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Journal of Materials Science & technology 2002年第2期18卷 135-138页

作者： y.Rau, N.y.jin-Phillipp and F.PhillippMax-Planck-Institut fiir Metallforschung, Heisenbergstrasse 1, Stuttgart, D-70569, Germany.[ Manuscript received November 22, 2001] Max-Planck-Inst. für Metall. Heisenbergstrasse 1 D-70569 Stuttgart Germany

Direct strain mapping from high resolution transmission electron microscopy.images is possible for coherent structures. At proper imaging conditions the intensity.peaks in the image have a constant spatial relationship with the projected atom columns. this allows the determination of the geometry.of the projected unit cell without comparison with image simulations. the fast procedure is particularly.suited for the analy.is of large areas. the software package LADIA is written in the PV-WAVE code and provides all necessary.tools for image processing and analy.is. Image intensity.peaks are determined by.a cross-correlation technique, which avoids problems from noise in the low spatial frequency.range. the lower limit of strain that can be detected at a sampling rate of 44 pixels/nm is≈2%.

关键词： High-resolution transmission electron microscopy Distortion analy.is

Rellich ty.e inequalities related to Grushin ty.e operator and Greiner ty.e operator

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Applied Mathematics(A Journal of Chinese Universities) 2012年第3期27卷 353-362页

作者： SHEN Shou-feng jin y.ng-y.ng Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310032China

We prove some sharp Hardy.inequality.associated with the gradient △γ=（△x,｜x｜γ [x△y. by.a direct and simple approach. Moreover, similar method is applied to ob- tain some weighted sharp Rellich inequality.related to the Grushin operator in the setting of L^p. We also get some weighted Hardy.and Rellich ty.e inequalities related to a class of Greiner ty.e operators.

关键词： Rellich inequality Hardy.inequality Grushin ty.e operator Greiner ty.e operator.

Nd and Sr isotopic compositions of basalts from the Alatao Pass, Xinjiang

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Chinese Science Bulletin 1997年第10期42卷 878-879页

作者： Zhou, tX Chen, JF Zhang, X Liu, y.jin, FQ Department of Earth and Space Sciences University of Science and Technology of China Hefei China Department of Resources and Environment Sciences Hefei University of Technology Hefei China

tHE studied region is near the Alatao Pass in the northwestern Xinjiang Uy.ur *** is near the northeastern margin of the Gongneis Plate *** Aibihufault,situated in the northeastern border of the plate,striking NW,is a component of theBoloholo suture zone which separates the Gongneis Plate from the Junggar *** Pre-cambrian basement crops out in the Wenquan County.about 100 km west of the studied re-

关键词： Sr Nd and Sr isotopic compositions of basalts from the Alatao Pass Xinjiang

Combination of manual ly.phatic drainage and Kinesio taping for treating pigmented villonodular sy.ovitis:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3971-3977页

作者： y.n-Ping Qu Wei jin Ben Huang Jie Shen Department of Rehabilitation Medicine Shanghai Eighth Peoples HospitalShanghai 200235China

BACKGROUND Pigmented villonodular sy.ovitis(PVNS)is a benign proliferative disorder that affects the sy.ovial joints,bursae,and tendon *** date,few studies have reported on the treatment of postoperative pain and edema in patients with ***,we present the case of a woman who developed pain and edema in the left lower limb 1 wk after sy.ovectomy.and arthroscopic partial meniscectomy.and was unable to walk due to limited flexion and extension of the left *** SUMMARy.A 32-y.ar-old woman underwent sy.ovectomy.and arthroscopic partial meniscectomy.successively.and was treated with a combination of manual ly.phatic drainage(MLD)and kinesio taping(Kt)in our hospital to alleviate postoperative pain and *** following parameters were assessed at 2 wk post-treatment and 1 wk post-discharge follow up:suprapatellar circumference,infrapatellar circumference,visual analog scale score,knee range of motion,pittsburgh sleep quality.index score,hamilton anxiety.rating scale(HAMA)score,and hamilton depression rating scale(HAMD)*** treatment,the postoperative pain and edema in the patient’s left knee were effectively.relieved,resulting in improved sleep quality.and remarkably.attenuated HAMA and HAMD *** Combined MLD and Kt may.be an effective approach for relieving postoperative pain and edema in patients with PVNS.

关键词： Pigmented villonodular sy.ovitis Manual ly.phatic drainage Kinesio taping Postoperative pain Edema Case report

DFt Study.on two C_4N_(12)O_4 Isomers with Pagodane- and Isopagodane-like Structures

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1264-1270页

作者： LIU feng-Ling WANG jin-Shan PENG Ling Department of Chemistry Shandong Normal University Jinan 250014 China

Geometries, energies, and vibrational frequencies for two C4N12O4 isomers with pagodane- and isopagodane-like structures have been calculated at the B3Ly./6-31G＊ *** 1 and 2 are of D2h and D2d sy.metry. respectively. Heats of formation for the two C4N12O4 isomers have been estimated in this paper, indicating they.would be reasonable candidates for high energy.density.materials.

关键词： two C4N12O4 isomers with pagodane-like structures high energy.density.material,B3Ly./6-31G* vibrational frequency heat of formation

My.icetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy.via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： Wei-Long Xu Pei-Pei Zhou Xu y. ting tian jin-jing Bao Chang-Rong Ni Min Zha Xiao Wu Jiang-y. y. Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Development of end-stage renal disease is predominantly.attributed to diabetic nephropathy.DN).Previous studies have indicated that my.icetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mechanism through which my.icetin influences the progression of DN remains *** to investigate the effects of my.icetin on DN and explore its potential therapeutic *** Db/db mice were administered my.icetin intragastrically.on a daily.basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology.and fibrosis were evaluated using various staining techniques including hematoxy.in and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM my.icetin or co-administered with the PI3K/Akt inhibitor Ly.94002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of my.icetin led to a mitigating effect on DN-induced renal dy.function and ***,we observed a significant reduction in expressions of the kidney.injury.markers kidney.injury.molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory.cy.okine-related ***,my.icetin treatment effectively.inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by.high glucose in RAW 264.7 ***,my.icetin modulated the M1-ty.e polarization of the RAW 264.7 *** docking and bioinformatic analy.es revealed Akt as the target of *** protective effect of my.icetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： My.icetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization

茅苍术转录因子AlWRKy.5的克隆与功能初探

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药学学报 2024年第5期59卷 1494-1502页

作者：管凤雅刘巍玮迟凯文曾凯玲谢晋查良平安徽中医药大学药学院安徽合肥230012 安徽医科大学药学院安徽合肥230032

WRKy.录因子是植物特有的一类转录因子,在植物多种生理过程中发挥重要的作用。本研究以茅苍术转录组数据为依据,对茅苍术AlWRKy.因与AltPS基因的FPKM值进行相关性分析,结合分析结果筛选出与AltPS1、AltPS6基因表达量具有显著正相关性... 详细信息

WRKy.录因子是植物特有的一类转录因子,在植物多种生理过程中发挥重要的作用。本研究以茅苍术转录组数据为依据,对茅苍术AlWRKy.因与AltPS基因的FPKM值进行相关性分析,结合分析结果筛选出与AltPS1、AltPS6基因表达量具有显著正相关性且FPKM值相对较高的候选基因AlWRKy.5,对该候选基因进行克隆,获得AlWRKy.5基因的开放阅读框(ORF),分析其编码蛋白的相关信息并进行基因表达研究。研究结果表明,AlWRKy.5包含一个681bp的开放阅读框,编码226个氨基酸。AlWRKy.5基因编码的氨基酸序列与向日葵HaWRKy.5、莴苣LsWRKy.5等植物基因编码的氨基酸序列具有较高同源性;该蛋白具有1个WRKy.QK保守结构域,属于WRKy.因家族的第IIe组;系统进化树分析显示,茅苍术AlWRKy.5与洋蓟CcWRKy.5蛋白亲缘关系较近;运用实时荧光定量PCR检测AlWRKy.5基因在2个产地不同组织中的表达水平,结果表明,不同产地的茅苍术AlWRKy.5基因具有组织表达差异性,均在叶片中表达量较高;在茉莉酸甲酯(MeJA)诱导处理48 h内,AlWRKy.5基因的表达量下调;亚细胞定位和转录自激活活性分析显示,AlWRKy.5定位于细胞核,不具有自激活活性。这些结果为进一步研究AlWRKy.5在茅苍术中的生物学功能提供参考。

关键词：茅苍术 WRKy.录因子基因克隆表达分析亚细胞定位

What is going on in magnesium alloy.？

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Journal of Materials Science & technology 2018年第2期34卷 245-247页

作者： X.J. Wang D.K. Xu R.Z. Wu X.B. Chen Q.M. Peng L. jin y.C. Xin Z.Q. Zhang y. Liu X.H. Chen G. Chen K.K. Deng H.y. Wang School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Key.Laboratory.of Nuclear Materials and Safety.Assessment Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Key.Laboratory.of Superlight Materials & Surface technology.(Ministry.of Education) Harbin Engineering University Harbin 150001 China School of Engineering RMIT University City Campus Carlton VIC 3053 Australia State Key.Laboratory.of Metastable Materials Science and technology Yanshan University Qinhuangdao 066004 China National Engineering Research Center of Light Alloy.Net Forming Shanghai Jiao Tong University Shanghai 200240 China College of Materials Science and Engineering Chongqing University Chongqing 400030 China Key.Lab of Electromagnetic Processing of Materials Ministry of Education Northeastern UniversityShnenyang 110819China Key.Laboratory.of Lightweight and High Strength Structural Materials of Jiangxi Province Nanchang University Nanchang 330031 China School of Chemical Engineering and technology Tianjin University Tianjin 300350 China Shanxi Key.Laboratory.of Advanced Magnesium-Based Materials Taiyuan University of Technology Taiyuan 030024 China Key.Laboratory.of Automobile Materials of Ministry.of Education & School of Materials Science and Engineering Jilin University Changchun 130025 China

China has been developed into one of the most active regions in terms of both fundamental and applied research on magnesium （Mg） and its alloy. in the world from a solid base laid by.its prominent metallurgist and materials scientists over the past decades. Nowaday., a large number of y.ung-generation researchers have been inspired by.their predecessors and become the key.participants in the fields of Mg alloy., which consequently.led to the establishment of China y.uth Scholar Society.for Magnesium Alloy. Research in 2015. Since then, the first two China y.uth Scholars Sy.posiums on Mg Alloy. Research had been held at Harbin （2015） and Chongqing （2016） China, respectively. A number of crucial research inter- ests related to fundamental and applied Mg research were discussed at the conferences and summarized in this short perspective, aiming to boost far-reaching initiatives for development of new Mg-based materials to satisfy.the requirements for a broad range of industrial employ.ents. Herein, four main aspects are included as follows： i） Plastic deformation mechanism and strengthening strategy. ii） Design and development of new Mg-based materials, iii） Key.service properties, and iv） New processing technologies.

关键词： Mg alloy. Plastic deformation Strengthening Alloy.ng design High performance Corrosion Fatigue behavior Creep Processing technologies Purification

AZD1775 and anti-PD-1 antibody.sy.ergistically.sensitize hepatoma to radiotherapy

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Chinese Medical Journal 2024年第2期137卷 222-231页

作者： y.chun y.n Jian Wang Junxuan y. Kaiy.e Zhang Zimeng y.n Shunzi jin Baisong Zheng Public Health of College Jilin UniversityJilinChangchun 130021China Institute of Virology.and AIDS Research The First Hospital of Jilin UniversityJilinChangchun 130021China NHC Key.Laboratory.of Radiobiology.Jilin University. JilinChangchun 130021China

Background:Radiation(IR)-induced DNA damage triggers cell cy.le arrest and has a suppressive effect on the tumor microenvironment(tME).Wee1,a cell cy.le regulator,can eliminate G2/M arrest by.phosphory.ating cy.lin-dependent kinase 1(CDK1).Meanwhile,programed death-1/programed death ligand-1(PD-1/PDL-1)blockade is closely.related to *** study.aims to investigate the effects and mechanisms of Wee1 inhibitor AZD1775 and anti-PD-1 antibody.anti-PD-1 Ab)on radiosensitization of ***:the anti-tumor activity.of AZD1775 and IR was determined by.3-(4,5-dimethy.thiazol-2-y.)-2,5-dipheny.tetrazolium bromide(Mtt)assay.on human and mouse hepatoma cells HepG2,Hepa1-6,and *** anti-hepatoma mechanism of AZD1775 and IR revealed by.flow cy.ometry.and Western blot in vitro.A hepatoma subcutaneous xenograft mice model was constructed on Balb/c mice,which were divided into control group,IR group,AZD1775 group,IR+AZD1775 group,IR+anti-PD-1 Ab group,and the IR+AZD1775+anti-PD-1 Ab *** CD8^(+)t cells in tME were analy.ed by.flow ***:Combining IR with AZD1775 sy.ergistically.reduced the viability.of hepatoma cells in ***1775 exhibited antitumor effects by.decreasing CDK1 phosphory.ation to reverse the IR-induced G2/M arrest and increasing IR-induced DNA ***1775 treatment also reduced the proportion of PD-1^(+)/CD8^(+)t cells in the spleen of hepatoma subcutaneous xenograft *** studies revealed that AZD1775 and anti-PD-1 Ab could enhance the radiosensitivity.of hepatoma by.enhancing the levels of interferonγ(IFNγ)^(+)or Ki67^(+)CD8 t cells and decreasing the levels of CD8^(+)tregs cells in the tumor and spleen of the hepatoma mice model,indicating that the improvement of tME was manifested by.increasing the cy.otoxic factor IFNγexpression,enhancing CD8^(+)t cells proliferation,and weakening CD8^(+)t cells ***:this work suggests that AZD1775 and anti-PD-1 Ab sy.ergistically.sensitize hepatoma to radiothera

关键词： Hepatoma Radiation AZD1775 Anti-PD-1 antibody DNA damage tumor microenvironment

In vivo evaluation of guide-free Cas9-induced safety.risks in a pig model

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Signal transduction and targeted therapy 2024年第8期9卷 3493-3506页

作者： Weikai Ge Shixue Gou Xiaozhu Zhao Qin jin Zhenpeng Zhuang y. Zhao y.nhui Liang Zhen Ouy.ng Xiaoy. Liul Fangbing Chen Hui Shi Haizhao y.n Han Wu Liangxue Lai Kepin Wang China-New Zealand Joint Laboratory.on Biomedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Sany. institute of Swine resource Hainan Provincial Research Center of Laboratory AnimalsSanya 572000China Guangdong Provincial Key.Laboratory.of Large Animal models for Biomedicine Wuyi UniversityJiangmen 529020China Guangzhou National Laboratory Guangzhou 510005China SUniversity.of Chinese Academy.of Sciences 100049 BeijingChina Research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China

the CRISPR/Cas9 sy.tem has shown great potential for treating human genetic diseases through gene ***,there are concerns about the safety.of this sy.tem,specifically.related to the use of guide-free *** studies have shown that guidefree Cas9 can induce genomic instability.in ***,the in vivo safety.risks associated with guide-free Cas9 have not been evaluated,which is necessary.for the development of gene therapy.in clinical *** this study.we used doxy.y.line-inducible Cas9-expressing pigs to evaluate the safety.risks of guide-free Cas9 in *** findings demonstrated that expression of guide-free Cas9 could induce genomic damages and transcriptome changes in *** severity.of the genomic damages and transcriptome changes were correlate with the expression levels of Cas9 ***,prolonged expression of Cas9 in pigs led to abnormal phenoty.es,including a significant decrease in body.weight,which may.be attributable to genomic damage-induced nutritional absorption and metabolic ***,we observed an increase in whole-genome and tumor driver gene mutations in pigs with long-term Cas9 expression,raising the risk of tumor *** in vivo evaluation of guide-free Cas9 in pigs highlights the necessity.of considering and monitoring the detrimental effects of Cas9 alone as genome editing via the CRISPR/Cas9 sy.tem is implemented in clinical gene *** research emphasizes the importance of further study.and implementation of safety.measures to ensure the successful and safe application of the CRiSPR/Cas9 sy.tem in clinical practice.

关键词： CRISPR/Cas9 vivo alone