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Inflammatory Factor IL1αInduces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca^(2+)/CaMK2b Pathway

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Neuroscience Bulletin 2024年第4期40卷 421-438页

作者： yu Xia Lu Ding Changlin Zhang Qi Xu Ming Shi Tianshun Gao Feng-Quan Zhou David y.B.Deng Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Department of Gynecology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Pelvic Floor Disorders Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Big Data Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310016China Orthopaedic and Neurological Repair Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Spinal cord injury(SCI)is one of the most devastating traumas,and the aberrant proliferation of astrocytes usually causes neurological ***,the mechanism underlying astrocyte over-proliferation after SCI is ***2c(glutamate ionotropic receptor type 2c)plays an essential role in cell *** bioinformatic analysis indicated that Grin2c and Ca^(2+)transport functions were inhibited in astrocytes after *** of Grin2c stimulated astrocyte proliferation by inhibiting the Ca^(2+)/calmodulin-dependent protein kinase 2b(CaMK2b)pathway in *** screening different inflammatory factors,interleukin 1α(IL1α)was further found to inhibit Grin2c/Ca^(2+)/CaMK2b and enhance astrocyte proliferation in an oxidative damage *** of IL1αusing neutralizing antibody resulted in increased Grin2c expression and the inhibition of astrocyte proliferation ***,this study suggests that IL1αpromotes astrocyte proliferation by suppressing the Grin2c/Ca^(2+)/CaMK2b pathway after SCI,revealing a novel pathological mechanism of astrocyte proliferation,and may provide potential targets for SCI repair.

关键词： IL1α Grin2c Astrocyte Spinal cord injury

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Hole-Selective Contact with Molecularly Tailorable Reactivity for Passivating High-Performing Inverted Perovskite Solar Cells

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CCS Chemistry 2024年第7期6卷 1654-1661页

作者： Wenlin Jiang yingie Hu Fengzhu Li Francis R.Lin Alex K-y.Jen Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong China 999077 Department of Chemistry City University of Hong KongKowloonHong Kong China 999077 Hong Kong Institute for Clean Energy City University of Hong KongKowloonHong Kong China 999077 State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong China 999077

The precisely customizable attributes of self-assembled monolayers(SAMs)molecules at the atomic level hold the potential to facilitate efficient hole selection and interface passivation ***,the correlation between the exposure of passivating groups on the surface and device performance remains ***,we introduce two newly designed SAM molecules,Cbz2S and Cbz2SMe,incorporating cyclic disulfide or two flanking thiomethyls by modifying the 4,5-position of carbazole to adjust the Lewis basicity of the SAM-modified *** possessing suitable energetic alignment,Cbz2S with more-exposed sulfur atoms exhibited inferior device performance due to excessive reactivity,leading to an overpopulation of PbI2 crystallites at the buried perovskite *** contrast,the screening effect from the methyl groups of Cbz2SMe optimized SAM reactivity,exquisitely integrating buried interface passivation and hole selection ***,the champion inverted perovskite solar cell(PSC)employing Cbz2SMe achieved an impressive power conversion efficiency of 24.42%,accompanied by prolonged *** work demonstrates the feasibility of incorporating Lewis-basic passivation groups into SAM molecules and elucidates the relationship between the reactivity of SAM passivation groups and device *** findings provide valuable insights for the design of novel multifunctional SAM molecules,further advancing the performance of PSCs.

关键词： self-assembled monolayer perovskite solar cell hole-selective layer carbazole derivatives defect passivation

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Recent innovations in laser additive manufacturing of titanium alloys

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International Journal of Extreme Manufacturing 2024年第3期6卷 2-37页

作者： Jinlong Su Fulin Jiang Jie Teng Lequn Chen Ming yan Guillermo Requena Lai-Chang Zhang y Morris Wang Ilya V Okulov Hongmei Zhu Chaolin Tan College of Materials Science and Engineering Hunan UniversityChangsha 410082People’s Republic of China Singapore Institute of Manufacturing Technology(SIM Tech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Centre for Advanced Materials and Manufacturing Edith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 900095United States of America Leibniz Institute for Materials Engineering-IWT Badgasteiner Str.328359 BremenGermany Faculty of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Key Laboratory of Hunan Province of Equipment Safety Service Technology under Extreme Environment University of South ChinaHengyangPeople’s Republic of China RWTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany

Titanium(Ti)alloys are widely used in high-tech fields like aerospace and biomedical *** additive manufacturing(LAM),as an innovative technology,is the key driver for the development of Ti *** the significant advancements in LAM of Ti alloys,there remain challenges that need further research and development *** recap the potential of LAM high-performance Ti alloy,this article systematically reviews LAM Ti alloys with up-to-date information on process,materials,and *** feasible solutions to advance LAM Ti alloys are reviewed,including intelligent process parameters optimization,LAM process innovation with auxiliary fields and novel Ti alloys customization for *** auxiliary energy fields(***,acoustic,mechanical deformation and magnetic fields)can affect the melt pool dynamics and solidification behaviour during LAM of Ti alloys,altering microstructures and mechanical *** kinds of novel Ti alloys customized for LAM,like peritecticα-Ti,eutectoid(α+β)-Ti,hybrid(α+β)-Ti,isomorphousβ-Ti and eutecticβ-Ti alloys are reviewed in ***,machine learning in accelerating the LAM process optimization and new materials development is also *** review summarizes the material properties and performance envelops and benchmarks the research achievements in LAM of Ti *** addition,the perspectives and further trends in LAM of Ti alloys are also highlighted.

关键词： additive manufacturing titanium alloys auxiliary field machine learning aerospace materials lightweight materials novel alloys

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On the use of deep learning for phase recovery

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Light(Science & Applications) 2024年第2期13卷 190-235页

作者： Kaiqiang Wang Li Song Chutian Wang Zhenbo Ren Guangyuan Zhao Jiazhen Dou Jianglei Di George Barbastathis Renjie Zhou Jianlin Zhao Edmund y.Lam Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina School of Physical Science and Technology Northwestern Polytechnical UniversityXi’anChina Department of Biomedical Engineering The Chinese University of Hong KongHong Kong SARChina School of Information Engineering Guangdong University of TechnologyGuangzhouChina Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Phase recovery(PR)refers to calculating the phase of the light field from its intensity *** exemplified from quantitative phase imaging and coherent diffraction imaging to adaptive optics,PR is essential for reconstructing the refractive index distribution or topography of an object and correcting the aberration of an imaging *** recent years,deep learning(DL),often implemented through deep neural networks,has provided unprecedented support for computational imaging,leading to more efficient solutions for various PR *** this review,we first briefly introduce conventional methods for ***,we review how DL provides support for PR from the following three stages,namely,pre-processing,in-processing,and *** also review how DL is used in phase image ***,we summarize the work in DL for PR and provide an outlook on how to better use DL to improve the reliability and efficiency of ***,we present a live-updating resource(https://***/kqwang/phase-recovery)for readers to learn more about PR.

关键词： networks phase optics

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Evolutionary history shapes variation of wood density of tree species across the world

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Plant Diversity 2024年第3期46卷 283-293页

作者： Fangbing Li Hong Qian Jordi Sardans Dzhamal y.Amishev Zixuan Wang Changyue Zhang Tonggui Wu Xiaoniu Xu Xiao Tao Xingzhao Huang Anhui Province Key Laboratory of Forest Resources and Silviculture Anhui Agricultural UniversityHefei 230036China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA CREAF Cerdanyola del VallesBarcelona 08193Spain Global Ecology Unit CREAF-CSIC-UAB CSICBellaterraBarcelona 08193Spain Key Laboratory of Ecosystem Carbon Source and Sink China Meteorological Administration(ECSS-CMA)School of Applied MeteorologyNanjing University of Information Science&Technology219 Ningliu RoadNanjing 210044China Department of Natural Resources Management Lakehead UniversityThunder BayOntario P7B 5E1Canada School of Forestry&Landscape of Architecture Anhui Agricultural UniversityHefei 230036China Research Institute of Subtropical Forestry Chinese Academy of ForestryHangzhou 311400China

The effect of evolutionary history on wood density variation may play an important role in shaping variation in wood density,but this has largely not been *** a comprehensive global dataset including 27,297 measurements of wood density from 2621 tree species worldwide,we test the hypothesis that the legacy of evolutionary history plays an important role in driving the variation of wood density among tree *** assessed phylogenetic signal in different taxonomic(e.g.,angiosperms and gymnosperms)and ecological(e.g.,tropical,temperate,and boreal)groups of tree species,explored the biogeographical and phylogenetic patterns of wood density,and quantified the relative importance of current environmental factors(e.g.,climatic and soil variables)and evolutionary history(i.e.,phylogenetic relatedness among species and lineages)in driving global wood density *** found that wood density displayed a significant phylogenetic *** density differed among different biomes and climatic zones,with higher mean values of wood density in relatively drier regions(highest in subtropical desert).Our study revealed that at a global scale,for angiosperms and gymnosperms combined,phylogeny and species(representing the variance explained by taxonomy and not direct explained by long-term evolution process)explained 84.3%and 7.7%of total wood density variation,respectively,whereas current environment explained 2.7%of total wood density variation when phylogeny and species were taken into *** angiosperms and gymnosperms were considered separately,the three proportions of explained variation are,respectively,84.2%,7.5%and 6.7%for angiosperms,and 45.7%,21.3%and 18.6%for *** study shows that evolutionary history outpaced current environmental factors in shaping global variation in wood density.

关键词： Wood density Phylogeny Angiosperms Gymnosperms Climate factors Biophysical parameters

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Energy Design and Optimization of Greenhouse by Natural Convection

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1903-1913页

作者： H.Benzzine H.Labrim Aouatif Saad y.Achour D.Zejli R.El Bouayadi Advanced Systems Engineering Laboratory(ASELab) National School of Applied SciencesIbn Tofail UniversityKenitraMorocco

This study addresses the pressing need for energy-efficient greenhouse management by focusing on the innovative application of natural *** primary objective of this study is to evaluate various ventilation strategies to enhance energy efficiency and optimize crop production in agricultural *** advanced numerical simulation tools,the study conducts a comprehensive assessment of natural ventilation’s effectiveness under real-world *** results underscore the crucial role of the stack effect and strategic window positioning in greenhouse cooling,providing valuable insights for greenhouse *** findings shed light on the significant benefits of optimized ventilation and also offer practical implications for improving greenhouse design,ensuring sustainable and efficient agricultural *** study demonstrated energy savings in cooling from November to April,with a maximum saving of 680 kWh in March,indicating the effectiveness of strategically positioning windows to leverage the stack *** approach enhances plant growth and reduces the need for costly cooling systems,thereby improving overall energy efficiency and lowering operational expenses.

关键词： Energy greenhouse cooling natural ventilation simulation temperature

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Greatly enhanced corrosion/wear resistances of epoxy coating for Mg alloy through a synergistic effect between functionalized graphene and insulated blocking layer

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Journal of Magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.y.Xue X.J.Li J.H.Chu M.M.Li D.N.Zou L.B.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy composite coating on Mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare Mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloys.

关键词： Mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer

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MRI征象预测极早期至中期肝细胞肝癌切除术后生存期

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国际医学放射学杂志 2024年第4期 497-498页

作者： H.y.Jiang y.Qin H.Wei T.y.Zheng T.yang y.A.Wu 程昊

摘要目的对比增强MRI可以为肝细胞肝癌（HCC）病人提供个体化的预后信息，研究旨在探讨MRI征象对早期无复发生存（≤2年，E-RFS）、晚期无复发生存（>2年，L-RFS）

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Rumen microbial degradation of bromoform from red seaweed(Asparagopsis taxiformis)and the impact on rumen fermentation and methanogenic archaea

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Journal of Animal Science and Biotechnology 2024年第1期15卷 412-426页

作者： Pedro Romero Alejandro Belanche Elisabeth Jiménez Rafael Hueso Eva Ramos-Morales Joan King Salwen Ermias Kebreab David R.yáñez-Ruiz Estacion Experimental del Zaidin Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Department of Animal Production and Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocean Barns Inc. Redwood CityCAUSA Department of Animal Science University of CaliforniaDavisCA 95618USA

Background The red macroalgae Asparagopsis is an effective methanogenesis inhibitor due to the presence of halogenated methane(CH_(4))analogues,primarily bromoform(CHBr_(3)).This study aimed to investigate the degradation process of CHBr3 from A taxiformis in the rumen and whether this process is *** in vitro batch culture system was used according to a 2×2 factorial design,assessing two A taxiformis inclusion rates[0(CTL)and 2%DM diet(AT)]and two diets[high-concentrate(HC)and high-forage diet(HF)].Incubations lasted for 72 h and samples of headspace and fermentation liquid were taken at 0,0.5,1,3,6,8,12,16,24,48 and 72 h to assess the pattern of degradation of CHBr_(3) into dibromomethane(CH_(2)Br_(2))and fermentation ***,an in vitro experiment with pure cultures of seven methanogens strains(Methanobrevibacter smithii,Methanobrevibacter ruminantium,Methanosphaera stadtmanae,Methanosarcina barkeri,Methanobrevibacter millerae,Methanorhermobacter wolfei and Methanobacterium mobile)was conducted to test the effects of increasing concentrations of CHBr3(0.4,2,10and 50μmol/L).Results The addition of AT significantly decreased CH_(4) production(P=0.002)and the acetate:propionate ratio(P=0.003)during a 72-h *** concentrations of CHBr_(3) showed a rapid decrease with nearly 90%degraded within the first 3 h of *** the contrary,CH_(2)Br_(2) concentration quickly increased during the first 6 h and then gradually decreased towards the end of the *** CHBr_(3) degradation nor CH_(2)Br_(2) synthesis were affected by the type of diet used as substrate,suggesting that the fermentation rate is not a driving factor involved in CHBr_(3)*** in vitro culture of methanogens showed a dose-response effect of CHBr3 by inhibiting the growth of ***,***,***,***,***,***,and *** The present work demonstrated that CHBr_(3) from *** is quickly degrad

关键词： Bromoform metabolism Dibromomethane metabolism Methane mitigation Methanogens Rumen microbiota Seaweed

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Seismic attribute and well-log analysis for channel characterization in the upper San Andres and Grayburg formations of the Midland Basin,Texas

Energy Geoscience

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Energy Geoscience 2024年第2期5卷 263-278页

作者： Sumit Verma Esra yalçın yılmaz Laura Ortiz Sanguino Justin yandell Miles A.Henderson Robert C.Trentham Department of Geosciences The University of Texas Permian BasinOdessaTXUSA School of Geosciences The University of OklahomaNormanOKUSA

The Permian Basin is one of the most prolific,and currently one of the most active,oil and gas basins in the *** Lower Permian strata in the Permian Basin have produced more than 14 billion barrels of oil(BBO),making it the largest volume of hydrocarbon in the *** in the Midland Basin during late Leonardian through early Guadalupian(ca.272e269 Ma)resulted in progradation of shelf edge and ultimately closure of the basin by Middle Permian *** analyzed a merged seismic survey covering parts of the Permian Basin(i.e.,Central Basin Platform and Midland Basin)in Andrews,Ector,and Midland Counties,*** seismic survey and well logs show the presence of gently dipping(ca.1°)clinoforms in the Upper San Andres and Grayburg Formations on the eastern edge of the Central Basin Platform and western Midland *** seismic attributes,curvature,and spectral decomposition identify low sinuosity slope channels oriented north-south,but such channels do not appear beyond the *** shelf edge shifts from north to south during deposition of the Upper San Andres and Grayburg *** identify five basinward shifts noted by the migration of the shelf edge toward the basin center and the presence of channel features along the depositional *** petrophysical analysis indicates that channels cut into carbonate rocks and are filled by siliciclastic sediments;this interpretation is supported by the most negative curvature anomalies along the channel axes caused by the differential compaction between the carbonate and siliciclastic *** are a few channels with a northwest-southeast strike,which matches the direction of the Concho Lineament observed by satellite *** observations are consistent with previous interpretations of the northern Midland Basin closure during Middle-Late Permian time.

关键词： Permian shelf carbonate

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