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Transparent cap adjusted the stent placed for stenosis after endoscopic injection of esophageal varices:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2614-2620页

作者： Fu-Long Zhang Jing Xu yuan-Dong Zhu Qian-Neng Wu yan shi Lei Fang Dan Zhou Hai Wang Chao-JunHuang Chun-Hua Zhou Qun Zhu Department of Gastroenterology Hangzhou Xixi hospitalHangzhou 310023Zhejiang ProvinceChina Department of Hepatopathy Hangzhou Xixi hospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The stent embedded in the esophageal mucosa is one of the complications after stenting for esophageal *** present a case of stent adjustment with the aid of a transparent cap after endoscopic injection of an esophageal varices *** SUMMARy A 61-year-old male patient came to the hospital with discomfort of the chest after the stent implanted for the stenosis because of endoscopic injection of esophageal *** gastroscopy was performed,and the stent embedded into the esophageal *** first,we pulled the recycling line for shrinking the stent,however,the mucosa could not be removed from the *** a forceps was performed to remove the mucosa in the stent,nevertheless,the bleeding form the mucosa was *** then,we used a transparent cap to scrape the mucosa along the stent,and the mucosa were removed successfully without *** A transparent cap helps gastroscopy to remove the mucosa embedded in the stent after endoscopic injection of the esophageal varices stent.

关键词： Stent Transparent cap Stenosis Endoscopic injection Esophageal varices Case report

基于离心机实验的海上风力机大直径单桩桩土作用研究

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太阳能学报 2024年第8期45卷 537-545页

作者：柳涛秦梦飞施伟中国电建集团华东勘测设计研究院有限公司杭州311122 大连理工大学建设工程学部大连116024

地基基础是海上风电结构所受载荷的最终承载者,针对中国沿海软弱超固结软土地基开展力学特性研究。通过离心模型试验方法对单桩基础形式的静力特性进行分析和对比。研究结果揭示通过离心模型试验模拟桩基础的有效性,该方法能准确捕捉现... 详细信息

地基基础是海上风电结构所受载荷的最终承载者,针对中国沿海软弱超固结软土地基开展力学特性研究。通过离心模型试验方法对单桩基础形式的静力特性进行分析和对比。研究结果揭示通过离心模型试验模拟桩基础的有效性,该方法能准确捕捉现场地基的应力分布及桩与土体之间的相互作用特性。在软黏土环境中,针对不同直径的单桩进行的分析表明,其变形行为及桩土相互作用机制呈现出显著的差异性。规范中的p-y曲线不适用于中国近海土质,据试验结果提出地基无量纲水平抗力系数随埋深变化和与循环应力幅值相关的循环弱化因子计算模型。

关键词：海上风电风力机桩土作用离心模型试验循环加载 p-y模型土抗力系数

Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

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Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao yongjia Song Minghui Hang Hao Xu Qiang Li Pengyu Wang Tao Chen Mengxiong Xia Qi shi yongjun Wang Xiaoyun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma

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Genes & Diseases 2024年第5期11卷 70-73页

作者： Haimin Song Bowen Ni Xuetao Peng Weijuan Xu Shaochun yang Runwei yang Ziyu Wang Kaishu Li Rui Lin yunxiao Zhang Jinglin Guo Kezhi Wu Guangwei shi Jichao Sun Chunming He yawei Liu Department of Neurosurgery The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China Department of Neurosurgery&Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Bidding and Procurement Office Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong 511518China Department of Neurosurgery The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China Department of Geriatrics Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China

The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely ***,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.

关键词： invasion prognosis Clinical

Development and validation of a novel criterion of histologic healing in ulcerative colitis defined by inflammatory cell enumeration in lamina propria mucosa:A multicenter retrospective cohort in China

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Chinese Medical Journal 2024年第11期137卷 1316-1323页

作者： Han Gao Kangsheng Peng yadi shi Shenshen Zhu Ruicong Sun Chunjin Xu Ping Liu Zhi Pang Lanxiang Zhu Weichang Chen Baisui Feng Huili Wu Guangxi Zhou Mingsong Li Junxiang Li Baijing Ding Zhanju Liu Center for IBD Research and Department of Gastroenterology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200085China Clinical Medicine Sanquan College of Xinxiang Medical UniversityXinxiangHenan 453003China Department of Gastroenterology The First People’s Hospital of Shangqiu City Affiliated to Xinxiang Medical UniversityShangqiuHenan 476100China Department of Gastroenterology Wuhu First People’s HospitalWuhuAnhui 241000China Department of Gastroenterology Suzhou Municipal Hospital Affiliated to Nanjing Medical UniversitySuzhouJiangsu 215008China Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 251006China Department of Gastroenterology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450014China Department of Gastroenterology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450000China Department of Gastroenterology The Affiliated Hospital of Jining Medical CollegeJiningShandong 272004China Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510140China Department of Gastroenterology Dongfang Hospital of Beijing University of Chinese MedicineBeijing 100078China

Background:Histological healing is closely associated with improved long-term clinical outcomes and lowered relapses in patients with ulcerative colitis(UC).Here,we developed a novel diagnostic criterion for assessing histological healing in UC ***:We conducted a retrospective cohort study in UC patients,whose treatment was iteratively optimized to achieve mucosal healing at Shanghai Tenth People’s Hospital of Tongji University from January 2017 to May *** identified an inflammatory cell enumeration index(ICEI)for assessing histological healing based on the proportions of eosinophils,CD177^(+)neutrophils,and CD40L^(+)T cells in the colonic lamina propria under high power field(HPF),and the outcomes(risks of symptomatic relapses)of achieving histological remission *** histological inflammation using Kaplan-Meier *** reliability and inter-reader reliability were evaluated by each *** relationships to the changes in the Nancy index and the Geboes score were also assessed for *** ICEI was further validated in a new cohort of UC patients from other nine university ***:We developed an ICEI for clinical diagnosis of histological healing,i.e.,y=1.701X_(1)+0.758X_(2)+1.347X_(3)-7.745(X_(1),X_(2),and X_(3)represent the proportions of CD177^(+)neutrophils,eosinophils,and CD40L^(+)T cells,respectively,in the colonic lamina propria under HPF).The receiver operating characteristics curve(ROC)analysis revealed that yy of 92.5%and a specificity of 83.6%(Py was 0.855(95%CI:0.781-0.909),and ICEI had good inter-reader reliability of 0.832(95%CI:0.748-0.894).During an 18-month follow-up,patients with histological healing had a substantially better outcome com

关键词： Ulcerative colitis Histological healing Inflammatory cell enumeration index Prognosis

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霞石岩的成因及深部碳循环

岩石学报 2024年第7期40卷 2238-2254页

作者：石苡宁张招崇程志国中国地质大学(北京) 地质过程与矿产资源国家重点实验室北京100083 中国地质大学(北京)深时数字地球前沿科学中心北京100083

霞石岩是以发育霞石和单斜辉石斑晶为特征的过碱性火山岩,其单体出露体积较小,常以碳酸岩-碱性杂岩体或小体积熔岩流的形式广泛分布在板内环境中,产出的时代跨度大(从太古宙至今),产出量总体上随地球的演化而增多。通常认为霞石岩在喷... 详细信息

霞石岩是以发育霞石和单斜辉石斑晶为特征的过碱性火山岩,其单体出露体积较小,常以碳酸岩-碱性杂岩体或小体积熔岩流的形式广泛分布在板内环境中,产出的时代跨度大(从太古宙至今),产出量总体上随地球的演化而增多。通常认为霞石岩在喷发过程中上升速度快且较少受到地壳物质混染,可以很好地反映地幔源区特征。然而,目前对其源区性质仍存在争议,其争论的焦点在于源区是否存在碳酸盐,即碳酸盐化源区是否是霞石岩形成的必要条件。本文基于全球各地霞石岩的地质-地球化学数据分析,将其分为两组:第一组霞石岩的SiO_(2)和碱含量(Na _(2)O+K_(2)O)变化范围较大,出现Rb、K、Pb、Zr、Hf、Ti、y元素的负异常,放射性同位素组成普遍较为亏损;第二组相较第一组具有更高的SiO_(2)、碱含量,更低的MgO、TiO_(2)、P_(2)O_(5)含量和Na _(2)O/K_(2)O比值,并出现U、Nb、Pb、Zr元素的正异常以及Ti元素的负异常,Nb-Ta及Zr-Hf发生分馏,放射性同位素组成较第一组更富集。结合实验岩石学结果,研究认为第一组霞石岩的原始熔体为碳酸盐化榴辉岩部分熔融熔体与地幔橄榄岩反应形成的富碳硅酸盐熔体,其直接喷发或只经历低程度的分离结晶作用;第二组霞石岩与第一组霞石岩具有相似的源区特征,但熔体经历了强烈的分离结晶及不混溶作用。因此,碳酸盐化源区是霞石岩形成的必要条件。对霞石岩露头的时间分布进行统计发现,霞石岩最早形成于太古宙,但形成量在约550Ma和80Ma突增,碳酸盐俯冲通量的增加可能是导致霞石岩形成量突增的原因,而形成于太古宙的霞石岩说明太古宙地幔中存在局部的“碳”富集或输入。

关键词：霞石岩岩石成因深部碳循环碳酸盐化地幔不混溶作用

Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus

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hLife 2024年第1期2卷 18-31页

作者： Zhenyang Liu Qi Peng Pu Han Lu Kuai Jianxun Qi yi shi CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Beijing Life Science Academy BeijingChina International Institute of Vaccine Research and Innovation Savaid Medical SchoolUniversity of Chinese Academy of SciencesBeijingChina Center for Influenza Research and Early-warning CAS-TWAS Center of Excellence for Emerging Infectious DiseaseChinese Academy of SciencesBeijingChina Research Unit of Adaptive Evolution and Control of Emerging Viruses Chinese Academy of Medical SciencesBeijingChina

Jingmenviruses are a group of flavi-like viruses with segmented genome and have been found in various types of hosts,including humans,cattle,monkeys,bats,rodents,sheep,ticks,mosquitoes and ***,including the Jingmen tick virus(JMTV)and Alongshan virus(ALSV),have been associated with febrile illness and flu-like symptoms in *** polymerase plays critical roles in genome replication and transcription and is an ideal target for antiviral ***,we determined the crystal structures of RNA-dependent RNA polymerase(RdRp)domains of JMTV and ALSV at 2.6Åand 3.2Åresolutions,*** overall structures of JMTV and ALSV RdRp domains are similar to those from the typical unsegmented viruses in Flaviviridae family,especially the Flavivirus *** and ALSV RdRps can be divided into three subdomains and the catalytical Motif A-G are conserved like the typical flaviviruses,whereas the zinc-binding pockets are absent from the JMTV and ALSV *** 50-ends of jingmenvirus genomes are varied in length and sequence,and a highly conserved 8-nucleotide element located on the tip of stem loop A was identified and shown to be required for binding with RdRp and performing de novo replication *** findings provide important structural insights into RdRp of segmented flavivirus and reveal the key region of virus genome responsible for replication initiation,which would promote molecular understanding of segmented flavivirus replication and the structure-based design of antiviral drugs against flaviviruses.

关键词： Jingmenviruses X-rays RNA-dependent RNA polymerase replication

Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer:Integrating Bioinformatics Analysis with Experimental Confirmation

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Current Medical Science 2024年第3期44卷 529-544页

作者： yan-min LIU Tie-cheng yANG Xiao-chang FANG Li-jie yANG Li-wen shi Hua-qiao WANG Ting-ting DOU Lin SHU Tian-Liang CHEN Jun HU Xiao-ming yU Xuan-fei LI Department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China Department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China Department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and *** We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western *** experiments were conducted in vitro to investigate the effects of SLC9A2 on tumor growth and *** We found 130 DEGs,with 45 up-regulated and 85 down-regulated in *** analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter *** pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling *** identified 10 hub genes:CXCL1,SLC26A3,CXCL2,MMP7,MMP1,SLC9A2,SLC4A4,CLCA1,CLCA4,and *** enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of *** expression analysis revealed that CXCL1,CXCL2,MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2,SLC26A3,and ZG16 were expressed at lower *** analysis revealed that 5 key genes were significantly associated with the prognosis of *** mRNA and protein expression levels of SLC9A2 were markedly reduced in CRC tissues and cell ***,SLC9A2 overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and *** blotting analysis revealed tha

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

强化异常威客汉姆酵母对白酒酿造中微生物结构及酯类合成的影响

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中国食品学报 2024年第6期24卷 278-287页

作者：石馨惠明田青王洪照河南工业大学生物工程学院郑州450001 工业微生物菌种保藏与选育河南省工程研究中心郑州450001 河南豫坡酒业有限责任公司河南驻马店463900

异常威客汉姆酵母在白酒酿造中利于酯类化合物的合成。酯类是白酒的重要风味物质,其种类、含量对白酒的品质起至关重要的作用。采用模拟固态发酵技术研究白酒生产中人工添加异常威客汉姆酵母改善白酒风味物质的机制。试验共分为两组:空... 详细信息

异常威客汉姆酵母在白酒酿造中利于酯类化合物的合成。酯类是白酒的重要风味物质,其种类、含量对白酒的品质起至关重要的作用。采用模拟固态发酵技术研究白酒生产中人工添加异常威客汉姆酵母改善白酒风味物质的机制。试验共分为两组:空白组(a组)和添加异常威客汉姆酵母y-1(b组),取不同发酵时期的酒醅样进行GC-MS分析,结果表明添加y-1菌株可显著提高酒醅样品中酯类及其它风味物质的含量,其中b组中浓香型白酒主体酯己酸乙酯含量显著高于a组(Py-1具有提升固态发酵白酒风味物质的能力,尚需在实际生产中做进一步验证。

关键词：异常威客汉姆酵母白酒固态发酵微生物强化高通量测序技术