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NF-κB in biology.and targeted therapy.new insights and translational implications

Signal transduction and targeted therapy 2024年第4期9卷 1322-1358页

作者： Qing Guo y.zi jin Xiny. Chen Xiaomin y. Xin Shen Mingxi Lin Cheng Zeng teng Zhou Jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key.Laboratory.of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly.40 ***,NF-κB signaling was identified as a pivotal pathway.in mediating inflammatory.***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety.of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory.mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathway.,including PI3K/AKt,MAPK,JAK-StAt,tGF-β,Wnt,Notch,Hedgehog,and tLR *** phy.iological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety.of human diseases,including cancers,inflammatory.and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,tKls,non-coding RNAs,immunotherapy.and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKt diseases involvement

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Microstructural Stability.of a Single Cry.tal Superalloy.DD8 during thermal Exposure

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Journal of Materials Science & technology 2008年第1期24卷 127-130页

作者： K.y.Cheng D.H.Kim y.S.y.o C.y.Jo t.jin Z.Q.Hu Superalloy.ivision Institute of Metal Research Chinese Academy of Sciences Sheny.ng 110016 China High temperature Materials Group KIMS Changwon Korea Materials test and Characterization Group KIMS Changwon Korea

Microstructural stability.of a nickel base single cry.tal alloy.DD8 has been *** heat treated specimen showed good microstructural stability.at 950℃.While under the as-cast condition,a kind of rod-like phase precipitated in the interdendritic region of as-cast specimen during thermal *** phase,which has bcc structure,was enriched with ***-calc also predicted precipitation of a bcc phase at around 950℃.the Cr-rich bcc phase was considered asα-Cr and formed due to the segregation of Cr under the as-cast condition.

关键词： DD-8 Single cry.tal alloy Microstructural stability Alpha chromium

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Effect of navigation endoscopy.combined with threedimensional printing technology.in the treatment of orbital blowout fractures

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International Journal of Ophthalmology.English edition) 2024年第3期17卷 570-576页

作者： jin-Hai y. y.o-Hua Wang Qi-Hua Xu Chao Xiong An-An Wang Hong-Fei Liao School of Optometry Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina the Affiliated Ey. Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Clinical Research Center for Ophthalmic Disease Nanchang 330006Jiangxi ProvinceChina Jiangxi Research Institute of Ophthalmology.and Visual Science Nanchang 330006Jiangxi ProvinceChina Jiangxi Provincial Key.Laboratory.for Ophthalmology Nanchang 330006Jiangxi ProvinceChina

●AIM:to explore the combined application of surgical navigation nasal endoscopy.NNE)and three-dimensional printing technology.3DPt)for the adjunctive treatment of orbital blowout fractures(OBF).●MEtHODS:Retrospective analy.is was conducted on the data of patients with OBF who underwent surgical treatment at the Affiliated Ey. Hospital of Nanchang University.between July.2012 and November *** control group consisted of patients who received traditional surgical treatment(n=43),while the new surgical group(n=52)consisted of patients who received NNE with *** difference in therapeutic effects between the two groups was evaluated by.comparing the duration of the operation,best corrected visual acuity.BCVA),enophthalmos difference,recovery.rate of ey. movement disorder,recovery.rate of diplopia,and incidence of postoperative complications.●RESULtS:the study.included 95 cases(95 ey.s),with 63 men and 32 *** patients’age ranged from 5 to 67y.35.21±15.75y..the new surgical group and the control group exhibited no statistically.significant differences in the duration of the operation,BCVA and enophthalmos *** recovery.rates of diplopia in the new surgical group were significantly.higher than those in the control group at 1mo[OR=0.03,95%CI(0.01–0.15),Pthe recovery.rates of ey. movement disorders at 1 and 3mo after surgery.were OR=0.08,95%CI(0.03–0.24),Ptoperative complications was lower in the new surgical group compared to the control group[OR=4.86,95%CI(0.95–24.78),Pthe combination of NNE and 3DPt can shorten the recovery.time of diplopia and ey. movement disorder in patients with OBF.

关键词： orbital blowout fracture three-dimensional printing endoscopy surgical navigation

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知识搜寻、动态能力与数字创业——基于盒马鲜生的纵向单案例研究

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经济管理 2024年第5期46卷 92-110页

作者：叶江峰陈珊靳瑞杰安徽大学商学院安徽合肥230601 四川大学商学院四川成都610044 长安大学经济与管理学院陕西西安710064 西安交通大学管理学院陕西西安710049

数字创业突破了传统创业实体运营的时间和空间限制,改变了企业的创业模式以及人们的消费方式,因而成为业界和学界关注的焦点。现有文献多从单一视角考察知识搜寻或动态能力对企业创业活动的影响,较少对数字创业过程进行动态解析,而关于... 详细信息

数字创业突破了传统创业实体运营的时间和空间限制,改变了企业的创业模式以及人们的消费方式,因而成为业界和学界关注的焦点。现有文献多从单一视角考察知识搜寻或动态能力对企业创业活动的影响,较少对数字创业过程进行动态解析,而关于二者交互效应对数字创业影响机理的研究则更是缺乏。本文以盒马鲜生为研究案例,基于知识搜寻和动态能力的双重视角,探索两类因素及其互促机制在数字创业过程中表现出的规律特征。研究发现,数字创业是一个包含“机会识别→体系构建→价值实现→模式改进”四个阶段的动态过程。其中,知识搜寻为数字创业提供资源保障,动态能力促进创业资源合理配置,二者在不同阶段的互动效应以及更迭转换推动了数字创业的不断演进。本文揭示了数字创业的过程及内在机理,为数字经济时代的数字创业提供了理论借鉴和实践参考。

关键词：数字创业知识搜寻动态能力盒马鲜生

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Ketogenic diet therapy.in children with epilepsy.caused by.SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： y.ng-y.n Wang y.n-Qing Zhou Li-Juan Luo Cui-jin Wang Nan Shen Hao Li Ji-Wen Wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background this retrospective study.assessed the efficacy.and safety.of ketogenic diet therapies in children with epilepsy.caused by.SLC2A1 genetic mutations and glucose transporter ty.e 1 deficiency.*** Pediatric patients with epilepsy.sy.ptoms admitted to our medical center between January.2017 and October 2021 were included if they.presented with an SLC2A1 genetic mutation on whole-exome *** analy.ed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different ty.es and frequencies,and they.took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analy.ed epilepsy.control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy.during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy.is very.effective and safe for the treatment of epilepsy.caused by.SLC2A1 ***,patients with glucose transporter ty.e 1 deficiency.sy.drome caused by.SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter ty.e 1 Ketogenic diet SLC2A1

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A mutation in tBXt causes congenital vertebral malformations in humans and mice

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Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： Shuxia Chen y.nping Lei y.jun y.ng Chennan Liu Lele Kuang Li jin Richard HFinnell Xuey.n y.ng Hongy.n Wang Obstetrics and Gy.ecology.Hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China Shanghai Key.Laboratory.of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key.Laboratory.of Contemporary.Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s Hospital Fudan University399 Wanyuan RoadShanghai 201102China

t-box transcription factor t(tBXt;t)is required for mesodermal formation and axial skeletal *** it has been extensively.studied in various model organisms,human congenital vertebral malformations(CVMs)involving t are not well ***,we report a family.with 15 CVM patients distributed across 4 *** affected individuals carry.a heterozy.ous mutation,t c.596A>G(p.Q199R),which is not found in unaffected family.members,indicating co-segregation of the genoty.e and *** vitro assay. show that t p.Q199R increases the nucleocy.oplasmic ratio and enhances its DNA-binding affinity.but reduces its transcriptional activity.compared to the *** determine the pathogenicity.of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozy.ous Q199R mice show subtle kinked or shortened tails,while homozy.ous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in t causes CVM in humans and mice,providing previously.unreported evidence supporting the function of t in the genetic etiology.of human CVM.

关键词： Congenital vertebral malformation tBXt t gene Loss-of-function mutation

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Repeatability.and reproducibility.of corneal higher-order aberrations measurements after small incision lenticule extraction using the Scheimpfug-Placido topographer

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Ey. and Vision 2024年第1期10卷 1-9页

作者： Rui Ning Rongrong Gao David PPiñero Jun Zhang Qingy. Gao y.li jin y.ran Wang Chenxiao Wang jinhai Huang Ey. Hospital and School of Ophthalmology.and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina Ey. Institute and Department of Ophthalmology Eye and ENT HospitalFudan UniversityShanghaiChina Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicanteSpain NHC Key.Laboratory.of My.pia(Fudan University. Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina Shanghai Research Center of Ophthalmology.and Optometry ShanghaiChina

Background:to evaluate the precision of corneal higher-order aberrations measurements after small incision lenticule extraction(SMILE)using the Sirius Scheimpfug-Placido topographer(CSO,Italy..Methods:Seventy.fve ey.s from 75 postoperative subjects were included in this prospective *** consecutive corneal aberrometric measurements were obtained with the Scheimpfug-Placido topographer by.two experienced operators to assess intra-and inter-observer *** within-subject standard deviation(Sw),test-retest repeatability.tRt)and the intraclass correlation coefcient(ICC)were ***:For intraobserver repeatability.of anterior and total corneal aberrations,all ICCs were more than 0.922,except for trefoil(0.722 to 0.768).the ICCs of total root mean square(RMS),coma Z(3,±1),and spherical aberration Z(4,0)were over 0.810 while higher-order RMS,trefoil Z(3,±3),and astigmatism II Z(4,±2)were below 0.634 for posterior corneal surface *** Sw values for all ty.es of aberrations were equal to or below 0.07μ*** interobserver reproducibility.all tRt values were no more than 0.12μm,0.05μm,and 0.11μm for anterior,posterior,and total corneal aberrations,*** ICC values ranged from 0.875 to 0.989,from 0.686 to 0.976 and over 0.834 for anterior,posterior,and total corneal aberrations,***:the repeatability.of measurements of anterior and total corneal aberrations with the Sirius sy.tem in corneas after SMILE surgery.was high,except for *** was some variability.in posterior corneal aberrometric *** reproducibility.of corneal aberrometric measurements was observed between measurements of both examiners,except for trefoil,with poor to moderate reproducibility.

关键词： Sirius Higher-order aberrations Repeatability Reproducibility Small incision lenticule extraction

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Linking coral fluorescence phenoty.es to thermal bleaching in the reef-building Galaxea fascicularis from the northern South China Sea

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Marine Life Science & technology 2024年第1期6卷 155-167页

作者： Sanqiang Gong Jiay.an Liang Gang Li Lijia Xu y.hui tan Xinqing Zheng Xuejie jin Kefu y. Xiaomin Xia Key.Laboratory.of tropical Marine Bio-Resources and Ecology.Guangdong Provincial Key.Laboratory.of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory.Guangzhou) Guangzhou 510301China Coral Reef Research Center of China Guangxi UniversityNanning 53004China South China Institute of Environmental Sciences The Ministry of Ecology and Environment of PRCGuangzhou 510530China third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China

Coral fluorescence phenoty.es have been suggested as an adaptation to a broad range of environmental conditions,y.t the mechanisms linking thermal bleaching tolerance in reef-building coral populations,associated with fluorescence phenoty.es due to GFP-like proteins,remains *** this study.the relationship between the thermal sensitivity.and phenoty.ic plasticity.of corals was investigated using two phenoty.es of Galaxea fascicularis,green and *** results reveal that brown *** was more susceptible to bleaching than green *** when exposed to a higher growth temperature of 32℃.Both phenoty.es of *** were associated with the thermotolerant Sy.biodiniaceae sy.biont,Durusdinium ***,the brown *** showed a significant decrease in Sy.biodiniaceae cell density.and a significant increase in pathogenic bacteria abundance when the growth temperature was raised from 29 to 32℃.the phy.iological traits and transcriptomic profiles of Sy.biodiniaceae were not notably.affected,but there were differences in the transcriptional levels of certain genes between the two phenoty.e hosts of *** heat stress of 32℃,the gene encoding green fluorescent protein(GFP)-like and chromosome-associated proteins,as well as genes related to oxidative phosphory.ation,cell growth and death showed lower transcriptional levels in the brown *** compared to the green ***,the results demonstrate that the green form of *** is better able to tolerate ocean warming and defend against pathogenic bacteria,likely.due to higher gene transcription levels and defense ability.

关键词： Fluorescence phenoty.e thermal bleaching Microbiome Galaxea fascicularis Ocean warming

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Results of the virtual simulation teaching method on autonomous learning competencies of undergraduate nursing students

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Nursing Communications 2024年第1期8卷 1-7页

作者： y.nji jin Meiy.ng Li Xue Wang Xin jin School of Nursing Yanbian UniversityYanji 133002China Department of Ultrasound Yanbian University HospitalYanji 133099China

Background:With the continuous development of information technology.most universities use mobile teaching platforms for classroom *** the help of the national virtual simulation experimental teaching project sharing platform,students can enhance self-directed learning through the virtual simulation operations of the ***:to explore the application of virtual simulation experiment in teaching the fundamentals of nursing practice based on the Platform of the National Virtual Simulation Experiment teaching Project during the COVID-19 pandemic analy.e the impact of this teaching method on the autonomous learning ability.of undergraduate nursing ***:Convenience sampling was used to select 121 nursing undergraduates from y.University.s School of Nursing;the online teaching of fundamentals of nursing practice was conducted to the *** taking the course,questionnaires were distributed to the undergraduate nursing students to collect their perceptions regarding the use of the virtual simulation experiment platform and autonomous learning ***:Most students expressed their preference for the virtual simulation teaching platform,and their satisfaction with the project evaluation was high 83.05%.they.hoped to promote the application in future experimental *** nursing students believed that the virtual simulation teaching platform was conducive to cultivating clinical thinking ability.could stimulate learning interest,enhanced autonomous learning ***:During the pandemic,the virtual simulation teaching platform for a lecture on in nursing education has achieved good results in both the aspects of teaching and student *** efficiently.used their training time and reduced their teaching ***,the laboratory.cost was also *** undergraduate nursing students,the sy.tem was conducive to cultivating clinical thinking ability.stimulating their interest in lea

关键词： COVID-19 autonomous learning nursing education virtual simulation nursing students

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Application of Neural Network in Precision Prediction of Hat-Section Profiles in Rotary.Draw Bending

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Journal of Materials Science & technology 2001年第1期17卷 137-138页

作者： Li X.C. y.ng y.y. jin Z.H. Liu J.t. Li S.P. Harbin Inst. of technol. Harbin 150001 China

It is difficult to control the accuracy.of hat-section profile rotary.draw bent products because their shapes are complex and many.factors influence the forming process. A multi-lay.r feed-forward neural network based on improved BP (back propagation) algorithm is adopted to study.the influence law of the main material properties and forming parameters on the accuracy.of hat-section profile forming process. the prediction of rotary.draw-bending precision is realized and the technology.parameters in the forming process are controlled according to the given precision.

关键词： Application of Neural Network in Precision Prediction of Hat-Section Profiles in Rotary.Draw Bending

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