity reached the *** Commission Internationale de L’Eclairage(CIE)coordinates of the phosphors were on the edge of the CIE diagram,illustrating that this double perovskite phosphor showed good color *** luminescence properties showed that the synthesized phosphors had great potential in solid-state lighting.

关键词： Double perovskite Structure evolution Phosphors White light emitting diodes

Spatio-temporal variations of harmful algal blooms along the coast of Guangdong,Southern China during 1980–2016

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Journal of Oceanology and Limnology 2019年第2期37卷 535-551页

作者： LI Li Lü Songhui cen Jingyi College of Life Science and Technology Jinan University Guangzhou 510632 China Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes Jinan University Guangzhou 510632 China

Harmful algal blooms (HABs) have become a recurring problem, posing severe impacts on marine ecosystems, fisheries, mariculture industry, and even public health. In this study, the geographic information system (GIS) was utilized to determine spatial and temporal characteristics of HAB events in the coastal waters of Guangdong from 1980–2016. We analyzed distribution patterns and characteristics of HABs by dividing the coast of Guangdong into well-known bays, estuary and coastal waters. Results showed that there were a total of 337 HABs recorded in Guangdong coastal waters. Spatial and temporal distributions varied among diff erent regions. Most HABs occurred in the Mirs Bay, followed by the west coast of Daya Bay, while a few occurred in the west and east coasts of Guangdong but with an increasing trend in the past two decades. HABs occurred mostly in warmer months of March to May in the western coast of Guangdong, March and April in Mirs Bay, April in Zhujiang (Pearl) River estuary, November in eastern coast of Guangdong. For Daya Bay, most HABs were reported between March and September. The most frequently occurring HABs species were Noctiluca scintillans , Phaeocystis globosa , Skeletonema costatum and Scrippsiella trochoidea , occurring mostly in Mirs Bay, western Guangdong coast area, eastern Guangdong coast area and Zhujiang River estuary and Daya Bay, respectively. Ichthyotoxic blooms were more common than toxic blooms, and Heterosigma akashiwo , Chattonella marina , Karenia mikimotoi and P haeocystis globosa were the most common ichthyotoxic species. Our results provide baseline information useful for policy making and management of HABs in the region.

关键词： harmful algal blooms Guangdong Province distribution geographic information system (GIS) kernel density estimation

Probing the top quark flavor-changing couplings at CEPC

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Chinese Physics C 2019年第11期43卷 36-48页

作者： Liaoshan Shi cen Zhang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

We propose to study the flavor properties of the top quark at the future Circular Electron Positron Collider(CEPC) in *** systematically consider the full set of 56 real parameters that characterize the flavor-changing neutral interactions of the top quark,which can be tested at CEPC in the single top production *** with the current bounds from the LEP2 data and the projected limits at the high-luminosity LHC,we find that CEPC could improve the limits of the four-fermion flavor-changing coefficients by one to two orders of magnitude,and would also provide similar sensitivity for the two-fermion flavor-changing ***,CEPC could explore a large fraction of currently allowed parameter space that will not be covered by the LHC *** show that the c-jet tagging capacity at CEPC could further improve its sensitivity to top-charm flavor-changing *** a signal is observed,the kinematic distribution as well as the c-jet tagging could be exploited to pinpoint the various flavor-changing couplings,providing valuable information about the flavor properties of the top quark.

关键词： top quark flavor-changing neutral current lepton collider

Ability to detect and locate gross errors on DEM matching algorithm

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International Journal of Digital Earth 2010年第1期3卷 72-82页

作者： T.Zhang M.cen Z.Ren R.y.ng y.Feng J.Zhu Department of Survey.ng Engineering School of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China College of Earth Sciences Chengdu University of TechnologyChengdu 610051China

Digital elevation model(DEM)matching techniques have been extended to DEM deformation detection by substituting a robust estimator for the least squares estimator,in which terrain changes are treated as gross ***,all existing methods only emphasise their deformation detecting ability,and neglect another important aspect:only when the gross error can be detected and located,can this system be *** paper employs the gross error judgement matrix as a tool to make an in-depth analysis of this *** theoretical analyses and experimental results show that observations in the DEM matching algorithm in real applications have the ability to detect and locate gross ***,treating the terrain changes as gross errors is theoretically feasible,allowing real DEM deformations to be detected by employ.ng a surface matching technique.

关键词： DEM matching gross error detection gross error location gross error judgement matrix least z-different algorithm deformation detection robust estimator