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Dysfunction of synaptic endocytic trafficking in Parkinson's disease

Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin yi ng Mian cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dy.ng back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SyNJ1/PARK20).The mouse models carry.ng these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

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Geek Talents:Who are the Top Experts on GitHub and Stack Overflow?

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Computers, Materials & Continua 2019年第8期61卷 465-479页

作者： yijun Tian Waii ng Jialiang cao Suzanne McIntosh New york University Courant Institute of Mathematical SciencesNew York10012USA

In the field of Computer Science,software developers need to use a wide array of social collaborative platforms for learning and *** most popular ones are GitHub and Stack *** platforms only support search queries to extract relevant repository information from GitHub,or questions and answers from Stack *** ignores the valuable coder-related part-who are the top experts(geek talents)in a specific area?This information is important to companies,open source projects,and to those who want to learn from an expert role ***,how to find the right developers is quite a crucial yet challenging *** of the current works mainly focus on recommending experts in a particular software engineering task and ignore the relationship between developers within different *** this paper,we propose a novel technique that automatically identifies geek talents from GitHub,Stack Overflow,and across both *** results show that our work performs well at recommending proper developers in diverse areas.

关键词： Developer recommendation collaborative filtering stack overflow GitHub

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Study on ceramic photonic bandgap structure with three-dimensional diamond lattice

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Journal of University of Science and Technology Beijing 2006年第5期13卷 461-464页

作者： Haiqing yin Wenbin cao y. Miyamoto Material Science and Engineering School University of Science and Technology Beijing Beijing 100083 China Joining and Welding Research Institute Osaka University Osaka 567-0047 Japan

A novel process, which was based on powder injection molding, was investigated for the fabrication of ceramic photonic bandgap structure with three-dimensional diamond lattice. The SiO2-TiO2 ceramic powder was mixed with a water-soluble agent to produce slurry. The slurry was then injected into an epoxy mold with inverse diamond lattice, fabricated by the stereolitographic rapid prototyping process. To increase the density of the green compact, cold isostatic pressing was applied on the unit. Using thermal debinding, the water-soluble agent and the epoxy were extracted at 360 and 650 K, respectively. Sintering was immediately done at 950 K for 5 h and the desired three-dimensional ceramic structure was obtained. The calculated band diagram for this structure indicated the existence of an absolute photonic bandgap for all wave vectors. At 14.7-18.5 GHz, a complete band gap was located with a maximum attenuation of 30 dB at 17 GHz, when transmission was measured in the 〈100〉 direction between 10 and 20 GHz.

关键词： photonic crystals (PCs) powder injection molding ceramic powder diamond lattice

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Low temperature oxidation of Cr-alloyed MoSi_2

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中国有色金属学会会刊：英文版 2007年第6期17卷 1282-1286页

作者： E. Strom y. cao y. M. yao Kanthal AB Box 502 SE-734 27 Hallstahammar Sweden Department of Materials and Manufacturing Technology Chalmers University Technology SE-412 96 Gothenburg Sweden

Cr-alloyed MoSi2 was compared with monolithic MoSi2 with respect to oxidation at 450 ℃ for 456 h. Phases formed on Cr-alloyed MoSi2 after exposure are Cr2(MoO4)3, MoO3, and cristobalite (SiO2) according to X-ray diffraction results. Monolithic MoSi2 forms MoO3 and mainly amorphous SiO2. X-ray photoelectron spectroscopy indicates that the main oxidation product on the outermost surface is SiO2 for all studied samples. The samples form a relatively loose oxide but the oxide adherence improves with increasing Cr content. It is indicated that Cr addition can benefit pesting control in MoSi2.

关键词：钼硅化合物合金有害物氧化作用

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A NEW CHROME GLyCOSIDE FROM SMILAX GLABRA ROXB

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Chinese Chemical Letters 1995年第7期6卷 587-588页

作者： cao, ZZ yi, yJ cao, y Leng, ZK Nanjing Inst Mat Med Nanjing 210009 Peoples R China

A new chrome glycoside, 5,7-dihydroxychromone-3-O-L-rhamnopyranoside, named smiglanin, was isolated from the root of Smilax glabra collected in Lanxi, Zhejiang province. Its structure was elucidated by special data an...

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Synthesis of dimethyl 3-perfluoroalkyl-4-(3-oxo-2-triphenyl-phosphoranylidenbutanylidene)-pent-2-enedioate and its cyclization

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Chinese Journal of Chemistry 1995年第5期13卷 468-474页

作者： Ding, Wy cao, WG yao, y Zhu, ZM SHAngHAI UNIV SCI & TECHNOL DEPT CHEMSHANGHAI 201800PEOPLES R CHINA

The title compounds 5a-5c were prepared via the reaction of methyl 2-perfluoroalkynoates (4) with methyl 5-oxo-4-(triphenylphosphoranylidene)hex-2-enoate (3), which was obtained from the reaction of methyl propynate (2) with acetylmethylenetriphenylphosphorane (1) at -5-0 degrees C. Intramolecular elimination of Ph(3)PO took place when compound 5 was heated in aqueous methanol at 115-120 degrees C in sealed tube, yielding dimethyl 2-trifluoromethyl-4-methylisophthalate (6a) from 5a and methyl 5-acetyl-4-hydroxy-2-heptafluoropropanylbenzoate (6b) from 5b, respectively. The structures of compounds 5, 6a and 6b were confirmed by IR, MS, H-1 NMR, F-19 NMR and C-13 NMR spectroscopy and elemental analyses. Rection mechanisms for the formation of compounds 5, 6a and 6b were proposed.

关键词： phosphorane polysubstituted arene intramolecular cyclization

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Study on Rotational Effects of Modern Turbine Blade on Coolant Injecting Nozzle Position with Film Cooling and Vortex Composite Performance

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Frontiers in Heat and Mass Transfer 2023年第1期21卷 1-31页

作者： JiefengWang Eddie yin Kwee ng Jianwu Li yanhao cao yanan Huang Liang Li School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China School of Mechanical and Aerospace Engineering College of EngineeringNanyang Technological University639798Singapore Shaanxi Engineering Laboratory of Turbomachinery and Power Equipment Xi’an710049China

The flow structure of the vortex cooling is asymmetrical compared to the traditional gas turbine leading edge cooling,such as the impingement cooling and the axial flow *** asymmetrical property will affect the cooling performance in the blade leading edge,whereas such effects are not found in most of the studies on vortex cooling due to the neglect of the mainstream flow in the airfoil *** study involves the mainstream flow field and the rotational effects based on the profile of the GE E3 blade to reveal the mechanism of the asymmetrical flow structure *** nozzle position on the characteristics of the vortex and film composite cooling in the turbine rotating blade leading edge is numerically *** cool-ant injecting nozzles are set at the side of the pressure surface(PS-side-in)*** is set at the side of the suction surface(SS-side-in)to compare the cooling characteristics at the rotating speed range of 0–4000 rpm with fluid and thermal conjugate *** show that the nozzle position presents different influences under low and higher rotational *** for the mainstream flow,rotation makes the stagnation line move from the pressure surface side to the suction surface side,which changes the coolant film attachment on the blade leading edge *** position of nozzles,however,indicates limited influence on the coolant film *** for the internal channel vortex flow characteristics,the coolant injected from the nozzles forms a high-velocity region near the target wall,which brings about enhancing convective heat *** flow direction of the vortex flow near the internal channel wall is opposite and aligns with the direction of Coriolis force in both the PS-side-in and SS-side-in,***,the Coriolis force augments the convective heat transfer intensity of the vortex cooling in the internal channel in SS-side-in while weakening the internal heat transfer in *** effects become mo

关键词： Vortex cooling injecting nozzle location gas turbine blade film cooling

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PROPERTIES　OF　ULTRAFINE　SnOx　THIN　FILM　MADE　By　PLASMA　POLyMERIZATION

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Chinese Chemical Letters 1996年第5期7卷 493-494页

作者： Zhang, y Zhou, KL cao, WM Liu, WM ACAD SINICA CHENGDU INST ORGAN CHEMCHENGDU 610011PEOPLES R CHINA ACAD SINICA LANZHOU INST CHEM PHYSLAB SOLID LUBRICATLANZHOU 730000PEOPLES R CHINA

Abstract: Ultrafine SnOx thin films were prepared from tetrabtltyltin by RF glow dis charge polymerization. Annealing behaviour of films under air and gas-sensitive probesty were investigated. The ultrafine SnOx thin film with average part ide size of 6nm exhibited a high sensitivity of 30 to 500ppm EtOH at 200℃.

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Accelerated Approach to the Synthesis of Fluoriated Polyether Dendrimers

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Chinese Chemical Letters 1998年第9期9卷 809-812页

作者： cao, XP Li, XH Chow, HF Li, y Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China Chinese Univ Hong Kong Dept Chem Shatin NT Hong Kong

Fluorinated polyether dendritic sectors 4, 7 and 10 from the first to the third generations, respectively, were prepared by a convergent approach from readily available pentafluorophenol, phloroglucinol and 1,3-dibromopropane. These dendritic sectors have good solubility properties and are stable in both acidic and basic media. Hence they are useful dendritic building blocks for the preparation of functional dendrimers.

关键词： synthesis fluoriated polyether dendrimers

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Great wall of solar panels to mitigate yellow dust storm

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Particuology 2014年第2期12卷 146-149页

作者： David y.H.Pui Junji cao Zhisheng An Jing Wang University of Minnesota Department of Mechanical EngineeringMinneapolisMN 55455USA Institute of Earth Environment Chinese Academy of Sciences ETH Zurich Institute of Environmental Engineering8093 ZurichSwitzerland EMPA Analytical Chemistry8600 Dubendorf Switzerland

Mitigation of the large scale yellow dust storm is a serious problem facing China. We propose the approach of building windbreak walls equipped with solar panels in the proximity of dust origins. The solar panels generate electricity in the sunny days; the walls break the wind and remove airborne dusts based on the impactor principle during wind storms. Preliminary calculation indicates the walls may be able to remove the major fraction of the airborne dusts and the generated electricity could be significant. More detailed studies are needed to prove the feasibility of the approach.

关键词： Solar panels Dust storm Mitigation Windbreak Sustainable development

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