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Lung cancer management during the COVID-19 pandemic:experience of a medical oncology unit at a tertiary hospital in Singapore

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 707-717页

作者： Elise Ky Vong Puey-Ling Chia Alex y.chang Department of Medical Oncology Tan Tock Seng HospitalSingapore Lee Kong Chian School of Medicine Singapore Johns Hopkins University School of Medicine BaltimoreMD 21836USA

Coronavirus disease 2019(COVID-19),caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was declared a pandemic by the World Health Organisation(WHO)on 11 March *** pandemic has had profound effects on healthcare systems across the world,and also poses unique challenges for oncology *** saw its first imported case of COVID-19 on 23 January 2020,and there has since been 52,000 confirmed cases and 27 deaths as of early August 2020 *** have a special duty to our patients to ensure patient safety and provide optimum care without undue disruption which may compromise long-term cancer-specific *** herein examine the impact that the COVID-19 pandemic has had on our clinical services,and share our experience with regards to manpower reconfiguration,infection control measures,diagnostic evaluation of patients with suspected COVID-19,oncological management of lung cancer patients,as well as changes in the education and training of juniors,from our unique position as a Medical Oncology department in Tan Tock Seng Hospital,a tertiary hospital affiliated with the National Centre of Infectious Diseases in Singapore.

关键词： COVID-19 lung cancer thoracic cancer

Study on the Synthesis and Adsorption Properties of KH-560 Modified PalygorskiteSupported β-Cyclodextrin

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复旦学报（自然科学版） 2007年第5期46卷 788-,791页

作者： D.M.ZHU L.yAN X.L.SHI y.chang Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical EngineeringNorthwest Normal University

1 Results Palygorskite (PGS) is a chain-layer magnesium-aluminum silicate mineral. Because of its developed interior channels and large specific surface area, and thus considerable adsorption capacity, it has been studied for the application as one of environmental mineral adsorbents[1-3]. Cyclodextrins (CD) possess a hydrophilic exterior and a hydrophobic interior into which a variety of hydrophobic organic molecules maybe introduced. The CD molecule not only affects a hydrophilic cavity on the nanomet...

关键词： KH-560 modified palygorskite β-cyclodextrin adsorption phenolic compounds

Determination of Aminoglycosides by Capillary Electrophoresis with Laser-induced Fluorescence Detection

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Determination of Aminoglycosides by Capillary Electrophoresi...

Congenital penile curvature: long-term results of operative treatment using the plication procedure

第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会

作者： Sarah y.chang yi-Fung Lin Department of Chemistry Tunghai University Taichung Taiwan Department of Chemistry Tunghai University Taichung Taiwan

Capillary electrophoresis (CE) is a useful technique to quantify drugs in biological fluids. Due to short optical length of CE, the sensitivity is not sufficient to quantify drugs in biological samples as they often need to be quantified in the lower μg/L range. A sensitive analytical method for aminoglycosides based on capillary electrophoretic separation and laser-induced fluorescence (LIF) has been developed. 6-Carboxyfluorescein succinimidyl ester (CFSE) was used

关键词： Determination of Aminoglycosides by Capillary Electrophoresis with Laser-induced Fluorescence Detection

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Asian Journal of Andrology 2004年第3期6卷 273-276页

作者： S.-S.Lee E.Meng F.-P.Chuang C.-y.yen S.-y.chang D.-S.yu G.-H.Sun Division of Urology Department of SurgeryTri-Service General HospitalNational Defense Medical CenterNationalDefense UniversityTaipeiChina

Aim: To determine the long-term outcome, effectiveness and patient satisfaction of congenital penile curvature correction by plication of tunica albuginea. Methods: From January 1992 to January 2002, 106 young patients underwent surgical correction of congenital penile curvature by corporeal plication. Indications for operation were difficult or impossible vaginal penetration and cosmetic problems. The technique of corporeal plication consists of placing longitudinal plication sutures of 2-zero braided polyester on the convex side of the curvature until the curvature is corrected when erection is artificially induced. Results of this procedure were obtained by retrospective chart reviews and questionnaires via mail. Long-term follow-up ranged from 11 to 132 (mean 69.3) months and data were available for 68 patients. Results: Penile straightening was excellent in 62 patients (91 %) and good with less than 15 degree of residual curvature in 6 patients (9 %). Sixty-seven patients reported no change in erectile rigidity or maintenance postoperatively, while 1 described early detumescence. Shortening of the penis without functional problems was noted by 26 patients (38 %). Thirty-Five patients (51 %) reported feeling palpable indurations (suture knots) on the penis. Temporary numbness of glans penis was described in 3 patients. Overall, 60 patients were very satisfied, 6 satisfied, 2 unsatisfied. Conclusion: Corporeal plication is an effective and durable procedure with a high rate of patient satisfaction.

关键词： penile curvature treatment plication procedure

Experimental Hamiltonian Learning of an 11-Qubit Solid-State Quantum Spin Register

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Chinese Physics Letters 2019年第10期36卷 11-16页

作者： P.-y.Hou L.He F.Wang X.-Z.Huang W.-G.Zhang X.-L.Ouyang X.Wang W.-Q.Lian X.-y.chang L.-M.Duan Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084

Learning the Hamiltonian of a quantum system is indispensable for prediction of the system dynamics and realization of high fidelity quantum ***,it is a significant challenge to efficiently characterize the Hamiltonian which has a Hilbert space dimension exponentially growing with the system ***,we develop and implement an adaptive method to learn the effective Hamiltonian of an 11-qubit quantum system consisting of one electron spin and ten nuclear spins associated with a single nitrogen-vacancy center in a *** validate the estimated Hamiltonian by designing universal quantum gates based on the learnt Hamiltonian and implementing these gates in the *** experimental result demonstrates a well-characterized 11-qubit quantum spin register with the ability to test quantum algorithms,and shows our Hamiltonian learning method as a useful tool for characterizing the Hamiltonian of the nodes in a quantum network with solid-state spin qubits.

关键词： Hamiltonian quantum system

Preparation and Catalysis of Aminomethylated Polystyrene Supported Unsymmetrical Schiff-Base Metal Complexes for the Oxidation of Cyclohexene

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复旦学报（自然科学版） 2007年第5期46卷 809-页

作者： X.L.Shi y.chang F.Zha y.G.Wang Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical Engineering Northwest Normal University

1 Results The dominant position of molecular oxygen as the oxidant for bulk chemical oxyfunctionalizations is due to the fact that it is the only economically and environmentally friendly feasible oxidant for large scale *** molecular oxygen is not better oxidant than others,such as PhIO,NaOCl,H2O2,alkyl hydroperoxides,percarboxylic acids,magnesium *** we have to select high reactivity and general utility *** oxidation of hydrocarbons catalyzed by transition metal ...

关键词： Schiff-base unsymmetry complexes catalysis

m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

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m6A mRNA methylation controls T cell homeostasis by targetin...

Supplementary Materials:Observation of topological links associated with Hopf insulators in a solid-state quantum simulator

第十二届全国免疫学学术大会

作者： Li Huabing Tong Jiyu Shu Zhu yuval Kluger Matthew D.Simon Howard y.chang Zhinan yin Richard A.Flavell Department of Immunobiology Yale University School of Medicine Shanghai Institute of Immunology Department of Microbiology and Immunology The First Affiliated Hospital Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Department of Pathology Yale University School of Medicine Department of Molecular Biophysics & Biochemistry Yale University Dynamic Regulomes Stanford University Howard Hughes Medical Institute

N6-methyladenosine(m6A)is the most common and abundant messenger RNA modification,modulated by‘writers’‘erasers’and‘readers’of this *** vitro data have shown that m6A influences all fundamental aspects of mRNA m... 详细信息

关键词： m6A methylation T cells STAT signaling Inflammation

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Chinese Physics Letters 2017年第6期 26-36页

作者： X.-X.yuan L.He S.-T.Wang D.-L.Deng F.Wang W.-Q.Lian X.Wang C.-H.Zhang H-L.Zhang X.-y.chang L.-M.Duan Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua University Department of Physics University of Michigan Condensed Matter Theory Center and Joint Quantum Institute Department of PhysicsUniversity of Maryland

MATERIALS AND METHODS Experimental setup We illuminate the diamond Nitrogen-Vacancy(NV)center and collect its fluorescence with a home-built confocal microscope with a 1.49 NA objective(Olympus 60X,under oil immersion... 详细信息

关键词： Supplementary Materials:Observation of topological links associated with Hopf insulators in a solid-state quantum simulator

根据加州强地面运动得到的浅壳地震的衰减关系

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世界地震译丛 1998年第3期29卷 50-57页

作者： K.Sadigh C.-y.chang J.A.Egan F.Makdisi R.R.youngs 吴子泉山东省地震局

主要依据加州地震的强地面运动数据给出了浅壳地震的峰值加速度和反应谱加速度衰减关系。计算了走滑及逆断层地震在岩石及坚实厚土壤沉积中矩震级M4～8+、距离达100km的衰减关系。

关键词：地壳地震衰减关系地面运动加州