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Salsolinol as an RnA m~6A methylation inducer mediates dopaminergic neuronal death by regulating yAP1 and autophagy

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neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang yuanyuan Ran Zihan li Tianyuan Zhao Fangfang zhang Juan Wang Zongjian liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of n~6-methyladenosine(m~6A)RnA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(AlKBH5).RnA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader yTH domain-containing family protein 2(yTHDF2)promoted the degradation of m~6A-containing yes-associated protein 1(yAP1)mRnA,which is a downstream key effector in the Hippo signaling ***,downregulation of yAP1 promoted autophagy,indicating that the mutual regulation between yAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RnA methylation and suggest that Sal may act as an RnA methylation inducer mediating dopaminergic neuronal death through yAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RnA methylation in the pathogenesis of Parkinson's disease.

关键词： AlKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RnA methylation salsolinol yAP1 yTHDF2

Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by Hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English letters) 2024年第2期37卷 255-265页

作者： X.y.yue S.y.Peng X.zhang C.n.He y.Z.Tian Key laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite Hot-pressed sintering Thermal stability Strength Electrical conductivity

nanograting‑Based Dynamic Structural Colors Using Heterogeneous Materials

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nano-Micro letters 2025年第3期17卷 138-151页

作者： Jingang Wang Haibo yu Jianchen Zheng yuzhao zhang Hongji Guo ye Qiu Xiaoduo Wang yongliang yang lianqing liu State Key laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Dynamic structuralcolors can change in response todifferent environmental *** ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,providing a promising sensingmechanism for solving microenvironmentalsensing problems inmicro-robotics and ***, the lack of dynamicstructural colors that can encoderapidly, easily integrate, and accuratelyreflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensionaldynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogelwith an IP-l photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollenstate, resulting in pH-tuned structural colors at a 45° incidence. Moreover, the patterned encoding and array printing of dynamic structuralcolors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamicstructural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips.

关键词： Dynamic structural colors Four-dimensional printing pH-responsive nanogrid Heterogeneous materials

<110> Fiber Texture Evolution of Ferrite Wires during Drawn-torsion and Drawn-annealing-torsion Process

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Journal of Materials Science & Technology 2012年第11期28卷 1010-1014页

作者： y.D. liu y.D. zhang A. Tidul l. Zuo Key laboratory for Anisotropy and Texture of Materials (Ministry of Education) Northeastern University Shenyang110004 China letam/Isgmp CNRS Metz 57000 France

In this paper, the texture and microstructure evolution of drawn-torsion and drawn-annealing-torsion ferrite wires are studied by electron back scattering diffraction （EBSD） in order to investigate the special torsion texture evolution. Compared to the simulation results, the stable texture components {110}〈 110 〉 and {110}〈112〉 in both drawn-torsion and drawn-annealing-torsion wires display different evolution processes. The texture of the drawn-annealing-torsion wire fits to the Taylor model. A special texture evolution is found in drawn-torsion wires, related to the grain shape, and the heterogeneous deformation. A new plastic deformation viewpoint is suggested based on the special microstructure of drawn ferrite wire.

关键词： Texture Electron back scattering diffraction (EBSD) Torsion Plastic deformation

Aerodynamic load control on a dynamically pitching wind turbine airfoil using leading-edge protuberance method

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Acta Mechanica Sinica 2020年第2期36卷 275-289页

作者： y.n.zhang M.M.zhang C.Cai J.Z.Xu Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China The Key laboratory of Wind Energy Utilization of CAS Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dalian national laboratory for Clean Energy Chinese Academy of SciencesDalian 116023China

The aerodynamic loads of wind turbine blades are substantially affected by dynamic stall induced by the variations of the angle of attack of local airfoil *** purpose of the present study is to explore the effect of leading-edge protuberances on the fluctuation of the aerodynamic performances for wind turbine airfoil during dynamic *** experimental investigation is carried out by a direct force measurement technique employing force balance at a Reynolds number Re=2×*** phase-averaged and instantaneous aerodynamic loads of the pitching airfoil,including the baseline and the wavy airfoil,are presented and *** phase-averaged results indicate that the effects of dynamic stall for the wavy airfoil can be delayed or minimized compared to the baseline airfoil,and the negative damping area of the wavy airfoil is significant decreased in full-stall *** effects of leading-edge protuberances are more notable at a higher reduced *** the instantaneous aerodynamic loads of the wavy airfoil,there is an observable reduction in fluctuations compared with baseline ***,spectral analysis is applied to quantitatively undercover the nonstationary features of the instantaneous aerodynamic *** is found that the leading edge protuberances can reduce the harmonics of the aerodynamic force signal,and enhance the stability of the aerodynamic loads under different reduced *** conclusion,leading-edge protuberances are found effective to reduce the fluctuation characteristics of the aerodynamic loads during the dynamic stall process,and help to improve the stability and prolong the service life of the wind turbine blades.

关键词： Wind turbine airfoil Dynamic stall loads control leading-edge protuberance Aerodynamic experiment

STUDy On VERTICAl WATER TEMPERATURE MODEl FOR MIyUn RESERVOIR

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Journal of Hydrodynamics 2000年第4期12卷 75-83页

作者： li, y.l. Chen, y.C. zhang, B.X. Dep. of Hydraulic Eng. Tsinghua Univ. Beijing 100084 China

According to the characters of the Miyun reservoir located in northeast Beijing, one-dimensional method is used to establish a mathematical model of temperature for the reservoir. In this model the heat exchange between water surface and atmosphere, effective diffusion, inflows, outflows, and thermal advection are considered comprehensively. The effective diffusion coefficient, decay coefficient of short wave in water, etc, are calibrated based on the observed stratification data of 1991 in the reservoir. The mathematical model is verified through the agreement with the data of 1992. This model can be used to predict the temperature distribution along the vertical direction for the Miyun reservoir and other similar reservoir.

关键词： Computer simulation Heat transfer Mathematical models Temperature distribution

Superb Strengthening Effect of net-like Distributed Amorphous Al_(2)O_(3)on Creep Resistance of(B_(4)C+Al_(2)O_(3))/Al neutron-Absorbing Materials

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Acta Metallurgica Sinica(English letters) 2022年第12期35卷 2007-2013页

作者： y.n.Zan X.lei J.F.zhang D.Wang Q.Z.Wang B.l.Xiao Z.y.Ma Key laboratory of nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.LtdBejing 100840China

B4C reinforced Al composites are widely used as neutron absorbing materials(nAMs)due to excellent neutron absorbing efficiency,however,such nAMs exhibit poor high-temperature *** meet the requirement for structure-function integration,nAMs with enhanced high-temperature mechanical properties are *** this work,a novel(B4 C+Al_(2)O_(3))/Al nAM with netlike distribution of Al_(2)O_(3)was fabricated by powder metallurgy method and subjected to high-temperature tensile creep *** was shown that the creep resistance was enhanced by several orders of magnitude via the addition of only2.1 vol.%netlike-distributed Al_(2)O_(3).(B_(4)C+Al_(2)O_(3))/Al exhibited high apparent stress exponents ranging from 16 to 25 and high apparent activation energy of 364 kJ/*** creep behaviour could be rationalized using the substructure-invariant model and its rupture behaviour could be described by the Dobes-Milicka equation.

关键词： neutron absorber material Al matrix composite Tensile creep B_(4)C/Al

DETERMInATIOn OF BlAnK HOlDER FORCE In SHEET METAl DEEP DRAWInG PROCESS

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Acta Metallurgica Sinica(English letters) 2003年第1期16卷 31-34页

作者： y.J.luo y.Q.zhang D.n.He Department of Plasticity Technology Shanghai Jiao Tong University Shanghai 200030 China

Blank holder force (BHF) is an important measure to control the sheet metal forming. BHF is identified quickly using artificial neural network (Ann) on the basis of its analytical description. And critical rupture and... 详细信息

关键词： blank holder force sheet metal deep drawing artificial neural network

Regulation of thermoelastic properties of concave-packaged DnA adsorption films and its relevant microcantilever detection signals

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Acta Mechanica Sinica 2021年第4期37卷 705-711,I0004页

作者： C.X.Wu n.H.zhang C.y.zhang J.Z.Wu School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China Shanghai Key laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsShanghai 200072China

The packing patterns have close correlation with the thermoelastic properties of DnA adsorption films and the relevant detection signals of *** this paper,we investigate the influence of packing patterns on the thermoelastic properties of DnA adsorption films,the detection signals of microcantilevers and their temperature ***,the Parsegian's empirical potential based on a mesoscopic liquid crystal theory is employed to describe the interaction energy among coarse-grained DnA cylinders;then,the thought experiment method and the force balance method of nonlinear elastic network nodes are combined to characterize the elastic modulus,prestress and thermal expansion coefficient of DnA adsorption films;finally,based on an effective macroscopic continuum model for DnA microbeam deformation,we study the microcantilever resonance frequency shifts caused by DnA adsorptions and the temperature effect on the microcantilever static deflections,*** show that,compared with the convex-packaged,the re-entrant honeycomb packing pattern endows DnA adsorption films with a larger adjustable range of the elastic modulus and prestress,so as to make DnA-microcantilevers having an enhanced dynamic detection signal whereas a weaker response to temperature *** results are expected to provide a new option for the regulation design of DnA composite materials and microbeam sensors.

关键词： DnA-microbeam Packaging pattern Elastic property Thermal expansion coefficient Detection signal