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美国小学体育课程指导

CoBRA: Containerized Bioinformatics Workflow for Reproducible Ch IP/ATAC-seq Analysis

2018年

作者：美国健康和体育教育协会 (美) 雪莉·霍尔特/哈勒 (shirley Holt/Hale) (美) 蒂娜·哈尔 (Tina Hall)

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Genomics, Proteomics & Bioinformatics 2021年第4期19卷 652-661页

作者： Xintao Qiu Avery S.Feit Ariel Feiglin yingtian Xie Nikolas Kesten Len Taing Joseph Perkins Shengqing Gu yihao Li Paloma Cejas Ningxuan Zhou Rinath Jeselsohn Myles Brown Xshirley Liu Henry W.Long Center for Functional Cancer Epigenetics Dana-Farber Cancer InstituteBostonMA 02215USA Department of Medical Oncology Dana-Farber Cancer InstituteHarvard Medical SchoolBostonMA 02215USA Albert Einstein College of Medicine BronxNY 10461USA Department of Biomedical Informatics Harvard Medical SchoolBostonMA 02215USA Department of Data Sciences Dana Farber Cancer InstituteHarvard T.H.Chan School of Public HealthBostonMA 02215USA

Chromatin immunoprecipitation sequencing(Ch IP-seq)and the Assay for Transposase-Accessible Chromatin with high-throughput sequencing(ATAC-seq)have become essential technologies to effectively measure protein–DNA interactions and chromatin ***,there is a need for a scalable and reproducible pipeline that incorporates proper normalization between samples,correction of copy number variations,and integration of new downstream analysis *** we present Containerized Bioinformatics workflow for Reproducible Ch IP/ATAC-seq Analysis(Co BRA),a modularized computational workflow which quantifies Ch IP-seq and ATAC-seq peak regions and performs unsupervised and supervised *** BRA provides a comprehensive state-of-the-art Ch IP-seq and ATAC-seq analysis pipeline that can be used by scientists with limited computational *** enables researchers to gain rapid insight into protein–DNA interactions and chromatin accessibility through sample clustering,differential peak calling,motif enrichment,comparison of sites to a reference database,and pathway *** BRA is publicly available online at https://***/cfce/cobra.

关键词： ChIP-seq ATAC-seq Snakemake Docker Workflow

历史建筑中的火锅“博物馆”——杭州GUD火锅餐厅旗舰店

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中国建筑装饰装修 2022年第10期 30-35页

作者：董雪莲 Andrea Maira Hutsov yakiv 杨溢 Valeria Pernice 张大齐(摄) 无不详八荒建筑设计咨询(上海)有限公司八荒设计团队

八荒设计八荒设计成立于上海,提供建筑、室内、视觉识别系统整体设计。八荒设计专注于由(品牌)概念诞生、发展直至最终于终端落实的一站式服务,站在空间的尺度,以建筑师的眼光,考量概念从孕育到落地的过程。是少数跨品牌设计和建筑室内... 详细信息

八荒设计八荒设计成立于上海,提供建筑、室内、视觉识别系统整体设计。八荒设计专注于由(品牌)概念诞生、发展直至最终于终端落实的一站式服务,站在空间的尺度,以建筑师的眼光,考量概念从孕育到落地的过程。是少数跨品牌设计和建筑室内设计领域的设计工作室。八荒设计拥有具有多文化、跨专业背景的国际化设计团队,主创团队多来自欧洲,融合中西文化,以人的体验出发、传播为目的、功能性为指导,结合潮流趋势设计理念。作为一家精品设计工作室,设计风格鲜明——用当代的笔触深入文化和功能细节,为客户度身定制整体、具实现性的设计解决方案。

关键词：设计工作室视觉识别系统一站式服务度身定制品牌设计融合中西室内设计领域设计理念

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中国老年人营养不良对健康和医疗花费的影响

中华老年医学杂志 2017年第8期36卷 929-933页

作者：韦军民樊琳琳张毓辉 Jamie Partridge 许凌李晓青 Suela Sulo 北京医院国家老年医学中心普通外科 100730 美国雅培营养研发部 60064 国家卫生计生委卫生发展研究中心 100191

目的评估中国老年人营养不良现状及其对日常生活自理能力、健康状况、慢性病和医疗花费的影响。方法本研究资料来自北京大学2013年中国健康与养老追踪调查（China Health and Retirement Longitudinal Survey，CHARLS）数据库，该数据... 详细信息

目的评估中国老年人营养不良现状及其对日常生活自理能力、健康状况、慢性病和医疗花费的影响。方法本研究资料来自北京大学2013年中国健康与养老追踪调查（China Health and Retirement Longitudinal Survey，CHARLS）数据库，该数据库涵盖了社区中老年居民的基本信息、家庭、健康状况和功能、医疗保健与保险以及工作收入信息。本研究抽取60岁及以上的老年人，最终样本量超过5900人。根据体质指数、体重减轻和握力下降定义营养不良，采用卡茨ADL指数和Lawton-Brody IADL指数测定日常生活自理能力，利用自我评价健康状况评估老年人的健康状况；运用Ordered Logistic回归分析营养不良对ADL、IADL和健康状况的影响。采用Logistic回归分析营养不良与不同慢性病的相关性。采用0LS回归分析由营养不良导致的健康状况所引起的医疗费用。结果30％的老年人患营养不良。营养不良与老年人IADL降低显著相关（OR=0．868，P〈0．05），并且降低老年人健康水平（OR=0．675，P〈0．001），增加患脑卒中（OR=1．399，P〈0．05）和慢性胃病（OR=1．241，P〈O．001）的概率。营养不良通过降低老年人健康水平与人均年医疗花费上升显著相关（增长了214元，14％，P〈0．01）。结论我国老年人营养不良发生率较高。营养不良导致老年人生活自理能力、健康水平的下降和相关医疗花费增加。常规对老年人进行营养风险筛查和评定，制定科学、个性化的营养支持方案，给予适时、适度的营养支持治疗，能提高患者的健康水平，并有效节约医疗成本。

关键词：营养不良健康状况日常生活能力

使用不重要的数字:绩效指标的潜功能如何解释其成功

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国际行政科学评论（中文版） 2021年第2期87卷 150-166页

作者：雪莉·肯佩尼尔沃特·范·多伦张琼(译) 熊缨(审校) 比利时安特卫普大学比利时安特卫普大学政治与公共治理研究小组政治科学系比利时安特卫普管理学院中国人事科学研究院不详

绩效指标正遭受严厉的批评,被指责缺乏准确性,鼓励玩游戏,而最终却无法提高绩效。然而,尽管这些指标的缺陷已被充分证明,但实际管理中使用绩效指标的情况仍比比皆是。本文探究的是,尽管这些绩效指标已被证明存在弱点和缺陷,但在哪些条... 详细信息

绩效指标正遭受严厉的批评,被指责缺乏准确性,鼓励玩游戏,而最终却无法提高绩效。然而,尽管这些指标的缺陷已被充分证明,但实际管理中使用绩效指标的情况仍比比皆是。本文探究的是,尽管这些绩效指标已被证明存在弱点和缺陷,但在哪些条件下绩效指标可以改善绩效结果。本文的研究案例是欧洲银行体系的压力测试,这是用于风险监管的一个备受瞩目的绩效指标。通过采访比利时各银行的风险经理以及欧洲央行(European Central Bank)、欧洲银行管理局(the European Banking Authority)和比利时国家银行(the National Bank of Belgium)的员工,我们发现,计算压力测试的过程本身就改善了绩效结果。它是通过培养银行自我调节的能力来改善绩效,这与福柯(Foucault)的治理理念相符。因此,从业人员和学者不仅要关注如何使用绩效结果,而且要研究如何设计计算绩效指标的过程,以提高潜在的绩效结果。

关键词：银行压力测试治理绩效指标绩效测评

Treatment-Plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary Brandon Gunn Amol J. Ghia Jay P. Reddy Shaan M. Raza Franco De Monte Mark S. Chambers Paul D. Brown shirley Su Jack Phan Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Oncologic Dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMPT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMPT, and compared the quality of the three sets of plans. Methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMPT were generated with multi-field optimization. The optimized VMAT and IMPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated Proton Therapy Spot Scanning Proton Therapy

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大型超级市场火灾风险的模糊综合评价

苏州大学学报（工科版） 2006年第3期26卷 20-22页

作者：马燕平芮延年周国梁吴冬敏何振华苏州大学机电工程学院江苏苏州215021

根据火灾风险评价过程中一些影响因素的不确定性和模糊性的特点,提出利用模糊理论对其进行模糊综合评价。并应用构建的评价模型对大型超级市场的火灾风险进行了评价实验,获得了满意的效果。

关键词：大型超级市场火灾风险模糊综合评价

Small P values may not yield robust findings:an example using REST-meta-PD

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei yan Jing yang Wan-Qun yang Nai-Lin yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang yan-Ling Zhang Cai-Hong Zhou Chao-Gan yan Xi-Nian Zuo Mark Hallett Tao Wu yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction