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Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-yong Hou Ni-yuan Zhang Lu Wang Mei-yu Lv Xiang-Peng Li Peng Zhang yue-Ze Wang Lei Shen Xiu-Hai Wu bo Fu Peng-yu Guo Zi-Qi Wang dong-Bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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Lithium Isotope Analytical Methods and Implications for Rare-Metal Mineralization in Granite-Pegmatite Systems: An Overview

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Journal of Earth Science 2024年

作者： Xiang-ying ye Bin Li dong-bo Tan Ke-Cheng Liu Zhi-yong Zhu Hafiz Muhammad Siddique yi-Lin Xiao Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring (Ministry of Education)， School of Geosciences and Info-physics， Central South University CAS Key Laboratory of Geospace Environment and Department of Plasma Physics and Fusion Engineering， University of Science and Technology of China Institute of Geology， Chinese Academy of Geological Sciences CAS Key Laboratory of Crust-Mantle Materials and Environments， School of Earth and Space Sciences， University of Science and Technology of China Chinese Academy of Sciences Center of Excellence in Comparative Planetology

The origin of highly-fractionated granite-pegmatite systems and their associated rare metal mineralization has been widely studied， but there is still ongoing debate. Prevailing hypotheses suggest that pegmatite formation and the associated rare metal mineralization are closely related to aqueous fluid processes. Lithium (Li) isotope analysis has been widely applied to trace granite-pegmatite evolution. This is because lithium is widely present in various minerals (e.g.， mica， tourmaline) that record the melt and fluid compositions， and lithium isotopes are sensitive to magmatic-hydrothermal processes. We briefly review the methodology of Li isotope analyses， the mechanisms of Li isotopic fractionation， and， in particular， Li isotope fractionation in granite-pegmatite system based on Li isotope data we have collected and the latest developments in Li isotope geochemistry. With the development of analytical technology， high-precision measurement of the Li content and isotopic compositions have facilitated a series of scientific breakthroughs in understanding the magmatic-hydrothermal evolution of rare-element ore deposits. Li isotope analysis on bulk mineral separates show ability to trace various hydrothermal processes (e.g. exotic or exsolved fluids). In situ Li isotope analysis methods has been enhanced by the development of new， homogeneous mineral reference materials. In situ SIMS and LA-MC-ICP-MS Li isotope measurements on minerals (e.g.， tourmaline) will likely become more important in studying the fluid–rock interactions in magmatic， metamorphic， and hydrothermal processes， as well as on pegmatite petrogenesis and rare-metal mineralization.

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Clions accelerating interface charge transfer in a Si/InSFaradaic junction photocathode for solar seawater splitting

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Science China Chemistry 2024年

作者： Jun Luo Ruotong Bao Hongzheng dong ye Fu dongjian Jiang bo Wang yuzhan Zheng Qiong Wang Wenjun Luo Zhigang Zou Eco-materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University National Laboratory of Solid State Microstructures and Department of Physics Nanjing University

Photoelectrocatalytic seawater splitting is a promising low-cost method to produce green hydrogen in a large *** effects of Cl-ions in seawater on the performance of a photoanode have been reported in previous ***,few researches have been done on the roles of Cl-ions in a ***,for the first time,we find that Cl-ions in the electrolyte improve the photocurrent of a Si/In2S3photocathode by 50%at-0.6 *** in-situ X-ray photoelectron spectroscopy （XPS） characterization combined with the time-of-flight secondary-ion mass spectrometry by simulating photoelectrochemical conditions was used to investigate the interface charge transfer *** results suggest that there is an In+32S3–x（OH）2xlayer on the surface of In2S3in the phosphate buffer solution （PBS） electrolyte,which plays a role as an interface charge transfer mediator in the Si/*** In+32S3–x（OH）2xsurface layer becomes In+32S3–x（Cl）2xin the PBS electrolyte with NaCl and accelerates the charge transfer rate at the In2S3/electrolyte *** results offer a new concept of regulating interface charge transfer mediator to enhance the performance of photoelectrocatalytic seawater splitting for hydrogen production.

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Coordinated Mining Procedures of Open Pit Mines Based on River Management

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Asian Agricultural Research 2024年第5期16卷 11-14,19页

作者： Baoyu CAO Zhiyong ZHANG bo WANG Ruirong dong Hongjian WANG Huolinhe South Surface Mine of Inner Mongolia Power Investment Energy Co. Ltd.Tongliao 029200China CCTEG Shenyang Engineering Company Shenyang 110015China

This paper primarily concerns the effective coordination of the procedures and methods employed in open pit mining operations under the background of river *** central objective of this study is to identify a viable approach for ensuring rational and efficient development of open pit mineral resources while simultaneously protecting and restoring the ecological environment of the *** approach should facilitate the realization of a harmonious symbiosis between mining and river *** intricate mutual influence relationship between river management and open pit mining is first analyzed in depth,which provides a solid foundation for the subsequent coordination strategy *** light of the aforementioned considerations,a set of coordination procedures for open pit mining based on river management conditions is *** procedures emphasize the integration of river protection into the overall layout of mining at the planning *** implementation of scientific mining schemes,accompanied by rigorous control of the scope and depth of mining operations,has proven to be an effective means of reducing the impact of mining activities on river *** approach has also facilitated the achievement of a balance and coordination between mining and river management.

关键词： River management Open pit mine Mining procedure Coordinated mining

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Multimodel Ensemble Forecast of Global Horizontal Irradiance at PV Power Stations Based on Dynamic Variable Weight

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Journal of Tropical Meteorology 2024年第3期30卷 327-336页

作者： yUAN Bin SHEN yan-bo DENG Hua yANG yang CHEN Qi-ying yE dong MO Jing-yue yAO Jin-feng LIU Zong-hui Public Meteorological Service Center China Meteorological AdministrationBeijing 100081 China Key Laboratory of Energy Meteorology China Meteorological AdministrationBeijing 100081 China Guangzhou Institute of Tropical and Marine Meteorology China Meteorological AdministrationGuangzhou 510641 China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 China Center for Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081 China Institute of Desert Meteorology China Meteorological AdministrationUrumqi 830002 China

In the present study,multimodel ensemble forecast experiments of the global horizontal irradiance(GHI)were conducted using the dynamic variable weight *** study was based on the forecasts of four numerical models,namely,the China Meteorological Administration Wind Energy and Solar Energy Prediction System,the Mesoscale Weather Numerical Prediction System of China Meteorological Administration,the China Meteorological Administration Regional Mesoscale Numerical Prediction System-Guangdong,and the Weather Research and Forecasting Model-Solar,and observational data from four photovoltaic(PV)power stations in yangjiang City,Guangdong *** results show that compared with those of the monthly optimal numerical model forecasts,the dynamic variable weight-based ensemble forecasts exhibited 0.97%-15.96%smaller values of the mean absolute error and 3.31%-18.40%lower values of the root mean square error(RMSE).However,the increase in the correlation coefficient was not ***,the multimodel ensemble mainly improved the performance of GHI forecasts below 700 W m-2,particularly below 400 W m-2,with RMSE reductions as high as 7.56%-28.28%.In contrast,the RMSE increased at GHI levels above 700 W *** for the key period of PV power station output(02:00-07:00),the accuracy of GHI forecasts could be improved by the multimodel ensemble:the multimodel ensemble could effectively decrease the daily maximum absolute error(AE max)of GHI ***,with increasing forecasting difficulty under cloudy conditions,the multimodel ensemble,which yields data closer to the actual observations,could simulate GHI fluctuations more accurately.

关键词： GHI forecast multimodel ensemble dynamic variable weight PV power station

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Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1960-1966页

作者： ya-Xiu Fang Xiao-Ming Zhou dong Zheng Guang-Hui Liu Peng-bo Gao Xiao-Zhen Huang Zhi-Cheng Chen Hui Zhang Lin Chen ya-Fang Hu Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing *** cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been *** report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)*** SUMMARy A young man in his 30s who presented with acute epileptic status was admitted to a local *** was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for *** 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were *** was then transferred to our *** Mini-Mental State Examination(MMSE)crude test results showed only 2 *** magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral ***-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and *** treatment,his mental symptoms were *** impairment was significantly improved,with a MMSE of 8 *** anti-GABABR antibody titer decreased to 1:*** patient received methylprednisolone and penicillin after *** months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:*** This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.

关键词： Anti-γ-aminobutyric acid-B receptor GABABR Neurosyphilis Tissue-based assay Magnetic resonance imaging Mini-mental state examination Case report

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Enhancing the stability of Ni Fe-layered double hydroxide nanosheet array for alkaline seawater oxidation by Ce doping

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Journal of Energy Chemistry 2024年第4期91卷 306-312页

作者： yongchao yao Shengjun Sun Hui Zhang Zixiao Li Chaoxin yang Zhengwei Cai Xun He Kai dong yonglan Luo yan Wang yuchun Ren Qian Liu dongdong Zheng Weihua Zhuang bo Tang Xuping Sun Wenchuang(Walter)Hu Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041SichuanChina College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014ShandongChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina Institute for Advanced Study Chengdu UniversityChengdu 610106SichuanChina Laoshan Laboratory Qingdao 266237ShandongChina

Electrocatalytic hydrogen production from seawater holds enormous promise for clean energy ***,the direct electrolysis of seawater encounters significant challenges due to poor anodic stability caused by detrimental chlorine ***,we present our recent discovery that the incorporation of Ce into Ni Fe layered double hydroxide nanosheet array on Ni foam(Ce-Ni Fe LDH/NF)emerges as a robust electrocatalyst for seawater *** the seawater oxidation process,CeO_(2)is generated,effectively repelling Cl^(-)and inhibiting the formation of Cl O-,resulting in a notable enhancement in the oxidation activity and stability of alkaline *** prepared Ce-Ni Fe LDH/NF requires only overpotential of 390 m V to achieve the current density of 1 A cm^(-2),while maintaining long-term stability for 500 h,outperforming the performance of Ni Fe LDH/NF(430 m V,150 h)by a significant *** study highlights the effectiveness of a Ce-doping strategy in augmenting the activity and stability of materials based on Ni Fe LDH in seawater electrolysis for oxygen evolution.

关键词： Ce doping NiFe layered double hydroxide Seawater oxidation Electrocatalysis Cl^(-) repulsion

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Effect of process parameters on microstructure and mechanical properties of a nickel-aluminum-bronze alloy fabricated by laser powder bed fusion

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Journal of Central South University 2024年第8期31卷 2944-2960页

作者： Han, Chang-jun Zou, yu-jin Hu, Gao-ling dong, Zhi Li, Kai Huang, Jin-miao Li, bo-yuan Zhou, Kun yang, yong-qiang Wang, Di School of Mechanical and Automotive Engineering South China University of Technology Guangzhou China Singapore Centre for 3D Printing School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore Singapore

This work investigated the effect of process parameters on densification, microstructure, and mechanical properties of a nickel-aluminum-bronze (NAB) alloy fabricated by laser powder bed fusion (LPBF) additive manufacturing. The LPBF-printed NAB alloy samples with relative densities of over 98.5% were obtained under the volumetric energy density range of 200–250 J/mm3. The microstructure of the NAB alloy printed in both horizontal and vertical planes primarily consisted of β′ martensitic phase and banded α phase. In particular, a coarser-columnar grain structure and stronger crystallographic texture were achieved in the vertical plane, where the maximum texture intensity was 30.56 times greater than that of random textures at the (100) plane. Increasing the volumetric energy density resulted in a decrease in the columnar grain size, while increasing the amount of α phase. Notably, β1′ martensitic structures with nanotwins and nanoscale κ-phase precipitates were identified in the microstructure of LPBF-printed NAB samples with a volumetric energy density of 250 J/mm3. Furthermore, under optimal process parameters with a laser power of 350 W and scanning speed of 800 mm/s, significant improvements were observed in the microhardness (HV 386) and ultimate tensile strength (671 MPa), which was attributed to an increase in refined acicular martensite.

关键词： additive manufacturing copper alloy laser powder bed fusion nickel-aluminum-bronze alloy

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A benchmark-based method for evaluating hyperparameter optimization techniques of neural networks for surface water quality prediction

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 13-27页

作者： Xuan Wang yan dong Jing yang Zhipeng Liu Jinsuo Lu School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an710055China Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an710055China State Key Laboratory of Green Building in West China Xi’an University of Architecture and TechnologyXi’an710055China

Neural networks(NNs)have been used extensively in surface water prediction tasks due to computing algorithm improvements and data *** essential step in developing an NN is the hyperparameter *** practice,it is common to manually determine hyperparameters in the studies of NNs in water resources *** may result in considerable randomness and require significant computation time;therefore,hyperparameter optimization(HPO)is *** study adopted five representatives of the HPO techniques in the surface water quality prediction tasks,including the grid sampling(GS),random search(RS),genetic algorithm(GA),Bayesian optimization(bo)based on the Gaussian process(GP),and the tree Parzen estimator(TPE).For the evaluation of these techniques,this study proposed a method:first,the optimal hyperparameter value sets achieved by GS were regarded as the benchmark;then,the other HPO techniques were evaluated and compared with the benchmark in convergence,optimization orientation,and consistency of the optimized *** results indicated that the TPE-based bo algorithm was recommended because it yielded stable convergence,reasonable optimization orientation,and the highest consistency rates with the benchmark *** optimization consistency rates via TPE for the hyperparameters hidden layers,hidden dimension,learning rate,and batch size were 86.7%,73.3%,73.3%,and 80.0%,*** the evaluation of HPO techniques directly based on the prediction performance of the optimized NN in a single HPO test,the proposed benchmark-based HPO evaluation approach is feasible and robust.

关键词： Neural networks Hyperparameter optimization Surface water quality prediction Bayes optimization Genetic algorithm

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A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

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Science China(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu Jian Sun Lian Jin Hai-Bing Xie Jian-bo Li Hui Xu dong-dong Wu Xiao-Lin Zhuang Min-Sheng Peng ya-Jun Guo Wei-Zhu Qian Newton OOtecko Wei-Jie Sun Liang-Hu Qu Jie He Zhao-Li Chen Rong Liu Ce-Shi Chen ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

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