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Quality management in a high-containment laboratory

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Journal of Biosafety and Biosecurity 2019年第1期1卷 34-38页

作者： M.Hou D.L.Song z.L.shi z.M.yuan National Biosafety Laboratory Wuhan Institute of VirologyChina Academy of SciencesWuhan 430071China

The National Biosafety Laboratory level 4 in Wuhan was accredited according to the Guo Biao(National standard)19489:2008 standard in 2017 by the China National Accreditation Service for Conformity Assessment and was then licensed to store and handle microorganisms of risk group *** current aim of laboratory management is to accredit this high-containment laboratory according to the ISO/IEC 17025:2017 standard to set up a quality management *** complement this standard,the ComitéEuropéen de Normalisation(CEN,i.e.,European Committee for Standardization)Working Agreement 15793:2011 is also used for safety and security against *** Chinese Guo Biao 19489:2008 standard is also taken into account to achieve two aims:to comply with Chinese legislation and to improve the level of detail in the laboratory’s ***,the management proposes to apply Good Research Laboratory Practices(published by the China National Accreditation Service for Conformity Assessment),in which ethical rules are laid *** a well-integrated and well-managed quality management system can master the implementation of all these different ***,it would be better if all the requirements were combined into one ***,there is a real need for drafting a new standard or guideline specifically for containment laboratories.

关键词： Biocontainment Biosecurity Bbiosafety BSL4 Accreditation

Combined treatment of Cyclosporine and Mycophenolate improves endothelial function in aorta of LDLR-/- mice

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Combined treatment of Cyclosporine and Mycophenolate improve...

Microstructural refinement mechanism and its effect on toughness in the nugget zone of high-strength pipeline steel by friction stir welding

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Meng M Li z Vanhoutte PM Leung SWS shi y Biomedical research center Zhongshan HospitalFudan University Department of Pharmacology and Pharmacy The University of Hong Kong

*** inflammation is a key player in the process of *** present study was designed to investigate effects of immunosuppressive agents on endothelial dysfunction in a mouse model of *** induce atherosclerosis,6-week old... 详细信息

关键词： western Combined treatment of Cyclosporine and Mycophenolate improves endothelial function in aorta of LDLR

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Journal of Materials Science & Technology 2021年第34期93卷 221-231页

作者： R.H.Duan G.M.Xie P.Xue z.y.Ma z.A.Luo C.Wang R.D.K.Misra State Key Laboratory of Rolling and Automation Northeastern UniversityNo.3 Wenhua RoadShenyang 110819China shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Metallurgy Northeastern UniversityNo.3 Wenhua RoadShenyang 110819China Department of Metallurgical Materialsand Biomedical EngineeringUniversity of Texas at El PasoTX 79968USA

High-strength pipeline steel was subjected to friction stir welding(FSW)at rotation rates of 400-700 rpm,and the grain refinement mechanism of the nugget zone(Nz)was *** thermomechanical process during FSW in the Nz was simulated by multi-pass thermal compression,thereby achieving the austenitic non-recrystallization temperature(T_(nr)).The austenitic non-recrystallization in the Nz at the lowest rotation rate of 400 rpm caused a significant grain ***,the reduced rotation rate also resulted in the formation of a high ratio of island-like martensite-austenite(M-A)*** toughness of the Nzs was enhanced as the rotation rate decreased,which is attributed to the fine effective grains and homogeneously distributed fine M-A constituents dramatically inhibiting crack initiation and propagation.

关键词： Pipeline steel Friction stir welding Grain refinement M-A constituent Toughness

Ion motion effects on the generation of short-cycle relativistic laser pulses during radiation pressure acceleration

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High Power Laser Science and Engineering 2014年第2期2卷 1-7页

作者： W.P.Wang X.M.zhang X.F.Wang X.y.zhao J.C.Xu y.H.yu L.Q.yi y.shi L.G.zhang T.J.Xu C.Liu z.K.Pei B.F.Shen State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences

The effects of ion motion on the generation of short-cycle relativistic laser pulses during radiation pressure acceleration are investigated by analytical modeling and particle-in-cell simulations. Studies show that the rear part of the transmitted pulse modulated by ion motion is sharper compared with the case of the electron shutter only. In this study, the ions further modulate the short-cycle pulses transmitted. A 3.9 fs laser pulse with an intensity of 1.33×1021W cm-2is generated by properly controlling the motions of the electron and ion in the simulations. The short-cycle laser pulse source proposed can be applied in the generation of single attosecond pulses and electron acceleration in a small bubble regime.

关键词： radiation pressure acceleration short-cycle pulses particle-in-cell simulations.

FEM Simulation of the Hydrogen Diffusion in X80 Pipeline Steel During Stacking for Slow Cooling

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Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 416-421页

作者： zhenyi Huang Qi shi Fuqiang Chen yunfeng shi School of Metallurgical Engineering Anhui University of Technology Heavy Plate Mill Baoshan Iron and Steel Co. Ltd

The influence of temperature on the hydrogen diffusion behavior in X80 pipeline steel during stacking for slow cooling was studied using electrochemical penetration method, the temperature field and the hydrogen diffusion in this pipeline steel during stacking for slow cooling were simulated by ABAQUS finite element method （FEM） software. The results show that in this process there is a reciprocal relationship between the natural logarithm of hydrogen diffusion coefficient and temperature. The cooling rate decreases gradually with the increase of steel plate thickness. The hydrogen content is higher at high temperature （500-400 ℃） than that in low temperature region （300-100 ℃）. The FEM simulation results are consistent with the experimental ones, and the model can be used to predict the hydrogen diffusion behavior in industrial production of X80 pipeline steel.

关键词： X80 pipeline steel Stacking Slow cooling Hydrogen diffusion Finite element method (FEM) Electrochemical penetration

Regularization by Multiple Dual Frames for Compressed Sensing Magnetic Resonance Imaging With Convergence Analysis

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IEEE/CAA Journal of Automatica Sinica 2023年第11期10卷 2136-2153页

作者： Baoshun shi Kexun Liu School of Information Science and Engineering Yanshan University the Hebei Key Laboratory of Information Transmission and Signal Processing Qinhuangdao 066004China IEEE

Plug-and-play priors are popular for solving illposed imaging inverse problems. Recent efforts indicate that the convergence guarantee of the imaging algorithms using plug-andplay priors relies on the assumption of bounded denoisers. However, the bounded properties of existing plugged Gaussian denoisers have not been proven explicitly. To bridge this gap, we detail a novel provable bounded denoiser termed as BMDual,which combines a trainable denoiser using dual tight frames and the well-known block-matching and 3D filtering(BM3D)denoiser. We incorporate multiple dual frames utilized by BMDual into a novel regularization model induced by a solver. The proposed regularization model is utilized for compressed sensing magnetic resonance imaging(CSMRI). We theoretically show the bound of the BMDual denoiser, the bounded gradient of the CSMRI data-fidelity function, and further demonstrate that the proposed CSMRI algorithm converges. Experimental results also demonstrate that the proposed algorithm has a good convergence behavior, and show the effectiveness of the proposed algorithm.

关键词： Bounded denoiser compressed sensing magnetic resonance imaging(CSMRI) dual frames plug-and-play priors regularization

Flow characteristic and wastewater treatment performance of a pilot-scale airlift oxidation ditch

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Frontiers of Environmental Science & Engineering 2009年第4期3卷 470-476页

作者： Hongtao PANG Hanchang shi Huiming shi Department of Environmental Science and Engineering Tsinghua UniversityBeijing 100084China

A pilot-scale airlift oxidation ditch using bubble diffuser and baffle as aerator was operated in a wastewater treatment plant(WWTP)to investigate its flow characteristic and wastewater treatment *** with the conventional oxidation ditch process,effective depth and oxygen utilization efficiency of this new process was improved by underwater ***,it had a reversed velocity distribution,which decreased from the bottom to the top on vertical *** measurement showed that a velocity over 0.2 m/s at the bottom was sufficient to prevent sludge settlement during long term *** of these concepts would save land area and energy consumption by about 25%–50%and 55%,*** this new system,organic biodegradation and nitrification could be well *** could occur steadily in the straight part by adjusting the airflow *** average TN removal rate of 63%was achieved with dissolved oxygen(DO)concentrations between 0.6 mg/L and 1.5 mg/*** main pollutants in the effluent could meet the strictest discharge standard(COD<50 mg/L,NH4_(+)^(–)N<5 mg/L,and TN<15 mg/L)in China now.

关键词： airlift oxidation ditch flow characteristic wastewater treatment

基于瓦片分区的雷达动态定量降水估测方法研究

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高原气象 2025年第1期44卷 122-133页

作者：李佳慧马建立陈明轩史朝成都信息工程大学四川成都610225 北京城市气象研究院北京100089

雷达定量降水估测(QPE)考虑雨滴谱的时空变异性,是提高QPE的有效途径。雷达采用z-R关系开展降水估测时,雨滴谱的差异,主要表现为z-R关系式不同;利用瓦片分区方法,将降水估测区域进行瓦片分区,每个瓦片内利用雷达和自动站数据动态拟合z-... 详细信息

雷达定量降水估测(QPE)考虑雨滴谱的时空变异性,是提高QPE的有效途径。雷达采用z-R关系开展降水估测时,雨滴谱的差异,主要表现为z-R关系式不同;利用瓦片分区方法,将降水估测区域进行瓦片分区,每个瓦片内利用雷达和自动站数据动态拟合z-R关系式开展QPE。文中利用六次天气过程对瓦片分区降水估测方法进行评估,从QPE各项评价指标看,误差较传统的固定z-R关系法和全域动态z-R关系法,有很好的提升,降水估测结果与强降水中心基本一致,各项误差指标均最小;结果表明瓦片分区降水估测方法是提升雷达QPE的有效方式。

关键词：降水估测雷达组网分区拟合

HIGH STRAIN RATE SUPERPLASTICITy IN A SiC_w/2024Al COMPOSITE MADE By SQUEEzE CASTING

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Acta Metallurgica Sinica(English Letters) 1998年第4期11卷 275-280页

作者： X.J.Xu D. zhang z.L. shi C.z.zhao and R.J. Wu (State Key Laboratory of Metal Matrir Composites, Shanghai Jiaotong University, Shanghai 200030, China) Shanghai Jiaotong Univ Shanghai China

In this paper,the superplastic characteristics of the beta-SiC whisker reinforced 2024aluminum composite, fabricated by squeeze casting and hot-rolling after extrusion were investigated. The compsite had a fine grain size of about 2μm, and exhibited a strain rate sensitivity of about 0.35 and a maximum elongation of 350% at an initial strain rate of 1.1×10-1s-1 at 803K. In addition, the superplastic deformation mechanisme of the composite were also examined.

关键词： high strain rate superplasticity aluminum matrix composite squeeze casting