检索结果-南通市图书馆

Contemporary Asymmetric Genetic Introgression Between Two Pelophylax Species in Shanghai

Asian Herpetological Research 2024年第1期15卷 1-11页

作者： Xu WEI Wenli LIU Gang WANG Rui MA Meiling HUANG Jiaxin ZHENG Tingwei dong Changqing yUAN Shunqi bo Xiao yUAN Ben LI Shuo MA Qu yUE youzhong DING Zhenghuan WANG School of Life Sciences East China Normal UniversityShanghai 200241China Shanghai Landscaping and City Appearance Administrative Bureau Shanghai 200041China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration East China Normal UniversityShanghai 200241China yangtze Delta Estuarine Wetland Ecosystem Observation and Research Station Ministry of Education&Shanghai Science and Technology CommitteeShanghai 202162China

Human disturbances are considered to break reproduction barriers among *** increases in hybridization events have been reported among a large number of taxonomic groups in anthropogenic environments,providing novel insights into species evolution mechanisms and conservation management in the *** Eastern Golden Frog(Pelophylax plancyi)and BlackSpotted Frog(***)are two sympatric anuran species with a long history of mitochondrial genome introgression in highly urbanized continental East ***,there is only limited understanding of the pattern of their contemporary hybridization and factors influencing their interspecific relationship under anthropogenic ***,interspecific hybridization between *** and *** at the population level was investigated in *** except two haplotypes obtained from both species in Shanghai were mixed together,and located in the introgression clade,implying multiple ancient mitochondrial introgression events occurred in the populations of our study *** genetic introgression was detected by microsatellite markers,with 0.7%of *** and 14.6%of *** identified as contemporary admixed *** with the trend of population density,higher genetic diversity of neutral microsatellite loci was found in the more abundant ***;however,variation in mitochondrial(Cyt-b)and nuclear(POMC)genes was higher in relatively rare *** population density of *** and number of water patches within local habitats were significantly positively correlated with both occurrences and proportions of admixed individuals in the populations of *** and *** the prevalent transformation of habitats in urbanized areas,these results imply that a high population density in isolated artificially altered habitats is likely to increase interspecific ***,population monitoring and improveme

关键词： anthropogenic disturbances interspecific hybridization Pelophylax species abundance urban landscape urbanization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

引用

Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi Suo-Qun Zhao Ru-yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui yang dong-Sheng Zhou Min Fang bo ying yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza *** Carthamus tinctorius L.

引用

Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 44-54页

作者： Linying Zhong Ling dong Jing Sun Jie yang Zhiying yu Ping He bo Zhu yuxin Zhu Siyuan Li Wenjuan Xu School of Life Sciences Bejing University of Chinese MedicineBeijing 102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBejing 102488China

Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(***,Dan Shen)and *** L.(***,Hong Hua)as an herb pair through network pharmacology and subsequent experimental ***:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of *** and *** as herb *** docking was used to verify the binding of the components of these herbs and their potential *** H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination *** blot was performed to detect the protein expression of these ***:Network pharmacology analysis revealed 5 pathways and 8 core targets of *** and *** in myocardial *** of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling *** achieved vascular tone mainly by regulating the target genes of the HIF-1 *** an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective *** docking verified the strong binding of Myric,Sal.B,and Ctan to *** blot further showed that the active ingredients synergistically upregulated the protein expressionof ***:The pharmacodynamic transmission analysis revealed that the active ingredients of *** and *** can synergistically resist ischemia through various targets and *** study provides a methodological reference for interpreting traditional Chinese medicine compatibility.

关键词： S.miltiorrhiza-C.tinctorius herb pair Compatibilitymechanism Networkpharmacology Multipletargeteffect Myocardial protection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transparent high-performance piezoceramics through pressureless sintering

引用

Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-Lim yu Woo-Seok Kang Ju-Hyeon Lee Temesgen Tadeyos Zate young-Jin Lee bo-Kun Koo dong-Jin Shin Min-Soo Kim Soon-Jong Jeong young Ghyu Ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer *** has been a consistent demand for transparent piezoelectric materials for optoelectrical ***,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric ***,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial ***,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline *** this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)*** utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/*** material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical features and prognostic analysis of the blastoid variant of mantle cell lymphoma: An analysis of 20 patients from two centers

引用

Cancer Pathogenesis and Therapy 2024年第1期2卷 62-64页

作者： Sai Huang Shaomei Liu Hongmei Jing Ping Chen Lili dong Xiaoyu Hao Jian bo Lu Sun yu Zhao Department of Hematology Senior Department of HematologyThe Fifth Medical Center of PLA General HospitalBeijing 100039China Department of Hematology The First Medical Center of PLA General HospitalBeijing 100853China Medical School of Chinese PLA General Hospital Beijing 100853China Department of Clinical Laboratory The First Medical Center of PLA General HospitalBeijing 100853China Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijing 100191China Department of Pathology The First Medical Center of PLA General HospitalBeijing 100853China

Managing Editor:Peng Lyu Mantle cell lymphoma(MCL),a relatively uncommon subtype of non-Hodgkin's lymphoma(NHL),constitutes approximately 2%-10%of NHL *** by its inertness,aggressiveness,and incurability,MCL has a med... 详细信息

关键词： lymphoma NHL Clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1

引用

当代医学科学（英文） 2024年第4期44卷 718-725页

作者： bo-lang DENG dong-xu LIN Zhi-peng LI Kang LI Peng-yu WEI Chang-cheng LUO Meng-yang ZHANG Quan ZHOU Zheng-long yANG Zhong CHEN Department and Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Rehabilitation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Objective:Bladder outlet obstruction(boO)results in significant fibrosis in the chronic stage and elevated bladder ***1 is a type of mechanosensitive(MS)channel that directly responds to mechanical *** identify new targets for intervention in the treatment of boO-induced fibrosis,this study investigated the impact of high hydrostatic pressure(HHP)on Piezo1 activity and the progression of bladder ***:Immunofluorescence staining was conducted to assess the protein abundance of Piezo1 in fibroblasts from obstructed rat *** fibroblasts were cultured under normal atmospheric conditions(0 cmH2O)or exposed to HHP(50 cmH2O or 100 cmH2O).Agonists or inhibitors of Piezol,yAP1,and ROCK1 were used to determine the underlying ***:The Piezo1 protein levels in fibroblasts from the obstructed bladder exhibited an elevation compared to the control *** significantly promoted the expression of various pro-fibrotic factors and induced proliferation of ***,the protein expression levels of Piezol,yAP1,ROCK1 were elevated,and calcium influx was increased as the pressure *** effects were attenuated by the Piezol inhibitor *** Piezo1 activator yoda1 induced the expression of pro-fibrotic factors and the proliferation of fibroblasts,and elevated the protein levels of yAP1 and ROCK1 under normal atmospheric conditions in ***,these effects could be partially inhibited by yAP1 or ROCK ***:The study suggests that HHP may exacerbate bladder fibrosis through activating Piezo1.

关键词： Piezo1 bladder outlet obstruction fibrosis high hydrostatic pressure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis

引用

Genes & Diseases 2024年第5期11卷 63-65页

作者： bo Liang Rui dong Sze Wan Hung yiran Li yuezhen Lin Ling Wu Tao Zhang Gene Chi Wai Man Hui Xu Jacqueline Pui Wah Chung Chi Chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancing Resistance to Bacterial Blight in Rice Using CRISPR-based Base Editing Technology

Enhancing Resistance to Bacterial Blight in Rice Using CRISP...

引用

中国植物病理学会2024年学术年会

作者： LI Chenhao LIU bo dong Hansong yANG Bing Division of Plant Sciences University of Missouri Department of Plant Pathology Nanjing Agricultural University Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang University College of Plant Protection Shandong Agricultural University

Bacterial blight(BB),caused by Xanthomonas oryzae pathovar oryzae(Xoo),poses a significant threat to rice production,particularly in Asia and West *** resistance against BB in elite rice varieties is crucial to advancing rice breeding program and supporting smallholder *** Activator-Like effectors(TALes) are key virulence factors in Xoo,with some targeting the susceptibility(S) genes such as the sugar transporter SWEET genes in *** this,SWEET14 is an important S genes,with its promoter binding by the TALe TalC which exists across all sequenced African Xoo *** the present study,we utilized CRISPR/Cas9-based cytidine and adenine base editors to alter the effector binding element(EBE) of TalC in the promoter of SWEET14 in rice cultivars Kitaake,IR24,and Zhonghua *** introducing C to T changes in EBE led to reduced SWEET14 induction by TalC-containing Xoo strains,resulting in resistance to African Xoo isolates reliant on TalC for ***,A to G changes retained SWEET14 inducibility and susceptibility to Xoo in edited ***,no off-target mutations were detected at predicated sites,and the edited lines exhibited no obvious defects in major agronomictraits in *** results underscore the effectiveness of base editing systems for both molecular biology research and crop improvement endeavors.

关键词： Base editing base editors CBE and ABE rice improvement bacterial blight resistance

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Profound loss of microbial necromass carbon in permafrost thaw-subsidence in the central Tibetan Plateau

引用

Advances in Climate Change Research 2024年第4期15卷 647-657页

作者： Wen-Ting ZHOU Quan-Lian LI Shi-Chang KANG Xiao-dong WU Tian MA Xiao-bo WU Xin XIONG Tanuj SHUKLA Maheswar RUPAKHETI Dipesh RUPAKHETI Da-He QIN Xiu-Feng yIN Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Norhwest Instiute of Eco-Evironment and ResourcesChinese Academy of Scienes Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China Lushan botanical Garden Chinese Academy of SciencesJiujiang 332900China Research Institute for Sustainability-Helmholtz Centre Potsdam Potsdam 14467Germany Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China

Climate warming is causing rapid permafrost degradation,including thaw-induced subsidence,potentially resulting in heightened carbon ***,our understanding of the levels and variations of carbon components in permafrost,particularly during the degradation process,remains *** uncertainties arising from this process lead to inaccurate assessments of the climate effects during permafrost *** vast expanses of permafrost in the Tibetan Plateau,there is limited research available on SOC components,particularly in the central Tibetan *** remarkable variations in hydrothermal conditions across different areas of the Tibetan Plateau,the existing limited studies make it challenging to assess the overall SOC components in the permafrost across the Tibetan Plateau and simulate their future *** this study,we examined the properties of soil organic carbon(SOC)and microbial necromass carbon(MicrobialNC)in a representative permafrost thaw-subsidence area at the southern edge of continuous permafrost in the central Tibetan *** results indicate that prior to the thaw-subsidence,the permafrost had a SOC content of 72.68±18.53 mg g^(-1),with MicrobialNC accounting for 49.6%.The thaw-subsidence of permafrost led to a 56.4%reduction in SOC,with MicrobialNC accounting for 70.0%of the lost *** constitutes the primary component of permafrost SOC,and it is the main component that is lost during thaw-subsidence *** in MicrobialNC are primarily correlated with factors pH,plant input,and microbial *** present study holds crucial implications for both the ecological and biogeochemical processes associated with carbon release from permafrost,and it furnishes essential data necessary for modeling the global response of permafrost to climate *** on this study and previous research,permafrost thawing in the Tibetan Plateau causes substantial loss of ***,there's remarkable heterogeneit

关键词： Tibetan Plateau Thaw-subsidence Soil organic carbon Microbial necromass carbon Amino sugars

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

引用

Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan yanhong Wei Qianhui Zhang Xin Shuai Min Chen yu-Lin Lin Tian-Chen Xiong Xiaoqi Chen bo Zhong Dandan Lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe ***,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral ***,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：