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Phase separation in cGAS-STING signaling

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Frontiers of Medicine 2023年第5期17卷 855-866页

作者： Quanjin li pu Gao CAS Key laboratory of Infection and Immunity National Laboratory of BiomacromoleculesCAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China

Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological ***-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor *** the same time,cGAS-STING signaling must be carefully regulated to maintain immune ***,exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling,including cGAS condensates,STING condensates,and IRF3 *** addition,several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING *** studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug ***,we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.

关键词： biomolecular condensates phase separation cGAS-STING pathway cGAS STING cGAMP interferon

DIAGNOSTIC VAlUE OF QUANTITATIVE MAPPING OF ATRIAl ACTIVATION FOR THE CARDIAC ACCESSARy PATHWAy lOCATION

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中华医学杂志(英文版) 1991年第1期104卷 36-39页

作者： C y lu y C Song J l pu R l Sun l S liu Cardiovascular Institute Chinese Academy of Medical Sciences Beijing.

The retrograde atrial activation sequence is very important in locating the cardiac accessory pathways (AP). The atrial mapping during orthodromic supraventricular tachycardia (SVT) showed that earlier left atrial activation was found in patients with left-sided AP (lAP), earlier right atrial activation in patients with right-sided AP (RAP) and normal retrograde atrial activation sequence in patients with septal AP (SAP). PATIENTS AND METHODS Patients. 50 SVT patients, male 23, female 27, aged 37±14 years, were selected by transesophageal atrial pacing. Their SVT attacks were recorded by electrocardiography (ECG) at least more than once. The SVT had a QRS wave less than 110 ms. No organic heart disease was found. All cardiovascular drugs were discontinued for more than five half-life times before study.

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Mapping Tree Species Using Advanced Remote Sensing Technologies: A State-of-the-Art Review and Perspective

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Journal of Remote Sensing 2021年第1期2021卷 211-236页

作者： Ruiliang pu School of Geosciences University of South Florida4202 E.Fowler Ave.NES 107TampaFL 33620USA

Timely and accurate information on tree species(TS)is crucial for developing strategies for sustainable management and conservation of artificial and natural *** the last four decades,advances in remote sensing technologies have made TS classification *** many studies on the topic have been conducted and their comprehensive results and novel findings have been published in the literature,it is necessary to conduct an updated review on the status,trends,potentials,and challenges and to recommend future *** review will provide an overview on various optical and light detection and ranging(liDAR)sensors;present and assess current various techniques/methods for,and a general trend of method development in,TS classification;and identify limitations and recommend future *** this review,several concluding remarks were *** include the following:(1)A large group of studies on the topic were using high-resolution satellite,airborne multi-/hyperspectral imagery,and airborne liDAR data.(2)A trend of“multiple”method development for the topic was observed.(3)Machine learning methods including deep learning models were demonstrated to be significant in improving TS classification accuracy.(4)Recently,unmanned aerial vehicle-(UAV-)based sensors have caught the interest of researchers and practitioners for the topic-related research and *** addition,three future directions were recommended,including refining the three categories of“multiple”methods,developing novel data fusion algorithms or processing chains,and exploring new spectral unmixing algorithms to automatically extract and map TS spectral information from satellite hyperspectral data.

关键词： directions liDAR Remote

Exceptional Cycles in the Bounded Derived Categories of Quivers

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Acta Mathematica Sinica,English Series 2020年第3期36卷 207-223页

作者： Peng GUO pu ZHANG School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai 200240P.R.C hina

An exceptional n-cycle in a Hom-finite triangulated category with Serre functor has been recently introduced by Broomhead,Pauksztello and *** n=1,it is a spherical *** explicitly determine all the exceptional cycles in the bounded derived category D^b(kQ)of a finite quiver Q without oriented *** particular,if Q is an Euclidean quiver,then the length type of exceptional cycles in D^b(kQ)is exactly the tubular type of Q;if Q is a Dynkin quiver of type E_m(m=6,7,8),or Q is a wild quiver,then there are no exceptional cycles in D^b(kQ);and if Q is a Dynkin quiver of type An or D_n,then the length of an exceptional cycle in D^b(kQ)is either h or h/2,where h is the Coxeter number of Q.

关键词： Exceptional cycle the Coxeter number the tubular type the length type

Hot Dust Acoustic Solitary Waves in Dust Plasma with Variable Dust Charge

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Chinese Physics letters 2001年第8期18卷 1088-1089页

作者： DUAN Wen-Shan lÜ Ke-pu ZHAO Jin-Bao Department of Physics Northwest Normal UniversityLanzhou 730070

Considering the variation of dust charges,We have analytically studied the governing equation for the system with the same model as that for cold dust acoustic waves in a demagnetized plasma but the contribution of hot *** result indicates that the governing equation is also a Korteweg-de Vries equaiton,although its amplitude and width will be smaller compared with the cold dust case.

关键词： equation governing charges

Experimental Study for Effect of Multi-Site Spark Ignition on Dedicated Hybrid Engine Performance under High Dilution Condition

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Journal of Thermal Science 2025年第1期 254-267页

作者： yAN Bowen WATERS Benjamin HAINES Andrew MCGHEE Mike HU Tiegang DENG Wei pu yongxian MA Tianyu Powertrain Engineering R&D Center Chongqing Changan Automobile Co.Ltd. Changan UK R&D Centre limited

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-l dedicated hybrid engine（DHE）.On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 MPa BMEP（brake mean effective pressure） show that with highly increased in-cylinder flow intensity,using only passive prechamber（PPC） has a lower lean limit than that with single central spark plug（CSP）,thereby leading to slightly higher minimum fuel consumption and nitrogen oxides（NOx） *** side spark plugs（SSP）based on PPC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs（TSP）.As the excess air ratio λincreases,the advantage of PPC and PPC with SSP in improving the combustion phasing compared with CSP gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSP based on PPC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of PPC and PPC with SSP in terms of combustion characteristics over CSP becomes much *** contrast,the TSP ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSP ignition achieves the lowest raw ***,it can also reduce the raw carbon monoxide（CO） and hydrocarbons（HC） emissions compared to CSP due to a more thorough combustion of the end gas *** on the excellent performance of TSP,the highest engine brake thermal efficiency（BTE） was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaust

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Experimental investigation on the yield behavior of metal foam under shear-compression combined loading

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Science China(Technological Sciences) 2021年第7期64卷 1412-1422页

作者： lUO Geng XUE pu lI yulong School of Automobile Chang’an UniversityXi’an710064China School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Joint International Research laboratory of Impact Dynamics and its Engineering Applications Northwestern Polytechnical UniversityXi’an710072China

Metal foams are typically subjected to quasi-static or dynamic shear-compression combined loading in applications such as energy absorbers and structure protectors. The yield behavior of a metal foam under dynamic and quasi-static shear-compression combined loadings is investigated in this study. First, quasi-static and dynamic compression-shear combined tests at different loading angles are conducted using a universal testing machine and a rotatable Hopkinson bar system, respectively. Shear deformation reduces the plateau stress as the loading angle increases. Subsequently, the yield modes of the metal foam under combined loadings are investigated. Only one yield band occurs under a combined loading with large loading angles(mode I),whereas several yield bands occur under a combined loading with small loading angles(mode II). Finally, the yield surface plot of metal foam indicates significant enhancement in terms of normal stress and shear stress under dynamic loading. Quasi-static and dynamic phenomenological yield criteria for a shear-normal stress space are established to provide a brief and precise prediction of the behavior of metal foam under quasi-static and dynamic combined loadings.

关键词： metal foam yield behavior shear-compression combined loading yield mode yield criterion

Dynamical Symmetry Breaking of Maximally Generalized yang-Mills Model and Its Restoration at Finite Temperatures

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Communications in Theoretical Physics 2008年第12期50卷 1387-1390页

作者： WANG Dian-pu Department of Physics Dalian Maritime University Dalian 116026 China

In terms of the Nambu-Jona-lasinio mechanism, dynamical breaking of gauge symmetry for the maximally generalized Vang-Mills model is investigated. The gauge symmetry behavior at finite temperature is also investigated and it is shown that the gauge symmetry broken dynamically at zero temperature can be restored at finite temperatures.

关键词： yang-Mills theory dynamical symmetry breaking finite temperature

Size focusing of colloidal quantum dots under high monomer concentration

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Nano Research 2022年第8期15卷 7622-7630页

作者： Huiyan liu Zhi liu Chaodan pu School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

The diffusion-controlled growth mode is widely used to narrow the size distribution of colloidal quantum ***,this growth mode always suffers from size broadening at the later growth *** monitoring the growth process of CdS colloidal quantum dots,we show the size broadening is a result of different growth rates of CdS colloidal quantum dots(CQDs)with different *** concentration-dependent growth experiments demonstrate the different growth rates are caused by the different ligand permeabilities of CdS *** cubic ones have lower ligand permeability but higher saturated surface reaction rate than the noncubic ones,leading to unexpected narrower size distribution under higher monomer *** efficient narrowing can be obtained by the addition of chloride ions,which can increase the ligand permeability of all CdS CQDs,as well as the opposite discrepancies in ligand permeability and surface reaction between cubic and noncubic CdS *** photoluminescence(Pl)full width at half maximum(FWHM)of CdS CQDs can be narrowed down to below 80 meV for Pl peaks from 430 to 500 *** the inevitable usage of the ligands in the solution synthesis of colloidal nanocrystals,the influence of morphology difference on growth rate should be *** results can provide an alternative solution to realize size focusing for the synthesis of colloidal nanocrystals.

关键词： CdS quantum dots surface reaction monomer diffusion ligand permeability