检索结果-南通市图书馆

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

在线全文

学校读者我要写书评

暂无评论

nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu zhao Hang Ma Conghui Zhang y.ngxin y.ng Shuyuan yu Haiye Zhu y.ngjiang Sun Hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China y.nnan y.ntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and n-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

Salsolinol as an RnA m~6A methylation inducer mediates dopaminergic neuronal death by regulating yAP1 and autophagy

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang yuanyuan Ran Zihan Li Tianyuan zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of n~6-methyladenosine(m~6A)RnA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RnA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader yTH domain-containing family protein 2(yTHDF2)promoted the degradation of m~6A-containing yes-associated protein 1(yAP1)mRnA,which is a downstream key effector in the Hippo signaling ***,downregulation of yAP1 promoted autophagy,indicating that the mutual regulation between yAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RnA methylation and suggest that Sal may act as an RnA methylation inducer mediating dopaminergic neuronal death through yAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RnA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RnA methylation salsolinol yAP1 yTHDF2

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of n-acetyl-alpha-glucosaminidase to Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan zhao yidan Zhang Xin Liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng y.ng Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DnA,mRnA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified n-acetyl-alpha-glucosaminidase as a differentially expressed protein.n-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal n-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that n-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that n-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,n-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal n-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that n-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes n-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

High-performance poly(aromatic pyridine) copolymers with crown ether moieties for high temperature polymer electrolyte membrane fuel cells

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Qian Wang Songhao zhao y.npeng Guo Wei Wei Lele Wang Jingshuai y.ng Department of Chemistry College of Sciences Northeastern University Institute of Metal Research Chinese Academy of Sciences

This study concentrates on the development of high temperature polymer electrolyte membranes（HT-PEMs）, which are essential components for HT-PEM fuel cells（HT-PEMFCs）. Although the phosphoric acid（PA）-doped polybenzimidazole（PBI） has been regarded as the successful HT-PEM, this system still suffers from several challenges, including the use of carcinogenic monomers, complex synthesis procedures, and poor solubility in organic solvents. To develop more cost-effective, readily synthesized and high-performance alternatives, this study employs a simply superacid-catalyzed Friedel-Crafts reaction to synthesize a series of poly（triphenyl-co-dibenzo-18-crown-6 pyridine） copolymers, denoted as P(TPx%-co-CEy%), using ptriphenyl, dibenzo-18-crown-6 and 4-acetylpyridine as monomers. The copolymerized hydrophilic and bulky crown ether unites introduce large free volumes and multiple interaction sites with PA molecules, as elucidated by theoretical *** microphase separation structures are formed as confirmed by atomic force microscope（AFM）, transmission electron microscopy（TEM） and small-angle X-ray scattering（SAXS）. Thus P(TPx%-co-CEy%) membranes exhibit excellent PA absorption and proton conduction abilities. For example, after immersing in 85 wt% PA at 30 °C, the P(TP91%-co-CE9%) membrane achieves a PA doping content of 205% and a high conductivity of 0.138 S cm-1at 180 °C, while maintaining a tensile strength of 7.5 MPa at room temperature. Without humidification and backpressure, the peak power density of an H2-O2cell equipped with P(TP91%-co-CE9%)/205%PA reaches nearly 1200 mW cm-2, representing one of the highest performances reported for PA-doped HT-PEMs to date. This work demonstrates the enormous potential of poly（triphenyl-co-crown ether pyridine） membranes in the HT-PEMFC applications.

关键词：

The Role of TnF Related Apoptosis-Inducing Ligand in neurodegenerative Diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2005年第2期2卷 113-122页

作者： y.Huang n.Erdmann H.Peng y.zhao ThelaboratoryofneurotoxicologyattheCenterforneurovirology.neurodegenerativeDisorders ／／Dept.Pharmacology Dept.ofSurgery UniversityofNebraskaMedicalCenterOmahaNE68198-5880USA／／InstituteofAnimalResearchChineseAcademyofScienceChina

A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions,and in many cases neuronal cell *** the etiology of neurodegenerative diseases may be distinct,different diseases display a similar pathogenesis,for example abnormal immunity within the central nervous system(CnS),activation of macrophage/microglia and the involvement of proinflammatory *** studies show that neurons in a neurodegenerative state undergo a highly regulated programmed cell death,also called ***-related apoptosis-inducing ligand(TRAIL),a member of the TnF family,has been shown to be involved in apoptosis during many *** one member of a death ligand family,TRAIL was originally thought to target only tumor cells and was not present in ***,recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages,a major disease inducing cell during HIV-1-assoeiated dementia(HAD).TRAIL is also induced on neuron by β-amyloid protein,an important pathogen for Alzheimer's *** this review,we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases,TRAIL induced apoptosis signaling in the CnS cells,and specific role of TRAIL in individual *** & Molecular Immunology.2005;2(2):113-122.

关键词： Alzheimer's disease HⅣ-1 associated dementia multiple sclerosis apoptosis TRAIL macrophage

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： y.nxi Li Jing Xue yuejia Ma Ke ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Day.ng Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

n6-methyladenosine(m^(6)A), the most prevalent and conserved RnA modification in eukaryotic cells, profoundly influences virtually all aspects of mRnA metabolism. mRnA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RnA methylation

Equivariant PT-symmetric real Chern insulators

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2020年第1期15卷 63-69,F0004页

作者： y.X.zhao national laboratory of solid state microstructures and department of physics nanjing universitynanjing 210093china Collaborative innovation center of advanced microstructures nanjing universitynanjing 210093china

It was understood that Chern insulators cannot be realized in the presence of PT *** this paper,we reveal a new class of PT-symmetric Chern insulators,which has internal degrees of freedom forming real representations of a symmetry group with a complex endomorphism *** a generalization to the conventional 2n-dimensional Chern insulators with integer n≥1,these PT-symmetric Chern insulators have the n-th complex Chern number as their topological invariant,and have a Z classification given by the equivariant orthogonal K ***,in a fairly different sense,there exist ubiquitously Chern insulators with *** generalizing the Thouless charge pump argument,we find that,for a PT-symmetric Chern insulator with Chern number *** are equally many v flavors of coexisting left-and right-handed chiral *** modes with opposite chirality are complex conjugates to each other as complex representations of the internal symmetry group,but are not *** the physical dimensionality d=2,the PT-symmetric Chern insulators may be realized in artificial systems including photonic crystals and periodic mechanical systems.

关键词： topological insulator Chern insulator

MUSCL TyPE SCHEMES AnD DISCRETE EnTROPy COnDITIOnS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 1997年第1期15卷 72-80页

作者： zhao, n Wu, HM nAnJInG UnIV DEPT AERODYNAMNANJING 210008PEOPLES R CHINA CHInESE ACAD SCI STATE KEY LAB SCI & ENGN COMPICMSECBEIJINGPEOPLES R CHINA

In this paper, the semi-discrete entropy conditions with so called the proper discrete entropy flux of a class of high resolution MUSCL type schemes are discussed for genuinely.nonlinear scalar conservation laws. It is shown that the high resolution schemes satisfy.ng such;semi-discrete entropy conditions cannot preserve second order accuracy in the rarefaction region.

关键词： Computational fluid dynamics Convergence of numerical methods nonlinear equations numerical methods

A ESTIMATE OF THE RATE OF EnTROPy DISSIPATIOn OF HIGH RESOLUTIOn MUSCL TyPE GODUnOV SCHEMES

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 1999年第4期17卷 369-378页

作者： Tang, HZ zhao, n Chinese Acad Sci ICMSEC State Key Lab Sci & Engn Comp Beijing 100080 Peoples R China nanjing Univ Aeronaut & Astronaut Dept Aerodynam Nanjing 210016 Peoples R China

In this paper, following the paper [7], we analysis the 'sharp' estimate of the rate of entropy dissipation of the fully discrete MUSCL type Godunov schemes by the general compact theory introduced by Coquel-LeFloch [1, 2], and find: because of small viscosity of the above schemes, in the vincity of shock wave, the estimate of the above schemes is more easily obtained, but for rarefaction wave, we must impose a 'sharp' condition on limiter function in order to keep its entropy dissipation and its convergence.

关键词： hyperbolic conservation laws MUSCL type Godunov schemes entropy dissipation shock wave rarefaction wave