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九价人乳头瘤病毒疫苗的保护效力、免疫原性和安全性:亚洲人群亚组分析

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中国病毒病杂志 2018年第4期8卷 336-342页

作者： S.M.Garland P.Pitisuttithum H.y.S.Ngan C.-H.Cho C.-y.Lee C.-A.Chen y.C.yang T.-y.Chu N.-F.Twu R.Samakoses y.takeuchi T.H.Cheung S.C.Kim L.-M.Huang B.-G.Kim y.-T.Kim K.-H.Kim y.-S.Song S.Lalwani J.-H.Kang M.Sakamoto H.-S.Ryu N.Bhatla H.yoshikawa M.C.Ellison S.R.Han E.Moeller S.Murata M.Ritter M.Sawata C.Shields A.Walia G.Perez A.Luxembourg 魏丽惠北京大学人民医院妇产科不详

预防性人乳头瘤病毒（HPV）疫苗接种可以降低HPV相关疾病负担。过去十年内上市的二价HPV疫苗（HPV16、18）和四价疫苗（HPV6、11、16、18）可以在全世界范围内（包括亚州）预防约70%的宫颈癌,同时四价疫苗还可以预防约90%的生殖器疣。

关键词：九价HPV疫苗亚洲宫颈癌人乳头瘤病毒疫苗

Zonal Flows and Geodesic Acoustic Mode Oscillations in Tokamaks and Helical Systems

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Plasma Science and Technology 2006年第1期8卷 105-109页

作者： T. WATARI y. HAMADA A. NISHIZAWA T. NOTAKE N. takeuchi National Institute for Fusion Science 322-6 Oroshi-cho Toki-city Gifu Japan Ariake National College of Technology 150 Higashihagio-Machi Omuta Fukuoka Japan

This paper reviews the theoretical foundations of zonal flow, putting emphasis on the linear response function of plasma to the external flow drive. An extension of the theory is made in order to apply it to helical systems and to study the properties of the zonal flow in the low frequency range. Further refinement of the theory is made incorporating the orbital effects of particles more precisely, and the role of neoclassical polarization current is identified.

关键词： zonal flow geodesic acousti mode finite orbit effect coupling to ion acoustic mode

Pathogenesis of NSAID-induced gastric damage:Importance of cyclooxygenase inhibition and gastric hypermotility

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World Journal of Gastroenterology 2012年第18期18卷 2147-2160页

作者： Koji takeuchi Department of Pharmacology and Experimental Therapeutics Division of Pathological SciencesKyoto Pharmaceutical UniversityKyoto 607-8414Japan

This article reviews the pathogenic mechanism of nonsteroidal anti-inflammatory drug(NSAID)-induced gastric damage,focusing on the relation between cyclooxygenase(COX) inhibition and various functional ***,such as indomethacin,at a dose that inhibits prostaglandin(PG) production,enhance gastric motility,resulting in an increase in mucosal permeability,neutrophil infiltration and oxyradical production,and eventually producing gastric *** lesions are prevented by pretreatment with PGE 2 and antisecretory drugs,and also via an atropine-sensitive mechanism,not related to antisecretory *** neither rofecoxib(a selective COX-2 inhibitor) nor SC-560(a selective COX-1 inhibitor) alone damages the stomach,the combined administration of these drugs provokes gastric ***-560,but not rofecoxib,decreases prostaglandin E 2(PGE 2) production and causes gastric hypermotility and an increase in mucosal ***-2 mRNA is expressed in the stomach after administration of indomethacin and SC-560 but not *** up-regulation of indomethacin-induced COX-2 expression is prevented by atropine at a dose that inhibits gastric *** addition,selective COX-2 inhibitors have deleterious influences on the stomach when COX-2 is overexpressed under various conditions,including adrenalectomy,arthritis,and Helicobacter *** summary,gastric hypermotility plays a primary role in the pathogenesis of NSAID-induced gastric damage,and the response,causally related with PG deficiency due to COX-1 inhibition,occurs prior to other pathogenic events such as increased mucosal permeability;and the ulcerogenic properties of NSAIDs require the inhibition of both COX-1 and COX-2,the inhibition of COX-1 upregulates COX-2 expression in association with gastric hypermotility,and PGs produced by COX-2 counteract the deleterious effect of COX-1 inhibition.

关键词： Non-steroidal anti-inflammatory drug Gastric damage Pathogenesis Gastric motility Neutrophil

Biology and treatment of cervical adenocarcinoma

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Chinese Journal of Cancer Research 2016年第2期28卷 254-262页

作者： Satoshi takeuchi Department of Obstetrics and Gynecology School of MedicineIwate Medical University

Uterine cervical adenocarcinoma （ADC） has been increasing in its prevalence world widely despite the decrease of squamous cell carcinoma （SCC）. It comprises nearly 20-25% of the all cervical malignancy in developed countries. The worse biological behavior had been reported in patients with intermediateand high risk factors after surgery, and in advanced stage over III, radiotherapy （RT） alone and concurrent chemo-radiotherapy （CCRT） with cisplatin was not always effective. As for chemotherapy （CT）, the iaduction CT has not established, as well. Further molecular targeted therapy （MTT） has been studied. The targets of oncogenic driver mutations were vascular endothelial growth factor （VEGF） in SCC, or tyrosine kinase （TK） of endothelial growth factor receptor 2 （EGFR2, Her2/neu）-Ras-MAPK-ERK pathway. Bevacizumab （Bey, anti-VEGF monoclonal antibody） is considered as one of key agent with paclitaxel and carboplatin in SCC, but not for ADC. This article focuses on up-to-date knowledge of biology and possible specific therapeutic directions to explore in the management of cervical ADC.

关键词： Cervical cancer adenocarcinoma (ADC) atypical glandular cell (AGC) gastric type adenocarcinoma (GAS)

In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation

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Light(Science & Applications) 2023年第5期12卷 877-893页

作者： Osamu yasuhiko Kozo takeuchi Central Research Laboratory Hamamatsu Photonics K.K5000 HirakuchiHamakita-kuHamamatsu 434-8601 ShizuokaJapan

Refractive index(RI)is considered to be a fundamental physical and biophysical parameter in biological imaging,as it governs light-matter interactions and light propagation while reflecting cellular *** tomography enables volumetric visualization of RI distribution,allowing biologically relevant analysis of a ***,multiple scattering(MS)and sample-induced aberration(SIA)caused by the inhomogeneity in RI distribution of a thick sample make its visualization *** paper proposes a deep RI tomographic approach to overcome MS and SIA and allow the enhanced reconstruction of thick samples compared to that enabled by conventional linear-model-based RI *** proposed approach consists of partial RI reconstruction using multiple holograms acquired with angular diversity and their backpropagation using the reconstructed partial RI map,which unambiguously reconstructs the next partial *** this operation efficiently reconstructs the entire RI tomogram while suppressing MS and *** visualized a multicellular spheroid of diameter 140μm within minutes of reconstruction,thereby demonstrating the enhanced deep visualization capability and computational efficiency of the proposed method compared to those of conventional RI ***,we quantified the high-RI structures and morphological changes inside multicellular spheroids,indicating that the proposed method can retrieve biologically relevant information from the RI *** from the excellent biological interpretability of RI distributions,the label-free deep visualization capability of the proposed method facilitates a noninvasive understanding of the architecture and time-course morphological changes of thick multicellular specimens.

关键词： properties refractive overcome

Cell-Based Biohybrid Sensor Device for Chemical Source Direction Estimation

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Cyborg and Bionic Systems 2021年第1期2021卷 55-63页

作者： H.Oda K.Kihara y.Morimoto S.takeuchi Department of Mechano-Informatics Graduate School of Information Science and TechnologyThe University of TokyoJapan

This paper describes a method to estimate the direction from which the signal molecule reaches the sensor by using living *** this context,biohybrid sensors that utilize a sophisticated sensing system of cells can potentially offer high levels of chemicaldetection sensitivity and ***,biohybrid-sensor-based chemical-source-direction estimation has not received research attention because the cellular response to chemicals has not been examined in the context of directional *** our approach,we fabricated a device that can limit the interface between the cell-laden hydrogel and the chemical solution of interest to enhance the time difference over which the chemical solution reaches the *** detection by cells that express specific receptors is reflected as the fluorescence of the calcium indicator within the *** device has eight chambers that each house 3D cell-laden collagen hydrogels facing circularly *** device also works as a cover to prevent chemicals from permeating the hydrogel from *** our study,by observing the time course of the fluorescence emission of each chamber,we were able to successfully estimate the chemical-source direction within an error range of 7-13°.Our results suggest that a combination of microstructure devices embedded with living cells can be used to exploit cell functionalities to yield chemical-source directional information.

关键词： directional utilize reflected

Thermal stability and mechanical properties of Gd-Co-Al bulk glass alloys

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中国有色金属学会会刊：英文版 2007年第6期17卷 1220-1224页

作者：陈鼎 A. takeuchi A. Inoue Institute for Metal Research Hunan University Institute for Materials Research Toho ku University Sendai 980-8577 Japan

The glass forming ability of Gd-Co-Al ternary alloy systems with a composition ranging from 50% to 70% (molar fraction) for Gd and from 5% to 40% (molar fraction) for Al were investigated by copper mold casting and Gd60Co25Al15 bulk glass alloy cylinders with the maximum diameter of 5 mm were obtained. The reduced glass transformation temperature (Tg/Tm) and the distance of supercooling region △Tx are 0.616 and 45 K, respectively for this Gd-Co-Al alloy. The compressive fracture strength (σf) and elastic modulus (E) of Gd-Co-Al glassy alloys are 1 170-1 380 MPa and 59-70 GPa, respectively. The Gd-Al-Co bulk glassy alloys with high glass forming ability and good mechanical properties are promising for the future development as a new type function materials.

关键词： Gd-Co-A1合金热稳定性机械性质玻璃合金

Immersed Interface CIP for One Dimensional Hyperbolic Equations

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Communications in Computational Physics 2014年第6期16卷 96-114页

作者： Kazufumi Ito Tomoya takeuchi Department of Mathematics North Carolina State UniversityRaleighNC 27695USA. Collaborative Research Center for Innovative Mathematical Modelling Institute of Industrial ScienceUniversity of TokyoTokyoJapan. FIRST Aihara Innovative Mathematical Modelling ProjectJSTKawaguchiJapan.

The immersed interface technique is incorporated into CIP method to solve one-dimensional hyperbolic equations with piecewise constant *** proposed method achieves the third order of accuracy in time and space in the vicinity of the interface where the coefficients have jump discontinuities,which is the same order of accuracy of the standard CIP *** numerical tests are given to verify the accuracy of the proposed method.

关键词： CIP method immersed interface method hyperbolic equations in discontinuous media.

Point Sources Identification Problems for Heat Equations

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Communications in Computational Physics 2009年第5期5卷 897-913页

作者： Leevan Ling Tomoya takeuchi Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong Graduate School of Mathematical Sciences University of Tokyo3-8-1 KomabaMeguroTokyo153-8914Japan

We considered the point source identification problems for heat equations from noisy observation data taken at the minimum number of spatially fixed measurement *** aim to identify the unknown number of sources and their locations along with their *** our previous work,we proved that minimum measurement points needed under the noise-free *** this paper,we extend the proof to cover the noisy cases over a border class of source *** show that if the regularization parameter is chosen properly,the problem can be transformed into a poles identification problem.A reconstruction scheme is proposed on the basis of the developed theoretical *** demonstrations in 2D and 3D conclude the paper.

关键词： Point source source identification heat equations noisy data convergence