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Locally advanced pancreatic cancer: staging, operability, and the importance of multimodality therapy

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 497-500页

作者： Rebecca y.kim Douglas B.Evans Kathleen K.Christians Department of Surgery and the LaBahn Pancreatic Cancer Program Medical College of WisconsinMilwaukeeWIUSA

The role for surgery in the management of locally advanced pancreatic cancer(LAPC)is nicely discussed in the manuscript by Gemenetzis et *** in the Annals of Surgery(1).As the authors acknowledge,therapeutic selection... 详细信息

关键词： Surgery cancer al.

Refinement of saliva microRNA biomarkers for sports-related concussion

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Journal of Sport and Health Science 2023年第3期12卷 369-378页

作者： Steven D.Hicks Cayce Onks Raymond y.kim Kevin J.Zhen Jayson Loeffert Andrea C.Loeffert Robert P.Olympia Gregory Fedorchak Samantha DeVita Zofia Gagnon Callan McLoughlin Miguel M.Madeira Scott L.Zuckerman Timothy Lee Matthew Heller Chuck Monteith Thomas R.Campbell Christopher Neville Elise Fengler Michael N.Dretsch Department of Pediatrics College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Orthopaedics and Rehabilitation College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Family Medicine College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Emergency Medicine College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Research and Development Quadrant Biosciences Inc.SyracuseNY 13210USA Department of Biology Marist CollegePoughkeepsieNY 12601USA Sports Concussion Center College of MedicineVanderbilt UniversityNashvilleTN 37212USA Department of Family Medicine College of Osteopathic MedicineNew York Institute of TechnologyOld WestburyNY 11568USA Department of Athletic Training Colgate UniversityHamiltonNY 13346USA Department of Rehabilitation Sciences Old Dominion UniversityNorfolkVA 23529USA Department of Physical Therapy Education Orthopedicsand NeuroscienceCollege of MedicineSUNY Upstate Medical UniversitySyracuseNY 13210USA Department of Exercise Science Syracuse UniversitySyracuseNY 13210USA Department of Medical Research—West Walter Reed Army Institute of ResearchUS Army Joint Base Lewis-McChordHillhurstWA 98433USA

Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom *** objective,biological marker could improve recognition and understanding of *** is emerging evidence that salivary micro-ribonucleic acids(miRNAs)may serve as biomarkers of concussion;however,it remains unclear whether concussion-related miRNAs are impacted by *** sought to determine whether40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact *** goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of ***:This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 *** of salivary miRNAs within 455 samples from 314 individuals were measured with RNA ***-subjects testing was used to identify and exclude miRNAs that changed with either(a)a single episode of exercise(166 samples from 83 individuals)or(b)season-long participation in contact sports(212 samples from 106 individuals).The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression(172 samples from 75 concussed and 97 non-concussed individuals).Results:Two miRNAs(miR-532-5p and miR-182-5p)decreased(adjusted py after contact sports ***-three miRNAs changed at the end of a contact sports *** of these miRNAs(miR-26b-3p and miR-29c-3p)were associated(R>0.50;adjusted py exercise or season-long contact sports participation,11 demonstrated a significant difference(adjusted pyed moderate ability(area under curve>0.70)to identify concussion.A

关键词： Biomarker Contact sports Football RNA Traumatic brain injury

胸部CT中气道的性别差异:COPD基因队列研究

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国际医学放射学杂志 2023年第1期46卷 112-113页

作者： S.P.Bhatt S.Bodduluri A.Nakhmani y.kim J.M.Reinhardt E.A.Hoffman 张颖

摘要女性慢性阻塞性肺疾病(COPD)的发病率正快速接近男性,并且女性症状更严重。虽然肺气肿的性别差异已有报道,气道的性别差异尚未见系统研究。目的评估气道是

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躯干和肢体软组织肉瘤的围手术期化疗与放疗（英文）

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中国临床医学 2019年第3期26卷 340-359页

作者： Lee D.Cranmer Edward y.kim 华盛顿大学肿瘤内科美国华盛顿州西雅图98109 华盛顿大学肿瘤放疗科美国华盛顿州西雅图98109

虽然手术是肢体和躯干原发软组织肉瘤的根治性治疗手段,但对于高危患者单纯手术常难以获得疾病的长期控制。治疗失败的主要原因为远处转移,其次为局部复发。一些局部进展期的患者可能面临无法手术切除,或仅边缘可切除,因此预后很差。围... 详细信息

虽然手术是肢体和躯干原发软组织肉瘤的根治性治疗手段,但对于高危患者单纯手术常难以获得疾病的长期控制。治疗失败的主要原因为远处转移,其次为局部复发。一些局部进展期的患者可能面临无法手术切除,或仅边缘可切除,因此预后很差。围手术期的系统治疗和放疗可提高手术疗效。如何确立围手术期系统治疗的价值颇具挑战。系统治疗可以缩小肿瘤。但要证明其对局部控制的价值从而促进实施更为保守的外科手术的证据仍不充分。对于那些原发肿瘤被认定为难以或不可能切除的患者,新辅助化疗可能为疾病的局部控制提供一种选择。围手术期的系统治疗也可以避免远处转移的发生。近期的研究表明,以蒽环类药物/异环磷酰胺为基础的辅助治疗能够使患者获益,虽然证据来自于对一项大型研究的再次分析。一项新辅助化疗的随机研究提示,对某些经过选择的肉瘤组织学亚型,以蒽环类药物/异环磷酰胺为基础的系统化疗可能改善患者无病生存和总生存期。其疗效的获得主要是通过改善远处无转移生存而不是局控率的提高。这两项研究所采用的方法均存在一定的局限性,因此需要进一步探索。尽管如此,我们相信这些结果支持在局部进展期、肢体和躯干原发的软组织肉瘤患者中进行新辅助化疗。放疗与手术结合在软组织肉瘤的治疗中有确切的疗效。虽然预后并不因放疗和手术的先后顺序而异,但不良反应却存在差异。辅助放疗较新辅助放疗有更低的围手术期伤口并发症,但相对于新辅助放疗而言,辅助放疗需要更高的放射剂量,对长期功能的预后差于新辅助放疗。因此,我们相信围手术期放疗与化疗一样,在可能的情况下,应尽可能在术前进行。

关键词：软组织肉瘤躯干肢体化疗放疗

Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

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Animal Models and Experimental Medicine 2020年第1期3卷 98-102页

作者： Alexander y.kim Joseph H.yacoub David H.Field Byoung Uk Park Bhaskar Kallakury Kyle E.Korolowicz Stephan Menne Department of Radiology Medstar Georgetown University HospitalWashingtonDistrict of Columbia Department of Pathology and Laboratory Medicine Medstar Georgetown University HospitalWashingtonDistrict of Columbia Department of Microbiology and Immunology Georgetown University Medical CenterWashingtonDistrict of Columbia

The most commonly used preclinical models of hepatocellular carcinoma(HCC)are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and *** encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or *** we describe the suitability of the woodchuck HCC model for testing of intra-arterial *** describe the techniques for pre-embolization imaging assessment using CT and MRI,technical tips on performing angiography and embolization,and pathological assessment of treated liver.

关键词： angiography animal model hepatocellular carcinoma woodchuck

Viral Diseases of Olive Flounder in Korean Hatcheries

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Journal of Ocean University of China 2006年第1期5卷 45-48页

作者： Oh M.-J. S.-J.Jung S.-I.Kitamura H.-y.kim Department of Aqua-Life Medicine yosu National University Dun-Duk Dong 96-1Yeosu Chunnam 550-749Republic of Korea

以便阐明，并且阻止病毒的疾病发生在橄榄疾病的状态，特别病毒的疾病挣扎育种站，包括流行病学的学习，研究的一个范围从 1997 ～ 2003 被执行。调查的育种站的地点在东方包括几个代表性的地点( Kangnung ， Uljin ， Pohang ， yangs... 详细信息

以便阐明，并且阻止病毒的疾病发生在橄榄疾病的状态，特别病毒的疾病挣扎育种站，包括流行病学的学习，研究的一个范围从 1997 ～ 2003 被执行。调查的育种站的地点在东方包括几个代表性的地点( Kangnung ， Uljin ， Pohang ， yangsan ，Ul圣，釜山)，南方( Wando ， Changheung ， Goheung ， yeosu ， Namhae ， Tongyeong ， Geoje ， Jeju )并且西方( Seosan ， Kunsan ， Gochang ， yeongkwang ， Mokpo ， Chindo )朝鲜半岛的肋骨的区域。A 总数 of2000 案例在 7 年，死亡由病毒的代理人报道 for22% ，或 446 个案例在引起了里被检验了。更加与病毒的感染联系的死亡在 2003 从 14% in1997 增加了到 27% 。许多病毒的疾病被观察，并且病毒的表皮的增生，病毒的腹水和病毒的畸形，病毒的紧张的坏死，和 hiramerhabdoviral 疾病的出现分别地是 14% ， 51% ， 25% ，和 8% 。由调查病毒的感染 ofbroodstock 挣扎，在育种站的海洋的 birnavirus (MABV ) 的感染率被识别因此，是约 30% 获得并且使窝雪鱼干非感染是高度必要的。

关键词：比目鱼孵卵所滤过性毒菌韩国

Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

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Microsystems & Nanoengineering 2020年第1期6卷 449-459页

作者： Kyungmin Hwang yeong-Hyeon Seo Daniel ykim Jinhyo Ahn Soyoung Lee Kyung Hee Han Koun-Hee Lee Sangyong Jon Pilhan kim Kate Eyu Hyungsin kim Shin-Hyuk Kang Ki-Hun Jeong Department of Bio and Brain Engineering KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Graduate School of Nanoscience and Technology KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences KAIST and KAIST Institute for the BioCenturyDaejeon 34141Republic of Korea Hyunjoo In-Tech Seoul 08390Republic of Korea VPIX Medical IncDeajeon 34141Republic of Korea Graduate School of Medical Science and Engineering Daejeon 34141Republic of Korea Department of Neurosurgery Korea University Anam HospitalKorea University MedicineSeoul 02842Korea

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular ***,we report a fully packaged handheld confocal endomicroscopic system for real-time,high-resolution,and in vivo cellular imaging using a Lissajous scanning fiber-optic *** endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph,a confocal microscope unit,and an image signal *** fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube,which resonantly scans both axes at~1 kHz to obtain a Lissajous *** fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective *** endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical *** probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous *** signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber *** confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.

关键词： fiber processor confocal

低温废气再循环及低压缩比对降低欧6柴油机氮氧化物排放的影响

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汽车与新动力 2014年第6期46卷 45-50页

作者： y.kim C.Park J.kim B.Min 黄磊

采用低温废气再循环（EGR）和低压缩比降低氮氧化物（NO;）排放,开发大型多功能运动车用欧6柴油机。低温EGR是通过低温EGR冷却液来降低再循环废气的温度,因而能在颗粒排放相同的情况下降低NO;排放。由于燃烧温度低,低压缩比可降低NO;排... 详细信息

采用低温废气再循环（EGR）和低压缩比降低氮氧化物（NO;）排放,开发大型多功能运动车用欧6柴油机。低温EGR是通过低温EGR冷却液来降低再循环废气的温度,因而能在颗粒排放相同的情况下降低NO;排放。由于燃烧温度低,低压缩比可降低NO;排放。这两种方法在实际应用中都适用于常规柴油机。另一方面,EGR冷却液温度和压缩比过低可能会导致一些问题,如EGR积炭和冷起动能力不足等。因此,必须具备避免产生这些异常现象的NO;排放降低策略。结果表明,低温EGR在EGR流量较低的低负荷条件下可显著降低NO;排放,在新欧洲行驶循环的14个工况点,可降低NO;排放约4%。考虑到冷起动的持续时间、怠速变动系数和生产偏差,将压缩比确定为15.2。在调整EGR率和主喷油定时以保持相同的颗粒排放后,将压缩比调至15.2可降低NO;排放约5%。

关键词：低温废气再循环低压缩比氮氧化物排放柴油机

RUFy4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong kim Hyunil Ha Taesoo kim Myeong Seon Jeong Suree kim Taesoo kim Han Sung kim Dongmin Kang Hyunbo Shim Soo young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FyVE domain-containing protein 4(RUFy4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFy4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFy4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic