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Effects of Potassium-Solubilizing Bacteria on Growth, Antioxidant Activity and Expression of Related Genes in Fritillaria taipaiensis P. y. Li

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 789-806页

作者： Jiaqi Lang Mingyan ye ya Luo yueheng Wang Zhifen shi Xiaotian Kong Xuan Li Nong Zhou Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region College of Biology and Food EngineeringChongqing Three Gorges UniversityChongqing404120China College of Modern Chinese Medicine Industry Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China

This study aimed to examine the effects of inoculating Fritillaria taipaiensis *** leaves with different strains ofpotassium-solubilizing bacteria (KSB), or combinations thereof, focusing on aspects of photosynthesis and physiologicaland biochemical characteristics. At present, some studies have only studied the rhizosphere microbialcommunity characteristics of F. taipaiensis and have not discussed the effects of different microbial species on thegrowth promotion of F. taipaiensis. This paper will start from the perspective of potassium-solubilizing bacteria toconduct an in-depth study. Seed cultivation commenced at the base with three different KSBs in early October2022. The growth of F. taipaiensis leaves was observed after different treatments. Both single-plant and compoundinoculations were executed. A total of eight treatment groups were established, with aseptic fertilizer and sterilizedsoil functioning as the control group. The results reveal that intercellular CO_(2) concentration (Ci), stomatal conductance(Gs), and transpiration rate (Tr) were at their apex in the S7 group. Most treatment groups exhibited anincrease in leaf area, photosynthetic pigment content, soluble sugar, soluble protein, Superoxide Dismutase(SOD), Peroxidase (POD), Catalase (CAT) activities, and proline content. The expression levels of POD, SOD,and CAT genes were evaluated, following inoculation with different KSB. The highest was the S7 group. Theinoculation with various KSB, or combinations thereof, appears to bolster the growth and development of F. *** composite inoculation group S7, comprising Bacillus cereus, Burkholderia cepacia, and Bacillus subtilis,manifested the most favorable impact on the diverse indices of F. taipaiensis, thereby furnishing valuableinsights for the selection of bacterial fertilizer in the artificial cultivation of F. taipaiensis.

关键词： Fritillaria taipaiensis bacteria antioxidant enzyme genes leaf physiology and biochemistry photosynthetic characteristics

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Targeting proprotein convertase subtilisin/kexin type 9(PCSK9):from bench to bedside

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Signal Transduction and Targeted Therapy 2024年第2期9卷 509-557页

作者： Xuhui Bao yongjun Liang Hanman Chang Tianji Cai Baijie Feng Konstantin Gordon yuekun Zhu Hailian shi yundong He Liyi Xie Institute of Therapeutic Cancer Vaccines Fudan University Pudong Medical CenterShanghaiChina Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina Department of Oncology Fudan University Pudong Medical CenterShanghaiChina Center for Clinical Research Fudan University Pudong Medical CenterShanghaiChina Clinical Research Center for Cell-based Immunotherapy Fudan UniversityShanghaiChina Department of Pathology Duke University Medical CenterDurhamNCUSA Center for Medical Research and Innovation Fudan University Pudong Medical CenterShanghaiChina Institute for Food Safety and Health Illinois Institute of TechnologyChicagoILUSA Department of Sociology University of MacaoTaipaMacaoChina Medical Institute Peoples’Friendship University of RussiaMoscowRussia A.Tsyb Medical Radiological Research Center ObninskRussia Department of Colorectal Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Shanghai Key Laboratory of Compound Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineZhangjiang Hi-tech ParkShanghaiChina Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina

Proprotein convertase subtilisin/kexin type 9(PCSK9)has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases(CVD).This comprehensive review delineates the intricate roles and wide-ranging implications of PCSK9,extending beyond CVD to emphasize its significance in diverse physiological and pathological states,including liver diseases,infectious diseases,autoimmune disorders,and notably,*** exploration offers insights into the interaction between PCSK9 and low-density lipoprotein receptors(LDLRs),elucidating its substantial impact on cholesterol homeostasis and cardiovascular *** also details the evolution of PCSK9-targeted therapies,translating foundational bench discoveries into bedside applications for optimized patient *** advent and clinical approval of innovative PCSK9 inhibitory therapies(PCSK9-iTs),including three monoclonal antibodies(Evolocumab,Alirocumab,and Tafolecimab)and one small interfering RNA(siRNA,Inclisiran),have marked a significant breakthrough in cardiovascular *** therapies have demonstrated unparalleled efficacy in mitigating hypercholesterolemia,reducing cardiovascular risks,and have showcased profound value in clinical applications,offering novel therapeutic avenues and a promising future in personalized medicine for cardiovascular ***,emerging research,inclusive of our findings,unveils PCSK9’s potential role as a pivotal indicator for cancer prognosis and its prospective application as a transformative target for cancer *** review also highlights PCSK9’s aberrant expression in various cancer forms,its association with cancer prognosis,and its crucial roles in carcinogenesis and cancer *** conclusion,this synthesized review integrates existing knowledge and novel insights on PCSK9,providing a holistic perspective on its transformative impact in reshaping therapeutic paradigms acr

关键词： PCSK9 metabolism convert

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Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities

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Science China(Life Sciences) 2024年第4期67卷 789-802页

作者： Jianguo Chen Xufang Chen Lishen Qian yazhou Zhang Bo Li Honghua shi Lu Sun Christian Schöb Hang Sun Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China College of Resources and Environment Yunnan Agricultural UniversityKunming 650500China Área de Biodiversidad y Conservación Universidad Rey Juan CarlosMóstoles 28933Spain

Foundational cushion plants can re-organize community structures and sustain a prominent proportion of alpine biodiversity,but they are sensitive to climate *** loss of cushion species can have broad consequences for associated *** potential plant community changes with the population dynamics of cushion plants remain,however,*** eight plant communities along a climatic and community successional gradient,we assessed cushion population dynamics,the underlying ecological constraints and hence associated plant community changes in alpine communities dominated by the foundational cushion plant Arenaria *** population dynamics of Arenaria are attributed to ecological constraints at a series of life history *** functions are constrained by increasing associated beneficiary plants;subsequent seedling establishment is constrained by temperature,water and light availability,extreme climate events,and interspecific competition;strong competitive exclusion may accelerate mortality and degeneration of cushion *** with cushion dynamics,species composition,abundance and community structure gradually *** cushion plants completely degenerate,previously cushion-dominated communities shift to relatively stable communities that are overwhelmingly dominated by *** warming may accelerate the degeneration process of *** of this foundational cushion plant will possibly induce massive changes in alpine plant communities and hence ecosystem functions in alpine *** assessment of the population dynamics of foundation species is critical for an effective conservation of alpine biodiversity.

关键词： alpine ecosystem biodiversity change climate change plant community dynamics foundation species global warming population dynamics

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Long-wave infrared emission properties of strain-balanced InAs/In_(x)Ga_(1-x)As_(y)Sb_(1-y)type-Ⅱsuperlattice on different substrates

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Rare Metals 2024年第7期43卷 3194-3204页

作者： Chao shi Xuan Fang Hong-Bin Zhao Deng-Kui Wang Xi Chen Dan Fang Dong-Bo Wang Xiao-Hua Wang Jin-Hua Li State Key Laboratory of High Power Semiconductor Lasers School of PhysicsChangchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Advanced Materials for Smart Sensing China General Research Institute for Nonferrous MetalsBeijing 100088China Department of Opto-Electronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

High-performance type-Ⅱsuperlattices ofⅢ-Ⅴsemiconductor materials play an important role in the development and application of infrared optoelectronic *** the quality of epitaxial materials and clarifying the luminescent mechanism are of great significance for practic al applic *** this work,strain-balanced and high-quality In As/In_(x)Ga_(1-x)As_(y)Sb_(1-y)superlattices without lattice mismatch were achieved on InAs and GaSb substrates *** grown on In As substrate could exhibit higher crystal quality and surface flatness based on high-resolution X-ray diffraction(HRXRD)and atomic force microscopy(AFM)measurements'***,the strain distribution phenomenon from geometric phase analysis indicates that fluctuations of alloy compositions in superlattices on GaSb substrate are more *** addition,the optical properties of superlattices grown on different substrates are discussed *** of the difference in fluctuations of element composition and interface roughness of superlattices on different substrates,the superlattices grown on In As substrate would have higher integral intensity and narrower full-width at half maximum of long-wave infrared ***,the thermal quenching of emission intensity indicates that the superlattices grown on the In As substrate have better recombination ability,which is beneficial for increasing the operating temperature of infrared optoelectronic devices based on this type of superlattices.

关键词： Photoluminescence Alloy compositions fluctuations InAs(Sb)/In_(x)Ga_(1-x)As_(y)Sb_(1-y) Type-Ⅱsuperlattice Substrate

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Unveiling the Re,Cr,and I diffusion in saturated compacted bentonite using machine-learning methods

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Nuclear Science and Techniques 2024年第6期35卷 65-77页

作者： Zheng-ye Feng Jun-Lei Tian Tao Wu Guo-Jun Wei Zhi-Long Li Xiao-Qiong shi yong-Jia Wang Qing-Feng Li Department of Engineering Huzhou UniversityHuzhou 313000China Institute of Theoretical Physics Shanxi UniversityTaiyuan 030006China College of Physics Science and Technology Shenyang Normal UniversityShenyang 110034China

The safety assessment of high-level radioactive waste repositories requires a high predictive accuracy for radionuclide diffusion and a comprehensive understanding of the diffusion *** this study,a through-diffusion method and six machine-learning methods were employed to investigate the diffusion of ReO_(4)^(−),HCrO_(4)^(−),and I−in saturated compacted bentonite under different salinities and compacted dry *** machine-learning models were trained using two *** dataset contained six input features and 293 instances obtained from the diffusion database system of the Japan Atomic Energy Agency(JAEA-DDB)and 15 *** other dataset,comprising 15,000 pseudo-instances,was produced using a multi-porosity model and contained eight input *** results indicate that the former dataset yielded a higher predictive accuracy than the *** gradient-boosting exhibited a higher prediction accuracy(R2=0.92)and lower error(MSE=0.01)than the other machine-learning *** addition,Shapley Additive Explanations,Feature Importance,and Partial Dependence Plot analysis results indicate that the rock capacity factor and compacted dry density had the two most significant effects on predicting the effective diffusion coefficient,thereby offering valuable insights.

关键词： Machine learning Effective diffusion coefficient Through-diffusion experiment Multi-porosity model Global analysis

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