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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning yu Hua-Tao Wu jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

[Construction of a 17 β-estradiol sensor based on a magnetic graphene oxide/aptamer separating material]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 87-95页

作者： Xin-yu Jin Le-yuan Chen ya-Nna liu Wen-jing Xie Han-yong Peng State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. University of Chinese Academy of Sciences Beijing 100049 China. School of Environment Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou 310024 China.

17-Estradiol (E2) is a natural steroidal estrogen essential for a variety of physiological functions in organisms. However, external E2, which is renowned for its potent biological effects, is also considered to be an endocrine-disrupting compound (EDC) capable of disturbing the normal operation of the endocrine system, even at nanogram-per-liter (ng/L) concentrations. Studies have revealed that medical and livestock wastewater can be contaminated with E2, which poses potential risks to human health. Currently, the primary method for detecting E2 relies on liquid chromatography-mass spectrometry, which is limited with regard to on-site or large-scale sample testing due to instrumental constraints. Herein, we developed a magnetic graphene oxide (MGO)/aptamer separating material. The MGO was synthesized by creating a water-in-oil microemulsion at 90 ℃, an agarose hydrogel to load the FeO nanoparticles, and layered graphene oxide (GO). In contrast to conventional methods, such as chemical co-precipitation and solvothermal approaches, this method is more time-efficient and does not require high temperature or pressure. Moreover, the use of a physical encapsulation technique for enwrapping the FeO nanoparticles and layered GO eliminates the need for chemical modification. This approach reduces the use of harmful chemicals, ensures complete loading, and results in highly efficient encapsulation. The MGO was characterized using Fourier-transform infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM), as well as dynamic light scattering (DLS) and Zeta potential analyses, which revealed that the FeO nanoparticles had been successfully loaded onto the GO to produce MGO particles mainly around 5 μm in size. Additionally, this study demonstrated that the aqueous MGO dispersion is highly stable. This substance was used to develop a fluorescent biosensor that uses a "turn-on" mechanism to rapidly and highly sensitively detect E2. MGO is capable of adsorbing a fl

关键词： 17-estradiol (E2) fluorescence biosensor magnetic graphene oxide (MGO) magnetic solid phase separation

Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第01期 134-151页

作者： jing Niu Shutao Xu yingxu Wei Zhongmin liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

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数字消费的劳动力资源再配置效应

东北师大学报（哲学社会科学版） 2025年第1期 32-47页

作者：刘伟江郝一哲李京京吉林大学数量经济研究中心吉林长春130012 吉林大学商学与管理学院吉林长春130012 吉林省科学技术信息研究所吉林长春130033

优化劳动力资源配置是人口红利消退趋势下提升全要素生产率的高质量方案。本文将数字消费纳入一个多部门竞争均衡的资源错配框架中,借助理论模型实证检验了以平台经济为代表的数字消费对劳动力资源错配的非线性影响及机制。研究表明:第... 详细信息

优化劳动力资源配置是人口红利消退趋势下提升全要素生产率的高质量方案。本文将数字消费纳入一个多部门竞争均衡的资源错配框架中,借助理论模型实证检验了以平台经济为代表的数字消费对劳动力资源错配的非线性影响及机制。研究表明:第一,数字消费规模对劳动力资源错配呈现出显著的“倒U形”非线性影响,且我国数字消费已处于对劳动力再配置的优化阶段,该结论经一系列检验后依然具有稳健性。第二,数字消费对劳动力资源错配的影响随着地理区位、环境规制以及资本配置效率的不同呈现出显著的异质性。第三,市场化进程、产业集聚以及政府经济目标是调节数字消费规模对劳动力资源错配“倒U形”非线性关系的重要机制。其中,市场化进程的深入会导致极值点向右偏移,并强化非线性关系;产业集聚水平、政府经济目标的提高使极值点向左移动,并弱化非线性关系。研究结果丰富了数字时代劳动力再配置理论,为发展新质生产力提出了新方案和新思路。

关键词：数字消费平台经济劳动力资源错配资源再配置

Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

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Tungsten 2025年第1期 100-111页

作者： Zhi-Qi Zhang liu yang Wen Luo Vladimir An jing Li Bao-Dan liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

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东江河口典型河段溶解氧时空动态及低氧成因解析

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湖泊科学 2025年第1期37卷 112-121页

作者：黄广灵黄本胜刘达邱静黄国如华南理工大学土木与交通学院广州510640 广东省水利水电科学研究院广州510635 广东省流域水环境治理与水生态修复重点实验室广州510635 华南理工大学亚热带建筑与城市科学全国重点实验室广州510640

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响... 详细信息

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响因子的相关性分析显示,DO与水温呈显著负相关,与盐度呈正相关,而与氨氮和总磷等营养物质呈显著负相关。这些营养物质的增加与DO的降低在空间上呈显著重叠,特别是在夏季。研究结果表明,东江南支流低氧现象受物理、化学和生物因素的共同影响,其中温度升高和营养物质浓度增加使得中下游水体的氧气消耗加快,河道汇流处的断面缩窄和下游水体的透光性差引起DO补给不足,从而导致下游沙田泗盛断面经常性出现氧亏(低氧)现象。

关键词：东江南支流溶解氧低氧营养物珠江

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现象学视域下农村集体经济的本质再诠释

西北农林科技大学学报（社会科学版） 2025年第1期25卷 60-68页

作者：李林峰刘启明饶静中国农业大学人文与发展学院北京100083 中共江西省委党校江西经济社会发展战略研究所南昌330108

鉴于当前政策、理论和实践领域对农村集体经济本质缺乏共识,本研究采用胡塞尔现象学的方法论,特别是一般现象学还原、本质还原和先验还原等技术,系统地审视了“农村集体经济应该是什么”这一核心议题。通过全面梳理当前对农村集体经济... 详细信息

鉴于当前政策、理论和实践领域对农村集体经济本质缺乏共识,本研究采用胡塞尔现象学的方法论,特别是一般现象学还原、本质还原和先验还原等技术,系统地审视了“农村集体经济应该是什么”这一核心议题。通过全面梳理当前对农村集体经济的多维认知,从而为其本质探索提供更为宽广的视角。在搁置既有认识的基础上,采用更加开放的态度识别出土地集体所有制是农村集体经济的共相,这一发现为理解其本质提供了关键线索。进一步从源初意向性与结构性剖析农村集体经济,揭示其本质在于注重公正,并凸显了其深厚的社会性和伦理性。这种本体论式反思既验证了马克思主义理论关于集体所有制经济的科学性及其生命力,更展示了中国农村集体经济独有的文化烙印。同时,跨学科的研究方法或为理解农村集体经济提供了新的视角,为推动其持续健康发展提供有益的思考。

关键词：农村集体经济现象学本质

[Determination of 12 halogenated organic pollutants in edible fish by ultra performance liquid chromatography-high resolution mass spectrometry combined with ultrasound-assisted extraction and gel permeation chromatography purification]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 68-77页

作者： yi-Zhe Zhu Rui-Fen Zheng Zi-Hao Fan Ling liu jing-yao ye Kai Wang Cai-Ming Tang Research Center for Eco-Environmental Engineering Dongguan University of Technology Dongguan 523808 China. Guangdong Key Laboratory of Environmental Resources Utilization and Protection Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China.

Halogenated organic pollutants (HOPs) have attracted considerable attention owing to their persistence, bioaccumulation, and toxicity. The development of methods to detect HOPs in fish is challenging owing to the compositional complexity of fish matrices, which contain high levels of lipids and relatively low concentrations of HOPs. In addition, the lipophilicity of most HOPs renders their extraction difficult. Moreover, the simultaneous determination of multiple HOPs to achieve the high-throughput screening of these analytes is complex. In this study, a reliable and efficient pretreatment method based on ultrasound-assisted extraction, gel permeation chromatography purification, and ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was developed for the determination of 12 HOPs in edible fish. The procedures of sample extraction and purification and LC-HRMS detection parameters were optimized to improve the performance of the method. Fresh fish samples were thoroughly rinsed with water, and non-edible parts, including the skin, bones, and phosphorus, were removed. The fish were weighed, cut into small pieces, and vacuum freeze-dried for 48 h. Subsequently, a freeze grinder was used to grind the dried fish into a fine powder. Exactly 2 g of the fish powder was weighed, fortified with isotope-labeled internal standards of the HOPs, and allowed to stand for 5 min. Methanol-acetonitrile (1∶1, v/v) was then added, followed by vortex mixing and ultrasonication. After centrifugation, the supernatant was transferred to a fresh tube. The extraction process was repeated twice and all extracts were combined. The extract was evaporated under a gentle nitrogen flow and redissolved in a mixture of ethyl acetate-cyclohexane (1∶1, v/v). The sample mixture was cleaned using gel permeation chromatography, and the eluate was collected and concentrated under a nitrogen flow. Sample residuals were reconstituted with water-methanol (1∶1, v/v) prior to

关键词： edible fish gel permeation chromatography (GPC) halogenated organic pollutants (HOPs) ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS)

A new study of neutrino energy loss of nuclides ^(53-60)Cr by electron capture in magnetars

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Research in Astronomy and Astrophysics 2013年第8期13卷 945-951页

作者： jing-jing liu College of Sciences and Technology Qiongzhou University

Following the theory of relativity, in the presence of an ultrastrong magnetic field （UMF） and utilizing a nuclear shell model, we carry out an estimation of the neutrino energy loss （NEL） rates of nuclides ^53-60Cr, which occur by electron capture in magnetars. The results show that the NEL rates greatly increase when a UMF is present, and can even exceed nine orders of magnitude at relatively lower density and temperature （e.g. ρ7 = 5.86, ye = 0.47, T9 = 7.33） in the range from 1013 G to 1018 G. However, the increase in rates was no more than six orders of magnitude at relatively higher density and temperature （e.g.ρ7 = 4.86 × 10^8, ye = 0.39, T9 = 14.35）.

关键词： physical data and processes: neutrinos nuclear reactions - stars: super- novae - stars: evolution

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